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Clinical trials for Aortic Valve Stenosis

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    The EU Clinical Trials Register currently displays   44366   clinical trials with a EudraCT protocol, of which   7389   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

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    48 result(s) found for: Aortic Valve Stenosis. Displaying page 2 of 3.
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    EudraCT Number: 2005-002580-85 Sponsor Protocol Number: 3d Start Date*: 2005-08-08
    Sponsor Name:Rigshospitalet
    Full Title: Acute haemodynanic effects of Treatment with ACE inhibitores in patients with severe Aortic Stenosis
    Medical condition: Aortic valve stenosis is a reduction of the aortic valve orifice to a degree where emptying of the left ventricule is compromised. The two major causes for aortic valve stenosis is calcific valve d...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-005306-39 Sponsor Protocol Number: VitaminKStudy Start Date*: 2009-06-29
    Sponsor Name:RWTH Aachen University, represented by the rector, himself represented by Clinical Trial Center Aachen (CTC-A)
    Full Title: Food supplementation with Vitamin K for MGP-activation and inhibition of progression of aortic valve calcification
    Medical condition: progression of aortic valve calcification
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10050559 Aortic valve calcification PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2016-001777-33 Sponsor Protocol Number: EARTH-TAVR01 Start Date*: 2016-09-01
    Sponsor Name:Charité Universitätsmedizin Berlin
    Full Title: EVALUATION OF CEREBRAL THROMBOEMBOLISM AFTER TAVR
    Medical condition: Patients with severe aortic stenosis that require Transcatheter aortic valve replacement are at risk for stroke. This study is to evaluate the occurrence and extent of cerebral embolization (total...
    Disease: Version SOC Term Classification Code Term Level
    19.0 10042613 - Surgical and medical procedures 10002916 Aortic valve replacement PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2015-001975-30 Sponsor Protocol Number: BAY59-7939/17938 Start Date*: 2016-01-12
    Sponsor Name:Bayer AG
    Full Title: Global multicenter, open-label, randomized, event-driven, active-controlled study comparing a rivAroxaban-based antithrombotic strategy to an antipLatelet-based strategy after transcatheter aortIc ...
    Medical condition: Patients with severe aortic stenosis that require Transcatheter aortic valve replacement are at risk of thrombus formation. Rivaroxaban (oral-anticoagulant) may reduce this risk, without increasing...
    Disease: Version SOC Term Classification Code Term Level
    19.0 10042613 - Surgical and medical procedures 10002916 Aortic valve replacement PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) ES (Prematurely Ended) BE (Prematurely Ended) NO (Prematurely Ended) AT (Prematurely Ended) DK (Prematurely Ended) SE (Prematurely Ended) NL (Prematurely Ended) GB (Prematurely Ended) FR (Prematurely Ended) CZ (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2021-004271-14 Sponsor Protocol Number: DAPAS Start Date*: 2021-12-06
    Sponsor Name:Aarhus University Hospital, department of Cardiology
    Full Title: Effect of Dapagliflozin on myocardial and renal function following aortic valve stenosis intervention
    Medical condition: Patients with aortic stenosis undergoing trans catheter aortic valve replacement.
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10058186 Aortic valve stenosis and insufficiency LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2015-000704-25 Sponsor Protocol Number: PASP01 Start Date*: 2017-02-28
    Sponsor Name:Queen Mary University of London
    Full Title: Prevention of Aortic Stenosis Pilot Trial
    Medical condition: Aortic Stenosis. It is caused by the build-up of calcium phosphate crystals on the aortic valve (aortic sclerosis). Progressive valve narrowing (stenosis) leads to symptoms (chest pain, syncope or ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2019-002037-11 Sponsor Protocol Number: IIISAS Start Date*: 2019-10-10
    Sponsor Name:Oslo University Hospital
    Full Title: Intravenous Iron supplement for Iron deficiency in patients with Severe Aortic Stenosis
    Medical condition: Iron deficiency, aortic stenosis
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004861 10022971 Iron deficiencies HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-001425-26 Sponsor Protocol Number: REDOX19032019 Start Date*: 2019-07-04
    Sponsor Name:Thoraxcentrum Erasmus MC
    Full Title: Rotterdam Edoxaban Leaflet Evaluation in Patients after Transcatheter Aortic Valve Implantation
    Medical condition: aortic stenosis
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-005224-32 Sponsor Protocol Number: OCMR 06.01 Start Date*: 2008-12-16
    Sponsor Name:University of Oxford
    Full Title: A randomised controlled trial of the angiotensin converting enzyme inhibitor ramipril in asymptomatic aortic stenosis
    Medical condition: Aortic stenosis of at least moderate degree (peak velocity >=3.0m/sec or aortic valve area <1.5cm2)
    Disease:
    Population Age: Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-005784-24 Sponsor Protocol Number: MEIXO-VALV-001 Start Date*: 2012-06-14
    Sponsor Name:Andres Iñiguez Romo
    Full Title: Dual antiplatelet therapy versus oral anticoagulation for a short time to prevent cerebral embolism after percutaneous aortic valve implantation. Multicenter randomized clinical trial.
    Medical condition: Evaluate the efficacy of dual antiplatelet therapy versus oral anticoagulation for primary prevention of cerebral thromboembolism at three months after percutaneous aortic valve implantation (TAVI).
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-001147-31 Sponsor Protocol Number: 140481 Start Date*: 2013-06-06
    Sponsor Name:Aarhus University Hospital, Department of Cardiology
    Full Title: Aortic Valve Stenosis and Myocardial Efficiency – a Prognostic Marker and a Target for Intervention?
    Medical condition: Aortic stenosis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-001930-34 Sponsor Protocol Number: 170674-3479 Start Date*: 2005-11-25
    Sponsor Name:Department of Cardiology, Odense University Hospital
    Full Title: Left ventricular reverse remodelling after aortic valve replacement in severe valvular aortic stenosis - effect of blockade of the angiotensin-II receptor
    Medical condition: Patients with severe aortic valve stenosis treated with Aortic Valve Replacement (AVR)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-001554-61 Sponsor Protocol Number: ACASA-TAVI-2.1 Start Date*: 2021-08-19
    Sponsor Name:Oslo University Hospital
    Full Title: Anti-Coagulation versus AcetylSalicylic Acid after Transcatheter Aortic Valve Implantation (ACASA-TAVI)
    Medical condition: Patients with aortic stenosis undergoing transcatheter aortic valve implantation.
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: NO (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2019-004860-23 Sponsor Protocol Number: REACTIC2019-HAC Start Date*: 2020-05-22
    Sponsor Name:Andres Iñiguez Romo
    Full Title: REACTIC-TAVI TRIAL: Platelet REACtivity according to TICagrelor dose after Trancathter Aortic Valve Implantation. A pilot study.
    Medical condition: Patients with severe aortic stenosis submitted for Transcatheter Aortic Valve Implantation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-004559-36 Sponsor Protocol Number: 1 Start Date*: 2006-03-23
    Sponsor Name:Abteilung für Herz-Thorax-Gefäß Anästhesie & Intensivmedizin (HTG)
    Full Title: Desmopressin in Acquired von Willebrand Syndrome caused by Aortic Valve Stenosis
    Medical condition: Acquired type 2A von Willebrand syndrome is common in patients with severe aortic valve stenosis (AS). It originates from the mechanical obstruction of blood flow and the consecutive proteolysis of...
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-003861-39 Sponsor Protocol Number: GLUCOTAVI Start Date*: 2023-03-07
    Sponsor Name:JUAN MIGUEL RUIZ NODAR
    Full Title: Glucocorticoid treatment in patients undergoing TAVI to reduce the incidence of atrioventricular block and pacemaker implantation
    Medical condition: aortic stenosis
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-001808-57 Sponsor Protocol Number: BICATOR Start Date*: 2015-11-27
    Sponsor Name:Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca (VHIR)
    Full Title: Assessment of atorvastatin efficacy on the progression of aortic dilatation and valvular degeneration in patients with bicuspid aortic valve (BICATOR)
    Medical condition: Valve Disease
    Disease: Version SOC Term Classification Code Term Level
    18.1 10007541 - Cardiac disorders 10007541 Cardiac disorders SOC
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-002376-95 Sponsor Protocol Number: RRK3535 Start Date*: 2009-01-05
    Sponsor Name:University Hospital Birmingham NHS Foundation Trust
    Full Title: Myocardial protection with Perhexiline in Left Ventricular Hypertrophy
    Medical condition: Patients with left ventricular hypertrophy undergoing aortic valve surgery (with or without coronary artery surgery)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2015-004144-20 Sponsor Protocol Number: CHUBX2014/24 Start Date*: 2015-11-17
    Sponsor Name:CHU de Bordeaux
    Full Title: Safety profile evaluation of TICagrelor Alone compared to a combination of lysine acetylsalicylate - Clopidogrel in the context of Transcatheter Aortic Valve Implantation (TAVI)
    Medical condition: Aortic valve stenosis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-001817-20 Sponsor Protocol Number: NL73805.100.20 Start Date*: 2021-05-07
    Sponsor Name:St. Antonius Hospital Nieuwegein, The Netherlands
    Full Title: Periprocedural continuation versus interruption of oral anticoagulant drugs during transcatheter aortic valve implantation
    Medical condition: Thromboembolic, bleeding and vascular complications after transcatheter aortic valve implantation in patients using oral anticoagulants
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) DK (Completed) IT (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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