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Clinical trials for Physiological effect

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44344   clinical trials with a EudraCT protocol, of which   7373   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    409 result(s) found for: Physiological effect. Displaying page 7 of 21.
    «« First « Previous 3  4  5  6  7  8  9  10  11  Next» Last»»
    EudraCT Number: 2013-004446-42 Sponsor Protocol Number: AIR Start Date*: 2014-02-09
    Sponsor Name:Skåne University Hospital
    Full Title: THE IMPORTANCE OF ALBUMIN INFUSION RATE FOR PLASMA VOLUME EXPANSION FOLLOWING MAJOR ABDOMINAL SURGERY
    Medical condition: Post operative patients who have been subjected to either a non-emergant Whipple operation or major gynecological cancer surgery ( including resection of ovaries, uterus, adnexa, oment and lymph ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-000419-42 Sponsor Protocol Number: Nalogexol-2014 Start Date*: 2015-05-11
    Sponsor Name:Aalborg University Hospital
    Full Title: Naloxegol and assessments of opioid induced bowel dysfunction
    Medical condition: Healthy volunteers (Opioid-induced bowel dysfunction)
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Adults Gender: Male
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2021-003373-64 Sponsor Protocol Number: 01-DIMS-2021 Start Date*: 2021-11-22
    Sponsor Name:NOEMI GUEMES VILLAHOZ
    Full Title: POST-MARKETING PARALLEL CLINICAL TRIAL TO DETERMINE THE EFFECTIVENESS AND TOLERABILITY OF DIMS LENSES IN THE CONTROL OF MYOPIA IN PEDIATRIC POPULATION
    Medical condition: MYOPIA IN PEDIATRIC POPULATION
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-003687-31 Sponsor Protocol Number: AGO/2018/005 Start Date*: 2019-01-31
    Sponsor Name:Ghent University Hospital
    Full Title: Influence of continuous administration of phenylephrine versus dobutamine on spinal oxygen saturation, measured with near-infrared spectroscopy (NIRS).
    Medical condition: spinal vasculature spinal oxygen saturation muscle oxygen saturation cerebral oxygen saturation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2014-005005-20 Sponsor Protocol Number: 2014-005005-20 Start Date*: 2015-01-28
    Sponsor Name:Karolinska Institute
    Full Title: Karisma Pilot: A randomized, open pilot study to investigate the mammographic density reduction in healthy women ,within the Karma cohort, for two different doses of tamoxifen.
    Medical condition: A randomized, open pilot study to investigate the mammographic density reduction in healthy women ,within the Karma cohort, for two different doses of tamoxifen.
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: SE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2017-004174-34 Sponsor Protocol Number: Citalopram2017 Start Date*: 2018-04-10
    Sponsor Name:Targid, KU Leuven
    Full Title: A placebo-controlled trial with citalopram for the treatment of typical reflux symptoms in patients with reflux hypersensitivity or functional heartburn with incomplete proton pump inhibitor response
    Medical condition: Functional heartburn and reflux hypersensitivity with incomplete respons to proton pomp inhibitors
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2021-000144-21 Sponsor Protocol Number: DIUR-016-AI Start Date*: 2022-01-14
    Sponsor Name:Diurnal Limited
    Full Title: A Double-Blind, Double-Dummy, Two-Way Cross-Over, Randomised, Phase II Study of Efficacy, Safety and Tolerability of Modified-Release Hydrocortisones: Chronocort® Versus Plenadren®, in Adrenal Insu...
    Medical condition: Adrenal Insufficiency (AI)
    Disease: Version SOC Term Classification Code Term Level
    20.0 10014698 - Endocrine disorders 10052381 Primary adrenal insufficiency PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2012-005640-14 Sponsor Protocol Number: 42994 Start Date*: 2013-04-15
    Sponsor Name:Erasmus MC
    Full Title: The effects of hormonal contraception on the HPA-axis functioning
    Medical condition: healthy female volunteers; hormonal contraception method used: combined method (oestrogens en progestins) and progesterone-only method.
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004865 10010812 Contraceptive methods female HLT
    Population Age: Adults Gender: Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-001702-30 Sponsor Protocol Number: 200175 Start Date*: 2022-02-08
    Sponsor Name:APHP
    Full Title: « Use of Levosimendan as treatment of aneurysmal SubArachnoid Hemorrhage »
    Medical condition: subarachnoid hemorrhages of aneurysmal origin (HSAa)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2013-001976-39 Sponsor Protocol Number: CHDR1227 Start Date*: 2013-07-30
    Sponsor Name:Centre for Human Drug Research
    Full Title: Randomized, open-label, crossover study into the contribution of the intestines and kidney in the diurnal variation of Levofloxacin pharmacokinetics
    Medical condition: The circadian variation in the relative contribution of intestinal uptake and renal elimination of levofloxacin
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-000961-19 Sponsor Protocol Number: 2019/376 Start Date*: 2019-08-26
    Sponsor Name:Helse Fonna
    Full Title: “Haemodynamic stability during induction of general anesthesia with propofol and remifentanil: A randomized, controlled, double-blind study comparing medium and low remifentanil doses.”
    Medical condition: In daily clinical work we observe a hypotensive effect and a reduction in heart rate when induction of general anesthesia is performed using propofol and remifentanil. It is difficult to differenti...
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-000958-56 Sponsor Protocol Number: 2019/375 Start Date*: 2019-08-16
    Sponsor Name:Helse Fonna
    Full Title: “Haemodynamic stability during induction of general anesthesia with propofol and remifentanil: A randomized, controlled, double-blind study comparing low vs high propofol doses.”
    Medical condition: In daily clinical work we observe a hypotensive effect and a reduction in HR when induction of general anesthesia is performed using propofol and remifentanil. It is difficult to differentiate the ...
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-000244-42 Sponsor Protocol Number: acid_permeability_healthyvolunteers Start Date*: 2015-04-21
    Sponsor Name:KU Leuven
    Full Title: The role of mast cells on duodenal permeability after duodenal acid perfusion in healthy volunteers
    Medical condition: To investigate the role of mast cells on duodenal permeability after duodenal acid perfusion. The study will be done in healthy volunteers and the results will give an indication about the role of ...
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004856 10064536 Functional dyspepsia LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2014-004742-10 Sponsor Protocol Number: NPE-01-2014 Start Date*: 2014-12-17
    Sponsor Name:Department of medical Research, Regional Hospital Holstebro
    Full Title: The effect of 0,9% NaCl on the kidney function, vasoactive hormones, biomarkers and glycosaminglycanes in plasma in patients operated on for primary hiparthrosis.
    Medical condition: Kidney function during operation
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004857 10023422 Kidney function abnormal LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-002675-17 Sponsor Protocol Number: TIGER-BVS Start Date*: 2014-05-30
    Sponsor Name:Fundació Clínic per a la Recerca Biomèdica
    Full Title: Ticagrelor and absorb bioresorbable vascular scaffold implantation for recovery of vascular function after successful chronic total occlusion recanalization
    Medical condition: Chronic total coronary occlusion
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2012-002947-74 Sponsor Protocol Number: 1-12 Start Date*: 2013-07-19
    Sponsor Name:Medizinische Universität Wien
    Full Title: A prospective randomized, double blind, placebo-controlled, cross-over study to investigate the analgesic effect of Aspirin® to prevent the pain during the treatment with capsaicin patch 8% (Qutenza®)
    Medical condition: Qutenza is an approved product for the treatment of pain due to postherpetic neuralgia and peripheral neuropathies. Since its application is painful, it is often necessary to give analgesics or loc...
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2018-003816-38 Sponsor Protocol Number: PHRC-N/2017-FJ-01 Start Date*: 2020-11-09
    Sponsor Name:CHU DE NIMES
    Full Title: Add-on buprenorphine at analgesic doses for the treatment of severe suicidal ideas during a major depressive episode
    Medical condition: Treatment of severe suicidal ideas in patients suffers from a current major depressive episode
    Disease: Version SOC Term Classification Code Term Level
    23.0 100000004873 10083288 Clinical depression LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2016-002385-31 Sponsor Protocol Number: 2015/582 Start Date*: 2017-08-28
    Sponsor Name:Professor Peter Humaidan, The Fertility Clinic Skive
    Full Title: A double-blind, placebo-controlled multicenter trial on the effect of clindamycin and a live biotherapeutic on the reproductive outcomes of IVF patients with abnormal vaginal microbiota
    Medical condition: Infertility
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004865 10021572 In vitro fertilization LLT
    Population Age: Adults Gender: Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2017-002189-39 Sponsor Protocol Number: 161802 Start Date*: 2017-12-11
    Sponsor Name:University of Oxford
    Full Title: A randomised placebo-controlled trial to assess the effect of melatonin on circadian sleep-wake disturbances in ocular disease.
    Medical condition: circadian sleep-wake disturbances associated with ocular disease.
    Disease: Version SOC Term Classification Code Term Level
    21.1 10029205 - Nervous system disorders 10009191 Circadian rhythm sleep disorder PT
    21.1 10029205 - Nervous system disorders 10009191 Circadian rhythm sleep disorder PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2016-001877-34 Sponsor Protocol Number: HOT-Treated Start Date*: 2016-11-25
    Sponsor Name:South London and Maudsley NHS Foundation Trust [...]
    1. South London and Maudsley NHS Foundation Trust
    2. King's College London
    Full Title: Improving understanding of Heroin Overdose Testing: diamorphine dose-escalation testing in a treated population
    Medical condition: Opioid Overdose
    Disease: Version SOC Term Classification Code Term Level
    21.1 10022117 - Injury, poisoning and procedural complications 10033295 Overdose PT
    20.0 10022117 - Injury, poisoning and procedural complications 10033299 Overdose effect LLT
    20.1 10022117 - Injury, poisoning and procedural complications 10067695 Acute overdose LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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