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Clinical trials for Third molars

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    31 result(s) found for: Third molars. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2007-006252-19 Sponsor Protocol Number: 1.0. Start Date*: 2008-07-24
    Sponsor Name:Univ.-Prof. DDr. Norbert Jakse, Universitätszahnklinik Graz, Dep. f. Orale Chirurgie u. Röntgenologi
    Full Title: Einfluss von peroraler Methylprednisolon-Gabe auf die postoperative Morbidität nach operativer Weisheitszahnenfernung im Unterkiefer. (Influence of peroral Methylprednisolone administration on the...
    Medical condition: To be investigated is the anti-inflammatory and anti-oedematous effect of methylprednisolone on the postoperative sequelae after surgical removal of lower third molars. 16 healthy patients will und...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2005-000200-14 Sponsor Protocol Number: Start Date*: 2005-07-08
    Sponsor Name:North Bristol NHS Trust
    Full Title: A randomised, double-blinded comparison of the effectiveness of intravenously administered Ketoralac versus Dexamethasone in the treatment of pain following surgical removal of third molar teeth un...
    Medical condition: Pain experienced after the surgical removal of impacted third molars.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-006617-32 Sponsor Protocol Number: 06/Q0605/1 Start Date*: 2007-05-02
    Sponsor Name:Kings College Hospital Trust R&D
    Full Title: A prospective randomised double blind parallel trial comparing Articaine versus Lignocaine for mandibular dentistry
    Medical condition: necessary dental surgery
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2017-004986-28 Sponsor Protocol Number: AMOXI Start Date*: 2019-03-25
    Sponsor Name:Medizinische Universität Graz, Klin. Abteilung für Orale Chirurgie und Kieferorthopädie
    Full Title: Effect of systemic antibiotic therapy on postoperative complications in patients undergoing wisdom teeth removal surgery. A double-blind, randomised, placebo-controlled Trial
    Medical condition: Surgical extraction of third molars
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10047991 Wisdom teeth removal PT
    20.0 10042613 - Surgical and medical procedures 10038349 Removal of wisdom teeth LLT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2019-000902-31 Sponsor Protocol Number: ECACOR19 Start Date*: 2019-09-05
    Sponsor Name:OMEQUI
    Full Title: Healing efficacy after impacted mandibular third molar surgery with the use of autologous platelet-rich fibrin: a randomized controlled clinical study
    Medical condition: If the addition of L-PRF reduces postoperative pain and inflammation, as well as complications, after extraction of lower third molars
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-000866-22 Sponsor Protocol Number: 01.01.08Jen Start Date*: 2008-05-15
    Sponsor Name:University of Aarhus, School of Dentistry
    Full Title: Vurdering af det operative forløb i forbindelse med fjernelse af mandiblens 3. molar med særligt henblik på forekomsten af smerte og hævelse
    Medical condition: pain after surgical removal of lower third molars
    Disease: Version SOC Term Classification Code Term Level
    9.1 10051059 Oral surgery LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-000622-35 Sponsor Protocol Number: 56872 Start Date*: 2017-10-23
    Sponsor Name:Aalborg University Hospital
    Full Title: Different dosis of corticosteroids in mandibular third molar surgery. A randomized, blinded clinical trial assessing pain, trismus, edema, and quality of life outcome measurements.
    Medical condition: The purpose is to investigate the postoperative morbidity after removal of mandibular third molar with different doses of methylprednisolone.
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004863 10036278 Postoperative complications NOS LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2017-005049-67 Sponsor Protocol Number: 19762 Start Date*: 2018-08-29
    Sponsor Name:Bayer HealthCare LLC
    Full Title: A Randomized, Double-Blind, Placebo-Controlled Trial to Compare the Duration of Analgesic Efficacy and Safety of Naproxen Sodium Tablets and Ibuprofen Tablets in Postsurgical Dental Pain
    Medical condition: Pain relief
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004856 10044049 Dental pain and sensation disorders HLT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2014-005270-11 Sponsor Protocol Number: BAY1019036/15529 Start Date*: 2015-02-09
    Sponsor Name:Bayer HealthCare AG
    Full Title: Comparative Onset of Action of a Fast Release Aspirin Tablet in a Dental Impaction Pain Model
    Medical condition: pain following extraction of impacted third molars
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004856 10044049 Dental pain and sensation disorders HLT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2016-000592-24 Sponsor Protocol Number: MR308-3501 Start Date*: 2017-03-15
    Sponsor Name:Mundipharma Research GmbH & Co. KG
    Full Title: A Randomized, Double-Blind, Multicenter, Placebo- and active Comparator-Controlled Study to evaluate Efficacy and Safety of MR308 in the Treatment of Acute Pain After Third Molar Tooth Extraction (...
    Medical condition: Acute pain after third molar tooth extraction; dental procedure must have involved extraction of at least two impacted third molars requireing bone removal. If only two impacted third molars are ex...
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000023314 10066714 Acute pain LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) PL (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2013-003323-11 Sponsor Protocol Number: ITIBU001 Start Date*: 2014-10-01
    Sponsor Name:"Sapienza" University of Rome
    Full Title: RANDOMIZED CLINICAL TRIAL, PLACEBO-CONTROLLED, SPLIT-MOUTH, A DOUBLE-BLIND, FOR THE EVALUATION OF THE EFFECTIVENESS OF PREemptive ANALGESIA BY ADMINISTRATION OF IBUPROFEN 400MG, FOR THE CONTROL ...
    Medical condition: POST-OPERATIVE ACUTE PAIN (DAPO)
    Disease: Version SOC Term Classification Code Term Level
    17.1 10017947 - Gastrointestinal disorders 10031009 Oral pain PT
    17.1 10017947 - Gastrointestinal disorders 10030973 Oral discomfort PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-015589-74 Sponsor Protocol Number: NYC-IBU-1 Start Date*: 2009-10-02
    Sponsor Name:Nycomed Sweden Holding 2 AB
    Full Title: A controlled, randomized, double-blind, cross-over study of the onset of analgesic effect of two formulations of ibuprofen for the treatment of pain after oral surgery.
    Medical condition: Pain
    Disease: Version SOC Term Classification Code Term Level
    12.0 10033371 Pain LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed) DK (Completed)
    Trial results: View results
    EudraCT Number: 2019-003513-33 Sponsor Protocol Number: 21069 Start Date*: 2020-05-20
    Sponsor Name:Bayer HealthCare LLC
    Full Title: A Randomized, Double-Blind, Single-Dose, Parallel, Placebo-Controlled Trial to Determine the Dose of Caffeine in a Fixed Dose Combination Tablet of Naproxen Sodium and Caffeine to Effectively Allev...
    Medical condition: Pain, Postoperative
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004863 10054711 Postoperative pain LLT
    20.0 10042613 - Surgical and medical procedures 10061812 Dental operation PT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2017-004493-34 Sponsor Protocol Number: 2017/06NOV/503 Start Date*: 2018-01-02
    Sponsor Name:Cliniques universitaires Saint-Luc
    Full Title: Evaluation of multiple subgingival irrigations with 10% povidone iodine after scaling and root planing : a randomized clinical trial
    Medical condition: Periodontitis is characterized by alveolar bone loss induced by the host immune response to bacterial insult. Because povidone iodine is known to be a powerful antiseptic, there is biologic rationa...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-005807-41 Sponsor Protocol Number: PRE-EMPTIVE Start Date*: 2013-04-28
    Sponsor Name:"Sapienza" University of Rome
    Full Title: RANDOMIZED CLINICAL TRIAL, PLACEBO-CONTROLLED, SPLIT-MOUTH, A DOUBLE-BLIND, FOR THE EVALUATION OF THE EFFECTIVENESS OF PRE-emptive ANALGESIA BY ADMINISTRATION OF PARACETAMOL 500MG + codeine 30mg, ...
    Medical condition: POST-OPERATIVE ACUTE PAIN (DAPO)
    Disease: Version SOC Term Classification Code Term Level
    14.1 10017947 - Gastrointestinal disorders 10031009 Oral pain PT
    14.1 10017947 - Gastrointestinal disorders 10030973 Oral discomfort PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2022-003274-22 Sponsor Protocol Number: 22093 Start Date*: 2022-10-25
    Sponsor Name:Bayer HealthCare LLC
    Full Title: A Randomized, Double-Blind, Single-Dose, Parallel, Placebo-Controlled Pivotal Trial to Confirm the Efficacy of a Fixed Dose Combination Tablet of Naproxen Sodium and Caffeine to Effectively Allevia...
    Medical condition: Postoperative dental pain
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004863 10054711 Postoperative pain LLT
    20.0 100000004856 10059723 Tooth pain LLT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2013-004637-33 Sponsor Protocol Number: FMLD-IOTRA-20_FIIIA Start Date*: 2014-06-11
    Sponsor Name:Laboratorios Farmalider S.A.
    Full Title: Clinical trial phase III, multicenter, randomised, double-blind, double-dummy, parallel treatment design, active-controlled and placebo, to evaluate the analgesic efficacy and safety of ibuprofen a...
    Medical condition: Moderate to severe pain following dental surgery.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-001133-18 Sponsor Protocol Number: PH-2006-1 Start Date*: 2006-05-25
    Sponsor Name:Pharmos Corp.
    Full Title: CANNABINOR DENTAL IMPACTION PAIN STUDY PROOF-OF-CONCEPT DOSE-RANGING STUDY
    Medical condition: Cannabinor is as an analgesic and anti-inflammatory agent. By its nature, it has been designed to be more active at the CB2 peripheral receptors and have less activity at the central CB1 receptors....
    Disease: Version SOC Term Classification Code Term Level
    8.1 10033371 Pain LLT
    Population Age: Adults Gender: Male
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-002778-21 Sponsor Protocol Number: ESTEVE-SACO4-201 Start Date*: 2012-01-12
    Sponsor Name:Laboratorios del Dr. Esteve, S.A
    Full Title: A randomized, double-blind, controlled with active treatment (tramadol 100 mg) and placebo, parallel groups, Phase II clinical trial to establish the effective dose between 4 strengths of E-58425 f...
    Medical condition: Adult patients with moderate to severe dental pain
    Disease: Version SOC Term Classification Code Term Level
    14.0 10018065 - General disorders and administration site conditions 10033371 Pain PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2020-005530-15 Sponsor Protocol Number: FMLD-IOTRA2-47_FIII Start Date*: Information not available in EudraCT
    Sponsor Name:Farmalíder S.A.
    Full Title: Randomized, double blind, placebo-controlled, active treatment clinical trial to assess the analgesic efficacy and the safety of an oral ibuprofen (arginine)-tramadol HCI combination administered t...
    Medical condition: Moderate-severe somatic pain
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004856 10044049 Dental pain and sensation disorders HLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Restarted)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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