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Clinical trials for Immunologic Deficiency Syndromes

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43865   clinical trials with a EudraCT protocol, of which   7286   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    32 result(s) found for: Immunologic Deficiency Syndromes. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2012-001766-15 Sponsor Protocol Number: MBL2012 Start Date*: 2013-02-12
    Sponsor Name:Fundación Pública Andaluza para la Gestion de la Investigación en Salud de Sevilla
    Full Title: Impact of azithromycin as an immunomodulator in patients with recurrent pneumonia and deficit of mannose-binding LECITHIN (MBL2012)
    Medical condition: Pediatric patients with recurrent pneumonia and MBL deficiency.
    Disease: Version SOC Term Classification Code Term Level
    15.1 10021428 - Immune system disorders 10061598 Immunodeficiency PT
    15.1 100000004862 10010120 Community acquired pneumonia LLT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-001480-36 Sponsor Protocol Number: 2015_31 Start Date*: 2016-07-11
    Sponsor Name:Centre Hospitalier Régional et Universitaire de Lille
    Full Title: Assessment of the IgG trough level in subjects with primary immunodeficiency switching from standard subcutaneous immunoglobulin (SCIG) to every other week HyQvia
    Medical condition: Primary immunodeficiencies
    Disease: Version SOC Term Classification Code Term Level
    19.0 10021428 - Immune system disorders 10061598 Immunodeficiency PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-000669-21 Sponsor Protocol Number: ML18243 Start Date*: 2005-04-26
    Sponsor Name:ROCHE
    Full Title: Pilot study of HIV Viral slope in naive patients treated with Enfuvirtide (ENF) based therapy compared to current standard treatment.
    Medical condition: advanced HIV management
    Disease: Version SOC Term Classification Code Term Level
    6.1 10000565 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2018-003842-18 Sponsor Protocol Number: OTL-103-4 Start Date*: 2019-01-08
    Sponsor Name:Orchard Therapeutics Ltd.
    Full Title: A Single Arm, Open Label Clinical Study of Haematopoietic Stem Cell Gene Therapy with Cryopreserved Autologous CD34+ Cells Transduced with Lentiviral Vector encoding WAS cDNA in Subjects with Wisko...
    Medical condition: Wiskott-Aldrich Syndrome
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021428 - Immune system disorders 10061598 Immunodeficiency PT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18, Adults Gender: Male
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-017346-32 Sponsor Protocol Number: 201228 Start Date*: 2010-03-15
    Sponsor Name:Fondazione Telethon
    Full Title: A PHASE I/II CLINICAL TRIAL OF HAEMATOPOIETIC STEM CELL GENE THERAPY FOR THE WISKOTT-ALDRICH SYNDROME
    Medical condition: Wiskott-Aldrich Syndrom
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021428 - Immune system disorders 10061598 Immunodeficiency PT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18, Adults Gender: Male
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-019518-25 Sponsor Protocol Number: MENHIR Start Date*: 2010-06-11
    Sponsor Name:AZIENDA OSPEDALIERA "OSPEDALI RIUNITI DI BERGAMO" (A.O. DI RILIEVO NAZIONALE)
    Full Title: (Maraviroc ENHancement of Immunological Response): A pilot study of maraviroc as an add-on in patients with reduced CD4 cell count despite full viral suppression
    Medical condition: HIV
    Disease: Version SOC Term Classification Code Term Level
    9.1 10052740 HLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-006188-35 Sponsor Protocol Number: IMMUNEF Start Date*: 2009-01-29
    Sponsor Name:AZIENDA OSPEDALIERA SAN GERARDO DI MONZA
    Full Title: Immunological efficacy of efavirenz based treatment in HIV-positive naive patients (a pylot study)
    Medical condition: HIV infection
    Disease: Version SOC Term Classification Code Term Level
    9.1 10052740 Acquired immunodeficiency syndromes HLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-007882-19 Sponsor Protocol Number: MI2-STAR2-2006 Start Date*: 2006-10-09
    Sponsor Name:AZIENDA OSPEDALIERA SPEDALI CIVILI DI BRESCIA
    Full Title: A pilot, randomized trial to evaluate the lipid profile after antiretroviral regimens including nevirapine or atazanavir boosted with ritonavir in HIV-positive patients naive for antiretrovirals
    Medical condition: immunodefic syndrome - patients naive antiretroviral therapy
    Disease: Version SOC Term Classification Code Term Level
    9.1 10000565 Acquired immunodeficiency syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-001681-16 Sponsor Protocol Number: Break Start Date*: 2006-06-06
    Sponsor Name:FONDAZIONE NADIR ONLUS
    Full Title: A pilot, open label, randomised clinical trial assessing the 12 week immunological response in HIV-1 failing subjects receiving monotherapy with emtricitabine 200 mg once a day or emtricitabine 200...
    Medical condition: HIV-Infection
    Disease: Version SOC Term Classification Code Term Level
    6.1 10000565 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-007934-21 Sponsor Protocol Number: MI2-INCA-2007 Start Date*: 2007-06-27
    Sponsor Name:AZIENDA OSPEDALIERA SPEDALI CIVILI DI BRESCIA
    Full Title: Intracellular concentration of Antiretrovirals)INCA STADY
    Medical condition: HIV -immunodefic syndrome-
    Disease: Version SOC Term Classification Code Term Level
    9.1 10000565 Acquired immunodeficiency syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-004646-29 Sponsor Protocol Number: GESIDA9016 Start Date*: 2017-05-31
    Sponsor Name:Fundación SEIMC-GESIDA
    Full Title: A phase IV open- label, randomized and pilot clinical trial, designed to evaluate the potential neurotoxicity of dolutegravir/lamivudine/abacavir in neurosymptomatic HIV patients and their reversi...
    Medical condition: HIV
    Disease: Version SOC Term Classification Code Term Level
    19.1 100000004862 10001509 AIDS LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-001621-26 Sponsor Protocol Number: MALINFITA006 Start Date*: 2006-03-13
    Sponsor Name:A.U.S.L. RIMINI
    Full Title: A RANDOMIZED, MULTICENTER STUDY OF USE INTERMITTENT HAART HIGHLY ACTIVE ANTIRETROVIRAL THERAPY THERAPY VERSUS CONTINUATIVE HAART THERAPY IN HIV PATIENTS
    Medical condition: PATIENTS POSITIVE HIV TO LOW RISK OF DEVELOPMENT OF OPPORTUNISTIC PATHOLOGIES CORRELATED-HIV.
    Disease: Version SOC Term Classification Code Term Level
    6.1 10052740 HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-007935-14 Sponsor Protocol Number: MI2-RIFART-2005 Start Date*: 2005-03-15
    Sponsor Name:AZIENDA OSPEDALIERA SPEDALI CIVILI DI BRESCIA
    Full Title: RIFART
    Medical condition: HIV- TB
    Disease: Version SOC Term Classification Code Term Level
    6.1 10000565 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2018-001158-82 Sponsor Protocol Number: GESIDA10418 Start Date*: 2018-09-21
    Sponsor Name:Fundación SEIMC-GESIDA
    Full Title: Phase IV, Open Label, Randomized, Clinical Trial to Evaluate the Reversibility of abacavir/lamivudine/dolutegravir CNS-Related Neurotoxicity After Switching to tenofovir alafenamide/emtricitabine/d...
    Medical condition: HIV
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004862 10001509 AIDS LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-002582-39 Sponsor Protocol Number: NADIR-02 Start Date*: 2006-07-10
    Sponsor Name:FONDAZIONE NADIR ONLUS
    Full Title: A multicenter, randomized, prospective, controlled study to evaluate the efficacy and the tolerability of a switch to a two different-dosed, nevirapine-based HAARTs in HIV-1 infected patients with ...
    Medical condition: pazienti HIV-1 positivi
    Disease: Version SOC Term Classification Code Term Level
    6.1 10000565 PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-002818-38 Sponsor Protocol Number: ML 19326 Start Date*: 2005-07-21
    Sponsor Name:ROCHE
    Full Title: ESPrES 500 - Evaluation of the safety profile of the new 500 mg film-coated tablet (FCT) formulation of boosted saquinavir (Invirase 500 mg) in HIV-1 infected patients
    Medical condition: HIV-! / AIDS
    Disease: Version SOC Term Classification Code Term Level
    9.1 10000565 Acquired immunodeficiency syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2014-000307-26 Sponsor Protocol Number: CeTMAd-VIH-2014 Start Date*: 2016-06-09
    Sponsor Name:Iniciativa Andaluza en Terapias Avanzadas-Fundación Pública Andaluza Progreso y Salud
    Full Title: Clinical trial Phase I/II, test of concept, double blind, randomized, controlled with placebo, to evalue the safety and efficiency of the treatment with expanded adult mesenchymal stem cells from a...
    Medical condition: Infection for HIV with controlled viral load and immunological discordant response
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004862 10001509 AIDS LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2015-003290-15 Sponsor Protocol Number: GTI1503 Start Date*: 2016-05-12
    Sponsor Name:Grifols Therapeutics Inc.
    Full Title: A Multi-Centre, Open-Label, Single Arm Trial to Evaluate Efficacy, Pharmacokinetics, and Safety and Tolerability of IGSC 20% in Subjects with Primary Immunodeficiency
    Medical condition: Primary Immunodeficiency (PI) diseases
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021428 - Immune system disorders 10061598 Immunodeficiency PT
    20.0 10021428 - Immune system disorders 10045792 Unspecified disorder of immune mechanism LLT
    20.0 10010331 - Congenital, familial and genetic disorders 10064859 Primary immunodeficiency syndrome PT
    Population Age: Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) CZ (Completed) ES (Completed) DE (Completed) PL (Completed) HU (Completed) FR (Completed)
    Trial results: View results
    EudraCT Number: 2017-004137-91 Sponsor Protocol Number: Gesida92016 Start Date*: 2018-01-23
    Sponsor Name:Fundacion SEIMC-GESIDA
    Full Title: A single-arm, open-label, multicenter phase IV trial to evaluate the efficacy and safety of elvitegravir / cobicistat / emtricitabine / tenofovir alfa-namide as first-line treatment in naïve patien...
    Medical condition: AIDS
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004862 10001509 AIDS LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-000515-14 Sponsor Protocol Number: GESIDA8014 Start Date*: 2014-06-26
    Sponsor Name:Fundación SEIMC-GESIDA
    Full Title: Comparative, randomized, open study to evaluate maintenance with Darunavir/ritonavir once daily plus Lamivudine once daily versus continuing Darunavir/ritonavir once-daily plus Tenofovir/Emtricitab...
    Medical condition: HIV chronic infection
    Disease: Version SOC Term Classification Code Term Level
    17.0 100000004862 10001509 AIDS LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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