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Clinical trials for Mild to Moderate

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44398   clinical trials with a EudraCT protocol, of which   7410   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    1,421 result(s) found for: Mild to Moderate. Displaying page 11 of 72.
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    EudraCT Number: 2019-004208-37 Sponsor Protocol Number: S63190 Start Date*: 2020-08-03
    Sponsor Name:UZ Leuven
    Full Title: Drug repurposing - Statins as microbiota modulating agents in ulcerative colitis
    Medical condition: There are two population groups, 20 healthy volunteers and at least 165 individuals diagnosed with IBD. Either with remission to mild/moderate active ulcerative colitis or remission to mild Crohn's...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2019-004113-13 Sponsor Protocol Number: M602011070 Start Date*: 2020-08-17
    Sponsor Name:Merz Pharmaceuticals GmbH
    Full Title: A prospective, randomized, double-blind, placebo-controlled, multicenter study with an open-label extension period to investigate the efficacy and safety of NT 201 in the simultaneous treatment of ...
    Medical condition: Moderate to severe upper facial lines (horizontal forehead lines, glabellar frown lines, and lateral canthal lines)
    Disease: Version SOC Term Classification Code Term Level
    20.0 10040785 - Skin and subcutaneous tissue disorders 10048042 Wrinkles LLT
    21.1 10040785 - Skin and subcutaneous tissue disorders 10052609 Glabellar frown lines LLT
    20.0 10040785 - Skin and subcutaneous tissue disorders 10052611 Crow's feet LLT
    21.1 10040785 - Skin and subcutaneous tissue disorders 10040954 Skin wrinkling PT
    20.0 10040785 - Skin and subcutaneous tissue disorders 10040785 Skin and subcutaneous tissue disorders SOC
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2020-002233-15 Sponsor Protocol Number: NICCAM-001 Start Date*: 2020-06-17
    Sponsor Name:Charité Research Organisation GmbH
    Full Title: A randomized, single blind, placebo-controlled, multiple dose, parallel-arm study to investigate the safety and preliminary efficacy of the combination of Niclosamide and Camostat to treat COVID-19...
    Medical condition: SARS-Coronavirus 2 disease 2019 (COVID-19)
    Disease: Version SOC Term Classification Code Term Level
    23.0 10021881 - Infections and infestations 10084268 COVID-19 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2011-004990-10 Sponsor Protocol Number: MF/UME01 Start Date*: 2012-01-09
    Sponsor Name:Sahlgrenska Academy
    Full Title: Double-blind placebo controlled study of the effects of OSU6162 on chronic fatigue in patients who suffered a mild traumatic brain injury
    Medical condition: Mental fatigue after traumatic brain injury
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-001519-38 Sponsor Protocol Number: CL2-47445-011 Start Date*: 2015-01-06
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: Efficacy and safety of 3 doses of S 47445 versus placebo in patients with Alzheimer's disease at mild to moderate stages with depressive symptoms. A 24-week international, multi-centre, randomized,...
    Medical condition: Mild to moderate Alzheimer's disease in patients with depressive symptoms
    Disease: Version SOC Term Classification Code Term Level
    19.0 10029205 - Nervous system disorders 10012296 Dementia of the Alzheimer's type, with depressed mood PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) CZ (Completed) HU (Completed) BG (Completed) SK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-002038-39 Sponsor Protocol Number: AVA105640 Start Date*: 2007-03-13
    Sponsor Name:GlaxoSmithKline R&D Ltd
    Full Title: A 24-week, double-blind, double-dummy, randomized, parallel-group study to investigate the effects of rosiglitazone (extended release tablets), donepezil, and placebo as monotherapy on cognition a...
    Medical condition: Mild to Moderate Alzheimer's Disease
    Disease: Version SOC Term Classification Code Term Level
    8.1 10001896 Alzheimer's disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) GR (Completed) EE (Completed) AT (Completed) HU (Completed) DE (Completed) BG (Completed)
    Trial results: View results
    EudraCT Number: 2012-003739-44 Sponsor Protocol Number: DS107E-02 Start Date*: 2012-11-23
    Sponsor Name:Dignity Sciences Limited
    Full Title: A Randomised, Double-blind, Placebo-Controlled, Phase II Study to Assess the Efficacy and Safety of Topically Applied DGLA Cream in Patients with Mild to Moderate Atopic Dermatitis
    Medical condition: Atopic Dermatitis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) SE (Prematurely Ended) HU (Completed) DK (Completed) BG (Completed)
    Trial results: View results
    EudraCT Number: 2015-000839-33 Sponsor Protocol Number: LP0053-1108 Start Date*: 2016-03-23
    Sponsor Name:LEO Pharma A/S
    Full Title: Safety and Effect of LEO 90100 aerosol foam on the HPA Axis and Calcium Metabolism in Adolescent Subjects (Aged 12 to < 17 Years) with Plaque Psoriasis A phase 2 trial evaluating the safety and e...
    Medical condition: Plague Psoriasis
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004858 10050576 Psoriasis vulgaris LLT
    Population Age: Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2005-001678-28 Sponsor Protocol Number: BAY 38-9456 / IMPACT 11875 Start Date*: 2005-09-15
    Sponsor Name:Bayer Healthcare AG
    Full Title: A randomized, explorative, double-blind, double-dummy, multi-center, parallel group study to assess sustainable efficacy of once daily vardenafil (10 mg) for 12 and 24 weeks versus vardenafil PRN i...
    Medical condition: Erectile Dysfunction
    Disease: Version SOC Term Classification Code Term Level
    10061461
    Population Age: Adults Gender: Male
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2007-003922-70 Sponsor Protocol Number: TUD-PPPDD1-021 Start Date*: 2007-11-28
    Sponsor Name:Technische Universität Dresden
    Full Title: Uncontrolled, open Phase IIa study to investigate efficacy and safety of efalizumab in patients with moderate to severe palmoplantar pustular psoriasis (PPP)
    Medical condition: moderate to severe palmoplantar pustular psoriasis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10037159 Psoriasis pustular LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2014-005302-38 Sponsor Protocol Number: MT10109L-006 Start Date*: 2019-12-18
    Sponsor Name:Allergan Ltd.
    Full Title: A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Evaluate the Safety and Efficacy of MT10109L (NivobotulinumtoxinA) for the Treatment of Lateral Canthal Lines Wi...
    Medical condition: Lateral Canthal Lines
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004858 10052609 Glabellar frown lines LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2013-000864-28 Sponsor Protocol Number: DAP-PEDOST-11-03 Start Date*: 2014-01-02
    Sponsor Name:Cubist Pharmaceuticals, LLC
    Full Title: A Multicenter, Randomized, Double-Blinded Comparative Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Daptomycin Versus Active Comparator in Pediatric Subjects With Acute Hematogeno...
    Medical condition: Acute Hematogenous Osteomyelitis Due to Gram-Positive Organisms
    Disease: Version SOC Term Classification Code Term Level
    19.1 100000004862 10009081 Chronic osteomyelitis LLT
    19.1 100000004862 10046076 Unspecified osteomyelitis LLT
    19.1 100000004862 10009091 Chronic osteomyelitis, site unspecified LLT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: DE (Completed) HU (Completed) IT (Completed) ES (Completed) GR (Completed) LV (Completed) GB (Completed) EE (Completed) BG (Completed) FR (Completed) SI (Completed) Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2004-002272-41 Sponsor Protocol Number: S194-INT-04 Start Date*: 2004-12-07
    Sponsor Name:Stiefel Laboratories International Division
    Full Title: A Multi-Centre, Single-Blind, Parallel Group, Clinical Evaluation of the Efficacy and Safety of Duac Gel (A Gel containing Clindamycin Phosphate [Equivalent to 1% Clindamycin] and 5% Benzoyl Peroxi...
    Medical condition: Acne Vulgaris
    Disease: Version SOC Term Classification Code Term Level
    10000519
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-002730-11 Sponsor Protocol Number: A091031 Start Date*: 2007-11-30
    Sponsor Name:Cambridge University Hospitals NHS Foundation Trust
    Full Title: Magnetic resonance (MR) angiography with a blood pool contrast medium.
    Medical condition: Abnormalities of the major venous system.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10047184 Vein disorder LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-006350-10 Sponsor Protocol Number: CMA-0633-PR-0012 Start Date*: 2007-08-20
    Sponsor Name:Chiesi Farmaceutici
    Full Title: DOUBLE BLIND, RANDOMISED, PARALLEL GROUP, MULTICENTRE STUDY TO EVALUATE THE EFFECTS OF MANIDIPINE 20 MG VS AMLODIPINE 10 MG AND THE COMBINATION OF MANIDIPINE 10 MG PLUS DELAPRIL 30 MG VS AMLODIPINE...
    Medical condition: mild to moderate essential hypertension.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2008-002642-32 Sponsor Protocol Number: Protocol No. PR-00908 Start Date*: 2009-01-06
    Sponsor Name:Warner Chilcott UK Limited
    Full Title: A Placebo Controlled, Single-Blind, Pilot Clinical Evaluation of the Effect of a Novel Antibiotic Preparation on the Cutaneous Microflora and Clinical Signs in Acne Patients.
    Medical condition: WC3018 will be indicated for the treatment of of mild to moderate acne vulgaris.
    Disease:
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-001204-39 Sponsor Protocol Number: MOB015B-III Start Date*: 2016-09-15
    Sponsor Name:Moberg Pharma AB (publ)
    Full Title: A multi-centre, randomized, two-armed, parallel group and evaluator-blinded study of efficacy and safety of topical MOB015B in the treatment of mild to moderate distal subungual onychomycosis (DSO)
    Medical condition: Distal Subungual Onychomycosis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021881 - Infections and infestations 10030338 Onychomycosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) PL (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2005-004412-70 Sponsor Protocol Number: A3051054 Start Date*: 2007-07-25
    Sponsor Name:PFIZER
    Full Title: A 12-WEEK, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER TRIAL WITH 40-WEEK FOLLOW-UP EVALUATING THE SAFETY AND EFFICACY OF VARENICLINE TARTRATE FOR SMOKING CESSATION IN PATIENTS WIT...
    Medical condition: Smoking Cessation
    Disease: Version SOC Term Classification Code Term Level
    14.1 10042613 - Surgical and medical procedures 10053325 Smoking cessation therapy PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2018-000189-12 Sponsor Protocol Number: LS2018 Start Date*: 2018-03-23
    Sponsor Name:Bispebjerg Hospital
    Full Title: Treatment of photodamaged skin of the décolleté with fractional laser, radio-frequency microneedling, and photodynamic therapy
    Medical condition: Photodamaged skin in the décolleté
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004858 10065944 Photodamaged skin LLT
    Population Age: Adults Gender: Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-003886-15 Sponsor Protocol Number: TELIT L 01747 Start Date*: 2006-09-12
    Sponsor Name:SANOFI-AVENTIS S.P.A
    Full Title: Steady state telithromycin pharmacokinetics and pharmacodynamic in adult patients with mild-moderate acute exacerbation of chronic obstructive pulmonary disease treated with a standard oral dos...
    Medical condition: Acute exacerbation of chronic-obstructive pulmonary disease.
    Disease: Version SOC Term Classification Code Term Level
    6.1 10029978 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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