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Clinical trials for Headaches

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    178 result(s) found for: Headaches. Displaying page 1 of 9.
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    EudraCT Number: 2004-000850-22 Sponsor Protocol Number: 044(2A)SC04030 Start Date*: 2004-09-17
    Sponsor Name:ANGELINI
    Full Title: Evaluation of tolerability and analgesic activity of paracetamol 1000 mg+caffeine 130 mg in the treatment of tension-type headache. Randomized, double blind, double-dummy, cross-over study vs. napr...
    Medical condition: Evaluation of tolerability and analgesic activity in the treatment of tension-type headache
    Disease: Version SOC Term Classification Code Term Level
    10043269 PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2015-004436-34 Sponsor Protocol Number: CSOM230Y2201 Start Date*: 2017-02-06
    Sponsor Name:Novartis Pharma AG
    Full Title: A Multicenter, Placebo-Controlled, Single Dose Study in Acute Episodic and Chronic Cluster Headache to Evaluate the Safety and Efficacy of SOM230 subcutaneous (s.c.)
    Medical condition: Cluster headache
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029205 - Nervous system disorders 10059133 Cluster headache PT
    20.0 10029205 - Nervous system disorders 10009698 Cluster headaches LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-003505-85 Sponsor Protocol Number: FHED-01 ANZ0009 Start Date*: 2005-10-07
    Sponsor Name:Dermal Laboratories Limited
    Full Title: 4head User Evaluation.
    Medical condition: Tension-type headaches.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2018-001763-23 Sponsor Protocol Number: 2018-001763-23 Start Date*: 2018-06-27
    Sponsor Name:Reinier van Arkel
    Full Title: Treatment of headaches post-ECT with oxygen therapy; a proof of concept study
    Medical condition: Headaches occuring after electro conculsion therapy.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-001969-17 Sponsor Protocol Number: VML 251-3MRM02 Start Date*: 2005-01-10
    Sponsor Name:Vernalis Development Limited
    Full Title: A double-blind, placebo-controlled, parallel group study, with an open-label extension phase, to assess the efficacy, tolerability and safety of oral frovatriptan in the prevention of menstrually-r...
    Medical condition: Menstrually-Related Migraine (MRM)
    Disease:
    Population Age: Adolescents, Under 18, Adults Gender: Female
    Trial protocol: FI (Completed) SE (Completed) DE (Completed) GB (Completed) IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-003846-97 Sponsor Protocol Number: PS-2016-01 Start Date*: 2016-12-08
    Sponsor Name:Section of Orofacial Pain and Jaw Function, Aarhus University
    Full Title: Phenotypic and genotypic characterization of a tension-type headache population
    Medical condition: Tension-type headache
    Disease: Version SOC Term Classification Code Term Level
    19.0 10029205 - Nervous system disorders 10043269 Tension headache PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2020-004399-16 Sponsor Protocol Number: CHERUB01 Start Date*: 2021-04-28
    Sponsor Name:Charité - Universitätsmedizin Berlin
    Full Title: Efficacy of erenumab in chronic cluster headache: A 10-week double-blind, randomized, placebo-controlled, multicentric trial
    Medical condition: chronic cluster headache
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004852 10009698 Cluster headaches LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-000149-22 Sponsor Protocol Number: I5Q-MC-CGAL Start Date*: 2015-07-02
    Sponsor Name:Eli Lilly and Company
    Full Title: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study of LY2951742 in Patients with Episodic Cluster Headache
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004852 10009698 Cluster headaches LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) GB (Completed) DK (Completed) BE (Completed) FI (Completed) ES (Completed) NL (Completed) GR (Completed)
    Trial results: View results
    EudraCT Number: 2014-005429-11 Sponsor Protocol Number: I5Q-MC-CGAM Start Date*: 2015-07-14
    Sponsor Name:Eli Lilly and Company
    Full Title: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study of LY2951742 with a Long-Term Open-Label Extension in Patients with Chronic Cluster Headache
    Medical condition: Chronic Cluster Headache
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004852 10009698 Cluster headaches LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed) ES (Completed) DK (Completed) FI (Completed) BE (Completed) FR (Completed) NL (Completed) GR (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2010-019058-42 Sponsor Protocol Number: LITIO-SUM-FC-002 Start Date*: 2010-05-26
    Sponsor Name:AZIENDA OSPEDALIERO UNIVERSITARIA DI CAGLIARI
    Full Title: Safety of sumatriptan in combination with lithium for treatment of cluster headache, Pilot Study,Phase II
    Medical condition: Cluster Headache
    Disease: Version SOC Term Classification Code Term Level
    12.1 10019232 Headaches cluster LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2012-000248-91 Sponsor Protocol Number: BTACH2012 Start Date*: 2013-01-08
    Sponsor Name:Institutt for nevromedisin, NTNU
    Full Title: Endoscopic block of the sphenopalatine ganglion with botulinum toxin in intractable cluster headache. Safety issues.
    Medical condition: Pharmacological refractory cluster headache with durations of periods of attacks normally more than 2 months
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004852 10009698 Cluster headaches LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: View results
    EudraCT Number: 2011-006204-13 Sponsor Protocol Number: PredCH Start Date*: 2013-01-17
    Sponsor Name:University of Duisburg-Essen
    Full Title: Efficacy and safety of oral prednisone as add-on therapy in the prophylactic treatment of episodic cluster headache: a randomized, placebo controlled parallel study.
    Medical condition: Episodic Cluster Headache (ECH)
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004852 10009698 Cluster headaches LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2012-003729-62 Sponsor Protocol Number: R-Verapamil-001 Start Date*: 2013-01-16
    Sponsor Name:CENTER LABORATORIES, INC
    Full Title: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Phase 2 Study to Evaluate the Safety and Efficacy of R-Verapamil in the Prophylaxis of Episodic Cluster Headache
    Medical condition: Episodic Cluster Headache
    Disease: Version SOC Term Classification Code Term Level
    15.0 10029205 - Nervous system disorders 10059133 Cluster headache PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-003736-38 Sponsor Protocol Number: BIA-2093-209 Start Date*: 2009-02-17
    Sponsor Name:BIAL-Portela & Ca, S.A.
    Full Title: Efficacy and safety of Eslicarbazepine acetate as preventive therapy for patients with migraine: a double-blind, randomised, placebo-controlled, parallel-group, multicentre clinical trial
    Medical condition: Adult patients with migraine with or without aura
    Disease: Version SOC Term Classification Code Term Level
    9.1 10027599 Migraine LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: LT (Completed) DE (Completed) AT (Completed) ES (Completed) PT (Completed) SK (Completed) CZ (Completed) BG (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2019-002603-17 Sponsor Protocol Number: H8H-MC-LAHX Start Date*: 2020-08-04
    Sponsor Name:Eli Lilly and Company
    Full Title: A Phase 1, Open-Label, Single-Dose Pharmacokinetic Study of Lasmiditan in Pediatric Patients With Migraine
    Medical condition: Migraine
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2007-002435-93 Sponsor Protocol Number: UNITHER/UN/07/001 Start Date*: 2007-09-20
    Sponsor Name:UNITHER PHARMACEUTICALS
    Full Title: Evaluation d'une solution hydro-alcoolique de sumatriptan administrée par voie sublinguale dans le traitement d'une crise d'algie vasculaire de la face, à la dose de 2mg, 4mg ou 6mg déterminée par ...
    Medical condition: Cluster headaches
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-004999-36 Sponsor Protocol Number: BCBe/04/FRO-CLU/001 Start Date*: 2006-11-06
    Sponsor Name:Berlin-Chemie AG
    Full Title: Effects of Frovatriptan as Prophylactic Treatment of Cluster Headache, a Multi-Center, Placebo Controlled, Randomized, Double-Blind Prospective Phase III Parallel-Group Trial Comparing Frovatriptan...
    Medical condition: Episodic cluster headache
    Disease: Version SOC Term Classification Code Term Level
    8.0 10009698 LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2020-001968-28 Sponsor Protocol Number: 19385A Start Date*: 2022-02-24
    Sponsor Name:H. Lundbeck A/S
    Full Title: Interventional, open-label, fixed-dose multiple administration study to evaluate long-term treatment with eptinezumab in patients with chronic cluster headache
    Medical condition: Chronic cluster headache
    Disease: Version SOC Term Classification Code Term Level
    24.0 10029205 - Nervous system disorders 10059133 Cluster headache PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) DK (Completed) NL (Completed) FI (Completed) ES (Ongoing) IT (Completed)
    Trial results: View results
    EudraCT Number: 2017-004351-23 Sponsor Protocol Number: I5Q-MC-CGAS Start Date*: 2021-02-22
    Sponsor Name:Eli Lilly and Company
    Full Title: A Randomized, Double-Blind, Placebo-Controlled Study of Galcanezumab in Patients 6 to 17 Years of Age with Episodic Migraine – the REBUILD-1 Study
    Medical condition: Episodic Migraine
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004852 10027602 Migraine headache LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: DK (Trial now transitioned) DE (Completed) IT (Trial now transitioned) NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2013-001707-36 Sponsor Protocol Number: 20120295 Start Date*: 2014-02-26
    Sponsor Name:Amgen Inc.
    Full Title: A Phase 2, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of AMG 334 in Chronic Migraine Prevention
    Medical condition: Prevention of chronic migraine
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004852 10027608 Migraine, unspecified LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) SE (Completed) NO (Completed) FI (Completed) DK (Completed) PL (Completed) CZ (Completed) GB (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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