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Clinical trials for depression

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    The EU Clinical Trials Register currently displays   43801   clinical trials with a EudraCT protocol, of which   7272   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

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    1,442 result(s) found for: depression. Displaying page 1 of 73.
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    EudraCT Number: 2016-001637-27 Sponsor Protocol Number: LQD Start Date*: 2016-09-20
    Sponsor Name:South London and Maudsley NHS Foundation Trust [...]
    1. South London and Maudsley NHS Foundation Trust
    2. King's College London
    Full Title: A randomised pragmatic trial comparing the clinical and cost effectiveness of lithium and quetiapine augmentation in treatment resistant depression.
    Medical condition: Treatment resistant major depressive disorder (single episode or recurrent). Treatment resistant depression, defined as failure to respond to two or more adequate doses of antidepressant in the cur...
    Disease: Version SOC Term Classification Code Term Level
    20.0 10037175 - Psychiatric disorders 10067373 Depression perimenopausal LLT
    21.1 10037175 - Psychiatric disorders 10066555 Chronic depression LLT
    21.1 10037175 - Psychiatric disorders 10057840 Major depression PT
    20.0 10037175 - Psychiatric disorders 10012391 Depression postpartum (excl psychosis) LLT
    20.0 10022117 - Injury, poisoning and procedural complications 10012390 Depression postoperative PT
    20.0 10037175 - Psychiatric disorders 10012386 Depression mental LLT
    21.1 10037175 - Psychiatric disorders 10066530 Acute depression LLT
    20.0 10037175 - Psychiatric disorders 10012389 Depression postmenopausal LLT
    20.0 10037175 - Psychiatric disorders 10012387 Depression NOS LLT
    20.0 10037175 - Psychiatric disorders 10012378 Depression PT
    21.1 10037175 - Psychiatric disorders 10045543 Unipolar depression LLT
    21.1 10037175 - Psychiatric disorders 10037998 Reactive depression LLT
    21.1 10037175 - Psychiatric disorders 10042457 Suicidal depression LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2020-001592-33 Sponsor Protocol Number: 0204 Start Date*: 2020-11-17
    Sponsor Name:Rigshospitalet
    Full Title: Maternal Mental Health (MAMA) Study. Short time estrogen as a candidate strategy to prevent postpartum depression in a high-risk group
    Medical condition: Perinatal depression with postpartum onset
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004873 10056393 Postpartum depression LLT
    Population Age: Newborns, Under 18, Adults Gender: Male, Female
    Trial protocol: DK (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-003437-10 Sponsor Protocol Number: CARTESIO Start Date*: 2023-04-05
    Sponsor Name:Azienda Socio Sanitaria Territoriale di Lodi
    Full Title: PILOT STUDY ON THE EFFECTIVENESS OF CHOLINE ALFOSCERATE IN THE UNDER THRESHOLD DEPRESSION OF THE ELDERLY
    Medical condition: Under threshold depression of the elderly.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10037175 - Psychiatric disorders 10012378 Depression PT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-004647-37 Sponsor Protocol Number: G0373 Start Date*: 2006-11-06
    Sponsor Name:Bangor University
    Full Title: Folate Augmentation of Treatment – Evaluation of Depression: a randomised controlled trial
    Medical condition: Individuals with moderate to severe depression according to ICD-10 criteria.
    Disease: Version SOC Term Classification Code Term Level
    8.1 10012378 Depression LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-001913-51 Sponsor Protocol Number: RC 15/08 Start Date*: 2009-03-23
    Sponsor Name:ISTITUTO PER L'INFANZIA BURLO GAROFOLO
    Full Title: SYNERGIC EFFECTS OF OXYTOCIN AND PSYCHOTHERAPY IN POSTPARTUM DEPRESSION. RANDOMIZED CONTROLLED STUDY.
    Medical condition: Postpartum depression.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10036235 Postnatal blues LLT
    Population Age: Adults Gender: Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-006089-40 Sponsor Protocol Number: 2006TUDOR_01 Start Date*: 2007-03-20
    Sponsor Name:University Hospitals Bristol NHS Foundation Trust
    Full Title: High dose corticosteroid pulses in treatment-resistant depression : a randomized double-blind placebo-controlled pilot study
    Medical condition: Resistant depression
    Disease: Version SOC Term Classification Code Term Level
    8.1 10012378 Depression LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-003654-40 Sponsor Protocol Number: APC031 Start Date*: 2011-10-21
    Sponsor Name:Department of Psychiatry
    Full Title: A Preliminary Study of Intravenous Ketamine in Selective Serotonin Reuptake Inhibitor (SSRI)-Resistant Depression
    Medical condition: Depression
    Disease: Version SOC Term Classification Code Term Level
    14.0 10037175 - Psychiatric disorders 10012378 Depression PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IE (Completed)
    Trial results: View results
    EudraCT Number: 2006-001618-34 Sponsor Protocol Number: 1208.24 Start Date*: 2006-12-11
    Sponsor Name:BOEHRINGER ING.
    Full Title: An eight-week, randomized, double-blind, two parallel groups, study to assess clinical response of Duloxetine 60 mg and 120 mg per day in patients hospitalized for severe depression
    Medical condition: Treatment of severely depressed patients
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012378 Depression LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed) FR (Completed)
    Trial results: View results
    EudraCT Number: 2010-023969-21 Sponsor Protocol Number: 724 Start Date*: 2011-10-28
    Sponsor Name:Gateshead Health NHS Foundation Trust
    Full Title: Vascular Augmentation of Late-life Unremitted Depression
    Medical condition: Late-life (aged 50 or over) unremitted vascular depression.
    Disease: Version SOC Term Classification Code Term Level
    14.0 10037175 - Psychiatric disorders 10012378 Depression PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2013-004276-35 Sponsor Protocol Number: PI-0290-2012 Start Date*: 2014-10-10
    Sponsor Name:Hospital Regional Universitario. IBIMA
    Full Title: Phase II, Double-blind, randomized, 1-way cross-over, to investigate the effectiveness of the combination of ascorbic acid (vitamin C) and tocopherol (vitamin E) versus placebo for the treatment of...
    Medical condition: The trial aims to treat depression. The incidence of major depression in the elderly accounts for between 3.6 and 4.8% and increases to 8 to 37.4% when depressive disorders in general is studied. B...
    Disease: Version SOC Term Classification Code Term Level
    17.0 10037175 - Psychiatric disorders 10012378 Depression PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-001829-33 Sponsor Protocol Number: F1J-US-HMFA Start Date*: 2008-09-15
    Sponsor Name:Eli Lilly and Company
    Full Title: Duloxetine Versus Placebo in the Long-Term Treatment of Patients with Late-Life Major Depression
    Medical condition: Major Depressive Disorder in elderly patients
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012378 Depression LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-003877-42 Sponsor Protocol Number: 7001 Start Date*: 2008-12-16
    Sponsor Name:Danish University Antidepressant Group (DUAG)
    Full Title: Relapse prevention in patients with major depression treated with electroconvulsive therapy using a fixed dose range of escitalopram compared to a fixed dose of nortriptyline (DUAG-7) A randomised ...
    Medical condition: Major depression
    Disease: Version SOC Term Classification Code Term Level
    14.0 10037175 - Psychiatric disorders 10012378 Depression PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2006-001750-28 Sponsor Protocol Number: 35456235 Start Date*: 2007-02-08
    Sponsor Name:Rigshospitalet, Psykiatrisk Klinik
    Full Title: Associationer mellem genpolymorfier, endofænotyper for depression og antidepressiv behandling
    Medical condition: Forsøget fortages på raske personer med disposition til affektiv lidelse.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012378 Depression LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-021044-17 Sponsor Protocol Number: CLOCK_depression Start Date*: 2010-08-11
    Sponsor Name:Medizinische Universität Wien
    Full Title: The effect of agomelatine on CLOCK gene expression in patients with major depressive disorder and healthy controls: an exploratory study.
    Medical condition: Major depressive disorder (MDD), Seasonal affective disorder (subtype of MDD)
    Disease: Version SOC Term Classification Code Term Level
    12.1 10012378 Depression LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2014-002451-26 Sponsor Protocol Number: 538264464328 Start Date*: 2015-05-15
    Sponsor Name:Department of Psychiatry, Helsinki University Central Hospital
    Full Title: The effect of intranasal ketamine on suicidality in severely depressed and suicidal patients. Randomized, placebo-controlled study
    Medical condition: Depression
    Disease: Version SOC Term Classification Code Term Level
    17.1 10037175 - Psychiatric disorders 10012378 Depression PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-022673-33 Sponsor Protocol Number: KIDSS Start Date*: 2011-09-07
    Sponsor Name:Psykiatri Nordväst, Karolinska Universitetssjukhuset Solna
    Full Title: The Dexametasone-CRH-test as a potential predictor of treatment effect in depression: a pilot study.
    Medical condition: In total 40 subjects, aged 20-65 years, with depressive symptoms, considered by their physician to need antidepressant treatment, will be recruited from primary care clinics in the Stockholm area.
    Disease: Version SOC Term Classification Code Term Level
    14.0 10037175 - Psychiatric disorders 10012378 Depression PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-005695-27 Sponsor Protocol Number: 8219 Start Date*: 2008-12-02
    Sponsor Name:Eli Lilly Nederland
    Full Title: Comparing Problem Solving Treatment combined with duloxetine with Problem Solving Treatment alone for patients with major depressive disorder in primary care
    Medical condition: Major depressive disorder (episode or recurrent), moderately severe as principal DSM-IV diagnosis.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012378 Depression LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-000426-62 Sponsor Protocol Number: CHDR1203-E Start Date*: 2013-04-10
    Sponsor Name:Centre for Human Drug Research
    Full Title: A randomized, double blind, placebo-controlled crossover study to investigate the effects of a selective serotonergic reuptake inhibitor on resting state fMRI in healthy volunteers.
    Medical condition: healthy volunteers 'depression, anxiety'
    Disease: Version SOC Term Classification Code Term Level
    15.1 10037175 - Psychiatric disorders 10012378 Depression PT
    15.1 10037175 - Psychiatric disorders 10002855 Anxiety PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2018-004208-20 Sponsor Protocol Number: GH001-MDD-102 Start Date*: 2019-08-21
    Sponsor Name:Gh Research Limited
    Full Title: A phase 1/2 study of GH001 in patients with treatment-resistant depression
    Medical condition: Treatment-resistant depression
    Disease: Version SOC Term Classification Code Term Level
    20.0 10037175 - Psychiatric disorders 10012378 Depression PT
    21.1 10037175 - Psychiatric disorders 10057840 Major depression PT
    21.1 10037175 - Psychiatric disorders 10025453 Major depressive disorder NOS LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-021142-21 Sponsor Protocol Number: QUET-SON-2010 Start Date*: 2010-09-23
    Sponsor Name:Fundación Institut de Recerca de l' Hospital de la Santa Creu i Sant Pau
    Full Title: ?Alteraciones del sueño en pacientes con depresión mayor resistente al tratamiento con inhibidores selectivos de la recaptación de serotonina: ensayo clínico, aleatorizado, abierto, de grupos paral...
    Medical condition: Depresión mayor resistente a Inhibidores Selectivos de la Recaptación de serotonina, Código de clasificación de la CIE : F-33
    Disease: Version SOC Term Classification Code Term Level
    12.1 10012378 Depression LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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