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Clinical trials for Periodontal Diseases

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44341   clinical trials with a EudraCT protocol, of which   7370   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    26 result(s) found for: Periodontal Diseases. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2019-002239-27 Sponsor Protocol Number: RAM-LIG-2019-01 Start Date*: 2019-09-24
    Sponsor Name:Clinica Dental AndreuDental
    Full Title: Study on the relationship between periodontal disease and serum levels of ultrasensitive Reactive C-Protein and fibrinogen
    Medical condition: Patients with a diagnosis of periodontitis: There is interdental LCI in two or more non-adjacent teeth, or two or more teeth have a vestibular LCI ≥ 3 with a PD > 3 mm
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-005883-25 Sponsor Protocol Number: Scil-MD05-C02 Start Date*: 2007-04-25
    Sponsor Name:Scil Technology GmbH
    Full Title: Pilot Study on Safety and Explorative Efficacy of MD05 in Comparison with Open Flap Debridement in Patients Undergoing Periodontal Surgery to Treat Deep Intrabony Defects
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    8.1 10034536 Periodontal disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-001367-36 Sponsor Protocol Number: DoxP-01/2006 Start Date*: 2006-12-05
    Sponsor Name:Prof. Dr. Peter Eickholz
    Full Title: Benefit of adjunctive systemic postsurgical doxycycline in regenerative periodontal surgery
    Medical condition: Periodontitis is an opportunistic infectious disease that destroys the periodontal attachment and bone. Bacterial plaque (biofilm) on the teeth adjacent to the gingiva is the necessary cause gingiv...
    Disease: Version SOC Term Classification Code Term Level
    8.1 10034539 Periodontitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2013-003940-21 Sponsor Protocol Number: 46361 Start Date*: 2014-03-20
    Sponsor Name:University Medical Center Groningen
    Full Title: Systemic antibiotic therapy (amoxicillin plus metronidazole) as an adjunct to surgical treatment of peri-implantitis; a single blind randomized controlled study
    Medical condition: peri-implantitis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-000741-39 Sponsor Protocol Number: 6996 Start Date*: 2019-11-07
    Sponsor Name:Hôpitaux Universitaires de Strasbourg
    Full Title: EFFECT OF AZITHROMYCIN ON THE PROPORTION OF FAILURES OF SEVERE PERIODONTITIS NON-SURGICAL TREATMENTS : A RANDOMIZED, DOUBLE-BLIND VERSUS PLACEBO STUDY
    Medical condition: Periodontology
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2014-002625-35 Sponsor Protocol Number: PERIOC_CTP001 Start Date*: 2015-01-26
    Sponsor Name:PerioC Ltd
    Full Title: The effect of locally delivered ciclosporin as an adjunct to healing after treatment of periodontal pockets
    Medical condition: Moderate to severe chronic periodontitis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-004825-42 Sponsor Protocol Number: Notapplicablenow Start Date*: 2016-12-22
    Sponsor Name:ACTA
    Full Title: Effect of Delmopinol on treatment of Peri - implant mucositis : a randomised controlled clinical trial
    Medical condition: Peri implant mucositis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2013-000383-28 Sponsor Protocol Number: CLI/016P Start Date*: 2015-01-12
    Sponsor Name:Dexcel Pharma Technologies Ltd.
    Full Title: The Efficacy and Safety of Chlorhexidine Gluconate Chip (PerioChip®) in Therapy of Peri-implantitis
    Medical condition: Peri-implantitis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2016-005062-61 Sponsor Protocol Number: Protocol01 Start Date*: 2017-03-30
    Sponsor Name:Cliniques universitaires Saint-Luc
    Full Title: Effects of vitamin D supplementation during a non-surgical treatment of generalized chronic periodontitis: a randomized double-blinded placebo-controlled clinical trial
    Medical condition: generalized chronic periodontitis
    Disease: Version SOC Term Classification Code Term Level
    19.1 100000004862 10009102 Chronic periodontitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2019-003541-15 Sponsor Protocol Number: 2019-Fungi Start Date*: 2020-02-19
    Sponsor Name:Aarhus University
    Full Title: Adjunct effect of fluconazole in the treatment of Candida-associated refractory severe periodontitis – A single-center, placebo-controlled, triple blind, randomized clinical trial
    Medical condition: Periodontitis. The participants are in good general health, but have at least 2 residual dental lesions after periodontal treatment (standard care).
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004862 10009102 Chronic periodontitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2012-000836-24 Sponsor Protocol Number: OP-P-5267 Start Date*: 2012-06-14
    Sponsor Name:OraPharma, Inc.
    Full Title: Multi-Center Phase 3 Trial of Minocycline HCl 1mg Microspheres for the Use in Subjects with Peri-Implantitis
    Medical condition: Peri-Implantitis, defined as a condition around an osseointegrated dental implant having at least one peri-implant site with probing depth (PD) ≥5 mm and ≤7 mm that exhibits bleeding on probing and...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-005202-19 Sponsor Protocol Number: DyMZIS-01 Start Date*: 2017-09-07
    Sponsor Name:Chemische Fabrik Kreussler & Co. GmbH
    Full Title: Multicenter, randomized, split-mouth study to evaluate the acceptance and preference of lidocaine gel compared to injection anesthesia after non surgical periodontal treatment
    Medical condition: Moderate parodontitis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2011-004711-23 Sponsor Protocol Number: DT11/9936 Start Date*: 2013-05-22
    Sponsor Name:Leeds Dental Institute
    Full Title: Comparative studies of the anaesthetic efficacy of 4% Articaine used as mandibular infiltration versus 2% Lidocaine used as inferior dental nerve block, in extraction and pulpotomy of mandibular pr...
    Medical condition: Dental caries in primary molars
    Disease:
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-000682-30 Sponsor Protocol Number: 01-09.02.15. Start Date*: 2015-04-27
    Sponsor Name:Tartu University Hospital
    Full Title: Botulinum neurotoxin type A treatment for sialorrhea in central nervous system diseases
    Medical condition: Hypersalivation
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004856 10020746 Hypersalivation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: EE (Completed)
    Trial results: View results
    EudraCT Number: 2017-001249-28 Sponsor Protocol Number: MU2017/001 Start Date*: 2019-05-21
    Sponsor Name:Mutua Universal MUGENAT
    Full Title: Phase III, Single-blinded, placebo-Controlled and randomized Clinical Trial with minimal intervention on the Treatment with Plasma Rich in Growth Factors (PRGF) of Work-site Acute Epicondylitis Res...
    Medical condition: Epicondylitis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10022117 - Injury, poisoning and procedural complications 10014971 Epicondylitis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-004046-41 Sponsor Protocol Number: 273551 Start Date*: 2021-12-09
    Sponsor Name:University of Bergen,
    Full Title: A multicentre clinical trial; Alveolar bone augmentation using Mesenchymal Stem Cells and biphasic calcium phosphate granules prior to dental implants
    Medical condition: Patients in need of dental implant(s) in the upper and lower jaws with presence of bone defects with loss in vertical height and < than 4 mm in lateral width
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-004564-26 Sponsor Protocol Number: BAS20 Start Date*: 2021-09-20
    Sponsor Name:Karolinska Institute
    Full Title: Role of antibiotics in conjunction with oral bone augmentation procedures (BAS20)
    Medical condition: Patients requiring bone augmentation procedure prior to, or in conjunction to installation of dental implants.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10049924 Infection prophylaxis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2012-003139-50 Sponsor Protocol Number: Maxillo1 Start Date*: Information not available in EudraCT
    Sponsor Name:University of Bergen, Faculty of medicin and dentistry, Dep. of Clinical Dentistry
    Full Title: International, multicenter phase II uncontrolled prospective clinical trial: Jaw bone reconstruction using a combination of biomaterial and autologous mesenchymal stem cells prior to dental impla...
    Medical condition: Men and women aged 18 years or more requiring jaw bone reconstruction prior to dental implant placement based on clinical and radiological examinations (CBCT Cone beam CT imaging). Areas suitable ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-004724-11 Sponsor Protocol Number: 294568 Start Date*: 2014-09-22
    Sponsor Name:Karolinska Institute
    Full Title: Surgical treatment of peri-implantitis with and without systemically adjunctive antibiotics A prospective, open, randomized, three armed, parallel, placebo controlled clinical trial
    Medical condition: peri-implantitis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2017-002402-13 Sponsor Protocol Number: R04684 Start Date*: 2018-02-02
    Sponsor Name:Manchester University NHS Foundation Trust
    Full Title: A Randomised controlled trial to Evaluate the effectiveness and cost benefit of prescribing high dose FLuoride toothpaste in preventing and treating dEntal Caries in high-risk older adulTs (REFLECT...
    Medical condition: Dental caries in high-risk older adults
    Disease: Version SOC Term Classification Code Term Level
    20.0 10017947 - Gastrointestinal disorders 10012318 Dental caries PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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