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Clinical trials for Heme A

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    31 result(s) found for: Heme A. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2008-005955-40 Sponsor Protocol Number: HPB01 Start Date*: 2009-06-08
    Sponsor Name:University of Edinburgh [...]
    1. University of Edinburgh
    2. NHS Lothian
    Full Title: Induction of Heme Oxygenase-1: a therapeutic approach to reduce hepatic ischaemia-reperfusion injury in liver surgery
    Medical condition: This trial is investigating a new treatment for hepatic ischaemia-reperfusion injury in liver resection.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-006922-32 Sponsor Protocol Number: HOADO Start Date*: 2009-02-09
    Sponsor Name:RUNMC
    Full Title: Heme oxygenase (HO) activity in humans. Effects of heme arginate (Normosang®) on parameters of HO activity and on adenosine induced vasodilation.
    Medical condition: Normosang treatment will be used to evaluate heme oxygenase induction in healthy subjects. Results will be used for future studies concerning diabetes related cardiovascular disease.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10051615 Atherosclerotic cardiovascular disease LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-004311-23 Sponsor Protocol Number: HOTstudy_Thomas11 Start Date*: 2011-11-29
    Sponsor Name:University of Edinburgh [...]
    1. University of Edinburgh
    2. NHS Lothian
    Full Title: A randomised, placebo controlled trial to study the effect of heme-arginate on heme-oxygenase-1 induction and renal function in recipients of deceased donor renal transplants.
    Medical condition: Ischaemia-reperfusion injury in renal transplantation
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004857 10014646 End stage renal disease (ESRD) LLT
    20.0 100000004865 10023438 Kidney transplant LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: Removed from public view
    EudraCT Number: 2011-000397-59 Sponsor Protocol Number: none Start Date*: 2011-03-21
    Sponsor Name:
    Full Title: Prevention of post-ERCP acute pancreatitis by heme-oxygenase activation through the administration of hemin: a prospective, randomized double blind controlled trial.
    Medical condition: Prevention of post-ERCP acute pancreatitis. So, patient with indications of ERCP (endoscopic retrograde cholangiopanreatography) will be included. These patients suffer from bilio-pancreatic disord...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-000131-27 Sponsor Protocol Number: AC17065 Start Date*: 2018-05-23
    Sponsor Name:University of Edinburgh [...]
    1. University of Edinburgh
    2. NHS Lothian
    Full Title: Heme arginate in transplantation - a multi-centre blinded parallel-group randomised trial of heme arginate versus placebo to reduce delayed graft function in kidney transplant recipients. (The HOT ...
    Medical condition: End stage renal disease patients undergoing a deceased donor kidney transplant
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004865 10023438 Kidney transplant LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2010-020875-22 Sponsor Protocol Number: MetSNS Start Date*: 2010-08-20
    Sponsor Name:RUNMC
    Full Title: In vivo induction of heme oxygenase-1 (HO-1) in the metabolic syndrome (MetS). Influence of heme arginate (Normosang) infusion on heme oxygenase-1 activity, endothelial dysfunction, insulin resista...
    Medical condition: Subjects suffer from the metabolic syndrome. Effects of study medication on insulin resistance and vascular function will be studied respectively.
    Disease: Version SOC Term Classification Code Term Level
    12.1 10022489 Insulin resistance LLT
    12.1 10052066 Metabolic syndrome LLT
    12.1 10048554 Endothelial dysfunction LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2008-006967-35 Sponsor Protocol Number: HEME 1.0 Start Date*: 2009-02-11
    Sponsor Name:Medizinische Universität Wien, Universitätsklinik für klinische Pharmakologie
    Full Title: The effects of intravenous heme arginate on functional magnetic resonance imaging during ischemia
    Medical condition: ischemia reperfusion injury
    Disease: Version SOC Term Classification Code Term Level
    9.1 10034578 Peripheral ischemia LLT
    Population Age: Adults Gender: Male
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2013-000887-27 Sponsor Protocol Number: 1.0 Start Date*: 2013-05-23
    Sponsor Name:Medizinische Universität Wien
    Full Title: Pilot Trial: The effects of intravenous heme arginate on HO-1 expression and oxidative stress in the human heart
    Medical condition: ischemia reperfusion injury
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004849 10055224 Cardiac ischemia LLT
    14.1 100000004849 10023031 Ischemia coronary artery origin LLT
    14.1 100000004849 10023033 Ischemia myocardial LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2013-004607-39 Sponsor Protocol Number: 2013-00460739 Start Date*: 2014-04-11
    Sponsor Name:CUB Hopital Erasme
    Full Title: Safety of preoperative administration of hemin to reduce the risk of acute kidney injury after on-pump cardiac surgery: a pilot randomised study in double blind.
    Medical condition: Acute kidney injury which is associated with on-pump cardiac surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2008-000771-17 Sponsor Protocol Number: DM2ATV Start Date*: 2008-05-05
    Sponsor Name:RUNMC
    Full Title: Hyperbilirubinemia, the favourable side effect of atazanavir? Influence of atazanavir treatment on endothelial dysfunction, vascular inflammation and heme oxygenase activity in type 2 diabetes mell...
    Medical condition: Type 2 diabetes mellitus
    Disease: Version SOC Term Classification Code Term Level
    9.1 10053246 Type II diabetes peripheral angiopathy LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2020-004995-17 Sponsor Protocol Number: NL7507301820 Start Date*: 2021-03-11
    Sponsor Name:AMsterdam UMC-AMC
    Full Title: Low dose iron chelation as TReatment of Oxidative stress in Sickle cell disease; TROS study
    Medical condition: Sickle cell disease (an hereditary hemoglobinopathy)
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-001585-36 Sponsor Protocol Number: AMC_SMILE_1.0 Start Date*: 2022-07-05
    Sponsor Name:Amsterdam UMC
    Full Title: EffectS of L-glutaMIne on oxIdative stress, sickLE erythrocyte viability, inflammation and endothelial activity in sickle cell disease (SMILE trial)
    Medical condition: Sickle Cell Disease
    Disease: Version SOC Term Classification Code Term Level
    21.0 10010331 - Congenital, familial and genetic disorders 10040644 Sickle cell disease PT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-002652-42 Sponsor Protocol Number: 2007IC007H Start Date*: 2007-08-14
    Sponsor Name:Royal Brompton and Harefield NHS Trsut
    Full Title: The use of clopidogrel and aprotonin in off pump coronary artery bypass grafting
    Medical condition: Bleeding after coronary artery bypass grafting
    Disease: Version SOC Term Classification Code Term Level
    9.1 10005645 Blood loss of (NOS) LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2013-004813-41 Sponsor Protocol Number: 1321.3 Start Date*: 2014-05-26
    Sponsor Name:Boehringer Ingelheim Pharma GmbH & Co. KG
    Full Title: A Phase III case series clinical study of the reversal of the anticoagulant effects of dabigatran by intravenous administration of 5.0g idarucizumab (BI 655075) in patients treated wtih dabigatran ...
    Medical condition: Hemorrhage
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004866 10019524 Hemorrhage LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) IE (Completed) PT (Completed) SE (Completed) ES (Completed) FI (Completed) EE (Completed) LV (Prematurely Ended) CZ (Completed) IT (Completed) SK (Completed) NL (Completed) BE (Completed) AT (Completed) NO (Completed) DK (Completed) FR (Completed)
    Trial results: View results
    EudraCT Number: 2010-022923-31 Sponsor Protocol Number: FIinTIC Start Date*: Information not available in EudraCT
    Sponsor Name:Medizinische Universität Innsbruck / Univ.-Klinik für Allgem. u. Chirurg. Intensivmedizin
    Full Title: A multicenter double-blind, placebo controlled, randomized, pilot trial to assess the efficacy of pre-hospital administration of Fibrinogen Concentrate (FGTW) in trauma patients, presumed to bleed ...
    Medical condition: Trauma patients with major bleeding or occult bleeding who received volume replacement
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004866 10018988 Haemorrhage NOS LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed) DE (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2015-000645-23 Sponsor Protocol Number: Borealis1 Start Date*: 2015-06-19
    Sponsor Name:CIBER (Centro de Investigacion Biomedica en Red)
    Full Title: Safety, tolerability and efficacy of nocturnal hypertension treatment with domperidone in the sleep apnea-hypopnea syndrome. Pilot study.
    Medical condition: Nocturnal hypertension in the sleep apnea-hypopnea syndrome.
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004855 10040976 Sleep apnea syndrome LLT
    17.1 100000004866 10019180 HBP LLT
    Population Age: Adults Gender: Male
    Trial protocol: ES (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-002287-24 Sponsor Protocol Number: 201105-RCTTEG Start Date*: 2012-07-11
    Sponsor Name:Erasmus MC
    Full Title: Massive blood loss in children during multiple trauma or major surgery: Fibrinogen therapy for massive blood loss during elective surgery for craniosynostosis repair, a double blinded randomized c...
    Medical condition: massive blood loss in surgery for premature fusion of cranial sutures, massive blood loss in fused bones of the skull
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004866 10005645 Blood loss of (NOS) LLT
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-000193-22 Sponsor Protocol Number: TRANESCOT-II Start Date*: 2007-03-30
    Sponsor Name:Servicio Anestesia Hopsital del Mar
    Full Title: Efectividad y seguridad del ácido tranexámico para reducir los requerimientos sanguíneos en artroplastia de cadera y rodilla. Evaluación de factores humorales, de hemostasia y complicaciones trombó...
    Medical condition: Sangrado excesivo perioperatorio en cirugía ortopédica de artroplastia de cadera y rodilla.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10005645 Blood loss of (NOS) LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-001867-22 Sponsor Protocol Number: PRETIC Start Date*: 2018-09-27
    Sponsor Name:Banc de Sang i teixits
    Full Title: TRANSFUSION OF RED BLOOD CELLS, TRANEXAMIC ACID AND FIBRINOGEN CONCENTRATE FOR SEVERE TRAUMA HEMORRHAGE AT PRE-HOSPITAL PHASE OF CARE. A PILOT TRIAL.
    Medical condition: TREATMENT OF SEVERE TRAUMA HEMORRHAGE AT PRE-HOSPITAL PHASE OF CARE.
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004866 10019524 Hemorrhage LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-003978-16 Sponsor Protocol Number: PRooF-iTH Start Date*: 2015-01-22
    Sponsor Name:Section for Transfusion Medicine, Capitol Region Blood Bank
    Full Title: Pilot Randomized trial of Fibrinogen in Trauma Haemorrhage (PRooF-iTH).
    Medical condition: Trauma patients with ongoing haemorrhage
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004866 10005103 Bleeding LLT
    17.1 100000004863 10044461 Trauma LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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