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Clinical trials for Sciatica

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    14 result(s) found for: Sciatica. Displaying page 1 of 1.
    EudraCT Number: 2006-001608-35 Sponsor Protocol Number: HUM-04-80 Start Date*: 2006-12-01
    Sponsor Name:Dr. Valérie gangji
    Full Title: TREATMENT OF SCIATICA BY ADALIMUMAB INJECTION : A RANDOMIZED, DOUBLE BLIND CONTROLLED TRIAL.
    Medical condition: To determine the efficacy of adalimumab in disc herniation-induced sciatica in a controlled randomised double blind pilot study.
    Disease: Version SOC Term Classification Code Term Level
    8.1 10039674 Sciatica LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-002119-33 Sponsor Protocol Number: 2017-02 Start Date*: 2017-09-07
    Sponsor Name:ZonMW
    Full Title: The PLUS study: Preventing LUmbar Disc Surgery
    Medical condition: Lumbosacral Radicular Syndrome
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000014640 10037739 R sciatica LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-002177-11 Sponsor Protocol Number: 80-83600-98-20013 Start Date*: 2015-04-16
    Sponsor Name:ZonMW GGG
    Full Title: Step-down versus step-up analgesics in patients with (sub)acute sciatica in primary care
    Medical condition: Patients with (sub)acute sciatica in primary care.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-002751-25 Sponsor Protocol Number: RG112-14 Start Date*: 2014-10-08
    Sponsor Name:The Walton Centre NHS Foundation Trust
    Full Title: Multi-centre randomised control trial comparing the clinical and cost effectiveness of trans-foraminal epidural steroid injection to surgical microdiscectomy for the treatment of chronic radicular ...
    Medical condition: Chronic radicular pain secondary to a prolapsed intervertebral disc herniation
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029205 - Nervous system disorders 10039674 Sciatica PT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-006583-35 Sponsor Protocol Number: 06/Q2601/33 Start Date*: 2007-02-13
    Sponsor Name:Shrewsbury & Telford Hospital NHS Trust
    Full Title: A comparison of two diluents commonly used in epidural steroid injection for the treatment of low back pain and sciatica
    Medical condition: Low back pain and sciatica
    Disease: Version SOC Term Classification Code Term Level
    9.1 10003989 Back pain (with radiation) LLT
    Population Age: Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-000636-15 Sponsor Protocol Number: 12/201/02 Start Date*: 2015-05-27
    Sponsor Name:Bangor University
    Full Title: A randomised controlled trial of adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica.
    Medical condition: Sciatica is a symptom defined as unilateral, well-localised leg pain, with a sharp, shooting or burning quality, that approximates to the dermatomal distribution of the sciatic nerve down the poste...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-003560-74 Sponsor Protocol Number: p2011-1 Start Date*: 2012-09-25
    Sponsor Name:Leiden University Medical Center
    Full Title: Effectiveness of Clonidine for the treatment of radicular pain: A randomized, double-blind and prospective study. (EFFOC study)
    Medical condition: Radicular lumbar pain
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-003564-57 Sponsor Protocol Number: Adalimumab1- 2006 Start Date*: 2006-11-02
    Sponsor Name:Kuopio University Hospital
    Full Title: Adalimumab (anti TNF alfa) in the management of acute lumbar disc prolapses -a one year, randomized, placebo controlled, double blind, single center trial
    Medical condition: Patients with acute or subacute (no more than 2 months) clinical sciatica caused by herniated disc prolapse
    Disease: Version SOC Term Classification Code Term Level
    8.1 10036852 Prolapsed lumbar disc LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-001571-17 Sponsor Protocol Number: 21-0148 Start Date*: 2021-08-25
    Sponsor Name:CHU de Nantes
    Full Title:
    Medical condition: refractory lumbosciatic patients
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004852 10024251 Lesion of sciatic nerve LLT
    Population Age: Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-023262-46 Sponsor Protocol Number: 20101005PH Start Date*: 2011-03-08
    Sponsor Name:Royal Devon & exeter Foundation trust
    Full Title: A Randomised Prospective Pilot Study Comparing the Outcomes of Patients with Lumbar Nerve Root Pain Secondary to Lumbar Disc Prolapse Treated by Nerve Root Block with or without the Addition of Clo...
    Medical condition: Lumbar nerve root pain secondary to disc prolapse.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2012-004444-30 Sponsor Protocol Number: Disc_allo_MSV Start Date*: 2013-04-23
    Sponsor Name:Citospin
    Full Title: Treatment of degenerative disc disease with allogenic mesenchymal cells—MSV--
    Medical condition: Treatment of degenerative disc disease
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2012-000255-13 Sponsor Protocol Number: 11-019 Start Date*: 2012-06-20
    Sponsor Name:Portola Pharmaceuticals, Inc.
    Full Title: Multicenter, Randomized, Active-Controlled Efficacy And Safety Study Comparing Extended Duration Betrixaban With Standard Of Care Enoxaparin For The Prevention Of Venous Thromboembolism In Acute Me...
    Medical condition: Prophylaxis of venous thromboembolism
    Disease: Version SOC Term Classification Code Term Level
    17.0 100000004865 10049909 Venous thromboembolism prophylaxis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) LV (Completed) DE (Completed) ES (Completed) GB (Completed) PL (Completed) LT (Completed) AT (Completed) DK (Completed) CZ (Completed) BG (Completed) IT (Completed) FI (Completed) SK (Completed)
    Trial results: View results
    EudraCT Number: 2004-003752-19 Sponsor Protocol Number: OXN3401 Start Date*: 2005-02-01
    Sponsor Name:Mundipharma Research GmbH & Co.KG
    Full Title: A Randomized, Double-blind, Placebo- and Active-controlled, Double-dummy, Parallel Group Study to Determine the Safety and Efficacy of Oxycodone/Naloxone Prolonged-release Tablets in Subjects with ...
    Medical condition: Moderate to severe chronic pain of low back that requires around-the-clock opioid therapy.
    Disease: Version SOC Term Classification Code Term Level
    7.0 10003988 pt
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) CZ (Completed) DK (Completed) SK (Completed) ES (Completed) AT (Completed)
    Trial results: View results
    EudraCT Number: 2014-001449-26 Sponsor Protocol Number: 6603/1132 Start Date*: 2015-01-22
    Sponsor Name:Seikagaku Corporation
    Full Title: A Multicenter, Open-label Study of SI-6603 in Patients with Lumbar Disc Herniation (Phase III)
    Medical condition: Lumbar disc herniation
    Disease: Version SOC Term Classification Code Term Level
    17.1 10028395 - Musculoskeletal and connective tissue disorders 10050296 Intervertebral disc protrusion PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) DE (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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