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Clinical trials for Methotrexate

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44338   clinical trials with a EudraCT protocol, of which   7368   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    1,059 result(s) found for: Methotrexate. Displaying page 2 of 53.
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    EudraCT Number: 2005-000871-16 Sponsor Protocol Number: JBJ-2005-01 Start Date*: 2006-03-07
    Sponsor Name:Dr John Berth-Jones
    Full Title: Methotrexate in adults with severe atopic dermatitis: a double-blind, randomised, parallel-group, placebo-controlled trial
    Medical condition: Severe atopic dermatitis in adults
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2006-003003-39 Sponsor Protocol Number: 06/075 Start Date*: 2006-08-10
    Sponsor Name:Academic Medical Center
    Full Title: Methotrexate versus expectant management in women with ectopic pregnancy (METEX study)
    Medical condition: Women with an ectopic pregnancy with low but plateauing serum hCG concentrations.
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-003700-12 Sponsor Protocol Number: 19CH114 Start Date*: 2020-03-13
    Sponsor Name:CHU Saint-Etienne
    Full Title: Association between methotrexate erythrocyte polyglutamate concentration and biological drug concentration and clinical response in rheumatoid arthritis patients treated with subcutaneous injectabl...
    Medical condition: rheumatoid arthritis
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004859 10042952 Systemic rheumatoid arthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-004201-18 Sponsor Protocol Number: 0881A-101696 Start Date*: 2005-02-15
    Sponsor Name:Wyeth Lederle Nordiska AB
    Full Title: A multicenter, open-label, randomized, pilot study to evaluate the efficacy and safety of the combination of etanercept (ETN) and methotrexate and of etanercept (ETN) alone in patients with active ...
    Medical condition: Plaque psoriasis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) DK (Completed) SE (Completed)
    Trial results: View results
    EudraCT Number: 2012-001984-66 Sponsor Protocol Number: EFC11574 Start Date*: 2013-04-25
    Sponsor Name:sanofi-aventis Recherche & Développement
    Full Title: A Randomized, Controlled Study of Sarilumab and Methotrexate (MTX) Versus Etanercept and MTX in Patients with Rheumatoid Arthritis (RA) and an Inadequate Response to 4 Months of Treatment with Adal...
    Medical condition: Rheumatoid Arthritis
    Disease: Version SOC Term Classification Code Term Level
    15.1 10028395 - Musculoskeletal and connective tissue disorders 10039073 Rheumatoid arthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed) HU (Completed) CZ (Completed) ES (Completed) GR (Completed) LT (Prematurely Ended) FI (Completed) LV (Prematurely Ended) IT (Prematurely Ended) NO (Completed)
    Trial results: View results
    EudraCT Number: 2006-003123-37 Sponsor Protocol Number: Start Date*: 2006-10-12
    Sponsor Name:University Hospital Sint Radboud
    Full Title: Treatment with high dose Methotrexate in patients with eosinophilic fasciitis
    Medical condition: Eosinophilic fasciitis (EF) is a skin disorder involving the deep fascia, resulting in pain and swelling of extremities, cutaneous induration and joint contractures. Most patients require therapy. ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-001630-14 Sponsor Protocol Number: DRN0307 Start Date*: 2007-10-30
    Sponsor Name:University Medical Centre St. Radboud, Department of Dermatology
    Full Title: Safety and efficacy of efalizumab in combination with methotrexate in patients with severe psoriasis: a comparative study.
    Medical condition: Moderate to severe chronic plaque psoriasis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10050576 Psoriasis vulgaris LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2010-023956-99 Sponsor Protocol Number: IM133-001 Start Date*: 2011-08-17
    Sponsor Name:Bristol-Myers Squibb International Corporation
    Full Title: A Phase IIB , Randomized, Multi-Center, Double-Blind, Dose-Ranging, Placebo/Active Controlled Study to Evaluate the Efficacy and Safety of BMS-945429 Subcutaneous Injection With or Without Methotre...
    Medical condition: RHEUMATOID ARTHRITIS,NOS
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004859 10039076 Rheumatoid arthritis and other inflammatory polyarthropathies LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) BE (Completed) NL (Completed) DE (Prematurely Ended) CZ (Prematurely Ended) ES (Ongoing) IT (Completed)
    Trial results: View results
    EudraCT Number: 2004-002306-29 Sponsor Protocol Number: RLH 2786 Start Date*: 2004-12-21
    Sponsor Name:Royal Liverpool and Broadgreen University Hospitals NHS Trust
    Full Title: Psoriasis, Folic Acid Supplementation and Plasma Homocysteine Levels
    Medical condition: Psoriasis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2015-003376-75 Sponsor Protocol Number: M15-555 Start Date*: 2016-06-23
    Sponsor Name:AbbVie Deutschland GmbH & Co. KG
    Full Title: A Phase 3, Randomized, Double-Blind Study Comparing ABT-494 Monotherapy to Methotrexate (MTX) in Subjects with Moderately to Severely Active Rheumatoid Arthritis with Inadequate Response to MTX
    Medical condition: Moderately to Severely Active Rheumatoid Arthritis (RA)
    Disease: Version SOC Term Classification Code Term Level
    19.0 10028395 - Musculoskeletal and connective tissue disorders 10039073 Rheumatoid arthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing) GR (Completed) CZ (Completed) BE (Completed) PL (Completed) HU (Completed) PT (Completed) AT (Completed) BG (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2007-005434-37 Sponsor Protocol Number: IM101-174 Start Date*: 2008-07-24
    Sponsor Name:Bristol Myers Squibb International Corporation
    Full Title: A Phase IIIB Multicenter, Randomized, Double-Blind, Double-Dummy Study to Compare the Efficacy and Safety of Abatacept Administered Subcutaneously and Intravenously in Subjects with Rheumatoid Arth...
    Medical condition: RHEUMATOID ARTHRITIS, NOS
    Disease: Version SOC Term Classification Code Term Level
    9.1 10039073 Rheumatoid arthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed) IE (Completed) HU (Completed) GB (Completed) BE (Completed) DE (Completed) NL (Completed) IT (Completed) AT (Prematurely Ended) GR (Completed)
    Trial results: View results
    EudraCT Number: 2015-000863-15 Sponsor Protocol Number: 6020 Start Date*: 2015-10-12
    Sponsor Name:Hôpitaux Universitaires de Strasbourg
    Full Title: RANDOMIZED CONTROLLED CLINICAL TRIAL EVALUATING METHOTREXATE + BIOLOGIC VERSUS METHOTREXATE, SALAZOPYRINE AND HYDROXYCHLOROQUINEIN PATIENTS WITH RHEUMATOID ARTHRITIS AND INSUFFICIENT RESPONSE TO ME...
    Medical condition: RHEUMATOID ARTHRITIS
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2004-003741-40 Sponsor Protocol Number: WA17822 Start Date*: 2004-11-26
    Sponsor Name:F. Hoffmann La-Roche AG
    Full Title: A randomized, double-blind, parallel group study of the safety and reduction of signs and symptoms during treatment with MRA versus placebo, in combination with methotrexate, in patients with moder...
    Medical condition: Rheumatoid Arthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed) DE (Completed) SK (Completed) HU (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2004-004602-25 Sponsor Protocol Number: M04-716 Start Date*: 2005-06-30
    Sponsor Name:Abbott GmbH & Co. KG
    Full Title: A Phase 3, Multicenter, Randomized, Double-Blind,Double-Dummy, Placebo-Controlled StudyComparing the Safety and Efficacy of Adalimumab to Methotrexate and Placebo in Subjects withModerate to Severe...
    Medical condition: Psoriasis Disease
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) AT (Completed) BE (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2015-002466-22 Sponsor Protocol Number: 990758 Start Date*: 2015-12-23
    Sponsor Name:Amgen Inc
    Full Title: A Randomized, Multi-center, Blinded, Placebo-controlled Study With an Open­label Run-in Period to Evaluate the Efficacy, Safety, and Pharmacokinetics of Daily, Single, Subcutaneous Injections of r-...
    Medical condition: Juvenile Rheumatoid Arthritis
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2005-000551-15 Sponsor Protocol Number: MTXa54 Start Date*: 2005-09-05
    Sponsor Name:University of Dundee
    Full Title: Effect of folic acid supplementation and allopurinol on endothelial function in patients with rheumatoid arthritis treated with methotrexate
    Medical condition: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory polyarthritis associated with excess cardiovascular (CV) mortality. Hyperhomocysteinaemia is recognized as an independent CV risk fact...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2010-019873-13 Sponsor Protocol Number: 1200/002 Start Date*: 2010-06-07
    Sponsor Name:UCL Cliniques Universitaires Saint Luc
    Full Title: Comparative study of the clinical response and cardiorespiratory endurance in early rheumatoid arthritis patients treated with Tociluzimab or Methotrexate Addendum protocol : Global gene expression...
    Medical condition: early rheumatoid arthritis
    Disease: Version SOC Term Classification Code Term Level
    12.1 10039075 Rheumatoid arthritis and associated conditions HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2005-003279-18 Sponsor Protocol Number: HLH-2004 Start Date*: Information not available in EudraCT
    Sponsor Name:Barncancerforskningsenheten, Astrid Lindgrens Barnsjukhus
    Full Title: HLH-2004. Hemophagocytic Lymphohistiocytosis Study Group. Treatment Protocol of the Second International HLH Study 2004.
    Medical condition: Hemophagocytic Lymphohistiocytosis (HLH), a life-threatening disease usually occurring in early childhood. HLH-2004 is an international treatment protocol which will be compared with the previous ...
    Disease:
    Population Age: Newborns, Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NO (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-001275-50 Sponsor Protocol Number: IM101-550 Start Date*: 2015-10-21
    Sponsor Name:Bristol-Myers Squibb International Corporation
    Full Title: A Phase 3B, Randomized, Double-Blind Clinical Trial to Evaluate the Efficacy and Safety of Abatacept SC in Combination with Methotrexate Compared to Methotrexate Monotherapy in Achieving Clinical R...
    Medical condition: Early Rheumatoid Arthritis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10039073 Rheumatoid arthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) AT (Completed) DE (Completed) GB (Completed) HU (Completed) SE (Completed) FR (Completed) FI (Completed) ES (Completed) NL (Completed) RO (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2014-001749-26 Sponsor Protocol Number: MK-3475-040 Start Date*: 2014-11-21
    Sponsor Name:Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.
    Full Title: A Phase III Randomized Trial of MK-3475 (Pembrolizumab) versus Standard Treatment in Subjects with Recurrent or Metastatic Head and Neck Cancer
    Medical condition: Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
    Disease: Version SOC Term Classification Code Term Level
    19.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10067821 Head and neck cancer PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed) LT (Completed) DE (Completed) BE (Completed) PT (Completed) NL (Completed) HU (Completed) IT (Completed) ES (Completed) FR (Completed) PL (Completed) SE (Completed)
    Trial results: View results
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    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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