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Clinical trials for Orthopedic surgery

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44347   clinical trials with a EudraCT protocol, of which   7375   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    71 result(s) found for: Orthopedic surgery. Displaying page 1 of 4.
    1  2  3  4  Next»
    EudraCT Number: 2023-000172-36 Sponsor Protocol Number: CHUB-Methadone Start Date*: 2023-02-28
    Sponsor Name:CHU Brugmann
    Full Title: Intraoperative methadone for the prevention of postoperative pain: a randomized, double-blind clinical study in orthopedic surgery.
    Medical condition: Orthopedic surgery
    Disease: Version SOC Term Classification Code Term Level
    23.1 10042613 - Surgical and medical procedures 10051079 Orthopedic procedure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2013-001607-36 Sponsor Protocol Number: 1 Start Date*: 2013-08-23
    Sponsor Name:SLL
    Full Title: Diagnosis of infection in prothesis by 18F-FDG-WBC-PET/CT
    Medical condition: orthopedic prothesis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2012-000941-11 Sponsor Protocol Number: GMRA-102,Am.No.1 Start Date*: 2013-03-27
    Sponsor Name:Bracco Imaging S.p.A.
    Full Title: A PROSPECTIVE MULTICENTER COHORT STUDY EVALUATING THE LONG TERM RETENTION OF GADOLINIUM IN HUMAN BONE AND SKIN AFTER THE RETROSPECTIVE ADMINISTRATION OF MULTIHANCE® OR PROHANCE® IN COMPARISON WITH...
    Medical condition: Nephrogenic Systemic Fibrosis (NSF)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: View results
    EudraCT Number: 2019-001134-33 Sponsor Protocol Number: 012329 Start Date*: 2019-06-18
    Sponsor Name:Aarhus University Hospital
    Full Title: Does repeated administration of cefuroxime after orthopedic surgery provide a better prophylactic profile regarding postoperativ infection than a single administration of preoperative antimicrobia...
    Medical condition: Orthopedic infections.
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10043658 Thumb osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2013-001138-17 Sponsor Protocol Number: 240583 Start Date*: 2013-07-11
    Sponsor Name:Orthopedic Research in Aarhus
    Full Title: In vivo measurement of cefuroxime in subcutaneous and bone tissue using microdialysis
    Medical condition: Orthopedic infections
    Disease: Version SOC Term Classification Code Term Level
    16.0 100000004865 10050155 Knee prosthesis insertion LLT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2020-003078-36 Sponsor Protocol Number: 727258 Start Date*: 2020-09-14
    Sponsor Name:Aarhus University Hospital
    Full Title: The RAS-study A reverse and anatomical prosthesis shoulder study Can we improve the prophylactic profile of antibiotic treatment in shoulder prosthesis surgery? - A clinical microdialysis study as...
    Medical condition: Orthopedic infections
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004862 10021799 Infection and inflammatory reaction due to other internal orthopedic device, implant, and graft LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2012-002328-34 Sponsor Protocol Number: KB056 Start Date*: Information not available in EudraCT
    Sponsor Name:KEDRION S.P.A
    Full Title: Efficacy and safety evaluation of Kedrion Fibrin Sealant as an adjuvant for the control of hemostasis in pediatric patients undergoing abdominal or orthopedic surgery. Multicenter, randomized, cont...
    Medical condition: Paediatric patients undergoing abdominal or orthopedic surgery
    Disease: Version SOC Term Classification Code Term Level
    18.0 10042613 - Surgical and medical procedures 10067439 Haemostasis PT
    Population Age: Preterm newborn infants, Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2011-004733-14 Sponsor Protocol Number: GSKET102011 Start Date*: 2012-03-22
    Sponsor Name:Medizinische Universität Wien
    Full Title: Intravenous S-Ketamine as an Analgesic Adjunct to General Anesthesia in chronic opioid-tolerant patient
    Medical condition: In the present investigation, we will compare the perioperative subanesthetic infusion of ketamine with placebo in opioid-resistant patients undergoing major orthopedic surgery. By powering the stu...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2018-000217-21 Sponsor Protocol Number: 310816 Start Date*: 2018-03-22
    Sponsor Name:Aarhus University Hospital
    Full Title: Do use of torniquete reduce the impact of the antibiotic treatment during orthopedic treatment?
    Medical condition: Orthopedic infections
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004865 10019095 Hallux Valgus correction LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2006-002890-31 Sponsor Protocol Number: Pregab1 Start Date*: 2006-08-25
    Sponsor Name:Dept. of Anaesthesia, Medical University of Vienna
    Full Title: Does Pregabalin reduce preoperative anxiety: a placebo controlled study
    Medical condition: Patients should receive Pregabalin or placebo as premedication one hour before ambulatory elective surgery. After this they have to assess their anxiety and pain with Visual Analog Scale (VAS) for ...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2018-001630-18 Sponsor Protocol Number: CWL15001 Start Date*: 2023-09-20
    Sponsor Name:5med GmbH
    Full Title: A randomized, parallel group, multi-center study of a fentanyl nasal spray compared with placebo nasal spray for postoperative pain management and prolonged open treatment over up to 120 hours post...
    Medical condition: Management of pain following orthopedic surgery
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004865 10036236 Postoperative pain relief LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Trial now transitioned) BG (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2010-018600-87 Sponsor Protocol Number: Peri-Trauma Start Date*: 2010-02-24
    Sponsor Name:AZIENDA OSPEDALIERA MAGGIORE DELLA CARITA` DI NOVARA
    Full Title: POST-OPERATIVE PAIN CONTROL OF PEDIATRIC PATIENTS UNDERWENT ORTHOPEDIC SURGERY: COMPARISON OF INTRAVENOUS ANALGESIA AND ONE-SHOT EPIDURAL LUMBAR NERVE BLOCK.
    Medical condition: POST-OPERATIVE PAIN CONTROL OF PEDIATRIC PATIENTS UNDERWENT ORTHOPEDIC SURGERY
    Disease: Version SOC Term Classification Code Term Level
    9.1 10028395 SOC
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-000258-12 Sponsor Protocol Number: 230189 Start Date*: 2014-10-15
    Sponsor Name:Orthopedic Research in Aarhus
    Full Title: Pharmacokinetics of vancomycin in cancellous and cortical bone obtained by microdialysis
    Medical condition: Orthopedic infections
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004865 10050155 Knee prosthesis insertion LLT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2020-005384-31 Sponsor Protocol Number: RSIv80 Start Date*: 2021-03-19
    Sponsor Name:Rigshospitalet
    Full Title: A single blinded multicenter randomized study comparing intubating conditions during rapid sequence induction with either suxamethonium 1.0 mg/kg or rocuronium 1.0 mg/kg in elderly patients (≥ 80 y...
    Medical condition: The aim of this study is to determine the proportion of excellent tracheal intubation conditions at 60 seconds after administration of either rocuronium 1.0 mg/kg or suxamethonium 1 mg/kg in patien...
    Disease: Version SOC Term Classification Code Term Level
    23.1 100000004865 10051079 Orthopedic procedure LLT
    20.0 100000004856 10000082 Abdominal pain generalised LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2010-019216-20 Sponsor Protocol Number: AZ2010 Start Date*: 2010-05-01
    Sponsor Name:AZIENDA OSPEDALIERO UNIVERSITARIA DI CAGLIARI
    Full Title: "Effects of drug treatment with bisphosphonates (zoledronic acid) in the prevention of skeletal events in breast cancer patients with osteoporosis. Significant correlation with some biological para...
    Medical condition: Breast cancer
    Disease: Version SOC Term Classification Code Term Level
    12.1 10057654 Breast cancer female LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-013481-10 Sponsor Protocol Number: 437 Start Date*: 2009-10-14
    Sponsor Name:Sint Maartenskliniek
    Full Title: Pharmacokinetics of high dose Ropivacaine with and without epinephrine for combined femoral and sciatic nerve block in lower extremity surgery. A pilot study.
    Medical condition: combined femoral and sciatic nerve block for lower extremity orthopedic surgery
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-001708-14 Sponsor Protocol Number: ABOGRAFT-01 Start Date*: 2021-06-29
    Sponsor Name:Region Östergötland
    Full Title: Antibiotic Impregnated Bone Graft to reduce infection in hip replacement. The ABOGRAFT trial
    Medical condition: Patients scheduled for any type of hip arthroplasty requiring bone grafting
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2005-005697-71 Sponsor Protocol Number: 060402 Start Date*: 2006-01-26
    Sponsor Name:Baxalta Innovations GmbH
    Full Title: Antihemophilic Factor (Recombinant) Plasma/Albumin-Free Method (rAHF PFM): A Phase 3/4, Prospective, Controlled, Randomized, Multi-Center Study to Compare the Efficacy and Safety of Continuous Infu...
    Medical condition: Subjects with Severe or Moderately Severe Hemophilia A (baseline factor VIII (FVIII) level <= 2% of normal) hemophilia A undergoing major orthopedic surgery
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004850 10060612 Hemophilia A LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed) SE (Completed) BE (Completed) PT (Completed) ES (Completed) HU (Completed) NL (Completed) GB (Completed) IT (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2019-000700-14 Sponsor Protocol Number: 2 Start Date*: 2019-07-08
    Sponsor Name:Medical University Graz
    Full Title: Pilot-Study comparing analgosedation concepts during placement of regional anaesthesia with either fentanyl, remifentanil, clonidine, EMLA-Patch or placebo in regard of patient's wellbeing, pain an...
    Medical condition: Patient with elective orthopedic surgery that will be administered a regional anaesthesia will be subject of the investigation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2014-000826-39 Sponsor Protocol Number: S-20130165 Start Date*: 2014-06-17
    Sponsor Name:Ortopædkirurgisk afdeling Odense Universitetshospital
    Full Title: Determining the tissue concentration of dicloxacillin using Microdialysis (on healthy male subjects)
    Medical condition: The trial is conducted on healthy male volunteers. An intravenous dose of 2 grams of dicloxacillin is administered intravenously and the muscle- and subcutaneous tissue concentrations are measured ...
    Disease: Version SOC Term Classification Code Term Level
    17.0 100000004862 10059428 Postoperative infection LLT
    Population Age: Adults Gender: Male
    Trial protocol: DK (Completed)
    Trial results: Removed from public view
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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