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Clinical trials for Proinsulin

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43881   clinical trials with a EudraCT protocol, of which   7295   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    67 result(s) found for: Proinsulin. Displaying page 1 of 4.
    1  2  3  4  Next»
    EudraCT Number: 2004-002757-31 Sponsor Protocol Number: CLAF237A 2303E1 Start Date*: 2004-12-16
    Sponsor Name:Novartis Sverige AB
    Full Title: A 28-Week Extension to a Multicenter, Double-Blind, Randomized, Parallel-Group Study to Compare the Effect of 24 Weeks Treatment with LAF237 (50 mg qd or bid) to Placebo as Add-On Therapy in Patien...
    Medical condition: Type 2 Dibetes
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2009-015993-37 Sponsor Protocol Number: SAN-FORST-001 Start Date*: 2009-11-06
    Sponsor Name:Institut für Klinische Forschung und Entwicklung (ikfe) GmbH
    Full Title: Beta Cell Relieving and Cardiovascular Protective Effects of LANTUS Treatment in Type 2 Diabetes Patients – Investigation on Postprandial Excursions of Proinsulin and PAI-1 Levels
    Medical condition: Type 2 Diabetes mellitus
    Disease: Version SOC Term Classification Code Term Level
    12.0 10045242 Type II diabetes mellitus LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-000179-17 Sponsor Protocol Number: ikfe-Lina-002 Start Date*: 2012-04-02
    Sponsor Name:ikfe GmbH
    Full Title: Effect of Linagliptin in comparison with Glimepiride as add on to Metformin on postprandial beta cell function, postprandial metabolism and oxidative stress in patients with type 2 diabetes mellitus
    Medical condition: Diabetes mellitus type 2 on metformin therapy
    Disease: Version SOC Term Classification Code Term Level
    14.1 10027433 - Metabolism and nutrition disorders 10067585 Type 2 diabetes mellitus PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-002136-25 Sponsor Protocol Number: CLAF237A2309E1 Start Date*: 2005-04-07
    Sponsor Name:Novartis Pharmaceuticals UK Ltd
    Full Title: A 52-week extension to a multicenter, randomized, double-blind, active controlled study to compare the effect of 52 weeks treatment with LAF237 50 mg bid to metformin up to 1000 mg bid in drug naïv...
    Medical condition: Type II Diabetes
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2019-002758-21 Sponsor Protocol Number: DTCI-PIT-001 Start Date*: Information not available in EudraCT
    Sponsor Name:Innovative Diabetes Treatments Studies LLC
    Full Title: PILOT STUDY FOR EVALUATION OF THE IMPACT OF PULSATILE INSULIN INFUSION THERAPY ON VASCULAR FUNCTION IN PATIENTS WITH TYPE 1 AND TYPE 2 DIABETES MELLITUS
    Medical condition: treatment of long-term effects of Diabetes Type 1 and Type 2
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2004-000577-65 Sponsor Protocol Number: 2993-114 Start Date*: 2004-08-30
    Sponsor Name:Eli Lilly and Company
    Full Title: A Phase 3, randomized, open label, comparator-controlled, parallel-group, multicentre study to compare the effects of exenatide and insulin glargine on beta cell function and cardiovascular risk ma...
    Medical condition: Type 2 diabetes mellitus
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: View results
    EudraCT Number: 2004-004226-28 Sponsor Protocol Number: ATS K016 Start Date*: 2005-01-17
    Sponsor Name:Takeda Pharma GmbH
    Full Title: Effects of Pioglitazone in Patients with Type 2 Diabetes Mellitus and Coronary Heart Disease at High Risk for Cardiovascular Complications
    Medical condition: Type 2 Diabetes mellitus
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2007-006109-26 Sponsor Protocol Number: LANT_001 Start Date*: 2008-12-10
    Sponsor Name:Institut für Klinische Forschung und Entwicklung (ikfe) GmbH
    Full Title: Impact of Insulin Glargine compared to Insulin Detemir in combination with Metformin (BOT) on prandial beta cell function and overall metabolic control in type 2 diabetic patients with insufficient...
    Medical condition: Diabetes mellitus Type 2
    Disease: Version SOC Term Classification Code Term Level
    9.1 10045242 Type II diabetes mellitus LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-004463-30 Sponsor Protocol Number: ATS K015 Start Date*: 2005-06-22
    Sponsor Name:Takeda Pharma GmbH
    Full Title: Effects of Pioglitazone in Combination with Atorvastatin in Comparison to Atorvastatin treatment alone on Intima-Media Thickness in patients at Risk for Vascular Complications
    Medical condition: Patients at risk for vascular complications (cardiovascular anamnesis, hypertension, hypercholesterolemia) and a carotid intima media thickness >= 0.8 mm at least at one side will be eligible for t...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2006-002237-20 Sponsor Protocol Number: ATS K021 Start Date*: 2006-08-21
    Sponsor Name:Takeda Pharma GmbH
    Full Title: Pilot trial studying the Effects of Pioglitazone in Comparison to Placebo on Myocardial Function and Oxidative Stress in Patients with Type II Diabetes and Insulin Resistance undergoing elective PTCA
    Medical condition: Type 2 diabetic patients treated with oral agents except PPAR gamma agonists and / or patients with insulin resistance measured by IRIS score > 50 with stable coronary artery disease and supposed e...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2020-004966-20 Sponsor Protocol Number: 20201013 Start Date*: 2021-08-05
    Sponsor Name:Radboud University Medical Center
    Full Title: A GLP-1 receptor PET imaging add-on study within the Ver-A-T1D trial investigating the effects of Verapamil or placebo on beta cell mass (ImageVer-A-T1D)
    Medical condition: Type 1 Diabetes
    Disease: Version SOC Term Classification Code Term Level
    20.0 10027433 - Metabolism and nutrition disorders 10012601 Diabetes mellitus PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Ongoing) FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-005881-11 Sponsor Protocol Number: EFC6015 Start Date*: 2008-07-18
    Sponsor Name:Sanofi-Aventis Recherche&Développement
    Full Title: A randomized, double-blind, placebo-controlled, 2-arm parallel-group, multicenter 24-week study followed by an extension assessing the efficacy and safety of AVE0010 on top of a sulfonylurea in pat...
    Medical condition: Type II Diabetes
    Disease: Version SOC Term Classification Code Term Level
    10.1 10067585 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) CZ (Completed) NL (Completed) BG (Completed)
    Trial results: View results
    EudraCT Number: 2012-002880-86 Sponsor Protocol Number: 936 Start Date*: 2013-01-25
    Sponsor Name:Liverpool Heart and Chest Hospital NHS Trust
    Full Title: PRESERVING ΒETA-CELLS: ‘RESTING THE PANCREAS’ IN CYSTIC FIBROSIS
    Medical condition: Cystic Fibrosis Related Diabetes (CFRD)
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004848 10022468 Insulin LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2011-003733-34 Sponsor Protocol Number: APIDR_L_05719 Start Date*: 2011-09-13
    Sponsor Name:ikfe – Institute for Clinical Research and Development
    Full Title: Human Insulin Analogs: Evaluation of inflammatory mRNA expression of Macrophages and Endothelial function of Short-acting insulin – HERMES Pilot Study
    Medical condition: Patients with Diabetes mellitus Type 2 and a stable basal supported oral therapy
    Disease: Version SOC Term Classification Code Term Level
    14.0 10027433 - Metabolism and nutrition disorders 10053247 Insulin-requiring type 2 diabetes mellitus PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-007970-47 Sponsor Protocol Number: fMRI-Ex-4 Start Date*: Information not available in EudraCT
    Sponsor Name:University of Leipzig
    Full Title: Central nervous effects of exendin-4 on hunger and satiety in obesity and diabetes mellitus type 2: an fMRI study
    Medical condition: Obesity (N=20) vs. obesity with type 2 diabetes (N=20); Randomised + controlled + cross-over + prospective + double-blind + stratified + 2 arms: Exendin-4 vs NaCl 0.9% iv ober 100 minutes on two s...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10029885 Obesity, unspecified LLT
    9.1 10012601 Diabetes mellitus LLT
    Population Age: Adults Gender: Male
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2016-001671-79 Sponsor Protocol Number: CAIN457ADE08 Start Date*: 2018-02-15
    Sponsor Name:Novartis Pharma GmbH
    Full Title: A randomized, multicenter 28 week study to compare the efficacy and safety of combining Cosentyx (Secukinumab) (4-weekly, 300 mg s.c.) with a lifestyle intervention to Cosentyx therapy alone in adu...
    Medical condition: Moderate to severe plaque type psoriasis
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004858 10071117 Plaque psoriasis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2021-002947-32 Sponsor Protocol Number: 02GPR2021 Start Date*: 2021-10-28
    Sponsor Name:Celon Pharma SA
    Full Title: A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Evaluate Efficacy, Safety and Pharmacokinetics after 2-weeks Administration of CPL207280 (GPR40 agonist) in Subjects...
    Medical condition: Type 2 Diabetes
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-001115-73 Sponsor Protocol Number: Regenerate-1 Start Date*: 2018-06-05
    Sponsor Name:Uppsala University Hospital
    Full Title: A Phase I/II, 2-Arm, Open Label, Single Centre Study to Investigate the Safety and Effect of Oral GABA Therapy on β-cell Regeneration in Type 1-diabetes Patients
    Medical condition: Type 1 diabetes
    Disease: Version SOC Term Classification Code Term Level
    20.0 10027433 - Metabolism and nutrition disorders 10067584 Type 1 diabetes mellitus PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2005-005448-21 Sponsor Protocol Number: H8O-EW-GWBE Start Date*: 2006-06-30
    Sponsor Name:Eli Lilly and Company Ltd.
    Full Title: Long-Term Treatment with Exenatide versus Glimepiride in Patients with Type 2 Diabetes Pretreated with Metformin
    Medical condition: Type 2 diabetes mellitus
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) ES (Completed) DE (Completed) HU (Completed) IT (Completed) IE (Completed) AT (Completed) CZ (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-004286-32 Sponsor Protocol Number: ikfe-Vilda-001 Start Date*: 2011-11-09
    Sponsor Name:ikfe GmbH
    Full Title: Effect of Adding Vildagliptin on Beta Cell Function and Cardiovascular Risk Markers in Patients with moderate Metabolic Control during Metformin Monotherapy
    Medical condition: Diabetes mellitus Type 2
    Disease: Version SOC Term Classification Code Term Level
    14.0 10027433 - Metabolism and nutrition disorders 10067585 Type 2 diabetes mellitus PT
    14.0 10027433 - Metabolism and nutrition disorders 10045242 Type II diabetes mellitus LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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