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Clinical trials for PPI

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44346   clinical trials with a EudraCT protocol, of which   7374   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    133 result(s) found for: PPI. Displaying page 1 of 7.
    1  2  3  4  5  6  7  Next»
    EudraCT Number: 2018-000283-28 Sponsor Protocol Number: 64821 Start Date*: 2018-09-05
    Sponsor Name:
    Full Title: Potential effect of proton-pump inhibitor on angiogenic markers in preeclampsia: a pilot study
    Medical condition: Angiogenic markers in preeclampsia
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-001383-10 Sponsor Protocol Number: 57340 Start Date*: 2016-07-04
    Sponsor Name:Rijnstate ziekenhuis
    Full Title: Evaluating the effect of short term withdrawal of PPI's in patients for reducing stomach wall uptake with 99mTc Sestamibi for myocardial perfusion imaging
    Medical condition: The goal is to acquire knowledge about the impact of the withdrawal of PPI’s, so as to minimize disturbance of the stomach wall in myocardial perfusion imaging. The associated main question is ther...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-000789-35 Sponsor Protocol Number: HPTM06/J/05 Start Date*: 2006-10-06
    Sponsor Name:INFAI GmbH
    Full Title: Two-way Crossover Comparison of the Sensitivity and Specificity of the Modified Helicobacter Test INFAI Using New Test Meal vs. Standard 13C-Urea Breath Test in Helicobacter Pylori Positive and Neg...
    Medical condition: Diagnosis of Helicobacter pylori infection for patients taking proton pump inhibitors (PPI) without interuption of medication two weeks prior to test.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-000059-17 Sponsor Protocol Number: RVK28353 Start Date*: 2011-02-22
    Sponsor Name:Koege Hospital
    Full Title: The clinical significance of acid rebound: Symptoms of reflux after 8 weeks of PPI treatment in patients with functional dyspepsia.
    Medical condition: "Acid-Rebound Hypersecretion" and "Functional dyspepsia"
    Disease: Version SOC Term Classification Code Term Level
    13.1 10017947 - Gastrointestinal disorders 10064536 Functional dyspepsia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2008-008010-39 Sponsor Protocol Number: HPTM11/J/08 Start Date*: 2009-04-23
    Sponsor Name:INFAI Institut für biomedizinische Analytik und NMR Imaging GmbH
    Full Title: The Sensivity and Specificity of the Modified Helicobacter Test INFAI Using New Test Meal with 13C-Urea Breath Test in Helicobacter Pylori Positive and Negative Patients with Dyspepsia Taking Proto...
    Medical condition: Diagnosis of Helicobacter pylori infection for patients taking proton pump inhibitors (PPI) with one day break of medication instead of two weeks prior to the test
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-001635-29 Sponsor Protocol Number: Start Date*: 2006-02-07
    Sponsor Name:Daniel Schmidt
    Full Title: Kontrollerad utsättning av långvarig behandling med protonpumpshämmare.
    Medical condition: Patienter med till synes obefogad kontinuerlig medicinering med protonpumpshämmare.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-004239-78 Sponsor Protocol Number: Start Date*: 2005-07-01
    Sponsor Name:Göteborgs Universitet, Institutionen för Invärtesmedicin
    Full Title: Förekomst av syrarelaterade besvär efter utsättning av protonpumpshämmare hos friska frivilliga.
    Medical condition: Studien skall göras på friska försökspersoner
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-001169-21 Sponsor Protocol Number: S55731 Start Date*: 2015-04-14
    Sponsor Name:Catholic University Leuven
    Full Title: Acid pocket: Determination of position and aspiration
    Medical condition: Gastro-oesophageal reflux disease Healthy volunteers and patients with reflux disease who respond to PPI therapy and who partially respond to PPI therapy will be studied It is known, that after the...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-001314-25 Sponsor Protocol Number: KIANANDR140701 Start Date*: 2015-03-10
    Sponsor Name:Karolinska Institutet
    Full Title: The effect of on demand versus continuous use of proton pump inhibitors on reflux symptoms, quality of life and self-rated health in patients with gastro-oesophageal reflux disease
    Medical condition: Gastrooesophageal reflux disease
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: View results
    EudraCT Number: 2009-017351-96 Sponsor Protocol Number: baclofen2009 Start Date*: 2009-12-23
    Sponsor Name:UZleuven
    Full Title: A placebo controlled trial with Baclofen for the treatment of GERD patients with incomplete PPI response
    Medical condition: Gastroesophageal reflux disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2012-000603-32 Sponsor Protocol Number: NL3364409612 Start Date*: 2012-08-27
    Sponsor Name:Annadalstichting
    Full Title: Proton pump inhibitors in the prevention of iron reaccumulation in patients with hereditary hemochromatosis
    Medical condition: Hereditary hemochromatosis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-003319-91 Sponsor Protocol Number: CX842A2201 Start Date*: 2021-02-08
    Sponsor Name:Cinclus Pharma AG
    Full Title: A randomized double-blind, double dummy, active comparator-controlled dose finding study in patients with reflux esophagitis Los Angeles grade C or D, and patients with at least partial symptom res...
    Medical condition: reflux esophagitis Los Angeles grade C or D and patients with grades A or B who partially responded to PPI patients with grades A or B who partially responded to PPI
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004856 10038262 Reflux esophagitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) CZ (Completed) BG (Completed)
    Trial results: View results
    EudraCT Number: 2017-004355-23 Sponsor Protocol Number: PPI-microbiome-FD Start Date*: 2018-01-04
    Sponsor Name:TARGID, KU Leuven
    Full Title: Effect of Proton Pump Inhibitors on the duodenal microbiome in Functional Dyspepsia patients
    Medical condition: Functional Dyspepsia (FD)
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2020-005340-39 Sponsor Protocol Number: S64807 Start Date*: 2021-02-01
    Sponsor Name:University Hospitals Leuven
    Full Title: Duodenal neuro-immune interactions and effects of proton pump inhibitors in functional dyspepsia
    Medical condition: Functional Dyspepsia (FD)
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-003541-16 Sponsor Protocol Number: D9120C00011 Start Date*: 2006-11-07
    Sponsor Name:AstraZeneca AB
    Full Title: A randomized, double-blind, placebo controlled, multi-centre, phase IIA study to assess the effect on GERD symptoms, pharmacokinetics, safety and tolerability of four weeks treatment with AZD3355 6...
    Medical condition: Gastroesophageal Reflux Disease (GERD)
    Disease: Version SOC Term Classification Code Term Level
    8.1 10017924 Gastroesophageal reflux LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed) NO (Completed) NL (Completed) DE (Completed) HU (Completed) BE (Completed)
    Trial results: View results
    EudraCT Number: 2016-004503-31 Sponsor Protocol Number: PSC-DSGERDAP16 Start Date*: 2017-03-14
    Sponsor Name:SOFAR S.P.A.
    Full Title: Evaluation of the effect of Gerdoff administered in combination to a treatment with protonic pump inhibitors vs the only treatment with protonic pump inhibitors, administered for 6 weeks, on higher...
    Medical condition: Gastroesophageal reflux disease
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004856 10018203 GERD LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2014-000334-30 Sponsor Protocol Number: INT27/14 Start Date*: 2014-09-17
    Sponsor Name:Fondazione IRCCS ''IStituto Nazionale dei Tumori''
    Full Title: Immunomodulatory effect of esomeprazole antitumoral and high-dose under neoadjuvant and adjuvant in patients with melanoma in stage III. Randomized pilot study treatment vs control
    Medical condition: metastatic melanoma BLS+ and BRAF wt
    Disease: Version SOC Term Classification Code Term Level
    16.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10025670 Malignant melanoma stage III PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2017-004175-31 Sponsor Protocol Number: Prucalopride2017 Start Date*: 2018-04-09
    Sponsor Name:TARGID, KU Leuven
    Full Title: A placebo-controlled trial with prucalopride for the treatment of typical reflux symptoms in patients with gastro-esophageal reflux disease with incomplete proton pump inhibitor response
    Medical condition: refractory gastro-esophageal reflux disease
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2017-004248-39 Sponsor Protocol Number: PPI-microbiome Start Date*: 2018-01-04
    Sponsor Name:TARGID, KU Leuven
    Full Title: Effect of Proton Pump Inhibitors on the duodenal microbiome in healthy volunteers
    Medical condition: We will assess the effect of Proton Pump Inhibitors (PPI) on the duodenal, oral and fecal microbiota composition in healthy volunteers
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2012-004470-25 Sponsor Protocol Number: GA1214 Start Date*: 2013-01-08
    Sponsor Name:Reckitt Benckiser Healthcare (UK) Ltd
    Full Title: A multicentre, randomised, double-blind, two arm, parallel group, pilot study to assess the effect of Gaviscon® Double Action Mint as add-on therapy in GORD patients with inadequate response to onc...
    Medical condition: Patients with Gastro Oesophageal Reflux Disease (GORD) with inadequate response to PPI treatment
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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