Flag of the European Union EU Clinical Trials Register Help

Clinical trials for Nicotine withdrawal

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
    How to search [pdf]
    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
    Advanced Search: Search tools
     
    47 result(s) found for: Nicotine withdrawal. Displaying page 1 of 3.
    1  2  3  Next»
    EudraCT Number: 2007-002374-55 Sponsor Protocol Number: S3250493 Start Date*: 2007-08-10
    Sponsor Name:GlaxoSmithKline Consumer Healthcare
    Full Title: Simultaneous fMRI/EEG of the 4 mg nicotine lozenge in relief of cognitive impairment associated with nicotine withdrawal
    Medical condition: Nicotine dependence
    Disease: Version SOC Term Classification Code Term Level
    9.1 10057852 Nicotine dependence LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-006433-28 Sponsor Protocol Number: RG_08_082_a02 Start Date*: 2009-01-20
    Sponsor Name:University of Birmingham
    Full Title: Rapid reduction versus abrupt quitting for smokers who want to stop soon: a randomised controlled non-inferiority trial.
    Medical condition: Smoking and nicotine addiction.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10056478 Nicotine addiction LLT
    9.1 10056484 Nicotine craving LLT
    9.1 10057852 Nicotine dependence LLT
    9.1 10008374 Cessation of smoking LLT
    9.1 10053325 Smoking cessation therapy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2007-003250-29 Sponsor Protocol Number: IPAB-07-002 Start Date*: 2008-03-14
    Sponsor Name:Independent Pharmaceutica AB
    Full Title: A randomised, placebo-controlled, multi-centre study on the efficacy of Niccine, a vaccine for nicotine, in smoking relapse prevention, assessed in abstinent, adult smokers.
    Medical condition: The intended indication for the drug under investigation is smoking relapse prevention. Tobacco smoking has been identified as the single largest preventable cause of morbidity and premature death ...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10056478 Nicotine addiction LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed) DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-006458-24 Sponsor Protocol Number: V00116 TD 201 Start Date*: 2008-01-23
    Sponsor Name:PIERRE FABRE MEDICAMENT
    Full Title: Analysis of the sensory profile of two new transdermal patches (V0116TD07AF019 and V0116TD07AF020) 21 mg/24h versus a reference transdermal patch (NICOTINELL TTS) 21 mg/24h.
    Medical condition: Healthy volunteers, occasional or regular smokers. Intended indication: Relief of nicotine withdrawal symptoms, in nicotine dependency as an aid to smoking cessation.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10057852 Nicotine dependence LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2007-002203-40 Sponsor Protocol Number: 07.0056 Start Date*: 2007-10-03
    Sponsor Name:St. George's, University of London
    Full Title: Effect of hydrocortisone on desire to smoke and tobacco withdrawal symptoms
    Medical condition: Nicotine addiction; specifically, cortisol deficiency following smoking cessation.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10056478 Nicotine addiction LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-005363-34 Sponsor Protocol Number: EC/2008/50/FAHS Start Date*: 2009-03-10
    Sponsor Name:University of Surrey
    Full Title: Investigation to explore whether there is a synergistic effect between nicotine replacement therapy and guided bodyscanning on cigarette cravings and withdrawal symptoms in temporarily abstinent sm...
    Medical condition: Healthy volunteers who currently smoke 10 or more cigarettes per day, for the last 3 years. The trial intends to explore whether there is a synergistic effect between the relaxation technique of g...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10056484 Nicotine craving LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-005565-20 Sponsor Protocol Number: QMUL111111 Start Date*: 2012-05-02
    Sponsor Name:QUEEN MARY, UNIVERSITY OF LONDON
    Full Title: Comparison of the effects of the electronic cigarette and nicotine inhalator on tobacco withdrawal symptoms over 24 hours of abstinence
    Medical condition: Nicotine withdrawal state
    Disease: Version SOC Term Classification Code Term Level
    14.1 10037175 - Psychiatric disorders 10056484 Nicotine craving LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-002498-11 Sponsor Protocol Number: NICTDP2010 Start Date*: 2008-11-28
    Sponsor Name:McNeil AB
    Full Title: PILOT STUDY ON USAGE PATTERNS OF A NOVEL NICOTINE REPLACEMENT THERAPY - A MULTI-CENTER, OPEN, 3-WEEK RANDOMIZED LOW INTERVENTION STUDY OF TWO DIFFERENT DIRECTIONS FOR USE IN SMOKERS MOTIVATED TO QUIT
    Medical condition: Smoking cessation
    Disease: Version SOC Term Classification Code Term Level
    9.1 10057852 Nicotine dependence LLT
    9.1 10059612 Tobacco withdrawal symptoms LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2004-001607-35 Sponsor Protocol Number: A3051044 Start Date*: 2005-01-26
    Sponsor Name:Pfizer Ltd.
    Full Title: AN OPEN-LABEL, MULTICENTER STUDY WITH FOLLOW-UP EVALUATING THE SAFETY AND EFFICACY OF VARENICLINE TARTRATE IN COMPARISON TO TRANSDERMAL NICOTINE PATCH FOR SMOKING CESSATION
    Medical condition: Partial nicotine agonist for use as an aid to smoking cessation.
    Disease: Version SOC Term Classification Code Term Level
    7.1 10057852 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2005-005307-42 Sponsor Protocol Number: S2540345 Start Date*: 2006-01-03
    Sponsor Name:GlaxoSmithKline Consumer Healthcare
    Full Title: An evaluation of the 4 mg nicotine mint lozenge for the relief of cognitive impairment associated with nicotine withdrawal.
    Medical condition: Nicotine dependence.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-002796-41 Sponsor Protocol Number: NICTDP0002 Start Date*: 2011-09-29
    Sponsor Name:McNeil AB
    Full Title: A PROOF OF CONCEPT WITH A NEW NICOTINE INHALER IN COMPARISON WITH NICOTINE INHALER 10 MG - AN EXPLORATORY STUDY IN ADULT HEALTHY SMOKERS
    Medical condition: Tobacco Dependence
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2017-004715-40 Sponsor Protocol Number: BRU-VCN-2017 Start Date*: 2018-07-04
    Sponsor Name:Fundació Hospital Universitari Vall d’Hebron-Institut de Recerca (VHIR)
    Full Title: An effectiveness and safety study of Varenicline for smoking cessation in hospitalized patients with psychiatric disorders.
    Medical condition: Smoking cessation in hospitalized patients with psychiatric disorders.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2010-022835-13 Sponsor Protocol Number: WS776945 Start Date*: 2010-10-18
    Sponsor Name:UNIVERSITA` DEGLI STUDI DI FIRENZE - DIPARTIMENTO DI PSICOLOGIA
    Full Title: The Effects of Nicotine withdrawal on Panic-like Response to Breath Holding: A Placebo-Controlled, Double-Blind, Cross-Over Patch Study
    Medical condition: healthy current smokers
    Disease: Version SOC Term Classification Code Term Level
    9.1 10009180 LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-006189-32 Sponsor Protocol Number: P1.3./23.12.05 Start Date*: 2006-09-29
    Sponsor Name:Steiermärkische Gebietskrankenkasse
    Full Title: Clinical evaluation study: "Bupropion versus Psychodynamic mental training according to Dr. Grohs for smoke withdrawal" (Klinische Evaluierungsstudie: "Bupropion versus Psychodynamisches Mentaltra...
    Medical condition: nicotine addiction
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-004229-10 Sponsor Protocol Number: CCSSMC000766 Start Date*: 2019-07-19
    Sponsor Name:McNeil AB
    Full Title: DOUBLE-BLIND, PLACEBO CONTROLLED STUDY OF PHARMACODYNAMIC EFFECTS OF 4 MG NICOTINE GUM. A STUDY IN HEALTHY SMOKERS WILLING TO QUIT
    Medical condition: Healthy Volunteers between 19 and 60 years of age motivated and willing to quit smoking.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10037175 - Psychiatric disorders 10057852 Nicotine dependence PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: PL (Completed)
    Trial results: View results
    EudraCT Number: 2009-017862-22 Sponsor Protocol Number: 200110005 Start Date*: 2010-09-28
    Sponsor Name:ZonMw
    Full Title: The effectiveness of Nicotine Replacement Therapy for young people aged 12 to 18 years
    Medical condition: Smoking among young people aged 12 – 18 years.
    Disease: Version SOC Term Classification Code Term Level
    12.1 10053325 Smoking cessation therapy LLT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-004692-36 Sponsor Protocol Number: VAR/01/011 Start Date*: 2011-11-30
    Sponsor Name:HOSPITAL UNIVERSITARI DE BELLVITGE
    Full Title: COMBIVAR. Randomized double-blind trial of two parallel groups design to evaluate the efficacy of smoking cessation with combined (varenicline plus nicotine patches) versus monotherapy (varenicline)
    Medical condition: NICOTINE DEPENDENCE.
    Disease: Version SOC Term Classification Code Term Level
    14.0 10037175 - Psychiatric disorders 10032707 Other specified drug dependence, continuous use LLT
    14.0 10037175 - Psychiatric disorders 10012336 Dependence addictive LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-003588-37 Sponsor Protocol Number: P150952J Start Date*: 2018-05-09
    Sponsor Name:ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
    Full Title: A randomized, placebo controlled, double blind, double dummy, multicenter trial comparing electronic cigarettes with nicotine to varenicline and to electronic cigarettes without nicotine
    Medical condition: Smokers smoking at least 10 cigarettes/day in the past year
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10053325 Smoking cessation therapy PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2018-002829-33 Sponsor Protocol Number: nl_060.32043 Start Date*: 2019-08-28
    Sponsor Name:TNO
    Full Title: Memory reconsolidation: a new treatment approach towards nicotine addiction.
    Medical condition: nicotine addiction
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-005894-36 Sponsor Protocol Number: ZonMw61200014/Nabi4508 Start Date*: 2009-04-27
    Sponsor Name:ZonMw [...]
    1. ZonMw
    2. nabi biopharmaceuticals
    Full Title: A Phase 2B, Multi-Center, Randomized, Double-Blinded, Parallel-Arm Study to Assess Efficacy and Safety of 3’-aminomethylnicotine-P. aeruginosa r-Exoprotein A Conjugate Vaccine (NicVAX®) or placebo,...
    Medical condition: Smoking: Subjects must be smoking an average of at least 10 cigarettes per day during the past year and over the month prior to the screening visit, with no period of abstinence greater than 3 mont...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10053325 Smoking cessation therapy LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    Download Options:
    Number of Trials to download:
    Download Content:
    Download Format:
    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
    1  2  3  Next»
    Query did not match any studies.
    For support, Contact us.
    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

    European Medicines Agency © 1995-Mon May 12 07:00:57 CEST 2025 | Domenico Scarlattilaan 6, 1083 HS Amsterdam, The Netherlands
    EMA HMA