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Clinical trials for Ivabradine AND Placebo

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44352   clinical trials with a EudraCT protocol, of which   7379   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    24 result(s) found for: Ivabradine AND Placebo. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2007-006793-28 Sponsor Protocol Number: CL3-16257-078 Start Date*: 2008-09-18
    Sponsor Name:Institut de Recherches Internationales Servier (I.R.I.S)
    Full Title: Effects of a 10 or 15 mg single intravenous bolus of ivabradine versus placebo on heart rate control during a multislice computed tomography coronary angiography for the evaluation of coronary arte...
    Medical condition: Heart rate control during a MultiSlice Computed Tomography Coronary Angiography (MST CA) for the evaluation of Coronary Artery Disease
    Disease: Version SOC Term Classification Code Term Level
    11.0 10060804 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed) GB (Completed) BE (Completed) PT (Completed) HU (Completed) ES (Completed) DE (Completed) FR (Completed) DK (Completed) IT (Completed) PL (Completed) BG (Completed)
    Trial results: View results
    EudraCT Number: 2006-000708-18 Sponsor Protocol Number: CL3-16257-063 Start Date*: 2006-08-23
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: Effects of ivabradine on cardiovascular events in patients with moderate to severe chronic heart failure and left ventricular systolic dysfunction. A three-year randomised double-blind placebo-cont...
    Medical condition: cardiac failure chronic
    Disease: Version SOC Term Classification Code Term Level
    9.0 10007558 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) HU (Completed) BE (Completed) DE (Completed) NL (Completed) LT (Completed) DK (Completed) LV (Completed) FI (Completed) SI (Completed) CZ (Completed) EE (Completed) SK (Completed) IE (Completed) GB (Completed) BG (Completed) IT (Completed) PT (Completed) GR (Completed) AT (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2011-001292-39 Sponsor Protocol Number: CL2-16257-090 Start Date*: 2011-09-28
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: Determination of the efficacious and safe dose of ivabradine in paediatric patients with dilated cardiomyopathy and symptomatic chronic heart failure aged from 6 months to less than 18 years. A ra...
    Medical condition: Paediatric dilated cardiomyopathy and symptomatic chronic heart failure
    Disease: Version SOC Term Classification Code Term Level
    16.0 100000004849 10008908 Chronic heart failure LLT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: FI (Completed) GB (Completed) BE (Completed) SE (Completed) DE (Completed) PT (Completed) IT (Completed) HU (Completed) BG (Completed) DK (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2012-002742-20 Sponsor Protocol Number: CL2-16257-101 Start Date*: 2013-03-20
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: Effect of ivabradine versus placebo on cardiac function, exercise capacity, and neuroendocrine activation in patients with Chronic Heart Failure with Preserved left ventricular Ejection Fraction A...
    Medical condition: Heart failure with preserved left ventricular ejection fraction
    Disease: Version SOC Term Classification Code Term Level
    17.0 100000004849 10008908 Chronic heart failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) PT (Completed) IT (Completed) DE (Completed) BE (Completed) GB (Completed) NL (Completed) ES (Completed) CZ (Completed) AT (Completed) SI (Completed)
    Trial results: View results
    EudraCT Number: 2012-004779-38 Sponsor Protocol Number: CL3-16257-102 Start Date*: 2013-04-16
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: Effects of ivabradine on plaque burden, morphology and composition in patients with clinically indicated coronary angiography. A randomised double-blind placebo-controlled international multicentre...
    Medical condition: Coronary artery disease
    Disease: Version SOC Term Classification Code Term Level
    16.1 10007541 - Cardiac disorders 10011078 Coronary artery disease PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Prematurely Ended) GB (Prematurely Ended) ES (Prematurely Ended) PT (Prematurely Ended) SK (Prematurely Ended) BE (Prematurely Ended) DE (Completed) CZ (Completed) HU (Prematurely Ended) PL (Prematurely Ended) SE (Prematurely Ended) NO (Prematurely Ended) DK (Prematurely Ended) GR (Prematurely Ended) FR (Completed)
    Trial results: View results
    EudraCT Number: 2018-003801-24 Sponsor Protocol Number: P160925J Start Date*: 2019-11-06
    Sponsor Name:Assistance Publique - Hôpitaux de Paris
    Full Title: A multicenter, prospective, randomized, placebo-controlled, double-blind, multi-arm, multi-stage clinical trial of Ivabradine for heart Rate control In Septic shock
    Medical condition: Trial subjects are adult patients with septic shock.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021881 - Infections and infestations 10040070 Septic shock PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2011-003933-32 Sponsor Protocol Number: A092358 Start Date*: 2011-09-21
    Sponsor Name:Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge
    Full Title: A randomised, blind, placebo controlled crossover study of the influence of the HCN channel-blocker ivabradine on the symptoms of neuropathic pain
    Medical condition: Neuropathic Pain
    Disease: Version SOC Term Classification Code Term Level
    14.0 10029205 - Nervous system disorders 10029223 Neuralgia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2009-011360-10 Sponsor Protocol Number: CL3-16257-083 Start Date*: 2009-10-13
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: Efectos de ivabradina en pacientes con arteriopatía coronaria estable sin insuficiencia cardíaca clínica. Estudio multicéntrico, internacional, aleatorizado, doble ciego, controlado con placebo St...
    Medical condition: Arteriopatia Coronaria Estable Stable coronary artery disease
    Disease: Version SOC Term Classification Code Term Level
    12.0 10011078 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) PT (Completed) GB (Completed) NL (Completed) FI (Completed) LV (Completed) HU (Completed) CZ (Completed) SK (Completed) IE (Completed) BE (Completed) FR (Completed) LT (Completed) DE (Completed) AT (Completed) SE (Completed) IT (Completed) GR (Completed) EE (Completed) SI (Completed) BG (Completed) DK (Completed) NO (Completed)
    Trial results: View results
    EudraCT Number: 2006-005475-17 Sponsor Protocol Number: CL3-16257-067 Start Date*: 2008-01-04
    Sponsor Name:Institut de Recherches Internationales Servier (I.R.I.S.)
    Full Title: Long-term (3 years) ophthalmic safety and cardiac efficacy and safety of ivabradine administered orally at the therapeutic doses (2.5/5/7.5 mg b.i.d.) on top of anti-anginal background therapy, to ...
    Medical condition: Stable angina pectoris
    Disease: Version SOC Term Classification Code Term Level
    14.1 10007541 - Cardiac disorders 10049194 Stable angina pectoris LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed) PT (Completed) BE (Completed) FI (Completed) GB (Prematurely Ended) HU (Completed) SE (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2006-006246-34 Sponsor Protocol Number: CL3-16257-068 Start Date*: 2007-11-28
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: Evaluation of the anti-anginal efficacy and safety of oral administration of ivabradine compared to placebo on top of a background therapy with a calcium antagonist (amlodipine or nifedipine) in pa...
    Medical condition: Stable angina pectoris
    Disease: Version SOC Term Classification Code Term Level
    14.1 10007541 - Cardiac disorders 10002383 Angina pectoris PT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: LV (Completed) LT (Completed) EE (Completed) HU (Completed) PL (Completed) SK (Completed) BG (Completed)
    Trial results: View results
    EudraCT Number: 2004-001959-11 Sponsor Protocol Number: CL3-16257-056 Start Date*: 2005-04-20
    Sponsor Name:Institut de Recherches Internationales
    Full Title: Effects of ivabradine on cardiovascular events in patients with stable coronary artery disease and left ventricular systolic dysfunction. A three-year randomised double-blind placebo-controlled int...
    Medical condition: Coronary artery disease
    Disease: Version SOC Term Classification Code Term Level
    7.0 10011078 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) LT (Completed) FI (Completed) LV (Completed) IT (Completed) CZ (Completed) SK (Completed) GB (Completed) DK (Completed) AT (Completed) SE (Completed) EE (Completed) DE (Completed) IE (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2015-002060-17 Sponsor Protocol Number: 2015/077/HP Start Date*: 2015-08-21
    Sponsor Name:CHU - Hôpitaux de Rouen
    Full Title: Effect of pharmacological heart rate reduction on visco-elastic properties of the arterial wall - Impact of aging
    Medical condition: Healthy subjects between 25 and 65 years old
    Disease: Version SOC Term Classification Code Term Level
    18.0 10022891 - Investigations 10007574 Cardiac imaging procedures HLT
    18.0 10022891 - Investigations 10052677 Vascular imaging PT
    18.0 10007541 - Cardiac disorders 10006093 Bradycardia PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-005627-32 Sponsor Protocol Number: IIVOP Start Date*: 2014-06-12
    Sponsor Name:Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge
    Full Title: A randomised, double blind, placebo controlled crossover study of the influence of the HCN channel blocker ivabradine in a healthy volunteer pain model - an enriched population study
    Medical condition: Neuropathic Pain
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004852 10054095 Neuropathic pain LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2012-000215-89 Sponsor Protocol Number: CL2-16257-099 Start Date*: 2013-06-14
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: Effects of ivabradine on vascular function in individuals at increased risk of developing cardiovascular disease and with impaired endothelial function An international, multicentre, randomised, d...
    Medical condition: Cardiovascular disease
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004849 10007648 Cardiovascular disease, unspecified LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended) GB (Prematurely Ended) NL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-005122-31 Sponsor Protocol Number: CL2-16257-060 Start Date*: 2006-04-25
    Sponsor Name:Institut de Recherches Internationales (for France) [...]
    1. Institut de Recherches Internationales (for France)
    2. International Centre for Therapeutic Research (for Spain)
    Full Title: Evaluation of the effects on heart rate, haemodynamic parameters, safety and tolerability of 5 mg bolus of ivabradine followed by 8-hour infusion at the dose of 5 mg of ivabradine given after a per...
    Medical condition: Acute Myocardial Infarction
    Disease: Version SOC Term Classification Code Term Level
    3.3 10028596 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) DE (Completed) BE (Completed)
    Trial results: View results
    EudraCT Number: 2016-004706-33 Sponsor Protocol Number: RH-HJE-LN-01 Start Date*: 2017-03-31
    Sponsor Name:Finn Gustafsson
    Full Title: The Effect of Ivabradine Treatment on Exercise Capacity in Patients with Cardiac Allograft Vasculopathy after Heart Transplantation
    Medical condition: Cardiac allograft vasculopathy and elevated resting heart rate in heart transplant recipients
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004849 10007648 Cardiovascular disease, unspecified LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-001960-30 Sponsor Protocol Number: CL3-16257-057 Start Date*: 2005-03-07
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: Evaluation of the anti-anginal efficacy and safety of oral administration of ivabradine compared to placebo on top of a background therapy with atenolol in patients with stable angina pectoris. A 4...
    Medical condition: stable angina pectoris
    Disease: Version SOC Term Classification Code Term Level
    7.0 10002383 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) NO (Completed) SE (Completed) SK (Completed) CZ (Completed) GB (Completed) IT (Completed) ES (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2009-018175-14 Sponsor Protocol Number: CL2-16257-088 Start Date*: 2010-04-16
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: Effects of ivabradine IV versus placebo on haemodynamic parameters in patients with a low cardiac output syndrome following planned coronary artery bypass surgery and requiring positive inotropic t...
    Medical condition: Coronary Artery Disease patients presenting a low cardiac output syndrome following a planned coronary artery bypass graft and requiring a positive inotropic treatment with dobutamine administered ...
    Disease: Version SOC Term Classification Code Term Level
    12.1 10068176 Coronary artery bypass graft LLT
    12.1 10024899 Low cardiac output syndrome PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2012-001989-15 Sponsor Protocol Number: HomRate04_2012 Start Date*: 2012-09-17
    Sponsor Name:Universität des Saarlandes
    Full Title: A randomised, placebo controlled, double blind, cross-over, single center clinical Study to investigate the effect of heart rate reduction with ivabradine on endothelial function and vascular stiff...
    Medical condition: Stable coronary heart disease.
    Disease: Version SOC Term Classification Code Term Level
    14.1 10007541 - Cardiac disorders 10068617 Coronary heart disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-004779-35 Sponsor Protocol Number: CL2-16257-096 Start Date*: 2012-04-20
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: Effects of oral chronic administration of ivabradine (7.5 mg bid) in comparison to placebo (bid) on top of beta-blockers, on central aortic blood pressure. Randomized, cross-over, double blind, mul...
    Medical condition: Coronary Artery Disease
    Disease: Version SOC Term Classification Code Term Level
    14.1 10007541 - Cardiac disorders 10011078 Coronary artery disease PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Prematurely Ended) IT (Prematurely Ended)
    Trial results: View results
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