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Clinical trials for Hypercapnia

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43871   clinical trials with a EudraCT protocol, of which   7290   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    12 result(s) found for: Hypercapnia. Displaying page 1 of 1.
    EudraCT Number: 2012-001849-41 Sponsor Protocol Number: DOX-101 Start Date*: 2012-06-18
    Sponsor Name:Leids Universitair Medisch Centrum (LUMC)
    Full Title: Two-part, Randomized, Placebo-controlled, Repeated Stepped Infusion Dose Study of the Pharmacodynamics of Doxapram when Co-administered with Opioids (Protocol – doxapram-101).
    Medical condition: acute respiratory insufficiency, including such conditions as opioid and anesthetic-induced respiratory depression, post-anesthetic atelectasis, and central apneas (e.g., apnea of prematurity).
    Disease: Version SOC Term Classification Code Term Level
    14.1 10038738 - Respiratory, thoracic and mediastinal disorders 10038738 Respiratory, thoracic and mediastinal disorders SOC
    Population Age: Adults Gender: Male
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-005222-19 Sponsor Protocol Number: BREATH Start Date*: 2016-07-14
    Sponsor Name:Leiden University Medical Center
    Full Title: Effect of neuromuscular blockade and reversal by sugammadex versus neostigmine on breathing when hypoxic or hypercapnic in volunteers
    Medical condition: Postoperative ventilatory control
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004855 10038680 Respiratory depression postoper LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-000497-38 Sponsor Protocol Number: DEX-PCH-VMNI Start Date*: 2016-08-23
    Sponsor Name:Ana Vallejo De la Cueva
    Full Title: Dexmedetomidine versus current clinical practice for non-invasive mechanical ventilation: a randomized clinical trial
    Medical condition: Accute respiratory insuffienciency
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-003781-17 Sponsor Protocol Number: CCM S78/407 Start Date*: 2007-07-16
    Sponsor Name:FONDAZIONE MONZINO CENTRO CARDIOLOGICO
    Full Title: COMPARED EFFECTS OF THREE DIFFERENT BETA BLOCKERS (CARVEDILOL, BISOPROLOL AND NEBIVOLOL) ON EXERCISE CAPACITY, PULMONARY FUNCTION AND RESPONSE TO HYPOXIA IN CHRONIC HEART FAILURE
    Medical condition: chronic heart failure
    Disease: Version SOC Term Classification Code Term Level
    6.1 10007558 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-005383-42 Sponsor Protocol Number: BREATH Start Date*: 2016-05-19
    Sponsor Name:FONDAZIONE TOSCANA GABRIELE MONASTERIO
    Full Title: Use of buspiron in chemioreflex modulation and central apnea treatment in heart failure patients (BREATH: BuspiRon for chEmoreflex modulation and central Apnea treatment in Heart failure patients)....
    Medical condition: patient with central apneas syndrome and heart failure
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10011949 Decompensation cardiac LLT
    20.0 100000004852 10040978 Sleep apnoeas HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2013-005107-13 Sponsor Protocol Number: 002083935121 Start Date*: 2015-01-27
    Sponsor Name:Epsom and St Helier University Hospitals NHS Trust R&D Dpt
    Full Title: A pilot study of the use of oral modafinil added to standard care in hypercapnic respiratory failure in COPD
    Medical condition: Hypercapnic respiratory failure in COPD
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2009-013340-36 Sponsor Protocol Number: RPT02 Start Date*: 2010-01-25
    Sponsor Name:IST. DI RICERCHE FARMACOLOG. M. NEGRI
    Full Title: PREVENTION OF REPERFUSION INJURY IN HUMAN LUNG TRANSPLANTATION FOR CYSTIC FIBROSIS BY TARGETING IL-8 ACTIVITY
    Medical condition: cystic fibrosis
    Disease: Version SOC Term Classification Code Term Level
    12.1 10011762 Cystic fibrosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2019-002498-80 Sponsor Protocol Number: 06062019 Start Date*: 2019-09-24
    Sponsor Name:Mikkel Brabrand
    Full Title: Will titrated oxygen flow to a peripheral oxygen saturation of 88-92% compared with oxygen flow to a saturation >94% reduce mortality in Chronic Obstructive Pulmonary Disease patients with acute ex...
    Medical condition: Acute COPD Exacerbation
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004855 10010953 COPD exacerbation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-002466-39 Sponsor Protocol Number: MVD-PROT-001 Start Date*: 2019-04-17
    Sponsor Name:University Medical Center Groningen
    Full Title: Morphine or Fentanyl for Refractory dyspnea in COPD
    Medical condition: Chronic Obstructive Pulmonary Disease, COPD
    Disease: Version SOC Term Classification Code Term Level
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10009033 Chronic obstructive pulmonary disease PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-007775-17 Sponsor Protocol Number: ALMED-07-C2-017 Start Date*: 2009-10-14
    Sponsor Name:Air Liquide
    Full Title: A single centre, exploratory, phase II, cross-over, randomised trial, evaluating the effect of spontaneously breathing Helium/Oxygen (65%/35%), to either spontaneously breating Nitrogen/Oxygen (65%...
    Medical condition: Severe chronic obstructive pneumonary disease (COPD) patients during a Six-Minute Walking Test
    Disease: Version SOC Term Classification Code Term Level
    12.0 10009033 Chronic obstructive pulmonary disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2005-005537-35 Sponsor Protocol Number: E5564-G000-301 Start Date*: 2006-08-30
    Sponsor Name:Eisai Limited
    Full Title: ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients with Severe Sepsis
    Medical condition: Severe Sepsis
    Disease: Version SOC Term Classification Code Term Level
    8.1 10040047 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) NL (Completed) AT (Completed) CZ (Completed) ES (Completed) DE (Completed) PT (Prematurely Ended) IT (Prematurely Ended) GB (Completed)
    Trial results: View results
    EudraCT Number: 2020-001349-37 Sponsor Protocol Number: COVID-19-HBO Start Date*: 2020-05-08
    Sponsor Name:Karolinska Institutet
    Full Title: A Randomized, Controlled, Open Label, Multicentre Clinical Trial to explore Safety and Efficacy of Hyperbaric Oxygen for preventing ICU admission, Morbidity and Mortality in Adult Patients With CO...
    Medical condition: COVID-19 (SARS-CoV-2)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Prematurely Ended) DE (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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