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Clinical trials for Hypothermia

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    137 result(s) found for: Hypothermia. Displaying page 1 of 7.
    1  2  3  4  5  6  7  Next»
    EudraCT Number: 2010-020103-70 Sponsor Protocol Number: 1 Start Date*: 2012-08-14
    Sponsor Name:University of Tartu
    Full Title: Pharmacokinetics of intravenous phenobarbital and lidocaine in the treatment of neonatal seizures of term neonates requireing therapeutic hypothermia
    Medical condition: Neonatal seizures
    Disease:
    Population Age: Newborns, Under 18 Gender: Male, Female
    Trial protocol: EE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-001814-34 Sponsor Protocol Number: OPI 04/006 Start Date*: 2006-09-12
    Sponsor Name:The Norwegian University of Science and Technology
    Full Title: Effects of hypothermia on the disposition of morphine, fentanyl, midazolam and propofol in intensive care unit patients
    Medical condition: Patients treated with therapeutic hypothermia (33-34 °C) and a control group of normothermic patients matched on sex, age and duration of morphine infusion.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: View results
    EudraCT Number: 2010-022679-71 Sponsor Protocol Number: Xenon-MTH-Studie Start Date*: 2011-01-07
    Sponsor Name:Clinical Trials Center Aachen, University of Aachen
    Full Title: Xenon and Therapeutical Hypothermia After Successful Cardiopulmonary Resuscitation
    Medical condition: In this clinical trial will be checked, whether 2 hours ventilation with xenon has neuroprotetctive effect on the patients, which had out of hospital cardiac arrest and successful cardiopulmonary r...
    Disease: Version SOC Term Classification Code Term Level
    16.1 10042613 - Surgical and medical procedures 10067221 Mechanical ventilation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2012-000184-24 Sponsor Protocol Number: EC11-222 Start Date*: Information not available in EudraCT
    Sponsor Name:ANTONIO JEREZ CALERO
    Full Title: Whole body hypothermia + melatonin vs whole body hypothermia + placebo in asphyctic newborns. A multicentric, ramdomized, controlled and double blind clinical trial
    Medical condition: Hipothermia plus melatonine neuroprotection terapy in asphixiated newborns.
    Disease:
    Population Age: Newborns, Under 18 Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-000836-23 Sponsor Protocol Number: FentanylTH Start Date*: 2021-09-22
    Sponsor Name:AZIENDA OSPEDALIERO-UNIVERSITARIA DI MODENA
    Full Title: Continous fentanyl infusion in newborns with hypoxic ischemic encephalopathy treated with therapeutic hypothermia: pharmacokinetics study
    Medical condition: Infants with perinatal asphyxiation and indication to hypothermic treatment with analgo-sedation performed with fentanyl
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004852 10070512 Hypoxic-ischemic encephalopathy LLT
    Population Age: Preterm newborn infants, Newborns, Under 18 Gender: Male, Female
    Trial protocol: IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2009-014344-11 Sponsor Protocol Number: prot-001-2009 Start Date*: 2010-06-02
    Sponsor Name:Imperial College London
    Full Title: Neuroprotective effects of hypothermia combined with inhaled xenon following perinatal asphyxia - the TOBY Xe trial
    Medical condition: Neonatal asphyxial encephalopathy
    Disease: Version SOC Term Classification Code Term Level
    12 10028946 neonatal hypoxia and asphyxia SOC
    Population Age: Newborns, Under 18 Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2014-000202-35 Sponsor Protocol Number: I13018 Start Date*: 2015-01-30
    Sponsor Name:CHU de LIMOGES
    Full Title: Prevention of early ventilator-associated pneumonia with antibiotic therapy in patients treated with mild therapeutic hypothermia after cardiac arrest. Randomized, multicenter double-blind placeb...
    Medical condition: Pneumonia
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004855 10047263 Ventilation pneumonitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2016-000222-19 Sponsor Protocol Number: H2020-PHC-18-2015-667224 Start Date*: 2017-08-02
    Sponsor Name:University Hospital Tuebingen
    Full Title: Effect of ALlopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome – a blinded randomized placebo-controlled parallel group multicenter trial for superiori...
    Medical condition: Perinatal Asphyxia, hypoxic-ischemic brain injury
    Disease: Version SOC Term Classification Code Term Level
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10028923 Neonatal asphyxia PT
    20.0 10029205 - Nervous system disorders 10014633 Encephalopathy neonatal PT
    Population Age: Preterm newborn infants, Newborns, Under 18 Gender: Male, Female
    Trial protocol: DE (Trial now transitioned) NL (Trial now transitioned) NO (Trial now transitioned) ES (Ongoing) FI (Trial now transitioned) EE (Trial now transitioned) AT (Trial now transitioned) BE (Trial now transitioned) PT (Prematurely Ended) IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2016-000936-17 Sponsor Protocol Number: GWEP1560 Start Date*: 2019-07-23
    Sponsor Name:GW Research Ltd
    Full Title: A Randomized, Double-Blind, Placebo-Controlled Single-Ascending Dose Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of GWP42003-P in Conjunction with Hypothermia in Neonates with ...
    Medical condition: Neonatal Hypoxic-Ischemic Encephalopathy
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004852 10070512 Hypoxic-ischemic encephalopathy LLT
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10050081 Neonatal hypoxia PT
    Population Age: Preterm newborn infants, Newborns, Under 18 Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA) ES (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2011-005696-17 Sponsor Protocol Number: 1645-CI-058 Start Date*: 2013-06-18
    Sponsor Name:Instituto de Investigacion Sanitaria La Fe
    Full Title: Multicenter, randomized, blinded clinical study comparing early use of total body moderate hypothermia plus topiramate or placebo in asphyxiated newborn infants evolving to moderate-to-severe hypox...
    Medical condition: Asphyxiated newborn infants evolving to moderate-to-severe hypoxic ischemic encephalopathy
    Disease:
    Population Age: Preterm newborn infants, Under 18 Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-002944-25 Sponsor Protocol Number: EuroHyp-1 Start Date*: 2014-08-20
    Sponsor Name:Universitätsklinikum Erlangen
    Full Title: EuroHYP-1: European multicentre, randomised, phase III clinical trial of therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke
    Medical condition: Acute ischaemic stroke
    Disease: Version SOC Term Classification Code Term Level
    17.0 10029205 - Nervous system disorders 10061256 Ischaemic stroke PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) FI (Completed) IT (Completed) IE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-005111-24 Sponsor Protocol Number: 3 Start Date*: 2006-01-16
    Sponsor Name:Dept. of Anaesthesia and Intensive Care, Haukeland University Hospital
    Full Title: Fluid therapy to patients reciving therapeutic hypothermia after cardiac arrest
    Medical condition: The study is carried out on patients at our Hospital, being treated with therapeutic hypothermia after cardiac arrest. The aim of the study is to tell if standard fluid therapy (RingerAC) leads to...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-000755-13 Sponsor Protocol Number: DACLEAN Start Date*: 2020-03-31
    Sponsor Name:CHU de Poitiers
    Full Title: ESTIMATION OF THE INCIDENCE OF COLONIZATION OF PERIPHERAL VENOUS CATHETERS AFTER SKIN DISINFECTION WITH 0.5% SODIUM HYPOCHLORITE, PRECEDED OR NOT BY AN APPLICATION OF 70% ETHANOL: PILOT, MONOCENTRI...
    Medical condition: Bacterial colonization of peripheral venous catheters
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004862 10069718 Bacterial colonization LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-002470-20 Sponsor Protocol Number: SANNI-project:01 Start Date*: 2017-04-11
    Sponsor Name:Skåne University Hospital
    Full Title: Fentanyl and Clonidine for analgesia during hypothermia in term asphyxiated infants – a prospective pharmacokinetic/ pharmacodynamic/ pharmacogenetic observational study. Cohort 1 in The SANNI proj...
    Medical condition: Infants with induced hypothermic treatment after perinatal asphyxia
    Disease:
    Population Age: Newborns, Under 18 Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-003265-26 Sponsor Protocol Number: 345 Start Date*: 2017-01-03
    Sponsor Name:Medical University of Vienna
    Full Title: Pharmacokinetic/Pharmacodynamic effects of add-on antiplatelet therapy with parenteral cangrelor as compared to standard dual antiplatelet treatment in patients with ST-elevation myocardial infarct...
    Medical condition: ST-elevation myocardial infarction, cardiac arrest
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: View results
    EudraCT Number: 2015-001788-37 Sponsor Protocol Number: HCA-2015-2 Start Date*: 2015-06-29
    Sponsor Name:Heart Center Co. Tampere University Hospital
    Full Title: Effects of volume changes to the plethysmography signal on major surgery patients
    Medical condition: Patients scheduled for elective CABG (Coronary artery bypass surgery). Patients scheduled for elective open major abdominal surgery (gastrointestinal surgery).
    Disease: Version SOC Term Classification Code Term Level
    18.0 10042613 - Surgical and medical procedures 10011090 Coronary artery surgery LLT
    18.0 10042613 - Surgical and medical procedures 10068093 Gastrointestinal surgery PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-015771-27 Sponsor Protocol Number: V3 Start Date*: 2010-01-21
    Sponsor Name:Medizinische Universität Wien, Univ.Klinik für Notfallmedizin
    Full Title: Requirement of Skeletal Muscle Paralysis in Hypothermic Patients after Cardiac Arrest. A pilot study
    Medical condition: skeletal muscle paralysis in hypothermic patients after cardiac arrest
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2007-005178-30 Sponsor Protocol Number: LRS-01-07-02 Start Date*: 2008-01-09
    Sponsor Name:Life Recovery Systems
    Full Title: Clinical Study of the LRS ThermoSuit™ System in Post Arrest Patients with Intravenous Infusion of Magnesium Sulfate
    Medical condition: Post resusucitation disease after resuscitation from cardiac arrest
    Disease: Version SOC Term Classification Code Term Level
    9.1 10007515 Cardiac arrest LLT
    9.1 10029286 Neurologic disorder NOS LLT
    9.1 10059485 Therapeutic hypothermia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2014-004265-25 Sponsor Protocol Number: 2-STEP Start Date*: 2015-04-15
    Sponsor Name:University Medical Centre Utrecht
    Full Title: 2-STEP: A single-centre, phase II study to evaluate the safety, tolerability and pharmacokinetics of 2-Iminobiotin (2-IB) in neonates with gestational age of ≥36 weeks with moderate to severe perin...
    Medical condition: Perinatal asphyxia
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004855 10003500 Asphyxia neonatal LLT
    19.0 100000004855 10004943 Birth asphyxia LLT
    Population Age: Preterm newborn infants, Newborns, Under 18 Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-017636-41 Sponsor Protocol Number: CRO1453 Start Date*: 2010-05-27
    Sponsor Name:Imperial College
    Full Title: Vasopressin and Corticosteroids in Septic Shock
    Medical condition: Septic shock - low blood pressure due to infection
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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