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Clinical trials for Osteoarthritis

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

  • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).


    The EU Clinical Trials Register currently displays   44393   clinical trials with a EudraCT protocol, of which   7405   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    374 result(s) found for: Osteoarthritis. Displaying page 15 of 19.
    EudraCT Number: 2010-023888-17 Sponsor Protocol Number: OMS103-MEN-003 Start Date*: 2011-05-11
    Sponsor Name:Omeros Corporation
    Full Title: A Randomized, Double-Blind, Parallel Group, Vehicle-Controlled Study to Evaluate the Safety and Efficacy of OMS103HP-S Administered in Joint Irrigation Solution to Subjects Undergoing Arthroscopic ...
    Medical condition: Arthroscopic surgery
    Disease: Version SOC Term Classification Code Term Level
    13.1 10042613 - Surgical and medical procedures 10058471 Arthroscopic surgery PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2010-024010-61 Sponsor Protocol Number: DRO/IV-ART-01 Start Date*: 2011-11-09
    Sponsor Name:BIOIBERICA, S.A.
    Full Title: NON-INFERIORITY CLINICAL TRIAL ON THE EFFICACY AND SAFETY OF CHONDROITIN SULFATE AND GLUCOSAMINE HYDROCHLORIDE IN COMBINATION VERSUS CELECOXIB IN PATIENTS WITH KNEE OSTEOARTHRITIS
    Medical condition: KNEE OSTEOARTHRITIS
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10003416 Arthrosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Completed) ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-000893-27 Sponsor Protocol Number: 230205 Start Date*: 2005-09-02
    Sponsor Name:Prof. Gustav Dobos, Kliniken Essen Mitte
    Full Title: Effectiveness of leech therapy in epicondylitis humeroradialis - a randomized controlled trial
    Medical condition: In the planned study patients with painful epicondylitis humeroradialis of the ellbow are treated with leeches or a standard treatment.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-003669-18 Sponsor Protocol Number: SVS/K/00604 Start Date*: 2006-11-15
    Sponsor Name:Seven Seas Limited
    Full Title: Efficacy an tolerability of a combinatzion of glucosamine sulphate and the tw omega-3 unsaturated fatty acids EPA and DHA in comparison to glucosamine sulphate in patients with ostearthritis
    Medical condition: Osteoarthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-003009-10 Sponsor Protocol Number: PRG-BUP-03/02 Start Date*: 2005-08-05
    Sponsor Name:Barts and The London NHS Trust
    Full Title: A randomized, open label pilot study to investigate the effect of chronic administration of buprenorphine prior to arthroplasty on the opioid requirements of patients intraoperatively and postopera...
    Medical condition: Patients with severe chronic pain due to osteoarthritis of the knee or hip, awaiting surgical joint replacement surgery. ICD10: M16.50 & M17.30
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-001580-30 Sponsor Protocol Number: 2006.SUR.ORT.01 Start Date*: 2006-10-13
    Sponsor Name:Royal Cornwall Hospitals NHS Trust
    Full Title: Investigation into the effects of steroid and local anaesthetic infiltration into soft tissues in total hip replacement wounds on post-operative pain relief.
    Medical condition: patients undergoing total hip replacement surgery for osteoarthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-004301-28 Sponsor Protocol Number: HUM 04-040 Start Date*: 2006-08-24
    Sponsor Name:KAS Glostrup
    Full Title: Treatment of painful knee osteoarthrosis with adalimumab (Humira (R)): Open-label study to evaluate safety and efficacy
    Medical condition: Osteoarthrosis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-005082-31 Sponsor Protocol Number: MP-TAP-2016-01 Start Date*: 2017-11-20
    Sponsor Name:MRI Research Unit, Radiology Department. Hospital del Mar.
    Full Title: Assessment of Tapentadol effects on patients with pain central sensitization using functional MRI
    Medical condition: Patients suffering from pain due to knee osteoarthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-017470-20 Sponsor Protocol Number: GRT-CG5503-2009-02-FR Start Date*: 2010-05-07
    Sponsor Name:Laboratoires Grünenthal
    Full Title: An open-label extension study for patients with severe chronic low back pain or severe chronic pain due to knee osteoarthritis who have completed any of the previous phase IIIb trials with tapentad...
    Medical condition: Severe chronic pain
    Disease: Version SOC Term Classification Code Term Level
    12.1 10049475 Chronic pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2015-000538-31 Sponsor Protocol Number: Neuroimpa2015 Start Date*: 2015-06-01
    Sponsor Name:Charité University medicine Berlin
    Full Title: NEUORIMPA - Intraarticular Application of Opioids in Chronic Arthritis of the knee joint
    Medical condition: chronic arthritis of the knee joint effusion as part of spondyloarthritis (Assessments in SpondyloArthritis international Society, ASAS criteria), Rheumatoid Arthritis, RA (according to American Co...
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004859 10067624 Knee arthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2019-000757-31 Sponsor Protocol Number: 2018/728 Start Date*: 2019-08-30
    Sponsor Name:Martina Hansens Hospital
    Full Title: A RANDOMIZED PLACEBO CONTROLLED TRIAL TESTING THE EFFECTS OF ZOLEDRONIC ACID ON HIP OSTEOARTHRITIS
    Medical condition: Investigated disease is osteoarthritis of the hip with concurrent Bone marrow lesions
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-002645-37 Sponsor Protocol Number: KC706-C05 Start Date*: 2006-08-25
    Sponsor Name:Kémia, Inc.
    Full Title: A Phase II randomized double-blind placebo-controlled Study of KC706 in patients with rheumatoid arthritis inadequately controlled with a stable dose of methotrexate
    Medical condition: Active rheumatoid arthritis (RA), patients taking stable doses of methotrexate
    Disease: Version SOC Term Classification Code Term Level
    8.1 10039073 Rheumatoid arthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-000624-20 Sponsor Protocol Number: ILONA Start Date*: 2021-06-17
    Sponsor Name:Leipzig University
    Full Title: Core decompression versus core decompression followed by infusion of Iloprost in the treatment of non-traumatic avascular necrosis of the femoral head
    Medical condition: non-traumatic avascular necrosis of the femoral head (N-ANFH)
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10003860 Avascular necrosis femoral head LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2021-005889-17 Sponsor Protocol Number: WATOS-PE Start Date*: 2023-05-22
    Sponsor Name:Fundació Institut d'Investigació i Innovació Parc Taulí (I3PT)
    Full Title: PAIN CONTROL WITH THE USE OF WALANT IN TOTAL TRAPEZECTOMY. RANDOMIZED CLINICAL TRIAL
    Medical condition: Thumb trapeziometacarpal joint osteoarthritis treated by total trapeziectomy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-001234-17 Sponsor Protocol Number: A3191084 Start Date*: 2006-06-15
    Sponsor Name:Pfizer Limited
    Full Title: Double-blind, triple dummy, parallel-group, randomized, six-month study to compare celecoxib (200 mg BID) with diclofenac SR (75 mg BID) plus omeprazole (20 mg QD) for gastrointestinal events in su...
    Medical condition: Treatment of osteoarthritis (OA) and/or rheumatoid arthritis (RA) in high GI risk patients
    Disease: Version SOC Term Classification Code Term Level
    8.0 10039073 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) ES (Completed) BE (Completed) SE (Completed) CZ (Completed) LT (Completed) DE (Suspended by CA) EE (Completed) PT (Completed) GR (Completed) IE (Completed) LV (Completed)
    Trial results: View results
    EudraCT Number: 2006-004514-40 Sponsor Protocol Number: KF5503/33-R331333-PAI-3002 Start Date*: 2007-02-14
    Sponsor Name:Johnson & Johnson Pharamceutical Research & Development, L.L.C.
    Full Title: A Randomized, Double-Blind, Active- And Placebo-Controlled, Parallel Group, Multicenter Study To Evaluate The Efficacy And Safety of Multiple Doses of CG5503 Immediate Release Formulation In Subjec...
    Medical condition: Pain
    Disease: Version SOC Term Classification Code Term Level
    8.1 10033371 Pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-006911-60 Sponsor Protocol Number: 42801PAI3001 Start Date*: 2007-06-15
    Sponsor Name:Janssen-Cilag International N.V.
    Full Title: Randomised, double-blind, placebo-controlled, parallel-group trial to investigate the analgesic effect of OROS hydromorphone hydrochloride in comparison with placebo in subjects with moderate to se...
    Medical condition: moderate to severe pain induced by osteoarthritis of the hip or the knee
    Disease: Version SOC Term Classification Code Term Level
    9.1 10003239 Arthralgia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) GB (Completed) SK (Completed)
    Trial results: View results
    EudraCT Number: 2007-005082-34 Sponsor Protocol Number: A2620383 Start Date*: 2007-12-14
    Sponsor Name:GlaxoSmithKline Consumer Healthcare
    Full Title: A Proof of Principle Study to Investigate the Efficacy of a Medical Device and Topical Analgesic Combination for the Treatment of Pain and Performance Related Function in Osteoarthritis
    Medical condition: To compare the efficacy of 72 hours (hrs) treatment of topical diclofenac plus a heat patch with 72 hrs treatment of topical diclofenac plus a placebo patch on the primary endpoint of mobility in p...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2005-000503-33 Sponsor Protocol Number: 01-05 Start Date*: 2005-09-02
    Sponsor Name:Department Integrative Medicine, Kliniken Essen Mitte
    Full Title: Effectiveness of leech therapy in osteoarthritis of the thumb joint (rhizarthrosis) - a randomized controlled trial
    Medical condition: Leeches therapy has been successully evaluated in symptomatic knee osteoarthrits for pain relief. In the planned study patients with painful rhizarthrosis (arthrosis of the thumb joint) will be rec...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-011492-73 Sponsor Protocol Number: 13.09 Start Date*: 2009-09-28
    Sponsor Name:Swindon and Marlborough NHS Foundation Trust
    Full Title: Analysis of Blood Loss With the Use of Fibrin Sealant in Total Knee Replacement Surgery – A Randomised Controlled Study
    Medical condition: Blood loss in total knee arthroplasty
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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