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Clinical trials for Physical dependence

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    The EU Clinical Trials Register currently displays   44336   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

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    80 result(s) found for: Physical dependence. Displaying page 1 of 4.
    1  2  3  4  Next»
    EudraCT Number: 2007-002315-92 Sponsor Protocol Number: 12013A Start Date*: 2008-11-12
    Sponsor Name:H. Lundbeck A/S
    Full Title: A 52-week, randomised, double-blind, placebo-controlled, parallel-group, safety, tolerability and efficacy study of nalmefene, as needed use, in patients with alcohol dependence
    Medical condition: Alcohol dependence
    Disease: Version SOC Term Classification Code Term Level
    9.1 10001594 Alcohol dependence syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) SK (Completed) EE (Completed) GB (Completed) LV (Completed) HU (Completed) LT (Completed)
    Trial results: View results
    EudraCT Number: 2022-002462-32 Sponsor Protocol Number: SHW01 Start Date*: 2022-12-09
    Sponsor Name:Suchthilfe Wien gGmbH
    Full Title: Pilot study on the safety and feasibility of intravenous opioid agonist therapy (OAT) with Hydagelan® (hydromorphone hydrochloride) in Vienna.
    Medical condition: Opioid dependence: Opioid dependence is a serious and usually chronic disease that requires treatment, encompasses various psychological and physical dimensions, and is associated with concomitant ...
    Disease: Version SOC Term Classification Code Term Level
    26.1 10037175 - Psychiatric disorders 10013658 Drug addiction LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-004024-11 Sponsor Protocol Number: 60-60600-97-103 Start Date*: 2014-07-23
    Sponsor Name:Academic Psychiatric Center - AMC-UvA
    Full Title: New pharmacotherapeutic treatment options for crack-cocaine dependent people in the Netherlands: A double-blind, placebo-controlled randomized feasibility study of sustained release dexamphetamine
    Medical condition: cocaine dependence (according DSM-IV)
    Disease: Version SOC Term Classification Code Term Level
    17.0 100000004873 10009817 Cocaine dependence LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2017-000736-33 Sponsor Protocol Number: CAFQ056X2201 Start Date*: 2017-10-25
    Sponsor Name:Novartis Farmacéutica S.A.
    Full Title: A randomized, subject and investigator blinded, placebo-controlled, parallel group study to investigate whether AFQ056 reduces cocaine use in patients diagnosed with Cocaine Use Disorder (CUD).
    Medical condition: Cocaine Use Disorder according to DSM 5
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000173266 10009815 Cocaine addiction LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2013-001154-98 Sponsor Protocol Number: 15660A Start Date*: 2013-10-14
    Sponsor Name:H Lundbeck A/S [...]
    1. H Lundbeck A/S
    2.
    Full Title: Interventional, randomized, double-blind, cross-over, placebo-controlled study to investigate the effects of nalmefene after single dose on the blood oxygen level dependent (BOLD) fMRI signal in th...
    Medical condition: Nalmefene (Selincro) is indicated for the reduction of alcohol consumption in adults with alcohol dependence who have a high drinking risk level, without physical withdrawal symptoms and who do not...
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004873 10001594 Alcohol dependence syndrome LLT
    Population Age: Adults Gender: Male
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2017-000069-57 Sponsor Protocol Number: P15-01 Start Date*: 2017-07-21
    Sponsor Name:BIOPROJET PHARMA
    Full Title: A Multisite Randomized Clinical Trial Evaluating BP1.3656 Versus Placebo For Alcohol Use Disorder Treatment
    Medical condition: Male or female with moderate or severe DSM-5 alcohol use disorder (based on the alcohol use disorders section of MINI)
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004873 10001590 Alcohol addiction LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: BG (Completed) NL (Completed)
    Trial results: View results
    EudraCT Number: 2011-002229-23 Sponsor Protocol Number: RB-UK-11-0018 Start Date*: 2012-05-09
    Sponsor Name:RB Pharmaceuticals Inc.
    Full Title: A randomised, double blind, placebo controlled, cross over study of the effects of Buprenorphine Hemiadipate Hydrochloride/Naloxone Hydrochloride Dihydrate intravenous challenges in opioid dependen...
    Medical condition: Maintenance/substitution agent for the treatment of opioid dependence.
    Disease: Version SOC Term Classification Code Term Level
    14.1 10037175 - Psychiatric disorders 10012346 Dependence on opiates LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2007-003250-29 Sponsor Protocol Number: IPAB-07-002 Start Date*: 2008-03-14
    Sponsor Name:Independent Pharmaceutica AB
    Full Title: A randomised, placebo-controlled, multi-centre study on the efficacy of Niccine, a vaccine for nicotine, in smoking relapse prevention, assessed in abstinent, adult smokers.
    Medical condition: The intended indication for the drug under investigation is smoking relapse prevention. Tobacco smoking has been identified as the single largest preventable cause of morbidity and premature death ...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10056478 Nicotine addiction LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed) DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-002374-55 Sponsor Protocol Number: S3250493 Start Date*: 2007-08-10
    Sponsor Name:GlaxoSmithKline Consumer Healthcare
    Full Title: Simultaneous fMRI/EEG of the 4 mg nicotine lozenge in relief of cognitive impairment associated with nicotine withdrawal
    Medical condition: Nicotine dependence
    Disease: Version SOC Term Classification Code Term Level
    9.1 10057852 Nicotine dependence LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2015-003035-35 Sponsor Protocol Number: HS-14-499 Start Date*: 2015-11-09
    Sponsor Name:Braeburn Pharmaceuticals
    Full Title: An Open-Label Multicenter Study Assessing the Long-Term Safety of a Once-Weekly and Once-Monthly, Long-Acting Subcutaneous Injection Depot of Buprenorphine (CAM2038) in Adult Outpatients with Opioi...
    Medical condition: Opioid Use Disorder
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed) SE (Completed) DK (Completed) HU (Completed)
    Trial results: View results
    EudraCT Number: 2010-021384-33 Sponsor Protocol Number: NTXMR1 Start Date*: 2010-08-20
    Sponsor Name:Beroendecentrum Stockholm
    Full Title: The Effect of Naltrexone on Amphetamine Cue Reactivity: An fMRI Study
    Medical condition: Amphetamine dependence
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-002203-40 Sponsor Protocol Number: 07.0056 Start Date*: 2007-10-03
    Sponsor Name:St. George's, University of London
    Full Title: Effect of hydrocortisone on desire to smoke and tobacco withdrawal symptoms
    Medical condition: Nicotine addiction; specifically, cortisol deficiency following smoking cessation.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10056478 Nicotine addiction LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2009-010584-16 Sponsor Protocol Number: 2009/001 Start Date*: 2010-10-25
    Sponsor Name:ZonMw
    Full Title: New pharmacotherapeutic treatment options for crack-cocaine dependent people in the Netherlands.
    Medical condition: Crack-cocaine dependence (according to DSM-IV)
    Disease: Version SOC Term Classification Code Term Level
    9.1 10001995 Amphetamine and other psychostimulant dependence LLT
    9.1 10001996 Amphetamine and other psychostimulant dependence, continuous use LLT
    9.1 10001997 Amphetamine and other psychostimulant dependence, episodic use LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-004692-36 Sponsor Protocol Number: VAR/01/011 Start Date*: 2011-11-30
    Sponsor Name:HOSPITAL UNIVERSITARI DE BELLVITGE
    Full Title: COMBIVAR. Randomized double-blind trial of two parallel groups design to evaluate the efficacy of smoking cessation with combined (varenicline plus nicotine patches) versus monotherapy (varenicline)
    Medical condition: NICOTINE DEPENDENCE.
    Disease: Version SOC Term Classification Code Term Level
    14.0 10037175 - Psychiatric disorders 10032707 Other specified drug dependence, continuous use LLT
    14.0 10037175 - Psychiatric disorders 10012336 Dependence addictive LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-005938-15 Sponsor Protocol Number: CloTASH-2021-2Version15.10.21 Start Date*: 2021-11-03
    Sponsor Name:Oslo University Hospital
    Full Title: Health risks and treatment of anabolic-androgenic steroid (AAS) induced hypogonadism among men – a pilot study exploring off-label use of clomiphene citrate to reduce symptoms of androgen deficienc...
    Medical condition: Anabolic androgenic steroid induced hypogonadism among men
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-017862-22 Sponsor Protocol Number: 200110005 Start Date*: 2010-09-28
    Sponsor Name:ZonMw
    Full Title: The effectiveness of Nicotine Replacement Therapy for young people aged 12 to 18 years
    Medical condition: Smoking among young people aged 12 – 18 years.
    Disease: Version SOC Term Classification Code Term Level
    12.1 10053325 Smoking cessation therapy LLT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-004211-40 Sponsor Protocol Number: MTI-107 Start Date*: 2018-06-07
    Sponsor Name:Menlo Therapeutics Inc.
    Full Title: An Open-Label Long-Term Safety Study of Serlopitant for the Treatment of Pruritus
    Medical condition: Pruritus associated with prurigo nodularis (PN), atopic dermatitis (AD), or psoriasis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10040785 - Skin and subcutaneous tissue disorders 10037087 Pruritus PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) AT (Prematurely Ended) PL (Completed)
    Trial results: View results
    EudraCT Number: 2011-000575-14 Sponsor Protocol Number: SMO032/10/03 Start Date*: 2012-05-09
    Sponsor Name:D&A PHARMA
    Full Title: Randomized, multicenter, double-blind, placebo-controlled study of the safety and efficacy of 4 dose regimens of SMO.IR, an oral solid formulation of sodium oxybate, in the maintenance of alcohol a...
    Medical condition: maintenance of alcohol abstinence in recently abstinent alcohol-dependent patients
    Disease: Version SOC Term Classification Code Term Level
    16.0 100000004873 10031519 Other and unspecified alcohol dependence LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) CZ (Completed) AT (Completed) IT (Completed) SK (Completed) DE (Completed) ES (Completed) PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-006741-40 Sponsor Protocol Number: CNIC002A2201 Start Date*: 2008-07-14
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A double blind, placebo-controlled, multi-centre study to evaluate the efficacy, safety, tolerability and immunogenicity of repeated s.c administrations of 100µg NIC002 vaccine in cigarette smokers...
    Medical condition: Smokers
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2022-001997-70 Sponsor Protocol Number: EXCELLENCE/0421/0543v1 Start Date*: 2022-11-16
    Sponsor Name:University of Cyprus
    Full Title: Efficacy of Ketamine for the Prevention of Relapse in Patients with Opioid-Use Disorders (OUD)
    Medical condition: Methadone and buprenorphine comprise a first-line, evidence-based opioid substitution treatment (OST) for OUD patients. Unfortunately, retention and adherence to OST treatment is currently a major ...
    Disease: Version SOC Term Classification Code Term Level
    20.1 10037175 - Psychiatric disorders 10019935 Heroin addiction LLT
    20.1 10037175 - Psychiatric disorders 10030900 Opium addiction LLT
    20.0 10037175 - Psychiatric disorders 10012378 Depression PT
    21.1 10037175 - Psychiatric disorders 10057840 Major depression PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: CY (Trial now transitioned)
    Trial results: (No results available)
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