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Clinical trials for Ketamine

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    142 result(s) found for: Ketamine. Displaying page 1 of 8.
    1  2  3  4  5  6  7  8  Next»
    EudraCT Number: 2022-003266-21 Sponsor Protocol Number: PSY-NIL-0012 Start Date*: 2023-03-31
    Sponsor Name:Medical University of Vienna
    Full Title: Acute effects of ketamine on the glutamatergic NMDA receptor quantified by PET and the radioligand (R)-[11C]-Me-NB1
    Medical condition: Acute effects of ketamine
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2014-003280-38 Sponsor Protocol Number: PSY-NIL-0006 Start Date*: 2016-05-04
    Sponsor Name:Medical University of Vienna
    Full Title: Positron Emission Tomography assessment of Ketamine Binding of the Serotonin Transporter and its Relevance for Rapid Antidepressant Response
    Medical condition: 20 patients with severe unipolar depression (structured clinical interview for DSM-IV and the 17-item Hamilton Depression Rating Scale), also 20 age and sex matched healthy controls. plus 12 HC f...
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004873 10045543 Unipolar depression LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2008-004961-25 Sponsor Protocol Number: 2008/0827 Start Date*: 2008-12-03
    Sponsor Name:CHRU de Lille
    Full Title: ETUDE COMPARATIVE KETAMINE DOSE UNIQUE VERSUS KETAMINE BOLUS ET PERFUSION CONTINUE DANS LA PRISE EN CHARGE DE L’ANALGESIE DES DOULEURS TRAUMATIQUES DES MEMBRES EN MEDECINE D’URGENCE PREHOSPITALIERE
    Medical condition: Limbs peripheral traumatisms in prehospital emergency medicine
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-000767-28 Sponsor Protocol Number: 20061 Start Date*: 2006-09-29
    Sponsor Name:Vienna Medical University
    Full Title: Standardisierte Verlaufsbeobachtung von Patienten mit intrathekalem S(+)-Ketamin
    Medical condition: Intrathecal S(+)-ketamine is a potent option in the treatment of chronic severe neuropathic pain in cancer patients refractory to conventional therapeutic strategies (Benrath et al. 2005). However,...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2018-001539-39 Sponsor Protocol Number: NV18-04-00260 Start Date*: 2019-06-17
    Sponsor Name:Národní ústav duševního zdraví
    Full Title: Clinical and neurobiological predictors of response to ketamine: towards personalized treatment of depression
    Medical condition: Moderate to severe depression without psychotic symptoms
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-003228-34 Sponsor Protocol Number: OCMDKET Start Date*: 2022-04-25
    Sponsor Name:Medical University of Vienna
    Full Title: Ketamine therapy and its effects on stress on neuropsychological function under stress in obsessive-compulsive disorder
    Medical condition: Obsessive-compulsive disorder
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2015-000550-37 Sponsor Protocol Number: NL52444.058.15 Start Date*: 2015-04-01
    Sponsor Name:LUMC
    Full Title: Effect of Sodium NItroprusside (SNP) on R,S- and S-Ketamine-induced psychotropic side effects, hemodynamic changes and pain relief in healthy volunteers
    Medical condition: Chronic pain
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-002979-40 Sponsor Protocol Number: 2006.05 Start Date*: 2006-08-07
    Sponsor Name:LUMC
    Full Title: Pharmacokinetic-pharmacodynamic modeling of S(+)-ketamine in healthy volunteers
    Medical condition: Healthy volunteers
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-004764-18 Sponsor Protocol Number: 01-17 Start Date*: 2017-07-24
    Sponsor Name:St Patrick’s Mental Health Services
    Full Title: Ketamine as an adjunctive therapy for Major Depression - a randomised controlled pilot trial: The KARMA-Dep Trial
    Medical condition: Depression
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed)
    Trial results: View results
    EudraCT Number: 2014-004535-40 Sponsor Protocol Number: 0189/DEV Start Date*: 2015-04-22
    Sponsor Name:Develco Pharma Schweiz AG
    Full Title: Prospective, single-blind, placebo-controlled, three-treatment, three-period, adaptive multi-centre Phase IIa (proof-of-concept) trial to investigate the efficacy, safety, and tolerability of Ketam...
    Medical condition: Chronic non-malignant neuropathic pain
    Disease: Version SOC Term Classification Code Term Level
    17.1 10029205 - Nervous system disorders 10029223 Neuralgia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2012-001908-38 Sponsor Protocol Number: 08042012 Start Date*: 2012-07-12
    Sponsor Name:Medizinische Universität Wien, Universitätsklinik für Anästhesie, Allgemeine Intensivmedizin und Schmerztherapie
    Full Title: The effect of intravenous ketamine on the MAC of sevoflurane – a randomized, placebo controlled, double blinded clinical trial
    Medical condition: We want to test if intravenous s-ketamine of two different doses has an effect on MAC of sevoflurane
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2020-002905-24 Sponsor Protocol Number: 74304 Start Date*: 2021-07-07
    Sponsor Name:University Medical Center Groningen
    Full Title: Efficacy and feasibility of intranasal ketamine on acute suicidality, a double blind randomized placebo-controlled trial (Ketamine Trial for Acute suicidalty, KETA)
    Medical condition: Acute suicidality, which is a rapid increase in suicidal ideation or behaviour from the patient's 'baseline' in the last 24 hours.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-023414-31 Sponsor Protocol Number: MD-KPSY-01/10 Start Date*: 2012-03-05
    Sponsor Name:Medizinische Fakultät. Otto von Guericke Universität
    Full Title: Ketamine in treatment resistant major depression (TRD)
    Medical condition: Therapy resistant depression
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2015-004745-70 Sponsor Protocol Number: 55438 Start Date*: 2018-11-06
    Sponsor Name:Academic Medical Center (AMC)
    Full Title: Efficacy of intranasal ketamine on acute suicidality, a double blind randomized placebo-controlled trial (Ketamine Trial Amsterdam, KETA)
    Medical condition: Acute suicidality, which is a rapid increase in suicidal ideation or behaviour from the patient's 'baseline' in the last 24 hours.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-004480-31 Sponsor Protocol Number: PSIKET_001CZE Start Date*: 2020-07-14
    Sponsor Name:Národní ústav duševního zdraví
    Full Title: Psilocybin versus ketamine – fast acting antidepressant strategies in treatment-resistant depression
    Medical condition: The study will include 60 patients with pharmaco-resistant depression (30 male, 30 female, aged 18–65). The basic inclusion criterion is the diagnosis of pharmaco-resistant moderate to severe depre...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: CZ (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2019-004812-73 Sponsor Protocol Number: BP18-1-501 Start Date*: 2022-05-16
    Sponsor Name:Leiden University
    Full Title: The influence of pharmacological conditioning with S-ketamine on pain sensitivity in patients with Fibromyalgia Syndrome
    Medical condition: Fibromyalgia Syndrome
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2008-002638-31 Sponsor Protocol Number: 2008_norket Start Date*: 2008-06-16
    Sponsor Name:LUMC
    Full Title: Contribution of norketamine to ketamine-induced antinociception, and cardiovascular and neurocognitive effects
    Medical condition: Pain induced in healthy volunteers
    Disease: Version SOC Term Classification Code Term Level
    9.1 10066714 Acute pain LLT
    Population Age: Adults Gender: Male
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-000506-21 Sponsor Protocol Number: Chumbley1 Start Date*: 2011-06-21
    Sponsor Name:Imperial College Healthcare NHS Trust
    Full Title: A double-blind, randomised placebo-controlled trial to determine whether low-dose intravenous ketamine peri-operatively can prevent chronic post-surgical pain, in patients undergoing thoracotomy or...
    Medical condition: Chronic post-surgical pain
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-003293-18 Sponsor Protocol Number: RGHT000470 Start Date*: 2009-03-16
    Sponsor Name:Belfast Health and Social Care Trust [...]
    1. Belfast Health and Social Care Trust
    2. Queen's University Belfast
    Full Title: Pharmacokinetics of ketamine in infants
    Medical condition: Pharmacokinetics of ketamine in infants
    Disease: Version SOC Term Classification Code Term Level
    9.1 10021723 Induction and maintenance of anaesthesia LLT
    Population Age: Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2009-010625-39 Sponsor Protocol Number: MZ09-PCP-SosPeter Start Date*: 2010-04-21
    Sponsor Name:Prague Psychiatric Center
    Full Title: QEEG cordance and EEG connectivity changes after administration of subanesthetic ketamine doses in depressive disorder patients
    Medical condition: INCLUSION CRITERIA: 1. Men and women at the age between 18 to 65 years, with dextromanual dominance. 2. Patients have to answer DSM IV criteria for the major depressive episode, without psychotic s...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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