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Clinical trials for Bone necrosis

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    64 result(s) found for: Bone necrosis. Displaying page 1 of 4.
    1  2  3  4  Next»
    EudraCT Number: 2010-022318-22 Sponsor Protocol Number: tutkijalähtöinen tutkimus, Start Date*: 2010-10-20
    Sponsor Name:Maarit Valkealahti / University hospital of Oulu
    Full Title: Tsoledronaatti hoito paikallista kiihtynyttä luunvaihdunta- oireyhtymää sairastavilla potilailla
    Medical condition: Tässä tutkimuksessa esitetään bisfosfonaatti –lääkkeen käyttöä uusissa indikaatioissa. Haemme tällä tutkimussuunnitelmalla lupaa kliiniseen tutkimukseen, jossa selvitetään, mikä on lääkkeen teho h...
    Disease: Version SOC Term Classification Code Term Level
    12.1 10031264 Osteonecrosis LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2015-000618-23 Sponsor Protocol Number: ORN-01 Start Date*: 2015-05-05
    Sponsor Name:Västra Götalandsregionen/NÄL
    Full Title: Treatment of osteoradionecrosis (ORN) with pentoxifylline and α-tocopherol (PENTO)
    Medical condition: Osteoradionecrosis
    Disease: Version SOC Term Classification Code Term Level
    18.0 10028395 - Musculoskeletal and connective tissue disorders 10031264 Osteonecrosis PT
    18.0 10022117 - Injury, poisoning and procedural complications 10067352 Osteoradionecrosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-000887-32 Sponsor Protocol Number: ORN-02 Start Date*: 2015-07-20
    Sponsor Name:Västra Götalandsregionen/NÄL
    Full Title: Prophylactic treatment of osteoradionecrosis (ORN) with pentoxifylline and α-tocopherol (PENTO)
    Medical condition: Osteoradionecrosis
    Disease: Version SOC Term Classification Code Term Level
    18.0 10028395 - Musculoskeletal and connective tissue disorders 10031264 Osteonecrosis PT
    18.0 10022117 - Injury, poisoning and procedural complications 10067352 Osteoradionecrosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-000886-35 Sponsor Protocol Number: AloFem Start Date*: 2018-06-27
    Sponsor Name:Enrique Gomez-Barrena
    Full Title: Evaluation of safety, feasibility and preliminary efficacy of MSCs from third party donors in the treatment of patients with osteonecrosis of the femoral head after allogeneic Stem Cell Transplanta...
    Medical condition: Osteonecrosis of the Femoral Head
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031264 Osteonecrosis PT
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10028395 Musculoskeletal and connective tissue disorders SOC
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10003860 Avascular necrosis femoral head LLT
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-019060-37 Sponsor Protocol Number: CH.MAX-FACC.02/2009 Start Date*: 2010-07-09
    Sponsor Name:AZIENDA OSPEDALIERA DI BOLOGNA POLICLINICO S. ORSOLA M. MALPIGHI
    Full Title: Clinical prospective study to evaluate the efficacy of hygienical therapy and metronidazole in addition to antibiotic therapy in patients affected by bisphosponate-associated osteonecrosis of the jaws
    Medical condition: patients affected by bisphosponate-associated osteonecrosis of the jaws and infection.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10031264 LLT
    9.1 10021864 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-012929-11 Sponsor Protocol Number: PREOB-ON3 Start Date*: 2011-10-17
    Sponsor Name:Bone Therapeutics S.A.
    Full Title: Phase III, pivotal, multicentre, randomised, double-blind controlled Study to evaluate the Efficacy and Safety of Autologous Osteoblastic Cells (PREOB®) Implantation in Early Stage Non Traumatic Os...
    Medical condition: Osteonecrosis of the Femoral Head
    Disease: Version SOC Term Classification Code Term Level
    18.1 10028395 - Musculoskeletal and connective tissue disorders 10031264 Osteonecrosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Prematurely Ended) DE (Completed) GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2012-002010-39 Sponsor Protocol Number: ORTHO-2 Start Date*: 2014-04-11
    Sponsor Name:Universidad Autónoma de Madrid
    Full Title: Evaluation of safety and feasibility of bone marrow derived autologous MSCs to enhance bone healing in patients with avascular necrosis of femoral head
    Medical condition: Early avascular necrosis of the femoral head (MRI diagnosis): Ficat and Arlet 0, 1, or 2 (Steinberg stages 0, I, IIA, IIB, or IIC)
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10028395 Musculoskeletal and connective tissue disorders SOC
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10003860 Avascular necrosis femoral head LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) IT (Ongoing) ES (Ongoing) RO (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-000624-20 Sponsor Protocol Number: ILONA Start Date*: 2021-06-17
    Sponsor Name:Leipzig University
    Full Title: Core decompression versus core decompression followed by infusion of Iloprost in the treatment of non-traumatic avascular necrosis of the femoral head
    Medical condition: non-traumatic avascular necrosis of the femoral head (N-ANFH)
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10003860 Avascular necrosis femoral head LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2017-002798-21 Sponsor Protocol Number: 13337 Start Date*: 2018-06-19
    Sponsor Name:University of Oxford
    Full Title: A multi-centre, blinded, randomised, placebo-controlled trial assessing the clinical and cost effectiveness of a 12 month course of oral alendronate (70mg weekly) in patients presenting with avascu...
    Medical condition: Early stage (Ficat 1 or 2), symptomatic, Avascular Necrosis (AVN) of the femoral head
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10005959 Bone disorders (excl congenital and fractures) HLGT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2014-001532-11 Sponsor Protocol Number: 01apr2014 Start Date*: 2014-09-11
    Sponsor Name:Ospedale San Raffaele
    Full Title: MONO-INSTITUTIONAL PHASE II TRIAL ADDRESSING TOLERABILITY AND ACTIVITY OF R-CHOP CHEMOIMMUNOTHERAPY PRECEDED BY BLOOD-BRAIN BARRIER PERMEABILIZATION BY NGR-TUMOR NECROSIS FACTOR IN PATIENTS WITH RE...
    Medical condition: Primary non-Hodgkin lymphoma in the central nervous system relapse / refractory
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-001820-51 Sponsor Protocol Number: BMC2012-PhaseII Start Date*: 2016-06-27
    Sponsor Name:Dekan der medizinischen Fakultät, Universitätsklinikum Frankfurt, Goethe-Universität
    Full Title: BMC2012, Cell based therapy by implanted bone marrow-derived mononuclear cells (BMC) for bone augmentation of plate-stabilized proximal humeral fractures - a randomized, open, multicentric study - ...
    Medical condition: Investigation of cell based therapy by implanted bone marrow-derived mononuclear cells for bone augmentation on osteosynthesis of proximal humeral fractures
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2010-019415-38 Sponsor Protocol Number: CZOL446HDE38T Start Date*: 2011-03-23
    Sponsor Name:Universitätsklinikum Würzburg
    Full Title: A prospective, bicentric, randomised, primarily double blind, placebo-controlled study to evaluate the efficacy of zoledronic acid for the treatment of bone marrow syndrome
    Medical condition: Determination of efficacy of Zoledronic Acid on the treatment of bone marrow edema syndrome.
    Disease: Version SOC Term Classification Code Term Level
    14.1 10005329 - Blood and lymphatic system disorders 10064277 Bone marrow edema syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2008-001972-55 Sponsor Protocol Number: 20963.091.08 Start Date*: 2009-09-30
    Sponsor Name:UMC St Radboud
    Full Title: Efficacy of hyperbaric oxygen therapy in the treatment of late radiation damage, osteoradionecrosis, of the lower jaw.
    Medical condition: Osteoradionecrosis of the jaw due to previous radiotherapy treatment in the head and neck region
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2017-003813-24 Sponsor Protocol Number: SIFU17 Start Date*: 2019-11-28
    Sponsor Name:Charité-Universitätsmedizin Berlin
    Full Title: A phase I/IIa, prospective, mono-center, randomized, open labeled, controlled study to assess the safety and efficacy of applying Iloprost locally in the fracture site to promote bone healing in pa...
    Medical condition: Proximal humeral fracture
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-019714-24 Sponsor Protocol Number: 10.002 Start Date*: 2010-09-02
    Sponsor Name:Research & Development Department
    Full Title: A phase II, open label, single site light dose escalation trial of single dose Verteporfin Photodynamic Therapy (PDT) in primary soft tissue sarcoma
    Medical condition: Primary soft tissue sarcoma in the upper and lower limbs of adults.
    Disease: Version SOC Term Classification Code Term Level
    13 10061271 Malignant soft tissue neoplasm LLT
    13 10039491 Sarcoma LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2016-005019-42 Sponsor Protocol Number: ET16-132 Start Date*: 2018-02-14
    Sponsor Name:Centre Léon Bérard
    Full Title: A European, multicenter, randomized, open-label, Phase II trial aiming to assess the clinical and biological activity of an anti-PD-L1 (atezolizumab) in operable localized soft tissue sarcomas pati...
    Medical condition: localised and operable soft tissue sarcomas
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10039491 Sarcoma PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2006-004817-16 Sponsor Protocol Number: MACI00206 Start Date*: 2008-01-23
    Sponsor Name:Genzyme Europe B.V.
    Full Title: A Prospective, Randomized, Open-Label, Parallel-Group, Multicenter Study to Demonstrate the Superiority of Matrix-induced Autologous Chondrocyte Implantation (MACI® implant) versus Arthroscopic Mi...
    Medical condition: Symptomatic Articular Cartilage Defects of the Femoral Condyle including the Trochlea. osteochondritis dissecans lesions that do not require a bone graft.
    Disease: Version SOC Term Classification Code Term Level
    13.1 10028395 - Musculoskeletal and connective tissue disorders 10031231 Osteochondritis dissecans LLT
    13.1 10022117 - Injury, poisoning and procedural complications 10007705 Cartilage damage LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed) CZ (Completed) SE (Completed) NL (Completed) PL (Completed) DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-003697-93 Sponsor Protocol Number: OXITIB2011 Start Date*: 2011-12-15
    Sponsor Name:Hospital Universitario de Canarias
    Full Title: Effectiveness of hyperbaric oxygen therapy in the treatment of the open tibial fractures. Open clinical trial, randomized, prospective and controlled.
    Medical condition: Open tibial fractures
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022117 - Injury, poisoning and procedural complications 10030647 Open fracture of unspecified part of tibia LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-003638-28 Sponsor Protocol Number: 2015/576 Start Date*: 2015-09-30
    Sponsor Name:Aarhus University Hospital
    Full Title: ALOSTRA Alendronate treatment of osteoporosis in rheumatoid arthritis – indication and duration. A randomized, doubleblind, placebocontrolled multi-centre study to evaluate the effects of disconti...
    Medical condition: Rheumatoid arthritis and osteoporosis
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10031289 Osteoporosis, unspecified LLT
    20.0 100000004859 10039076 Rheumatoid arthritis and other inflammatory polyarthropathies LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-006817-12 Sponsor Protocol Number: 2031-38 Start Date*: 2022-06-24
    Sponsor Name:ASSITANCE PUBLIQUE HOPITAUX DE MARSEILLE
    Full Title: Evaluation of the efficacy of an intra-articular injection of autologous microfat combined with autologous platelet-enriched plasma in the treatment of radiocarpal osteoarthritis: a randomized cont...
    Medical condition: radiocarpal osteoarthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
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