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Clinical trials for Liver

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    5,504 result(s) found for: Liver. Displaying page 1 of 276.
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    EudraCT Number: 2010-024604-10 Sponsor Protocol Number: S52898 Start Date*: 2011-03-18
    Sponsor Name:UZ Gasthuisberg Leuven
    Full Title: An open-label, Phase II clinical study to evaluate the efficacy and safety of lanreotide autogel 90mg every 4 weeks in the treatment of symptomatic polycystic liver disease, including a dose escala...
    Medical condition: Polycystic liver disease
    Disease: Version SOC Term Classification Code Term Level
    12.1 10048834 Polycystic liver disease LLT
    12.1 10048834 Polycystic liver disease PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2009-016640-39 Sponsor Protocol Number: PCLD003 Start Date*: 2010-05-31
    Sponsor Name:Radboud University Nijmegen Medical Centre
    Full Title: Everolimus added to long acting octreotide as a volume reducing treatment of polycystic livers.
    Medical condition: Isolated polycystic liver disease
    Disease: Version SOC Term Classification Code Term Level
    12.1 10048834 Polycystic liver disease LLT
    12.1 10048834 Polycystic liver disease PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2012-000834-21 Sponsor Protocol Number: POCHER-2/AIRC11770 Start Date*: 2012-04-01
    Sponsor Name:ISTITUTI FISIOTERAPICI OSPITALIERI
    Full Title: Molecular Biomarkers for Colorectal Liver Metastases Resectability after Chemotherapy with Cetuximab
    Medical condition: PATIENTS WITH LIVER COLORECTAL METASTASES NOT CANDIDATED TO SURGERY
    Disease: Version SOC Term Classification Code Term Level
    14.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10024700 Liver metastases LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-005197-51 Sponsor Protocol Number: 14650 Start Date*: 2008-07-24
    Sponsor Name:The Netherlands Cancer Institute/ Antoni van Leeuwenhoek hospital [...]
    1. The Netherlands Cancer Institute/ Antoni van Leeuwenhoek hospital
    2. Radboud University Nijmegen Medical Center
    Full Title: Accelerated growth of synchronous colorectal liver metastases: effects of neo-adjuvant therapy
    Medical condition: synchronous liver metastases in patients with the primary colorectal tumour in situ
    Disease: Version SOC Term Classification Code Term Level
    8.1 10024700 Liver metastases LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-021333-31 Sponsor Protocol Number: TOP2010-LMU Start Date*: 2011-08-23
    Sponsor Name:Klinikum der Universität München
    Full Title: Reduktion des Ischämie-Reperfusionsschadens durch ex-vivo Tacrolimus-Perfusion marginaler Organe vor Lebertransplantation (Tacrolimus-Organ-Perfusion TOP-Studie)
    Medical condition: Chonical terminal liver insufficiency
    Disease: Version SOC Term Classification Code Term Level
    14.1 10042613 - Surgical and medical procedures 10024714 Liver transplant PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-003275-40 Sponsor Protocol Number: 63/2007/O/Sper Start Date*: 2008-07-29
    Sponsor Name:AZIENDA OSPEDALIERA DI BOLOGNA POLICLINICO S. ORSOLA M. MALPIGHI
    Full Title: New immunosuppressive treatments to reduce the rate of recurrence of hepatocellular carcinoma after liver transplantation
    Medical condition: Liver transplantation in patients with hepatocellular carcinoma
    Disease: Version SOC Term Classification Code Term Level
    9.1 10019695 Hepatic neoplasm LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-001222-83 Sponsor Protocol Number: HHSC/001 Start Date*: 2005-12-09
    Sponsor Name:Imperial College London
    Full Title: A phase I/II safety and tolerability dose escalation study following the autologous infusion of expanded adult haemopoietic stem cells to patients with liver insufficiency
    Medical condition: Chronic liver insufficiency
    Disease: Version SOC Term Classification Code Term Level
    9.1 10024667 Liver cirrhosis LLT
    9.1 10024670 Liver disorder LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2020-006023-33 Sponsor Protocol Number: SIMFIB Start Date*: 2021-10-26
    Sponsor Name:Institut d’Investigacions Biomèdiques August Pi i Sunyer
    Full Title: Efficacy of simvastatin reducing liver fibrosis in patients with advanced fibrosis due to alcohol: a randomized, double-blind, placebo-controlled clinical trial.
    Medical condition: reduction of liver fibrosis in patients with advanced fibrosis due to alcohol
    Disease: Version SOC Term Classification Code Term Level
    20.1 10019805 - Hepatobiliary disorders 10001627 Alcoholic liver disease PT
    20.0 10019805 - Hepatobiliary disorders 10019668 Hepatic fibrosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-008319-24 Sponsor Protocol Number: AGO/2008/015 Start Date*: 2009-02-17
    Sponsor Name:University Hospital Ghent
    Full Title: A single-center, randomized, double blind, placebo-controlled study to evaluate the efficacy and safety of Somatostatin used as inflow modulator in liver transplantation.
    Medical condition: Cirrhotic patients receiving a primary liver transplant
    Disease: Version SOC Term Classification Code Term Level
    9.1 10024667 Liver cirrhosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-005454-35 Sponsor Protocol Number: MG001 Start Date*: 2013-03-13
    Sponsor Name:Hanna Pitkänen
    Full Title: Can magnesium enhance blood coagulation amongst patients with alcohol induced liver cirrhosis?
    Medical condition: Liver transplant candidates with alcohol induced liver cirrhosis and hypomagnesemia (P-Mg under 0,71 or magnesium substitution at least 750 mg/day)
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004871 10024667 Liver cirrhosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2011-006227-38 Sponsor Protocol Number: 11.017 Start Date*: 2012-05-01
    Sponsor Name:Ove B. Schaffalitzky de Muckadell
    Full Title: “Assessment of fibrotic liver disease in a medical admission ward and intervention with losartan as antifibrotic therapy in patients with alcoholic liverdisease”
    Medical condition: Fibrotic alcoholic liver disease is in early stages often completely asymptomatic. Fully developed cirrhosis affect a wide range of physiological conditions. Eksamples are portal hypertension and f...
    Disease: Version SOC Term Classification Code Term Level
    14.1 10019805 - Hepatobiliary disorders 10001627 Alcoholic liver disease PT
    14.1 10019805 - Hepatobiliary disorders 10001626 Alcoholic liver damage, unspecified LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2009-012115-18 Sponsor Protocol Number: IMP13617 Start Date*: 2010-03-22
    Sponsor Name:UMC Utrecht
    Full Title: Primovist enhanced MRI for the detection and evaluation of focal liver lesions
    Medical condition: All benign and malignant focal liver lesions e.g. colorectal liver metastases, HCC, haemangioma, adenoma, cysts, FNH.
    Disease: Version SOC Term Classification Code Term Level
    12.0 10024658 Liver carcinoma LLT
    12.0 10027479 Metastatic liver carcinoma LLT
    12.0 10019827 Hepatocellular adenoma LLT
    12.0 10049010 Carcinoma hepatocellular LLT
    12.0 10019396 Hemangioma of liver LLT
    12.0 10048834 Polycystic liver disease LLT
    12.0 10052285 Focal nodular hyperplasia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-001361-15 Sponsor Protocol Number: CAEB071B2101 Start Date*: 2008-01-28
    Sponsor Name:NOVARTIS FARMA
    Full Title: An open-label, two-period, multi-center, single dose study to assess the pharmacokinetics of AEB071 in de novo liver transplant patients
    Medical condition: liver transplant
    Disease: Version SOC Term Classification Code Term Level
    6.1 10024714 PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2009-015890-11 Sponsor Protocol Number: AGO/2009/007 Start Date*: 2009-11-03
    Sponsor Name:University Hospital Ghent
    Full Title: Conditioning with volatile anesthetics in liver transplantation
    Medical condition: Liver transplantation
    Disease: Version SOC Term Classification Code Term Level
    12.0 10024716 Liver transplantation LLT
    Population Age: Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2005-001503-19 Sponsor Protocol Number: IEO S 238/205 Start Date*: 2005-07-06
    Sponsor Name:ISTITUTO EUROPEO DI ONCOLOGIA
    Full Title: CLINICAL AND BIOLOGICAL STUDY ON THE ADMINISTRATION OF THALIDOMIDE IN PATIENTS WITH PRIMARY CANCER OF THE LIVER
    Medical condition: PRIMARY CANCER OF THE LIVER
    Disease: Version SOC Term Classification Code Term Level
    6.1 10019695 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-007989-34 Sponsor Protocol Number: PENTA-CIRRO Start Date*: 2009-09-09
    Sponsor Name:AZIENDA OSPEDALIERA POLICLINICO DI MODENA
    Full Title: Use of policlonal immunoglobulins (Pentaglobin) in the treatment of sepsis in cirrhotic patients awaiting for liver transplantation.
    Medical condition: Sepsis in cirrhotic patients.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10019641 PT
    9.1 10053840 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2012-001449-42 Sponsor Protocol Number: VITDCirrhosis2012 Start Date*: 2014-10-03
    Sponsor Name:Medizinische Universität Graz, Kl. Abt. f. Endokrinoloie u. Stoffwechsel & Kl. Abt. f. Gastroenterologie u. Hepatologie
    Full Title: A randomized, double-blind, placebo controlled trial to evaluate vitamin D supplementation on serum 25 hydroxy- vitamin D level in cirrhotic patients
    Medical condition: decompensated and compensated liver cirrhosis
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004871 10024667 Liver cirrhosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2009-010335-41 Sponsor Protocol Number: RRK3728 Start Date*: 2009-06-30
    Sponsor Name:University of Birmingham
    Full Title: A MULTICENTRE, PHASE II, OPEN LABEL, RANDOMISED CONTROLLED TRIAL OF REPEATED AUTOLOGOUS INFUSIONS OF G-CSF MOBILISED CD133+ BONE MARROW STEM CELLS IN PATIENTS WITH CIRRHOSIS
    Medical condition: Liver Cirrhosis
    Disease: Version SOC Term Classification Code Term Level
    14.1 10010331 - Congenital, familial and genetic disorders 10001806 Alpha-1 anti-trypsin deficiency PT
    14.1 10019805 - Hepatobiliary disorders 10009211 Cirrhosis liver LLT
    14.1 10019805 - Hepatobiliary disorders 10024667 Liver cirrhosis LLT
    14.1 10019805 - Hepatobiliary disorders 10064844 Compensated cirrhosis LLT
    14.1 10019805 - Hepatobiliary disorders 10019641 Hepatic cirrhosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2013-002409-75 Sponsor Protocol Number: Dota-PrimoLIV Start Date*: 2014-01-06
    Sponsor Name:Charite
    Full Title: Intra-individual, comparison of the MRI contrast agents gadoxetic acid (Primovist®) versus gadoterate meglumine (Dotarem®) in liver MRI of patients with HCC and underlying cirrhosis
    Medical condition: Patients with liver cirrhosis and diagnosis of hepatocellular carcinoma based on noninvasive HCC diagnostic (EASL) criteria
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004871 10024667 Liver cirrhosis LLT
    18.1 100000004864 10049010 Carcinoma hepatocellular LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2016-000628-24 Sponsor Protocol Number: MO16/053 Start Date*: 2018-01-12
    Sponsor Name:University of Leeds
    Full Title: A randomised placebo-controlled phase III trial of the effect of the omega-3 fatty acid eicosapentaenoic acid (EPA) on colorectal cancer recurrence and survival after surgery for resectable liver m...
    Medical condition: Colorectal cancer liver metastases
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004864 10007095 Cancer of liver, secondary LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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