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Clinical trials for Reverse transcriptase inhibitors

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    48 result(s) found for: Reverse transcriptase inhibitors. Displaying page 1 of 3.
    1  2  3  Next»
    EudraCT Number: 2006-006076-38 Sponsor Protocol Number: RLBUHT3173 Start Date*: 2007-04-26
    Sponsor Name:University of Liverpool [...]
    1. University of Liverpool
    2. Royal Liverpool & Broadgreen University Hospitals Trust
    Full Title: The Liverpool HIV TDM Registry: Studying influences upon plasma HIV drug exposure
    Medical condition: Pharmacogenetic study of HIV+ patients receiving antiretroviral therapy. We wish to correlate drug concentration with host genetic patients receiving certain HIV drugs. No dosage modification wil...
    Disease:
    Population Age: Preterm newborn infants, Newborns, Infants and toddlers, Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-003425-81 Sponsor Protocol Number: RLBUHT2763 Start Date*: 2007-03-29
    Sponsor Name:University of Liverpool
    Full Title: Host genetic factors influencing drug disposition and response to HIV treatment
    Medical condition: Pharmacogeneric study of HIV+ patients receiving antiretroviral therapy. We wish to correlate drug concentration with host genetic patients receiving certain HIV drugs. No dosage modification will...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2004-000532-85 Sponsor Protocol Number: T-20 Maint Start Date*: 2004-11-12
    Sponsor Name:Penine Acute NHS Trust, North Manchester General Hospital
    Full Title: Enfuvirtide induction in heavily drug experienced patients
    Medical condition: Heavily drug experienced HIV infected patients at switch of anti- HIV therapy.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2014-004297-42 Sponsor Protocol Number: IN-NL-2641449 Start Date*: 2015-06-15
    Sponsor Name:UMC Utrecht
    Full Title: Effect of Switching Atripla to Eviplera on neurocognitive and emotional functioning
    Medical condition: neurocognitive and emotional functioning in HIV positive men using antiretroviral therapy
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-021785-30 Sponsor Protocol Number: A4001095 Start Date*: 2011-12-07
    Sponsor Name:ViiV Healthcare UK Limited
    Full Title: A MULTICENTER, RANDOMIZED, DOUBLE BLIND, COMPARATIVE TRIAL OF MARAVIROC + DARUNAVIR/RITONAVIR VERSUS EMTRICITABINE/TENOFOVIR + DARUNAVIR/RITONAVIR FOR THE TREATMENT OF ANTIRETROVIRAL NAÏVE HIV INFE...
    Medical condition: HIV infection
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004862 10068341 HIV-1 infection LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) HU (Completed) SE (Prematurely Ended) FI (Prematurely Ended) BE (Prematurely Ended) ES (Prematurely Ended) GB (Prematurely Ended) AT (Completed) DK (Prematurely Ended) NL (Completed) PT (Prematurely Ended) PL (Prematurely Ended) IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-005127-34 Sponsor Protocol Number: 0518-018 Start Date*: 2006-03-14
    Sponsor Name:Merck & Co. Inc.
    Full Title: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety and Antiretroviral Activity of MK-0518 in Combination With an Optimized Background Therapy (OBT), Versus Opt...
    Medical condition: Unspecified human immuno-deficiency virus [HIV] disease
    Disease: Version SOC Term Classification Code Term Level
    9.1 10020160 HIV disease LLT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) DK (Completed) ES (Completed) PT (Completed) BE (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2011-002107-15 Sponsor Protocol Number: Kirby-MARCH Start Date*: 2011-12-16
    Sponsor Name:Kirby Institute, University of New South Wa
    Full Title: Maraviroc Switch collaborative study A randomised, open-label study to evaluate the efficacy and safety of maraviroc (MVC) as a switch for either nucleoside or nucleotide analogue reverse transcr...
    Medical condition: Chronic HIV-1 infection
    Disease: Version SOC Term Classification Code Term Level
    14.0 10021881 - Infections and infestations 10008919 Chronic HIV infection LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed) GB (Completed) DE (Completed) ES (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2004-004990-27 Sponsor Protocol Number: TMC114-C151 Start Date*: 2005-05-09
    Sponsor Name:TIBOTEC PHARMACEUTICALS LTD.
    Full Title: The pharmacokinetic interaction between TMC114, lopinavir and ritonavir, in HIV-1 infected subjects.
    Medical condition: Treatment of HIV-1 infected subjects
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2006-005609-76 Sponsor Protocol Number: SSAT 018 Start Date*: 2006-11-28
    Sponsor Name:St Stephens Aids Trust
    Full Title: EFFECT OF DIFFERENT MEALS ON THE PHARMACOKINETIC PROFILE OF SAQUINAVIR AT STEADY STATE IN HIV-INFECTED PATIENTS TREATED WITH SAQUINAVIR/RITONAVIR 1000/100 mg BID.
    Medical condition: HIV
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-006260-52 Sponsor Protocol Number: THV01-11-01 Start Date*: 2012-10-12
    Sponsor Name:THERAVECTYS
    Full Title: A multi-center, randomized, double blind, placebo-controlled Phase I/II trial to compare the safety, tolerability and immunogenicity of the therapeutic THV01 vaccination at 5x10E6 TU, 5x10E7 TU or ...
    Medical condition: Human Immunodeficiency Virus type 1 infection
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004862 10068341 HIV-1 infection LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed) FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-002843-81 Sponsor Protocol Number: 057 Start Date*: 2020-01-07
    Sponsor Name:IMEA
    Full Title: Switch to Tenofovir Alafenamide (TAF), Emtricitabine (FTC), Bictegravir (BIC)(Biktarvy®) in HIV-1-infected patients over 65 years old at risk of polymedication
    Medical condition: HIV-1-infected patient Age > 65 years old Plasma HIV RNA ≤ 50 copies/mL for ≥ 6 months: one blip between 50 et 200 cp/ml is allowed in the last 6 months before screening. Currently receiving an ant...
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-001778-21 Sponsor Protocol Number: A4001028 Start Date*: 2005-02-02
    Sponsor Name:PFIZER LTD
    Full Title: A multicentre, randomised, double-blind, placebo-controlled trial of a novel CCR5 antagonist, UK-427,857 in combination with optimised background therapy versus optimised background therapy alone f...
    Medical condition: UK-427,857 is an antagonist of the human chemokine receptor, and is intended to help prevent the development and progression of AIDS in indivuduals HIV-1 positive.
    Disease:
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) DE (Completed) ES (Completed) IT (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-004476-12 Sponsor Protocol Number: NCHECR001 Start Date*: 2007-07-10
    Sponsor Name:University of New South Wales
    Full Title: A randomised open-label study comparing the safety and efficacy of three different combination antiretroviral regimens as initial therapy for HIV infection.
    Medical condition: Chronic HIV infection
    Disease: Version SOC Term Classification Code Term Level
    8.1 10020161 HIV infection LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing) IE (Completed) DE (Ongoing) GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-000799-32 Sponsor Protocol Number: PROTEST Start Date*: 2011-06-08
    Sponsor Name:Fundació Lluita contra la SIDA
    Full Title: Use of genotypic HIV-1 tropism testing in proviral DNA to guide CCR5 antagonist treatment in subjects with undetectable HIV-1 viremia
    Medical condition: Human immunodeficiency virus (HIV) infection.
    Disease: Version SOC Term Classification Code Term Level
    14.0 10021881 - Infections and infestations 10008922 Chronic infection with HIV LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2009-013795-44 Sponsor Protocol Number: NCHECR-ENCORE1 Start Date*: 2012-06-21
    Sponsor Name:The Kirby Institute (formerly National Centre in HIV Epidemiology and Clinical Research (NCHECR)), University of New Sou
    Full Title: A randomised, double-blind, placebo-controlled, clinical trial to compare the safety and efficacy of reduced dose efavirenz (EFV) with standard dose EFV plus two nucleotide reverse transcriptase in...
    Medical condition: Human Immunodeficiency Virus infection
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022891 - Investigations 10070257 Human immunodeficiency virus test positive LLT
    14.1 10021881 - Infections and infestations 10020161 HIV infection PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-002743-24 Sponsor Protocol Number: STEPS in Geno Type 3 Cirrhotics Start Date*: 2007-08-22
    Sponsor Name:Queen Mary University of London
    Full Title: Study to evaluate different duration of treatment regimes of 40kD pegylated interferon alfa 2a (Pegasys) plus ribavirin on sustained virological responses (SVR) in Genotype 3 HCV infected cirrhotic...
    Medical condition: Chronic hepatitis C infection with genotype 3 and advanced fibrosis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10008912 Chronic hepatitis C LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2005-005119-76 Sponsor Protocol Number: AI424-227 Start Date*: 2006-05-24
    Sponsor Name:Bristol-Myers Squibb S.A.
    Full Title: Phase IIIb Multicenter, Single Arm, Open-label Pilot Study to Evaluate the Effectiveness and Safety of Maintenance with Atazanavir/ritonavir as Single Enhanced Protease Inhibitor Therapy in HIV-Inf...
    Medical condition: HIV-Infected Patients Evidencing Virologic Suppression Pacientes infectados de VIH, con supresión virológica evidente
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2010-023178-37 Sponsor Protocol Number: GS-US-264-0106 Start Date*: 2011-02-04
    Sponsor Name:Gilead Sciences, Inc.
    Full Title: A Phase 3 Randomized, Open Label Study to Evaluate Switching from Regimens Consisting of a Ritonavir-boosted Protease Inhibitor and Two Nucleoside Reverse Transcriptase Inhibitors to Emtricitabine/...
    Medical condition: Human Immunodeficiency Virus (Type 1) Infection
    Disease: Version SOC Term Classification Code Term Level
    14.1 10021881 - Infections and infestations 10020192 HIV-1 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed) ES (Completed) BE (Completed) IT (Completed) AT (Completed)
    Trial results: View results
    EudraCT Number: 2011-004420-35 Sponsor Protocol Number: GS-US-104-0423 Start Date*: 2013-02-13
    Sponsor Name:Gilead Sciences, Inc.
    Full Title: A Phase 4 Cross-Sectional Study of Bone Mineral Density in HIV-1 Infected Subjects
    Medical condition: Human Immunodeficiency Virus-1 (HIV-1) Infections
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004862 10068341 HIV-1 infection LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) ES (Completed) GB (Completed) AT (Completed) NL (Completed) IT (Completed) IE (Completed) PT (Completed) SE (Completed)
    Trial results: View results
    EudraCT Number: 2005-001057-21 Sponsor Protocol Number: PO3672 Start Date*: 2005-12-16
    Sponsor Name:Schering-Plough Research Insititute, a division of Schering Corporation
    Full Title: Vicriviroc in Combination Treatment with Optimized ART Regimen in Experienced Subjects (VICTOR-E1)
    Medical condition: HIV infection (R5-tropism only) with previous therapy
    Disease: Version SOC Term Classification Code Term Level
    9.1 10200172 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) GB (Completed) PT (Completed) IT (Prematurely Ended)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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