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Clinical trials for Levosimendan

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44380   clinical trials with a EudraCT protocol, of which   7392   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    57 result(s) found for: Levosimendan. Displaying page 1 of 3.
    1  2  3  Next»
    EudraCT Number: 2012-004979-39 Sponsor Protocol Number: 8.1 Start Date*: 2014-12-19
    Sponsor Name:VieCuri Medical Center
    Full Title: Levosimendan in Acute Kidney Injury Study, a prospective, randomized, monocenter, double blind, placebo-controlled study to investigate the efficacy and safety of Levosimendan in Intensive Care Pat...
    Medical condition: Acute Kidney Injury (AKI) in adult ICU patients
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-001623-39 Sponsor Protocol Number: Levo1010 Start Date*: 2018-07-26
    Sponsor Name:Verein zur Förderung der Forschung auf dem Gebiet der Arteriosklerose, Thrombose und vaskulären Biologie (ATVB)
    Full Title: Assessment of body composition changes after Levosimendan treatment in patients with advanced heart failure
    Medical condition: Advanced heart failure
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-001702-30 Sponsor Protocol Number: 200175 Start Date*: 2022-02-08
    Sponsor Name:APHP
    Full Title: « Use of Levosimendan as treatment of aneurysmal SubArachnoid Hemorrhage »
    Medical condition: subarachnoid hemorrhages of aneurysmal origin (HSAa)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2012-000588-26 Sponsor Protocol Number: ICCE12.001 Start Date*: 2012-10-16
    Sponsor Name:Leiden University Medical Center
    Full Title: Pharmacokinetics of Levosimendan in children with acute heart failure
    Medical condition: Acute heart failure in children
    Disease:
    Population Age: Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing) FI (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2008-007407-86 Sponsor Protocol Number: LevoRep Start Date*: 2009-09-14
    Sponsor Name:Medizinische Universität Innsbruck - Universitätsklinik für Innere Medizin III
    Full Title: Efficacy and safety of pulsed infusions of levosimendan in outpatients with advanced heart failure
    Medical condition: Chronic heart failure
    Disease: Version SOC Term Classification Code Term Level
    9.1 10008908 Chronic heart failure LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed) GR (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2018-004063-31 Sponsor Protocol Number: FIM-PRELEVD-2018-01 Start Date*: 2019-04-26
    Sponsor Name:Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud (FIMABIS)
    Full Title: Mechanisms of cardio and nephroprotection in patients who are going on cardiac surgery with right ventricular dysfunction, with preoperative treatment of levosimendan compared with placebo. (PREL...
    Medical condition: Perioperative right ventricle dysfunction
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-007953-30 Sponsor Protocol Number: cv-07/126 Start Date*: 2008-02-11
    Sponsor Name:Fundación Investigación y Desarrollo en el Área Cardiovascular
    Full Title: Levosimendan como agente inmunomodulador en la insuficiencia cardiaca aguda. Estudio Piloto Levosimendan as an immunomodulatory agent in acute heart failure. Pilot study.
    Medical condition: Analysis of the short-term treatment with levosimendan, a cardiac stimulant drug, of the acute exacerbation of chronic heart failure Estudio del tratamiento a corto plazo con levosimendan, fármac...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-002431-80 Sponsor Protocol Number: LEV1068 Start Date*: 2006-09-15
    Sponsor Name:AZIENDA UNIVERSITARIA POLICLINICO UMBERTO I DI ROMA
    Full Title: Renal Effects of Levosimendan in Patients Admitted with Acute Decompensated Heart Failure
    Medical condition: Patients with acute decompensated heart failure.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10060953 Ventricular failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-004180-31 Sponsor Protocol Number: 3119003 Start Date*: 2019-04-29
    Sponsor Name:Orion Corporation
    Full Title: Effects of oral Levosimendan (ODM-109) on respiratory function in patients with ALS: open label extension for patients completing study 3119002
    Medical condition: Amyotrophic Lateral Sclerosis (ALS)
    Disease: Version SOC Term Classification Code Term Level
    21.1 10029205 - Nervous system disorders 10002026 Amyotrophic lateral sclerosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) ES (Prematurely Ended) DE (Prematurely Ended) FI (Prematurely Ended) AT (Prematurely Ended) NL (Prematurely Ended) IE (Prematurely Ended) GB (GB - no longer in EU/EEA) FR (Completed) IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2007-007197-31 Sponsor Protocol Number: 3001088 Start Date*: 2008-04-22
    Sponsor Name:Orion Corporation Orion Pharma
    Full Title: EFFECTS OF ORAL LEVOSIMENDAN ON AMBULATORY ELECTROCARDIOGRAPHIC VARIABLES AND CEREBROVASCULAR REACTIVITY IN PATIENTS WITH RECENT STROKE OR TIA. A RANDOMISED, DOUBLE BLIND, PLACEBO-CONTROLLED, DOSE ...
    Medical condition: Stroke or TIA
    Disease: Version SOC Term Classification Code Term Level
    9.1 10042244 Stroke LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) SE (Prematurely Ended) HU (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2004-001225-16 Sponsor Protocol Number: 3001077 Start Date*: 2004-10-28
    Sponsor Name:Orion Pharma
    Full Title: Survival of patients with acute heart failure in need of intravenous inotropic support; a multicentre parallel- group, randomised, double- blind, double- dummy study of levosimendan versus dobutami...
    Medical condition: Acutely decompensated heart failure
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2014-003589-25 Sponsor Protocol Number: Levo-AKI Start Date*: 2014-11-11
    Sponsor Name:Sahlgrenska Universitetssjukhuset/Sahlgrenska
    Full Title: The effect of levosimendan, on renal blood flow, function and oxygen uptake during acute renal failure after cardiac surgery
    Medical condition: Acute kidney injury postoperatively in connection with heart surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-005310-19 Sponsor Protocol Number: PI-0697-2012 Start Date*: 2013-06-05
    Sponsor Name:FUNDACION PARA LA INVESTIGACIÓN BIOSANITARIA DE ANDALUCIA ORIENTAL_ FPA
    Full Title: Double-blind randomized clinical trial to evaluate the efficacy and safety of levosimendan as preischemic myocardial conditioner in pediatric cardiac surgery
    Medical condition: Children aged 1 month to 14 years in the health area of the province of Granada who will be undergoing heart surgery with a clinical high risk of developing acute heart failure after surgery, treat...
    Disease:
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2022-003628-42 Sponsor Protocol Number: NBK182/1/2022 Start Date*: 2023-03-24
    Sponsor Name:Medical University of Gdańsk
    Full Title: A Randomized, Double-Blind, Placebo-Controlled Multicenter Study of Levosimendan Therapy in low ejection fraction Takotsubo Syndrome (LevoTako Trial)
    Medical condition: Takotsubo syndrome (TTS), also known as apical ballooning syndrome, Takotsubo cardiomyopathy, broken heart syndrome, and stress-induced cardiomyopathy, is a rare condition and accounts for 1–3% of ...
    Disease: Version SOC Term Classification Code Term Level
    20.1 10007541 - Cardiac disorders 10067676 Takotsubo syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2007-004674-49 Sponsor Protocol Number: LEVOHLM Start Date*: 2007-12-28
    Sponsor Name:Charité - Universitätsmedizin Berlin
    Full Title: Levosimendan vor Herz-Lungen-Maschine bei Coronary artery bypass graft-Operationen
    Medical condition: The drug Levosimendan / Simdax (R) will be investigated in patients undergoing coronary artery bypass graft operations. The study population will be patients with impaired myocardial function as st...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2004-004225-10 Sponsor Protocol Number: 3001081 Start Date*: 2005-03-07
    Sponsor Name:Orion Pharma
    Full Title: Effects of peroral levosimendan in the prevention of further hospitalisations in patients with chronic heart failure. A randomised, double-blind, placebo-controlled, multi-centre, parallel-group study
    Medical condition: Cardiac Failure
    Disease: Version SOC Term Classification Code Term Level
    7.1 10007554 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) LT (Completed) LV (Completed) EE (Completed)
    Trial results: View results
    EudraCT Number: 2014-001461-27 Sponsor Protocol Number: FIM-BGC-2014-01 Start Date*: 2015-01-19
    Sponsor Name:FIMABIS
    Full Title: Evaluation of the effect of organic preservation with the use of levosimendan after cardiac surgery in patients with low output syndrom compared with dobutamine.
    Medical condition: Low cardiac output syndrome
    Disease: Version SOC Term Classification Code Term Level
    17.1 10007541 - Cardiac disorders 10024899 Low cardiac output syndrome PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-003105-25 Sponsor Protocol Number: MiLe-1 Start Date*: 2014-08-27
    Sponsor Name:Sahlgrenska University Hospital / The Queen Silvia Children´s Hospital
    Full Title: The prophylactic effect of levosimendan in reducing acute kidney injury postoperatively in pediatric patients undergoing corrective heart surgery
    Medical condition: Acute kidney injury postoperatively in connection with surgery for congenital heart disease
    Disease:
    Population Age: Preterm newborn infants, Newborns, Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: SE (Completed) FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-002643-10 Sponsor Protocol Number: HCA-2011_1 Start Date*: 2012-01-17
    Sponsor Name:Heart Center Co. Tampere University Hospital
    Full Title: Intracoronary administration of levosimendan in cardiac surgery patients
    Medical condition: Dysfunction after opening of aortic cross-clamp in patients undergoing aortic valve and coronary artery bypass (AVR+CABG) operation.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-004384-29 Sponsor Protocol Number: Levosepsis1 Start Date*: 2005-05-23
    Sponsor Name:Dr GED DEMPSEY, University Hospital Aintree
    Full Title: Double blind randomised controlled trial of Levosimendan versus Dopexamine in septic shock
    Medical condition: Septic Shock
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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