Flag of the European Union EU Clinical Trials Register Help

Clinical trials for Periprosthetic

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44344   clinical trials with a EudraCT protocol, of which   7373   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
    How to search [pdf]
    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
    Advanced Search: Search tools
     
    15 result(s) found for: Periprosthetic. Displaying page 1 of 1.
    EudraCT Number: 2016-001108-47 Sponsor Protocol Number: BARIFER Start Date*: 2016-05-29
    Sponsor Name:Fundació Hospital Universitari Vall Hebron-Institut de Recerca (VHIR)
    Full Title: Impact of eradication of asymptomatic bacteriuria on reducing the incidence of early infection in patients with periprosthetic femoral fractures requiring hip hemiarthroplasty
    Medical condition: Early infection in patients with periprosthetic femoral fracture
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2010-020215-36 Sponsor Protocol Number: CL3-12911-037 Start Date*: 2011-05-03
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: A prospective, controlled, double blind, international study to assess the effects of strontium ranelate vs. placebo on the reduction of periprosthetic bone loss in patients with total hip arthropl...
    Medical condition: Reduction of periprosthetic bone loss in patients with total hip arthoplasty for coxarthrosis
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022117 - Injury, poisoning and procedural complications 10052306 Periprosthetic osteolysis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) ES (Completed) IT (Completed) BE (Completed)
    Trial results: View results
    EudraCT Number: 2004-002965-19 Sponsor Protocol Number: 1 Start Date*: 2005-03-14
    Sponsor Name:Orthopaedic department, Karolinska Institutet, Danderyd's Hospital
    Full Title: Can risedronate prevent periprosthetic bone loss after hip arthroplasty? A randomized, double-blind, placebo-controlled trial
    Medical condition: Periprosthetic bone loss after total hip arthroplasty (THA) is the main factor in limiting the longevity of implants used för treatment of osteoarthritis. Bone loss leads to implant destabilization...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-002557-68 Sponsor Protocol Number: CDJN608 FI01 Start Date*: 2006-11-06
    Sponsor Name:Hospital District of Southwest Finland
    Full Title: A randomized, double-blind, placebo-controlled study to evaluate the efficacy of zoledronic acid in enhancement of early stability of cementless primary hip prosthesis
    Medical condition: Bone loss occurring around cementless hip prosthesis in postmenopausal women treated for primary hip osteoarthritis
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-002438-35 Sponsor Protocol Number: 860 Start Date*: 2019-09-16
    Sponsor Name:Radboudumc [...]
    1. Radboudumc
    2. Sint Maartenskliniek
    Full Title: Multiple doses versus single dose of cefazolin to prevent periprosthetic joint infection after revision arthroplasty: a multicenter open-label, randomized clinical trial.
    Medical condition: Prevention of periprosthetic joint infection on patients undergoing revision surgery of the hip or knee.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10057129 Revision of total knee arthroplasty LLT
    20.0 10042613 - Surgical and medical procedures 10057128 Revision of hip arthroplasty LLT
    20.0 10042613 - Surgical and medical procedures 10049924 Infection prophylaxis PT
    20.0 10042613 - Surgical and medical procedures 10064736 Antibiotic prophylaxis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-014414-98 Sponsor Protocol Number: 58185 Start Date*: 2009-10-29
    Sponsor Name:Department of Orthopaedic Surgery University Hospital Linköping
    Full Title: The impact of local bisphosphonate treatment on prosthetic fixation
    Medical condition: Osteoarthritis of the hip joint treated with total hip replacement
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-000663-45 Sponsor Protocol Number: PREVENT-iT-2021.07 Start Date*: 2023-02-01
    Sponsor Name:Hamilton Health Sciences Corporation
    Full Title: Prospective Randomized Evaluation of Emerging Novel Treatments for Infection prophylaxis in Total Joint Replacement (PREVENT-iT): A Pilot Study
    Medical condition: Persistent Draining Wound and Periprosthetic Joint Infection prevention in patients undergoing total joint replacement
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-000628-14 Sponsor Protocol Number: ISS20109714 Start Date*: 2013-09-13
    Sponsor Name:Turku University Hospital
    Full Title: Denosumab in enhancement of bone bonding of hip prosthesis in postmenopausal women: a randomized, double-blind, placebo-controlled study
    Medical condition: Hip osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004865 10020104 Hip total replacement LLT
    Population Age: Elderly Gender: Female
    Trial protocol: FI (Completed)
    Trial results: View results
    EudraCT Number: 2020-003444-80 Sponsor Protocol Number: 2020-01471 Start Date*: 2020-11-17
    Sponsor Name:Sahlgrenska University Hospital
    Full Title: Evaluation of the clinical implementation of biofilm susceptibility to antibiotics using Minimum Biofilm Eradication Concentration (MBEC) in addition to Minimum Inhibitory Concentration (MIC) to gu...
    Medical condition: Periprosthetic hip or knee joint infections
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2012-001285-15 Sponsor Protocol Number: IIBSP-DEN-2012-24 Start Date*: 2012-10-05
    Sponsor Name:Institut de Recerca Hospital Sant Pau
    Full Title: Ensayo clínico aleatorizado, doble ciego, de grupos paralelos, controlado con placebo para la valoración de la eficacia del denosumab subcutáneo para la disminución de la resorción periprotésica en...
    Medical condition: Periprosthetic bone mineral density Masa ósea periprotésica
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-002673-35 Sponsor Protocol Number: Fos.06/2016 Start Date*: 2017-03-29
    Sponsor Name:PRO-IMPLANT Foundation
    Full Title: Efficacy and safety of intravenous fosfomycin in prosthetic joint infection (PJI) caused by staphylococci, streptococci, enterococci and gram-negative bacilli, including mixed infections and cultur...
    Medical condition: Prosthetic joint infection of knee, hip or shoulder
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-000541-20 Sponsor Protocol Number: STH15714 Start Date*: 2011-09-20
    Sponsor Name:Sheffield Teaching Hospitals NHS Foundation Trust
    Full Title: Effect of Denosumab on Osteolytic Lesion Activity in Total Hip Arthroplasty (THA)
    Medical condition: Prosthesis-related osteolysis after total hip arthroplasty
    Disease: Version SOC Term Classification Code Term Level
    14.0 10042613 - Surgical and medical procedures 10057128 Revision of hip arthroplasty LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2013-004940-48 Sponsor Protocol Number: 2013-004940-48 Start Date*: 2014-11-12
    Sponsor Name:Danderyds Hospital, Department of Clinical Sciences, Division of Orthopaedics
    Full Title: Denosumab For Treating Periprosthetic Osteolysis After Uncemented Total Hip Arthroplasty. A randomized, double-blind, placebo-controlled trial using volumetric computed tomography.
    Medical condition: Patients with titanium press-fit acetabular components with polyethylene liners will be screened for osteolytic lesions. The patients had primary surgery at least 7 years before screening and all o...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-004046-15 Sponsor Protocol Number: TKA4 Start Date*: 2013-07-03
    Sponsor Name:ORtopædkirurgisk Forskningsenhed, Aarhus Universitetshospital
    Full Title: A 4-way randomized double-blinded migration (RSA), bone density (DXA), and biomarker study assessing adaptive bone changes and implant fixation and longevity of the new Regenerex Porous Titanium Ti...
    Medical condition: Osteoarthritis in the knee treated with cementless total knee arthroplasty
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2021-004469-11 Sponsor Protocol Number: PP-SA-001 Start Date*: 2022-01-11
    Sponsor Name:PHERECYDES PHARMA
    Full Title: PhagoDAIR I: A Phase I/II Multicenter, Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Phage Therapy in Patients with Hip or Knee Prosthetic Joint Infection due to Staphylococcus ...
    Medical condition: knee or hip prosthetic joint infection (PJI) due to Staphylococcus aureus, with the indication of DAIR and Suppressive Antibiotics Therapy (SAT
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned) ES (Prematurely Ended)
    Trial results: (No results available)
    Download Options:
    Number of Trials to download:
    Download Content:
    Download Format:
    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
    Query did not match any studies.
    For support, Contact us.
    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

    European Medicines Agency © 1995-Tue Jun 17 19:55:40 CEST 2025 | Domenico Scarlattilaan 6, 1083 HS Amsterdam, The Netherlands
    EMA HMA