interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development
EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
Clinical Trials Information System (CTIS).
The EU Clinical Trials Register currently displays
44347
clinical trials with a EudraCT protocol, of which
7375
are clinical trials conducted with subjects less than 18 years old.
The register also displays information on
18700
older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).
Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see
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7 result(s) found for: Histiocytic sarcoma.
Displaying page 1 of 1.
EudraCT Number: 2021-002150-91
Sponsor Protocol Number: ACT16941
Start Date*: 2022-01-31
Sponsor Name:Sanofi-Aventis Recherche & Développement
Full Title: Phase 2 non-randomized, open-label, multi-cohort, multicenter study assessing the clinical benefit of SAR444245 (THOR-707) with or without other anticancer therapies for the treatment of adults and...
Medical condition: Classic Hodgkin Lymphoma
Diffuse large B-cell lymphoma
Disease:
Version
SOC Term
Classification Code
Term
Level
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10020206
Hodgkin's disease
PT
21.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10012818
Diffuse large B-cell lymphoma
PT
Population Age: Adolescents, Under 18, Adults, Elderly
Full Title: MULTI-CENTER, PHASE II STUDY TO ASSESS THE SAFETY AND EFFICACY OF HAPLOIDENTICAL BONE MARROW TRANSPLANTATION USING REDUCED INTENSITY CONDITIONING (RIC) REGIMEN AND POST-TRANSPLANT CYCLOPHOSPHAMIDE,...
Medical condition: Patients with lymphomas (any histology) relapsed after high dose chemotherapy and in complete remission or partial remission after the last CT line
Disease:
Version
SOC Term
Classification Code
Term
Level
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10003908
B-cell small lymphocytic lymphoma
PT
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10003899
B-cell lymphoma
PT
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10008958
Chronic lymphocytic leukaemia
PT
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10012818
Diffuse large B-cell lymphoma
PT
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10020206
Hodgkin's disease
PT
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: Optymalizacja czasu leczenia i dawkowania wemurafenibu u małoletnich pacjentów z opornymi na konwencjonalną terapię rozrostami z komórek histiocytarnych z obecnością mutacji w genie BRAF.
Medical condition: histiocytic cell proliferation
Disease:
Version
SOC Term
Classification Code
Term
Level
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10069698
Langerhans' cell histiocytosis
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10078782
Langerhans cell sarcoma
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10060801
Erdheim-Chester disease
PT
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10063397
Rosai-Dorfman syndrome
PT
Population Age: Infants and toddlers, Children, Adolescents, Under 18
Full Title: Optimalization Of The Time And Dosage Of Trametinib In BRAF Negative Juvenile Patients With Refractory Histiocytosis Or After Failure Of Vemurafenib Treatment.
Medical condition: histiocytic cell proliferation
Disease:
Version
SOC Term
Classification Code
Term
Level
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10069698
Langerhans' cell histiocytosis
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10078782
Langerhans cell sarcoma
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10060801
Erdheim-Chester disease
PT
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10063397
Rosai-Dorfman syndrome
PT
Population Age: Infants and toddlers, Children, Adolescents, Under 18
Full Title: A PHASE 1/2, MULTICENTER, OPEN-LABEL STUDY TO ASSESS SAFETY, PHARMACOKINETICS, AND PRELIMINARY EFFICACY OF CC-220, ALONE AND IN COMBINATION WITH AN ANTI-CD20 MONOCLONAL ANTIBODY (MAB) IN SUBJECTS W...
Medical condition: Relapsed or refractory lymphoma including the following subtypes:
Aggressive B-cell lymphoma, follicular lymphoma, marginal zone lymphoma, mantle cell lymphoma, peripheral T-cell lymphoma and class...
Disease:
Version
SOC Term
Classification Code
Term
Level
20.0
10005329 - Blood and lymphatic system disorders
10025319
Lymphomas Hodgkin's disease
HLGT
20.0
10005329 - Blood and lymphatic system disorders
10025320
Lymphomas non-Hodgkin's B-cell
HLGT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10076596
Marginal zone lymphoma
PT
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10034623
Peripheral T-cell lymphoma unspecified
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10061275
Mantle cell lymphoma
PT
21.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10012818
Diffuse large B-cell lymphoma
PT
21.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10023699
Large B-cell lymphoma subtype primary mediastinal (Thymic) large B-cell lymphoma
Full Title: A Phase 1-2, First-in-Human Study of CX-2029 in Adults with
Metastatic or Locally Advanced Unresectable Solid Tumors or
Diffuse Large B-cell Lymphomas
Medical condition: Metastatic or locally advanced unresectable solid tumor or diffuse large B-cell lymphoma
Disease:
Version
SOC Term
Classification Code
Term
Level
20.0
100000004851
10012819
Diffuse large B-cell lymphomas
HLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10061873
Non-small cell lung cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10067821
Head and neck cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10033606
Pancreatic cancer non-resectable
LLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10065147
Malignant solid tumor
LLT
Population Age: Adults, Elderly
Gender: Male, Female
Trial protocol:ES(Ongoing)GB(GB - no longer in EU/EEA)
Trial results:(No results available)
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