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Clinical trials for Pharmacodynamics

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43881   clinical trials with a EudraCT protocol, of which   7295   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    1,478 result(s) found for: Pharmacodynamics. Displaying page 1 of 74.
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    EudraCT Number: 2012-005443-24 Sponsor Protocol Number: Dex-PKPD/01 Start Date*: 2013-03-05
    Sponsor Name:UMCG
    Full Title: Development of a pharmacokinetic/pharmacodynamic model of dexmedetomidine, and the effect of repeated auditory stimulation on pharmacodynamics of dexmedetomidine
    Medical condition: To develop a PKPD dexmedetomidine model, and to assess the effect of continuous auditory stimulation on dexmedetomidine pharmacodynamics.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-004207-22 Sponsor Protocol Number: CLCZ696B2319 Start Date*: 2017-04-06
    Sponsor Name:Novartis Pharma Services AG
    Full Title: Multicenter, open-label, study to evaluate safety, tolerability, pharmacokinetics and, pharmacodynamics of LCZ696 followed by a 52-week randomized, double-blind, parallel group, active-controlled s...
    Medical condition: Pediatric heart failure 1 month to <18 years old
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10019279 Heart failure LLT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: DE (Completed) FI (Completed) NL (Ongoing) SE (Completed) NO (Completed) ES (Completed) GB (GB - no longer in EU/EEA) CZ (Completed) IT (Completed) FR (Completed) BG (Completed) PL (Completed) HU (Completed) HR (Completed) AT (Completed) PT (Completed) RO (Completed)
    Trial results: View results
    EudraCT Number: 2008-007647-14 Sponsor Protocol Number: Nabu1A2 Start Date*: 2009-01-07
    Sponsor Name:Turku University Hospital
    Full Title: The effect of fluvoxamine and ciprofloxacin on the pharmacokinetics and pharmacodynamics of nabumetone: A three-phase double-blind placebo-controlled cross-over study.
    Medical condition: Pharmacokinetics and pharmacodynamics, healthy volunteer trial
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2023-000150-20 Sponsor Protocol Number: 1 Start Date*: 2023-03-22
    Sponsor Name:Bispebjerg-Frederiksberg Hospital
    Full Title: The effect of exercise on pharmacodynamics and pharmacokinetics of a single dose of unfractionated heparin: A randomized, controlled, cross-over study
    Medical condition: Unfractionated heparin is used for the prevention and treatment of deep vein thrombosis and complications hereof
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-005200-13 Sponsor Protocol Number: SafePed002 Start Date*: 2015-07-09
    Sponsor Name:Ghent University
    Full Title: study of the pharmacokinetics and pharmacodynamics of desmopressin oral lyophilisate - route of administration in the pediatric patient population - SAFEPEDRUG
    Medical condition: therapeutic population: monosympthomatic enuresis nocturna diagnostic population: children with a history of a urinary tract infection or suspicion of renal damage who need a renal concentration...
    Disease:
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2021-000841-42 Sponsor Protocol Number: RBHP2021GODET2 Start Date*: 2021-04-28
    Sponsor Name:CHU de CLERMONT-FERRAND
    Full Title: Cardiac Output Response to Vasopressine in major abdominal surgery patients under mechanical ventilation. A clinical pharmacodynamics study
    Medical condition: -
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-000537-69 Sponsor Protocol Number: PROP2% Start Date*: 2015-09-21
    Sponsor Name:Universitair Ziekenhuis Brussel
    Full Title: Real time monitoring of blood propofol concentration
    Medical condition: - General anaesthesia - Pharmacokinetics and Pharmacodynamics of Propofol - Inflammatory parameters - Elective thyroid, oncologic breast,ENT or cervical arthrodesis surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-002803-15 Sponsor Protocol Number: 12096 Start Date*: 2006-08-18
    Sponsor Name:Aarhus Sygehus
    Full Title: Bioavailability, Pharmacokinetics and Pharmacodynamics of Insulin Aspart administered in the Duodenum in healthy volunteers – an open single blinded and uncontrolled exploratory trial
    Medical condition: Diabetes Mellitus
    Disease: Version SOC Term Classification Code Term Level
    9.0 10012601 PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2019-002353-29 Sponsor Protocol Number: HUB-NEF-HEMOCIONA.EC Start Date*: 2019-11-12
    Sponsor Name:HOSPITAL UNIVERSITARI DE BELLVITGE- IDIBELL
    Full Title: PHARMACOKINETICS, PHARMACODYNAMICS AND SAFETY OF APIXABAN IN PATIENTS IN HEMODAFILTRATION
    Medical condition: Chronic kidney disease, non-valvular atrial fibrillation
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004857 10076412 Chronic kidney disease stage 5 LLT
    20.0 10007541 - Cardiac disorders 10003658 Atrial fibrillation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2004-000808-40 Sponsor Protocol Number: 2004-27-IMP-2 Start Date*: 2005-01-13
    Sponsor Name:Hexal AG
    Full Title: Randomized, open label, multi-center, phase III study on pharmacokinetics, pharmacodynamics, efficacy and safety of Goserelin 1M Implant HEXAL in patients with advanced prostatic cancer in comparis...
    Medical condition: Palliative treatment of advanced prostatic cancer
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: LT (Completed)
    Trial results: View results
    EudraCT Number: 2005-002873-62 Sponsor Protocol Number: 2005-34-IMP-2 Start Date*: 2006-02-15
    Sponsor Name:HEXAL AG
    Full Title: RANDOMIZED, OPEN LABEL, MULTICENTER, PHASE II STUDY ON PHARMACOKINETICS, PHARMACODYNAMICS, EFFICACY AND SAFETY OF BUSERELIN 3M IMPLANT HEXAL IN PATIENTS WITH ADVANCED PROSTATIC CANCER IN COMPARISON...
    Medical condition: Palliative treatment of advanced prostatic cancer
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: CZ (Completed)
    Trial results: View results
    EudraCT Number: 2005-001279-36 Sponsor Protocol Number: 2005-01-IMP-2 Start Date*: 2005-08-24
    Sponsor Name:Hexal AG
    Full Title: RANDOMIZED, OPEN LABEL, MULTICENTER, PHASE II STUDY ON PHARMACOKINETICS, PHARMACODYNAMICS, EFFICACY AND SAFETY OF GOSERELIN 3M IMPLANT HEXAL IN PATIENTS WITH ADVANCED PROSTATIC CANCER IN COMPARISON...
    Medical condition: Palliative treatment of advanced prostatic cancer
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: LT (Completed)
    Trial results: View results
    EudraCT Number: 2010-020204-30 Sponsor Protocol Number: E5564-G000-103 Start Date*: Information not available in EudraCT
    Sponsor Name:Eisai Limited [...]
    1. Eisai Limited
    2. Eisai Inc.
    Full Title: A Multicenter, Open-label, Sequential, Multiple-dose Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, Tolerability, and Efficacy or Eritoran in Descending Age Groups of Pediatric S...
    Medical condition: Severe Sepsis
    Disease:
    Population Age: Newborns, Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2016-003004-31 Sponsor Protocol Number: NP25139 Start Date*: 2016-08-09
    Sponsor Name:F. Hoffmann-La Roche AG
    Full Title: An Open Label, Prospective, Pharmacokinetic/Pharmacodynamic and Safety Evaluation of Intravenous Oseltamivir (Tamiflu) in the Treatment of Children 1 to 12 Years of Age With Influenza Infection
    Medical condition: Influenza
    Disease:
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2004-002701-68 Sponsor Protocol Number: PSN9301CS01 Start Date*: 2004-12-13
    Sponsor Name:Prosidion Ltd.
    Full Title: A randomised, double-blind, placebo-controlled, multiple dose, time-lagged parallel groups trial, investigating the pharmacodynamics, the safety and tolerability and the pharmacokinetics of PSN9301...
    Medical condition: Diabetes mellitus type 2
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-002100-42 Sponsor Protocol Number: ARD-0301-003 Start Date*: 2005-08-24
    Sponsor Name:Ardana Bioscience Ltd
    Full Title: A Phase II single centre, open-label study investigating the pharmacokinetics, pharmacodynamics, efficacy and safety of a loading dose regimen of a new GnRH antagonist, Teverelix, long-acting formu...
    Medical condition: advanced prostate cancer
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: LT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-001658-25 Sponsor Protocol Number: A6391002 Start Date*: 2005-06-16
    Sponsor Name:Pfizer Global Research and Development
    Full Title: An open label, two period crossover study to explore the safety, pharmacokinetics and pharmacodynamics of PHA-794428 after single subcutaneous injections in adult male patients with growth hormone ...
    Medical condition: AGHD Adult Growth Hormone Deficiency
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2018-001988-23 Sponsor Protocol Number: AEZS-130-P01 Start Date*: 2018-11-07
    Sponsor Name:Aeterna Zentaris GmbH
    Full Title: Open label, group comparison, dose escalation trial to investigate safety, tolerability, pharmacokinetics and pharmacodynamics of macimorelin acetate after single oral dosing of 0.25 mg/kg, 0.5 mg/...
    Medical condition: Diagnosis of Growth Hormone Deficiency
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004848 10073227 Growth hormone stimulation test LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: HU (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2022-000427-20 Sponsor Protocol Number: NL76691.100.22 Start Date*: 2022-05-11
    Sponsor Name:Inreda Diabetic
    Full Title: A stable glucagon analog administered by a bihormonal closed loop system; a feasibility study
    Medical condition: Type 1 Diabetes mellitus
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2022-001373-31 Sponsor Protocol Number: NL79588.091.22 Start Date*: 2022-07-21
    Sponsor Name:Inreda Diabetic B.V.
    Full Title: Fully Automated glycemic control with ultrarapid insulin in a bihormonal closed loop System in patients with Type 1 diabetes
    Medical condition: Type 1 diabetes mellitus
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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