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Clinical trials for Vitrectomy

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
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    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    48 result(s) found for: Vitrectomy. Displaying page 1 of 3.
    1  2  3  Next»
    EudraCT Number: 2010-018919-16 Sponsor Protocol Number: TG-MV-010 Start Date*: 2010-06-28
    Sponsor Name:ThromboGenics NV
    Full Title: An Open-Label, Ascending- Exposure-Time, Single Center Trial to Evaluate the Pharmacokinetic Properties of Ocriplasmin (Generic Name of the Molecule Microplasmin) Intravitreal Injection in Subjects...
    Medical condition: Patients who require primary pars plana vitrectomy. A sample of vitreous will be taken at beginning of surgery for PK analysis.
    Disease: Version SOC Term Classification Code Term Level
    12.1 10047644 Vitrectomy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2007-000780-21 Sponsor Protocol Number: CHEF1005 Start Date*: 2007-10-12
    Sponsor Name:Moorfields Eye Hospital
    Full Title: A randomised, single-masked, Phase IV pilot study of the efficacy and safety of adjunctive intravitreal Avastin® (bevacizumab) in the prevention of early postoperative vitreous haemorrhage followin...
    Medical condition: Vitreous haemorrhage secondary to proliferative diabetic retinopathy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-001171-36 Sponsor Protocol Number: TG-MV-001 Start Date*: 2005-05-13
    Sponsor Name:ThromboGenics Ltd.
    Full Title: A Dose-Escalation Clinical Trial of Intravitreal Microplasmin in Patients Undergoing Surgical Vitrectomy for Vitreomacular Traction Maculopathy
    Medical condition: Vitreomacular Traction Maculopathy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2010-024062-22 Sponsor Protocol Number: BAIJ1006 Start Date*: 2011-03-22
    Sponsor Name:Moorfields Eye Hospital
    Full Title: A prospective, randomised controlled trial of Ranibizumab pre-treatment in Diabetic Vitrectomy – a pilot study.
    Medical condition: Proliferative diabetic retinopathy
    Disease: Version SOC Term Classification Code Term Level
    13 10036857 Proliferative diabetic retinopathy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2012-001006-24 Sponsor Protocol Number: RAVIT-DME_7.12.2011 Start Date*: 2013-08-23
    Sponsor Name: [...]
    1.
    2. Augenklinik Universitaetsallee
    Full Title: Ranibizumab and Vitrectomy in the Therapy of Diabetic Macular Edema (The RAVIT-DME-Trial)
    Medical condition: therapy of diabetic macular edema
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2012-002895-15 Sponsor Protocol Number: EPROBRI-2011 Start Date*: 2012-12-19
    Sponsor Name:Fundación Oftalmológica del Mediterráneo
    Full Title: Prophylactic effect of brimonidine on bleeding subconjunctival in 23G vitrectomy
    Medical condition: Subconjunctival haemorrhages after surgery of vitrectomía with 23G
    Disease: Version SOC Term Classification Code Term Level
    15.0 10015919 - Eye disorders 10042341 Subconjunctival haemorrhage LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2007-000658-30 Sponsor Protocol Number: prot PDR 1 Start Date*: 2007-03-02
    Sponsor Name:Royal Victoria Eye and Ear hospital
    Full Title: Randomised controlled trial of Intravitreal Bevacizumab vs. conventional treatment for proliferative diabetic retinopathy.
    Medical condition: Proliferative diabetic retinopathy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-015559-25 Sponsor Protocol Number: KCH1724 Start Date*: 2010-04-22
    Sponsor Name:King's College Hospital NHS Foundation Trust
    Full Title: Preoperative intravitreal ranibizumab for persistent diabetic vitreous haemorrhage: A randomized, double-masked, controlled study
    Medical condition: Retinopathy is a well recognised complication of diabetes and is a leading cause of vision loss in this patient group. The severity of diabetic retinopathy varies, but in its most severe form (pro...
    Disease: Version SOC Term Classification Code Term Level
    12. 10047655 Vitreous Haemorrhage LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-006085-42 Sponsor Protocol Number: TG-MV-004 Start Date*: 2007-01-24
    Sponsor Name:ThromboGenics Ltd.
    Full Title: A Randomized, Sham-Injection Controlled, Double-Masked, Ascending-Dose, Dose-Range-Finding, Multicenter Trial of Microplasmin Intravitreal Injection for Non-Surgical PVD Induction for Treatment of ...
    Medical condition: Vitreomacular Traction Syndrome
    Disease: Version SOC Term Classification Code Term Level
    8.1 10051065 Vitreomacular traction syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2008-005228-10 Sponsor Protocol Number: TG-MV-008 Start Date*: 2008-10-03
    Sponsor Name:ThromboGenics NV
    Full Title: An Open Label, Single Center Trial of Microplasmin Intravitreal Injection for Non-Surgical Treatment of Focal Vitreomacular Adhesion
    Medical condition: Focal vitreomacular adhesion
    Disease: Version SOC Term Classification Code Term Level
    9.1 10051065 Vitreomacular traction syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2004-001991-37 Sponsor Protocol Number: WICL1001 Start Date*: 2004-11-18
    Sponsor Name:Moorfields Eye Hospital
    Full Title: A pilot study investigating the effects of a combination of local and systemic anti-inflammatory adjuncts in patients undergoing vitrectomy and silicone oil for established Proliferative Vitreoreti...
    Medical condition: Proliferative Vitreoretinopathy This is a scarring process that occurs in patients who have developed a retinal detachment. It is the primary cause of failure in retinal detachment surgery and oc...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-003297-81 Sponsor Protocol Number: PDRPOZU1 Start Date*: 2011-09-12
    Sponsor Name:St Eriks Eye Hospital
    Full Title: A prospective, randomized study on intravitreal Ozurdex for preventing recurrent vitreous hemorrhage following pars plana vitrectomy for proliferative diabetic retinopathy
    Medical condition: Proliferative diabetic retinopathy
    Disease: Version SOC Term Classification Code Term Level
    14.0 10015919 - Eye disorders 10036857 Proliferative diabetic retinopathy LLT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-001856-36 Sponsor Protocol Number: MEDICARE Start Date*: 2013-08-05
    Sponsor Name:CHU DE POITIERS
    Full Title: Efficacy and safety of Aflibercept (Eylea®) in proliferative diabetic retinopathy
    Medical condition: Percentage of patients showing regression of retinal neovascularization between baseline and month 12 in the Aflibercept group versus laser group
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004853 10036857 Proliferative diabetic retinopathy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-004917-10 Sponsor Protocol Number: TIGER Start Date*: 2023-06-29
    Sponsor Name:King's College London [...]
    1. King's College London
    2. King's College Hospital NHS Foundation Trust
    Full Title: Vitrectomy, subretinal Tissue plasminogen activator and Intravitreal Gas for submacular haemorrhage secondary to Exudative age-Related macular degeneration (TIGER): a phase 3, pan-European, two-gro...
    Medical condition: Submacular haemorrhage secondary to exudative age-related macular degeneration
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004853 10075718 Exudative age-related macular degeneration LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2016-002656-24 Sponsor Protocol Number: CTSULENS1 Start Date*: 2018-01-23
    Sponsor Name:University of Oxford (Clinical Trials and Research Governance))
    Full Title: A randomised placebo-controlled clinical trial of fenofibrate to prevent progression of non-proliferative retinopathy in diabetes
    Medical condition: Diabetic retinopathy and diabetic maculopathy
    Disease: Version SOC Term Classification Code Term Level
    20.1 10015919 - Eye disorders 10012689 Diabetic retinopathy PT
    20.0 10015919 - Eye disorders 10025425 Maculopathy PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2014-000388-41 Sponsor Protocol Number: OZR-2013-27 Start Date*: 2014-05-05
    Sponsor Name:The Rotterdam Eye Hospital
    Full Title: Does oral administration of dabigatran etexilate, a direct thrombin inhibitor, achieve clinical significant concentrations of dabigatran and thrombin inhibiting activity in vitreous and subretinal ...
    Medical condition: Ocular accessibility of dabigatran in patients with retinal detachment
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2013-001421-55 Sponsor Protocol Number: CRFB002GFR02 Start Date*: 2013-06-13
    Sponsor Name:Novartis Pharma S.A.S
    Full Title: An open-label Extended Clinical Protocol of ranibizumab to evaluate Safety and Efficacy in rare VEGF driven ocular diseases.
    Medical condition: Choroidal neovascularization not related to wet Age-related macular degeneration (wAMD), pathologic myopia (PM)or Pseudoxanthoma elasticum (PXE), as well as in Macular Edema (ME) not related to Ret...
    Disease: Version SOC Term Classification Code Term Level
    18.0 10015919 - Eye disorders 10047060 Retina, choroid and vitreous haemorrhages and vascular disorders HLGT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2019-002591-14 Sponsor Protocol Number: CTC0128 Start Date*: 2020-05-29
    Sponsor Name:Belfast Health & Social Care Trust
    Full Title: The Fenofibrate And Microvascular Events in Type 1 diabetes Eye (FAME 1 Eye): A randomised trial to evaluate the efficacy on retinopathy and safety of fenofibrate in adults with type 1 diabetes. A...
    Medical condition: To evaluate the effects of once daily oral fenofibrate compared with placebo on clinically meaningful retinopathy progression over at least 3 years in adults with Type 1 diabetes (T1D) and existing...
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004861 10012608 Diabetes mellitus insulin-dependent LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2006-004626-93 Sponsor Protocol Number: TG-MV-002 Start Date*: 2006-12-19
    Sponsor Name:ThromboGenics N.V.
    Full Title: A Randomized, Sham-Injection Controlled, Double-Masked, Ascending-Dose, Dose-Range-Finding Trial of Microplasmin Intravitreal Injection for Non-Surgical PVD Induction for Treatment of Diabetic Macu...
    Medical condition: Diabetic macular edema
    Disease: Version SOC Term Classification Code Term Level
    8.1 10057934 Diabetic macular edema LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) DE (Completed) NL (Completed) GB (Completed) ES (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2014-002193-37 Sponsor Protocol Number: CHAD1031 Start Date*: 2014-09-05
    Sponsor Name:Moorfields Eye Hospital NHS Foundation Trust
    Full Title: A phase 3 multi-centre double-masked randomised controlled trial of adjunctive intraocular and periocular steroid (triamcinolone acetonide) versus standard treatment in eyes undergoing vitreoretina...
    Medical condition: retinal detachment and the development of scarring (proliferative vitreoretinopathy) in patients with open globe trauma
    Disease: Version SOC Term Classification Code Term Level
    17.0 10015919 - Eye disorders 10057896 Proliferative vitreoretinopathy LLT
    17.0 10015919 - Eye disorders 10038848 Retinal detachment PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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