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Clinical trials for End of life care

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44336   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    2,192 result(s) found for: End of life care. Displaying page 1 of 110.
    1  2  3  4  5  6  7  8  9  Next» Last»»
    EudraCT Number: 2017-000039-16 Sponsor Protocol Number: LUMC-PHEG-20172022 Start Date*: 2017-10-10
    Sponsor Name:Leiden University Medical Center
    Full Title: Paracetamol to enhance quality of life and daily function and to decrease care dependency in advanced dementia: A randomized, double-blind, placebo-controlled crossover trial in long-term care faci...
    Medical condition: We will investigate the effect of regularly scheduled administration of paracetamol on Quality of life, daily functioning, care dependency, pain, change in challenging behaviour and antipsychotic m...
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000171288 10066844 Behavioral and psychiatric symptoms of dementia LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-001328-21 Sponsor Protocol Number: ABR65448 Start Date*: 2019-01-08
    Sponsor Name:Leiden University Medical Center
    Full Title: Chronotherapy with aspirin for reduction of cardiovascular disease
    Medical condition: The medical condioton to be investigated is recurrent cardiovascular disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2017-001950-33 Sponsor Protocol Number: 15/0592 Start Date*: 2018-01-19
    Sponsor Name:UCL
    Full Title: Methylphenidate versus placebo for fatigue in advanced cancer (MePFAC)
    Medical condition: Cancer-related fatigue
    Disease: Version SOC Term Classification Code Term Level
    20.0 10018065 - General disorders and administration site conditions 10016256 Fatigue PT
    Population Age: Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2005-005658-37 Sponsor Protocol Number: 2006-1 Start Date*: 2006-07-07
    Sponsor Name:Dpt. of Urology -K. Aarhus University Hospital
    Full Title: A randomized, multi-center study to assess the effect of Darbepoetin alfa (Aranesp®) for the treatment of anemia in patients with advanced hormone independent prostate cancer and anaemia
    Medical condition: In an open randomised, multi-center study to identify the haematopoietic response to Aranesp® (Darbepoetin 6,75 mcg/kg) administrated every fourth week compared to standard care of treatment in pat...
    Disease: Version SOC Term Classification Code Term Level
    6.1 10038444 PT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-003019-24 Sponsor Protocol Number: 80-87200-98-1017 Start Date*: 2021-08-18
    Sponsor Name:University Medical Center Utrecht
    Full Title: Effectiveness of analgesic ear drops as add-on treatment to oral analgesics in children with acute otitis media: a pragmatic randomised controlled trial
    Medical condition: Acute otitis media
    Disease:
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2017-000632-34 Sponsor Protocol Number: AAUH-ICU-01 Start Date*: 2017-04-25
    Sponsor Name:Department of Anaesthesia and Intensive Care Medicine, Aalborg University Hospital
    Full Title: Handling oxygenation targets in adults with acute hypoxaemic respiratory failure in the intensive care unit: A randomised clinical trial of a lower versus a higher oxygenation target Addendum: Tri...
    Medical condition: Acute hypoxaemic respiratory failure in patients admitted to the intensive care unit Addendum: Acute hypoxaemic respiratory failure in patients admitted to the intensive care unit with COVID-19
    Disease: Version SOC Term Classification Code Term Level
    21.1 10038738 - Respiratory, thoracic and mediastinal disorders 10001053 Acute respiratory failure PT
    21.1 10042613 - Surgical and medical procedures 10022519 Intensive care PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended) FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-006994-48 Sponsor Protocol Number: EMPATICC-INCOR1 Start Date*: 2022-07-25
    Sponsor Name:Universitätsklinikum Essen
    Full Title: Empower the Heart of Patients with Terminal Cancer using Cardiac Medicines Trial
    Medical condition: Patients with terminal cancer in palliative care
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10059513 Palliative care PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-000218-23 Sponsor Protocol Number: 131188 Start Date*: 2015-03-26
    Sponsor Name:Aarhus University Hospital, Skejby
    Full Title: Concentration of Meropenem in Plasma and Subcutis in Patients on ECMO Treatment
    Medical condition: Infections related to ECMO-hospitalisation
    Disease: Version SOC Term Classification Code Term Level
    17.1 10042613 - Surgical and medical procedures 10022519 Intensive care PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2014-001314-25 Sponsor Protocol Number: KIANANDR140701 Start Date*: 2015-03-10
    Sponsor Name:Karolinska Institutet
    Full Title: The effect of on demand versus continuous use of proton pump inhibitors on reflux symptoms, quality of life and self-rated health in patients with gastro-oesophageal reflux disease
    Medical condition: Gastrooesophageal reflux disease
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: View results
    EudraCT Number: 2015-004836-36 Sponsor Protocol Number: HD202 Start Date*: 2016-02-03
    Sponsor Name:Department of Anaesthesiology and Intensive Care, University of Tartu
    Full Title: Dose dependent effects of dobutamine on central and regional blood flow in preterm and term neonates
    Medical condition: Hypoperfusion status of preterm and term newborns during the first days of life.
    Disease:
    Population Age: Preterm newborn infants, Newborns, Under 18 Gender: Male, Female
    Trial protocol: EE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2010-021797-10 Sponsor Protocol Number: TIS2012 Start Date*: 2012-01-19
    Sponsor Name:VU university medical center
    Full Title: A phase II randomized multicenter study on efficacy and safety of cultured autologous skin (Tiscover®) and acellular dermal matrix (AS210) in chronic (arterio-)venous ulcers
    Medical condition: The autologous cultured skin substitute (Tiscover) or acellular donor dermis (AS210) is applied to patients with chronic (arterio-) venous leg wounds.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2020-001456-18 Sponsor Protocol Number: AZIQUINE-ICU-25032020 Start Date*: 2020-04-09
    Sponsor Name:Nadační fond Donatio intensivistam
    Full Title: Azithromycin added to Hydrochloroquine in Patients Admitted to Intensive Care due to Coronavirus Disease 2019 (COVID-19) - Randomised Controlled Trial, phase III
    Medical condition: Severe COVID-19
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2019-000312-28 Sponsor Protocol Number: P170901J Start Date*: 2019-12-18
    Sponsor Name:APHP / DRCI
    Full Title: Extending time without diabetes after bariatric surgery: a randomized controlled trial comparing the metformin addition or not to standard care
    Medical condition: Type 2 Diabetes complete remission after Bariatric surgery under antidiabetic drug
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2011-002411-29 Sponsor Protocol Number: M13-045 Start Date*: 2012-04-26
    Sponsor Name:AbbVie Deutschland GmbH & Co. KG
    Full Title: An Open-Label Multicenter Study to Evaluate the Impact of Adalimumab on Quality of Life, Health Care Utilization and Costs of Ulcerative Colitis Subjects in the Usual Clinical Practice Setting.
    Medical condition: Ulcerative Colitis
    Disease: Version SOC Term Classification Code Term Level
    14.1 10017947 - Gastrointestinal disorders 10017947 Gastrointestinal disorders SOC
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) ES (Completed) GB (Completed) DE (Completed) BE (Completed) DK (Completed) GR (Completed) PT (Completed) AT (Completed) IE (Completed) IT (Completed) FI (Completed) CZ (Completed) SK (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2016-003582-25 Sponsor Protocol Number: NL59128 Start Date*: 2017-01-23
    Sponsor Name:University Medical Center Groningen
    Full Title: The added effect of oral ondansetron to care-as-usual on persisting vomiting in children aged 6 months to 6 years, presenting at primary care out of hours service with acute gastro-enteritis and co...
    Medical condition: Gastroenteritis
    Disease:
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-005271-16 Sponsor Protocol Number: 2010NE02 Start Date*: 2012-11-29
    Sponsor Name:University of Dundee & NHS Tayside
    Full Title: Does oral sodium bicarbonate therapy improve function and quality of life in older patients with chronic kidney disease and low-grade acidosis? A multicentre randomized placebo controlled trial
    Medical condition: Chronic kidney disease stages 4/5 with metabolic acidosis
    Disease: Version SOC Term Classification Code Term Level
    17.0 100000004857 10064848 Chronic kidney disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2014-005344-17 Sponsor Protocol Number: CBDV_2014 Start Date*: 2015-08-21
    Sponsor Name:Department of Anesthesiology and Operative Intensive Care Medicine, Charité (CBF)
    Full Title: Oral cannabidivarin (CBDV) solution for treatment of HIV-associated neuropathic pain – a randomized, double-blind, placebo-controlled phase II study.
    Medical condition: Chronic painful HIV-associated neuropathy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2022-001041-20 Sponsor Protocol Number: F001AM0222_1 Start Date*: 2022-10-14
    Sponsor Name:University Hospital Wuerzburg
    Full Title: Prednisolone and vitamin B1, B6, and B12 in patients with Post-COVID-19-Syndrome (PC19S) – a randomized controlled trial in primary care
    Medical condition: Post-COVID-19-Syndrome (PC19S)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-000292-83 Sponsor Protocol Number: Tallisur Start Date*: 2017-08-30
    Sponsor Name:Servier Deutschland GmbH
    Full Title: Prospective, Multicenter, Open-label Phase IV trial of Trifluridine/Tipiracil to Evaluate the Health-related Quality of Life in Patients with Metastatic Colorectal Cancer
    Medical condition: Histologically or cytologically confirmed UICC stage IV carcinoma of colon or rectum with metastasis (metastatic colorectal cancer) with need for treatment due to progression
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2013-004726-28 Sponsor Protocol Number: ILIT2Linköping-Jönköping Start Date*: 2014-01-10
    Sponsor Name:Allergy Centre
    Full Title: Double-blind randomised controlled study to down regulate allergic responses in adults with allergic rhinoconjunctivitis by using three intralymphatic injections of grass and/or birch allergen one ...
    Medical condition: Allergic rhinoconjunctivitis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Prematurely Ended)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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