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Clinical trials for Paracetamol

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    436 result(s) found for: Paracetamol. Displaying page 1 of 22.
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    EudraCT Number: 2010-019488-12 Sponsor Protocol Number: Protocol No 1 Start Date*: 2010-12-08
    Sponsor Name:Joint Research Office, Barts and The London NHS Trust
    Full Title: A Single Centre Prospective Randomised Study to Investigate the Metabolism of Intravenous Paracetamol in Humans
    Medical condition: The study is looking at the cerebrospinal fluid pharmacokinetics of intravenous paracetamol.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-002466-20 Sponsor Protocol Number: 4087 Start Date*: 2012-08-16
    Sponsor Name:Royal Liverpool And Broadgreen University Hospitals NHS Trust
    Full Title: An exploratory, randomised, 3-way crossover study to determine the effect of paracetamol on urinary cystine excretion in cystinuria
    Medical condition: Cystinuria
    Disease: Version SOC Term Classification Code Term Level
    14.1 10010331 - Congenital, familial and genetic disorders 10011778 Cystinuria PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2006-002208-32 Sponsor Protocol Number: PAR06 Start Date*: 2006-08-14
    Sponsor Name:York Hospital NHS Trust
    Full Title: A comparison of the analgesic efficacy of oral and intravenous paracetamol (perfalgan) in a day case setting
    Medical condition: We will perform a double blind randomised comparison of oral paracetamol versus intravenous paracetamol (Perfalgan) in patients undergoing knee arthroscopy in a day surgery setting.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2018-005006-62 Sponsor Protocol Number: ASZ-001 Start Date*: 2019-12-10
    Sponsor Name:Albert Schweitzer hospital
    Full Title: Pharmacokinetics of Paracetamol before and after Roux-en-Y gastric bypass
    Medical condition: Roux-en-Y gastric bypass
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004848 10033762 Paracetamol LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-002295-40 Sponsor Protocol Number: 08-06-2018-paracet Start Date*: 2018-09-11
    Sponsor Name:Copenhagen Neuromuscular Center
    Full Title: Pharmacokinetics and safety of treatment with paracetamol in children and adults with spinal muscular atrophy and cerebral palsy
    Medical condition: Spinal muscular atrophy type II (SMA II) Cerebral palsy (CP)
    Disease:
    Population Age: Children, Under 18, Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-019678-34 Sponsor Protocol Number: not applicable Start Date*: 2011-07-29
    Sponsor Name:
    Full Title: Paracetamol intravenously in neonates with a gestational age of less than 32 weeks
    Medical condition: Neonatal pain
    Disease:
    Population Age: Preterm newborn infants, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-002119-16 Sponsor Protocol Number: NORM2016-IQ Start Date*: 2016-11-10
    Sponsor Name:Aflofarm Farmacja Polska Sp. z o.o.
    Full Title: Multi-center phase 3 clinical study of fever reduction effectiveness in children age 24-72 months using combined therapy (ibuprofen plus paracetamol) compared to monotherapy with paracetamol and/or...
    Medical condition: Fever due to viral infection
    Disease: Version SOC Term Classification Code Term Level
    20.1 10021881 - Infections and infestations 10051998 Febrile infection PT
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-023485-53 Sponsor Protocol Number: IJG-PAR-2010 Start Date*: 2011-04-20
    Sponsor Name:IDIAP JORDI GOL I GURINA
    Full Title: Evaluation of the relationship between effervescent acetaminophen and blood pressure. A clinical trial.
    Medical condition: Evaluation of whether paracetamol effervescent formulation increases blood pressure compared with effervescent paracetamol formulation does not
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2019-000203-33 Sponsor Protocol Number: 9119 Start Date*: 2019-10-16
    Sponsor Name:Klinisk Farmakologisk Afdeling
    Full Title: Paracetamol Discontinuation in the Elderly after long-term consumption (PARADISE)
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004867 10049475 Chronic pain LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-004578-29 Sponsor Protocol Number: P.sitsen.01 Start Date*: 2007-06-15
    Sponsor Name:Leids Universitair Medisch Centrum
    Full Title: The efficacy of intravenous versus rectal paracetamol: A randomized, prospective, double-blind placebo-controlled study
    Medical condition: Aims of the study 1)to compare the analgesic efficacy of intravenous versus rectal paracetamol versus placebo as assessed by VAS scores and PCA morphine consumption. 2)To assess the pharmacokinet...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-011753-41 Sponsor Protocol Number: 0902-127 Start Date*: 2010-12-23
    Sponsor Name:Neonatal intensive care unit, VU medical center Amsterdam
    Full Title: Pain treatment of newborns: paracetamol rectal versus intraveneous administration, an open randomised clinical trial.
    Medical condition: Pain treatment of neonates and premature neonates.
    Disease:
    Population Age: Preterm newborn infants, Newborns, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-002908-39 Sponsor Protocol Number: FEPODPara2020-1 Start Date*: 2020-10-30
    Sponsor Name:Helsinki University Hospital
    Full Title: Detection of paracetamol concentration in blood-, saline- and urine samples with an electrochemical indicator in healthy volunteers - a validation study for a novel technique.
    Medical condition: This is a laboratory equipment validation study. All subjects are healthy volunteered individuals.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: View results
    EudraCT Number: 2021-000360-30 Sponsor Protocol Number: FEPODPara2021-1 Start Date*: 2021-05-03
    Sponsor Name:Helsinki University Hospital
    Full Title: Determination of serum paracetamol concentration with an electrochemical measurement tool from blood and saliva samples in patients using also other medication.
    Medical condition: Patients with any medical condition that requires regular medication and who are undergoing elective surgery.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-000351-33 Sponsor Protocol Number: 2005/2:5 Start Date*: 2007-07-26
    Sponsor Name:Karolinska Universitetssjukhuset Solna
    Full Title: Will paracetamol reduce the opioid requirements and the (opioid)related postoperative nausea?
    Medical condition: Paracetamol is used as a complimentary painrelief. Using sealed envelopes, 140 patients will be randomly assigned to receive either 1g paracetamol as tablets (Panodil® Glaxo Smith Kline) or 1g plac...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10028818 Nausea postoperative LLT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-012585-30 Sponsor Protocol Number: 1 Start Date*: 2009-08-21
    Sponsor Name:NHS Grampian Research and Development
    Full Title: The pharmacokinetics of single and multiple doses of intravenous paracetamol in children
    Medical condition: There is no medical condition to be investigated. This is a pharmacokinetic study to be performed in children routinely treated with intravenous paracetamol for post surgical pain in line with loca...
    Disease:
    Population Age: Newborns, Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2018-000566-11 Sponsor Protocol Number: 39-2018 Start Date*: 2018-06-05
    Sponsor Name:University of Oulu
    Full Title: Extremely low gestational age infants' PARAcetamol Study
    Medical condition: Open ductus arteriosus of a premature infant
    Disease:
    Population Age: Preterm newborn infants, Under 18 Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-002724-25 Sponsor Protocol Number: 08-2018-07-31 Start Date*: 2017-11-16
    Sponsor Name:Helle Holst
    Full Title: Intravenous and oral paracetamol in neonates: safety and ethanol-drug interactions – the PARASHUTE Trial
    Medical condition: Liver toxicity following prolonged administration of i.v. or oral paracetamol
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004871 10019850 Hepatotoxic effect LLT
    Population Age: Preterm newborn infants, Newborns, Under 18 Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-000627-17 Sponsor Protocol Number: PAR007 Start Date*: Information not available in EudraCT
    Sponsor Name:University of Iceland
    Full Title: Serum profiles of paracetamol and glutathione after high doses of paracetamol for 6 days
    Medical condition: Healthy volunteers
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: IS (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-002370-21 Sponsor Protocol Number: 06/Q2002/25 Start Date*: 2006-09-20
    Sponsor Name:North Bristol NHS Trust
    Full Title: Comparison of oral and intravenous paracetamol plasma levels when given as premedication for perioperative analgesia
    Medical condition: Peri-operative analgesia
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2007-000805-32 Sponsor Protocol Number: 2911 Start Date*: 2007-04-03
    Sponsor Name:The Royal Marsden NHS Foundation Trust
    Full Title: AN INVESTIGATION INTO THE ROLE OF PARACETAMOL (ACETAMINOPHEN) AT STEP 3 OF THE WHO ANALGESIC LADDER
    Medical condition: The management of cancer pain in patients on step 3 of the WHO analgesic ladder, ie patients on a regular opioids for moderate to severe pain and paracetamol.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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