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Clinical trials for Extracellular fluid

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44338   clinical trials with a EudraCT protocol, of which   7368   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    31 result(s) found for: Extracellular fluid. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2006-002770-22 Sponsor Protocol Number: SOB06 Start Date*: 2006-09-26
    Sponsor Name:York Hospital NHS Trust
    Full Title: The effects of oral sodium bicarbonate on extracellular water in patients with chronic renal failure
    Medical condition: We will investiagte the use of sodium bicarbonate on extracellular water in patients with CHRONIC RENAL FAILURE
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2019-004292-40 Sponsor Protocol Number: GODIF Start Date*: 2020-02-17
    Sponsor Name:Department of Anesthesia and Intensive Care Medicine, Nordsjællands hospital
    Full Title: Goal directed fluid removal with furosemide in intensive care patients with fluid overload - A randomised, blinded, placebo-controlled trial (GODIF).
    Medical condition: Treatment of fluid overload in critically ill adult patients in intensive care unit.
    Disease: Version SOC Term Classification Code Term Level
    22.1 100000004861 10015766 Extracellular fluid increased LLT
    20.0 100000004861 10016808 Fluid retention in tissues LLT
    24.0 100000004861 10022608 Interstitial fluid increased LLT
    24.1 100000004861 10033303 Overhydration LLT
    20.0 100000004867 10030102 Oedema generalised LLT
    20.1 100000004867 10034611 Peripheral oedema LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned) NO (Prematurely Ended) FI (Prematurely Ended) NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2011-000158-47 Sponsor Protocol Number: J&P002/2011 Start Date*: 2012-01-19
    Sponsor Name:Klin. Abtlg. für Thorax- & Hyperbare Chirurgi
    Full Title: Assessment of extracellular concentrations of linezolid and other currently approved antibiotics in patients presenting with severe bacterial lung infection
    Medical condition: Subjects who are scheduled to undergo elective open-chest lung surgery will be included in the study.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-018343-34 Sponsor Protocol Number: 09P07 Start Date*: 2011-10-25
    Sponsor Name:Ludwigs Maximilians University
    Full Title: Comparison of 6% Hydroxyethyl Starch and 5% Albumin for Volume Replacement Therapy in Patients Undergoing Cystectomy (CHART study)
    Medical condition: Comparison of 6% Hydroxyethyl Starch and 5% Albumin for Volume Replacement Therapy in Patients Undergoing Cystectomy
    Disease: Version SOC Term Classification Code Term Level
    15.1 100000004861 10021139 Hypovolemia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-005175-10 Sponsor Protocol Number: ABD03 Start Date*: 2009-04-08
    Sponsor Name:Guys and St Thomas' NHS Foudation Trust
    Full Title: Volume Expansion using a balanced gelatin solution in patients undergoing major abdominal surgery.
    Medical condition: Intravascular volume deficits in major abdominal surgery
    Disease: Version SOC Term Classification Code Term Level
    9.1 10021137 Hypovolaemia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2017-001840-37 Sponsor Protocol Number: 2017-001840-37 Start Date*: 2019-01-15
    Sponsor Name:VU University Medical Center
    Full Title: ERtugliflozin triAl in DIabetes with preserved or reduced ejeCtion FrAcTion mEchanistic evaluation in Heart Failure: "ERADICATE-HF"
    Medical condition: Diabetes Mellitus Type 2 and Heart failure
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-001846-24 Sponsor Protocol Number: 1 Start Date*: 2016-06-29
    Sponsor Name:Antwerp University Hospital
    Full Title: Metabolism of Isotonic versus Hypotonic Maintenance Solutions in fasting healthy Adults (MIHMoSA), a Single-Blind Randomized Crossover Trial
    Medical condition: Healthy adult volunteers
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-001324-18 Sponsor Protocol Number: 202100178 Start Date*: 2021-09-30
    Sponsor Name:University Medical Center Groningen
    Full Title: A Study to Assess the Effects of the Endothelin Receptor Antagonist Zibotentan and the SGLT2 Inhibitor Dapagliflozin in Patients with elevated Albuminuria: a Randomized Double Blind Cross-Over Trial
    Medical condition: Patients with elevated Albuminuria
    Disease: Version SOC Term Classification Code Term Level
    27.1 10038359 - Renal and urinary disorders 10061835 Diabetic nephropathy PT
    27.0 10027433 - Metabolism and nutrition disorders 10016807 Fluid retention PT
    20.0 10038359 - Renal and urinary disorders 10001580 Albuminuria PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed) DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-003815-71 Sponsor Protocol Number: AK-1-2012 Start Date*: 2013-02-08
    Sponsor Name:Department of Medical Research
    Full Title: The effect of furosemide on fluid volumes and biomarkers in urine for measurement of sodium and water channel activity in healthy subjects
    Medical condition: healthy people
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004848 10049506 Investigation NOS LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-002162-30 Sponsor Protocol Number: HC-G-H-1504 Start Date*: 2017-04-12
    Sponsor Name:Fresenius Kabi Deutschland GmbH
    Full Title: Prospective, randomized, controlled, double-blind, multicentre, multinational study on the safety and efficacy of 6% Hydroxyethyl starch (HES) solution versus an electrolyte solution in patients u...
    Medical condition: Hypovolaemia due to acute blood loss in elective abdominal surgery
    Disease: Version SOC Term Classification Code Term Level
    20.0 10027433 - Metabolism and nutrition disorders 10021137 Hypovolaemia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) CZ (Completed) NL (Completed) ES (Restarted) FR (Ongoing) AT (Completed) HR (Completed) RO (Ongoing)
    Trial results: View results
    EudraCT Number: 2012-003398-24 Sponsor Protocol Number: FP2012/01 Start Date*: 2012-10-29
    Sponsor Name:FUNDACIÓ PUIGVERT
    Full Title: Randomized clinical trial to compare the effect of mannitol and hydroelectrolytic solutions as kidney function protector, in partial laparoscopic nephrectomies (MANCOL Study)
    Medical condition: partial laparoscopic nephrectomy
    Disease: Version SOC Term Classification Code Term Level
    15.0 10027433 - Metabolism and nutrition disorders 10047691 Volume depletion LLT
    15.0 10042613 - Surgical and medical procedures 10034072 Partial nephrectomy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-002176-27 Sponsor Protocol Number: HC-G-H-1505 Start Date*: 2017-08-30
    Sponsor Name:Fresenius Kabi Deutschland GmbH
    Full Title: Pragmatic, prospective, randomized, controlled, double-blind, multicentre, multinational study on the safety and efficacy of a 6% Hydroxyethyl starch (HES) solution versus an electrolyte solution ...
    Medical condition: Hypovolaemia due to acute blood loss in trauma surgery
    Disease: Version SOC Term Classification Code Term Level
    20.0 10027433 - Metabolism and nutrition disorders 10021137 Hypovolaemia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) BE (Completed) CZ (Completed) NL (Completed) ES (Restarted) FR (Ongoing)
    Trial results: View results
    EudraCT Number: 2007-002122-30 Sponsor Protocol Number: 1978 Start Date*: 2007-09-14
    Sponsor Name:Medical University Vienna Division of Anesthesie and Pain Management
    Full Title: The effect of different solvents of HES preparations on coagulation and platelet function (Effekt der Trägerlösung von HES Präparaten auf Blutgerinnung und Thrombozytenfunktion)
    Medical condition: treatment and prophylaxis of acute hypovolaemia and shock acute normovolaemic haemodilution
    Disease: Version SOC Term Classification Code Term Level
    9.1 10021139 Hypovolemia LLT
    9.1 10011954 Decreased and nonspecific blood pressure disorders and shock HLGT
    9.1 10059489 Hemodilution LLT
    Population Age: Adults Gender: Male
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2021-001247-27 Sponsor Protocol Number: 202100166 Start Date*: 2021-09-30
    Sponsor Name:University Medical Center Groningen
    Full Title: SeMaglutide and Albuminuria Reduction Trial in obese individuals without diabetes
    Medical condition: Overweight and obese individuals at high risk of chronic kidney disease progression.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10027433 - Metabolism and nutrition disorders 10029883 Obesity PT
    20.0 10038359 - Renal and urinary disorders 10001580 Albuminuria PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed) DE (Completed) ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-004042-42 Sponsor Protocol Number: DEER Start Date*: 2014-06-19
    Sponsor Name:King’s College London [...]
    1. King’s College London
    2. Guy's and St Thomas NHS Foundation Trust
    Full Title: A study to investigate the potential renoprotective role of sodium-glucose transporter-2 (SGLT-2) antagonist Dapagliflozin in Type 2 diabetic patients with diabetic nephropathy
    Medical condition: Diabetic Nephropathy
    Disease: Version SOC Term Classification Code Term Level
    20.1 10038359 - Renal and urinary disorders 10061835 Diabetic nephropathy PT
    20.0 10027433 - Metabolism and nutrition disorders 10067585 Type 2 diabetes mellitus PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2018-004149-17 Sponsor Protocol Number: 40346527ALZ1001 Start Date*: 2019-06-07
    Sponsor Name:University of Oxford / Clinical Trials and Research Governance
    Full Title: A randomised, placebo-controlled, single-blind study to characterise the biomarker effects of the CSF-1 receptor antagonist JNJ-40346527 in participants with mild cognitive impairment
    Medical condition: Mild Cognitive Impairment
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004852 10001896 Alzheimer's disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2006-001428-38 Sponsor Protocol Number: RRK2939 Start Date*: 2006-09-18
    Sponsor Name:University Hospitals Birmingham NHS Foundation Trust
    Full Title: Remission Induction in Very Early Rheumatoid Arthritis (RIVERA): a comparison of etanercept plus methotrexate plus steroid with standard therapy
    Medical condition: Patients with early inflamatory arthritis (duration of symptoms of < 12 weeks) who are at very high risk of the development of rheumatoid arthritis (seropositivity for Rheumatoid factor and anti-C...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-003343-29 Sponsor Protocol Number: RG_12-179 Start Date*: 2013-01-18
    Sponsor Name:University of Birmingham
    Full Title: Simvastatin as adjuvant therapy to correct neutrophil dysfunction in older pneumonia patients - a randomised double blind placebo controlled trial
    Medical condition: Acute episodes of Pneumonia and sepsis in older adults
    Disease: Version SOC Term Classification Code Term Level
    14.1 10021881 - Infections and infestations 10035664 Pneumonia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-001602-16 Sponsor Protocol Number: 25706 Start Date*: 2008-05-13
    Sponsor Name:Rigshospitalet
    Full Title: Effects of Insulin Levemir and Insulin Insulatard on renal handling of sodium, fluid retention and weight in type 2 diabetic patients
    Medical condition: Diabetes mellitus type 2
    Disease: Version SOC Term Classification Code Term Level
    9.1 10045242 Type II diabetes mellitus LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2005-005026-31 Sponsor Protocol Number: EFC6125 [AVE0005A/3001] Start Date*: 2006-04-24
    Sponsor Name:Sanofi-Synthelabo Recherche, a subsidiary of sanofi-aventis group
    Full Title: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm Study of the Effect of Intravenous AVE0005 (VEGF Trap) Administered Every 2 Weeks in Advanced Ovarian Cancer Patients with ...
    Medical condition: pacientes con cáncer de ovario avanzado con ascitis maligna sintomática recurrente
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: ES (Completed) GB (Completed) HU (Completed) AT (Prematurely Ended) BE (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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