Flag of the European Union EU Clinical Trials Register Help

Clinical trials for Orthopedic surgery

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44347   clinical trials with a EudraCT protocol, of which   7375   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
    How to search [pdf]
    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
    Advanced Search: Search tools
     
    71 result(s) found for: Orthopedic surgery. Displaying page 4 of 4.
    « Previous 1  2  3  4 
    EudraCT Number: 2017-002751-28 Sponsor Protocol Number: PVO-2A-201 Start Date*: 2018-10-16
    Sponsor Name:Clementia Pharmaceuticals Inc.
    Full Title: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Palovarotene in Subjects with Multiple Osteochondromas
    Medical condition: Multiple Osteochondromas (MO)
    Disease: Version SOC Term Classification Code Term Level
    20.0 10010331 - Congenital, familial and genetic disorders 10079019 Hereditary multiple osteochondromas PT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: ES (Prematurely Ended) GB (Completed) PT (Prematurely Ended) FR (Completed) IT (Prematurely Ended) NL (Completed) BE (Completed) Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2013-003310-40 Sponsor Protocol Number: 1SPR11002 Start Date*: 2014-01-27
    Sponsor Name:Luitpold Pharmaceuticals, Inc.
    Full Title: A Single Arm, Open Label Study of the Safety, Efficacy, and Pharmacokinetics of SPRIX® (intranasal ketorolac tromethamine) in 0 to 11 year-Old Patients Undergoing Open Surgical Procedures
    Medical condition: post open surgery pain (incuding but not limited to orthopedic, abdominal, thoracic, plastic/reconstructive, neurologic [spine], or urologic procedures)
    Disease: Version SOC Term Classification Code Term Level
    18.0 10018065 - General disorders and administration site conditions 10033371 Pain PT
    Population Age: Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-004163-50 Sponsor Protocol Number: FIBHGM-ECNC002-2013(CETSEVOREM) Start Date*: 2014-04-29
    Sponsor Name:Fundación para la Investigación Biomédica del Hospital
    Full Title: Comparative, randomized, double-blind clinical trial on end-tidal concentration of sevoflurane associated to remifentanil required for insertion of the Supreme Laryngeal Mask vs. Pro-Seal Laryngea...
    Medical condition: Patients requiring general anesthesia in whom the control of the airway is usually done with a supraglottic device.
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004865 10018061 General anesthesia LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-002955-40 Sponsor Protocol Number: 69HCL20_0111 Start Date*: 2020-08-12
    Sponsor Name:Hospices Civils de Lyon
    Full Title: Postoperative analgesic effect of orally administrated nefopam after a total knee arthroplasty: a randomized controlled trial
    Medical condition: Major patients who have a surgery in the orthopedic surgery department of the Croix Rousse hospital for a total knee replacement.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10042613 Surgical and medical procedures SOC
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2013-003439-31 Sponsor Protocol Number: CBYM338D2201 Start Date*: 2014-06-17
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A 24-week Double-blind Treatment and 24-week Follow-up, Randomized, Multicenter, Placebo-controlled, Phase IIa/IIb Study to Evaluate Safety and Efficacy of i.v. Bimagrumab on Total Lean Body Mass a...
    Medical condition: Patients with muscle wasting (atrophy) after hip fracture surgery and subsequent postsurgical rehabilitation
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10028371 Muscular wasting and disuse atrophy, not elsewhere classified LLT
    20.0 10022117 - Injury, poisoning and procedural complications 10020100 Hip fracture PT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: BE (Completed) GB (Completed) DE (Completed) HU (Completed) CZ (Completed) AT (Completed)
    Trial results: View results
    EudraCT Number: 2010-024115-14 Sponsor Protocol Number: 05-AnIt-09/UKM10_0027 Start Date*: 2011-04-29
    Sponsor Name:University Hospital Muenster
    Full Title: Preoperative Intravenous Ferric Carboxymaltose (Ferinject) in Patients with Orthopaedic Surgery and High Risk of Blood Loss
    Medical condition: Patients with iron deficiency anemia scheduled to undergo orthopedic surgery with high risk of bleeding
    Disease: Version SOC Term Classification Code Term Level
    14.1 10042613 - Surgical and medical procedures 10058829 Elective surgery PT
    14.1 10042613 - Surgical and medical procedures 10044088 Total hip replacement LLT
    14.1 10022117 - Injury, poisoning and procedural complications 10005127 Bleeding postoperative LLT
    14.1 10005329 - Blood and lymphatic system disorders 10066573 Chronic iron deficiency anemia LLT
    14.1 10042613 - Surgical and medical procedures 10057129 Revision of total knee arthroplasty LLT
    14.1 10022117 - Injury, poisoning and procedural complications 10051536 Intraoperative bleeding LLT
    14.1 10005329 - Blood and lymphatic system disorders 10022975 Iron deficiency anemia secondary to blood loss (chronic) LLT
    14.1 10042613 - Surgical and medical procedures 10069749 Internal fixation of spine PT
    14.1 10022117 - Injury, poisoning and procedural complications 10051386 Wound bleeding LLT
    14.1 10042613 - Surgical and medical procedures 10020096 Hip arthroplasty PT
    14.1 10005329 - Blood and lymphatic system disorders 10022976 Iron deficiency anemia secondary to inadequate dietary iron intake LLT
    14.1 10042613 - Surgical and medical procedures 10051060 Hip surgery PT
    14.1 10042613 - Surgical and medical procedures 10039727 Scoliosis surgery PT
    14.1 10042613 - Surgical and medical procedures 10049130 Back surgery LLT
    14.1 10042613 - Surgical and medical procedures 10023469 Knee arthroplasty PT
    14.1 10005329 - Blood and lymphatic system disorders 10022977 Iron deficiency anemia, unspecified LLT
    14.1 10042613 - Surgical and medical procedures 10020102 Hip replacement LLT
    14.1 10042613 - Surgical and medical procedures 10057128 Revision of hip arthroplasty LLT
    14.1 10042613 - Surgical and medical procedures 10044094 Total knee replacement LLT
    14.1 10042613 - Surgical and medical procedures 10049662 Knee surgery NOS LLT
    14.1 10005329 - Blood and lymphatic system disorders 10022974 Iron deficiency anemia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-004075-36 Sponsor Protocol Number: R-01270-A016 Start Date*: 2007-04-25
    Sponsor Name:Baxter R&D Europe S.C.R.L.
    Full Title: A randomized, double blind, placebo-controlled, single-dose, parallel-group comparison of the analgesic efficacy, safety and local tolerability of intravenous Paracetamol 1% solution Bioren (test),...
    Medical condition: Post-surgical orthopedic pain after primary, cemented total hip replacement associated with moderate to severe pain
    Disease: Version SOC Term Classification Code Term Level
    9.1 10054710 Postoperative hip pain LLT
    9.1 10054711 Postoperative pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed)
    Trial results: View results
    EudraCT Number: 2017-003003-22 Sponsor Protocol Number: N-20170060 Start Date*: 2017-11-27
    Sponsor Name:Aalborg University Hospital, Department of Orthopedics [...]
    1. Aalborg University Hospital, Department of Orthopedics
    2. Mogens Brouw Jørgensen
    Full Title: postoperative effect of optimal multimodal pain management supplemented with systemic single dose of Dexamethason in the first week after UKA. Low dose (8mg) or mean dose
    Medical condition: knee osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10031165 Osteoarthritis knee LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2019-000753-31 Sponsor Protocol Number: RC19_0055 Start Date*: 2019-07-04
    Sponsor Name:CHU Nantes
    Full Title: Evaluation of REMIFENTANIL as an alternative to curare for rapid sequence anesthetic induction in patients at risk of gastric fluid inhalation
    Medical condition: anesthetic induction
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004865 10002326 Anesthetic induction LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2016-003214-27 Sponsor Protocol Number: UTOTXA_2016_01 Start Date*: 2017-02-09
    Sponsor Name:Irene Barrientos Ruiz
    Full Title: Randomized, double-blind, 3-arm trial to evaluate the impact of blood loss following administration of three tranexamic acid regimens in patients undergoing bone or soft tissue sarcomas.
    Medical condition: Oncological orthopedic surgery (bone and soft tissue sarcomas in the appendicular skeleton, pelvis and scapular girdle).
    Disease: Version SOC Term Classification Code Term Level
    15.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10041299 Soft tissue sarcomas HLGT
    19.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10039498 Bone sarcomas HLT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-001527-22 Sponsor Protocol Number: AXS02-301 Start Date*: 2015-09-25
    Sponsor Name:Axsome Therapeutics, Inc.
    Full Title: CREATE-1 Study: CRPS Treatment Evaluation 1 Study. A Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of AXS-02 (Disodium Zoledronate Tetrahydrate) Administered ...
    Medical condition: Complex regional pain syndrome (CRPS-I).
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004852 10064334 Complex regional pain syndrome Type I LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    Download Options:
    Number of Trials to download:
    Download Content:
    Download Format:
    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
    « Previous 1  2  3  4 
    Query did not match any studies.
    For support, Contact us.
    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

    European Medicines Agency © 1995-Sat Jul 05 17:55:21 CEST 2025 | Domenico Scarlattilaan 6, 1083 HS Amsterdam, The Netherlands
    EMA HMA