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Clinical trials for Respiratory depression

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    112 result(s) found for: Respiratory depression. Displaying page 1 of 6.
    1  2  3  4  5  6  Next»
    EudraCT Number: 2017-004973-15 Sponsor Protocol Number: TETRO Start Date*: 2018-04-09
    Sponsor Name:Leiden University Medical Center
    Full Title: Reversal through TRH of opioid-induced respiratory depression (OIRD) in healthy volunteers
    Medical condition: opioid-induced respiratory depression
    Disease: Version SOC Term Classification Code Term Level
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10038678 Respiratory depression PT
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10038680 Respiratory depression postoper LLT
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10078059 Central respiratory depression LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2022-001824-13 Sponsor Protocol Number: OXIS Start Date*: 2022-09-12
    Sponsor Name:Leiden University Medical Center
    Full Title: Influence of oxycodone on individuals taking an SSRI
    Medical condition: Depression
    Disease: Version SOC Term Classification Code Term Level
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10038678 Respiratory depression PT
    20.0 10037175 - Psychiatric disorders 10012378 Depression PT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2016-002148-17 Sponsor Protocol Number: ORKA Start Date*: 2016-08-24
    Sponsor Name:LUMC
    Full Title: Reversal of opioid-induced respiratory depression (OIRD) by ketamine in healthy volunteers – the ORKA trial
    Medical condition: Respiratory depression
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004855 10069144 Acute respiratory insufficiency LLT
    19.0 100000004855 10038701 Respiratory insufficiency LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-003504-22 Sponsor Protocol Number: UCDCRC/015/006 Start Date*: 2015-10-09
    Sponsor Name:UCD
    Full Title: The NAPRESSIM trial. The use of low dose prophylactic naloxone infusion to prevent respiratory depression with intrathecal morphine.
    Medical condition: Respiratory Depression
    Disease: Version SOC Term Classification Code Term Level
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10038678 Respiratory depression PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed)
    Trial results: View results
    EudraCT Number: 2021-000598-95 Sponsor Protocol Number: HS-20-674 Start Date*: 2021-07-30
    Sponsor Name:Camurus AB
    Full Title: A Phase 2, randomized, double-blind, placebo-controlled, multi-center trial to assess the efficacy and safety of octreotide subcutaneous depot (CAM2029) in patients with acute respiratory distress ...
    Medical condition: Acute respiratory distress syndrome (ARDS) caused by COVID-19 or other disorders
    Disease: Version SOC Term Classification Code Term Level
    21.1 10038738 - Respiratory, thoracic and mediastinal disorders 10001052 Acute respiratory distress syndrome PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2013-003873-85 Sponsor Protocol Number: PCS02 Start Date*: 2016-04-12
    Sponsor Name:Helsinki University Central Hospital
    Full Title: Doxapram as an Additive to Propofol Sedation in Sedation for ERCP - a Placebo controlled, randomized, double-blinded, prospective study
    Medical condition: Respiratory depression caused by propofol sedation during an ERCP procedure
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: View results
    EudraCT Number: 2009-012658-19 Sponsor Protocol Number: Protocol_KET-MET_2009 Start Date*: 2009-08-27
    Sponsor Name:Leiden University Medical Center
    Full Title:
    Medical condition: Acute pain to be tested in healthy volunteers
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-001849-41 Sponsor Protocol Number: DOX-101 Start Date*: 2012-06-18
    Sponsor Name:Leids Universitair Medisch Centrum (LUMC)
    Full Title: Two-part, Randomized, Placebo-controlled, Repeated Stepped Infusion Dose Study of the Pharmacodynamics of Doxapram when Co-administered with Opioids (Protocol – doxapram-101).
    Medical condition: acute respiratory insufficiency, including such conditions as opioid and anesthetic-induced respiratory depression, post-anesthetic atelectasis, and central apneas (e.g., apnea of prematurity).
    Disease: Version SOC Term Classification Code Term Level
    14.1 10038738 - Respiratory, thoracic and mediastinal disorders 10038738 Respiratory, thoracic and mediastinal disorders SOC
    Population Age: Adults Gender: Male
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-003302-25 Sponsor Protocol Number: PRG-OXYCODONE-06/01 Start Date*: 2006-11-30
    Sponsor Name:Barts and The London NHS Trust
    Full Title: A prospective, randomised, double-blind, placebo-controlled trial to assess the respiratory effects of oxycodone versus morphine in anaesthetised patients
    Medical condition: Patients scheduled to undergo surgery of more than 30 minutes duration under general anaesthesia will be recruited. We are not investigating a medical disease.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2019-002569-37 Sponsor Protocol Number: APHP180584 Start Date*: 2020-05-13
    Sponsor Name:Assistance Publique Hôpitaux de Paris
    Full Title: Empirical steroids and/or antifungals in immunocompromised patients with acute respiratory failure from undetermined etiology: a multicenter double-blind randomized controlled trial
    Medical condition: immunocompromised patients with acute respiratory failure
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2018-002669-20 Sponsor Protocol Number: 03KET2018 Start Date*: 2018-09-18
    Sponsor Name:Celon Pharma SA
    Full Title: A multicentre, double-blind, randomised, placebo - controlled phase II study to assess efficacy, safety and pharmacokinetics of inhaled Esketamine in subjects with treatment-resistant bipolar depre...
    Medical condition: Eketamine, ketamine’s enantiomer, is designed for use in tretment resistant depression, both unipolar and bipolar. Many publications have demonstrated the effect of ketamine/esketamine (mainly admi...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-003515-22 Sponsor Protocol Number: SURF Start Date*: 2018-11-29
    Sponsor Name:Leiden University Medical Center
    Full Title: Respiratory effects of tapentadol and oxycodone assessed by pharmacokinetic-pharmacodynamic and response surface modeling in healthy volunteers
    Medical condition: Chronic pain
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-002797-42 Sponsor Protocol Number: ANST-2013-Alcohol Start Date*: 2013-09-11
    Sponsor Name:Leiden University Medical Centre
    Full Title: Alcohol and Oxycodone - The influence of the combination of alcohol and an opioid on ventilation in healthy young and elderly volunteers - the 'A&O' study
    Medical condition: Respiratory depression
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-005802-29 Sponsor Protocol Number: RD/505/06 Start Date*: 2007-06-26
    Sponsor Name:Gwent Healthcare NHS Trust
    Full Title: Postoperative analgesia for Total knee replacement: A comparision between intrathecal morphine and peripheral nerve block.
    Medical condition: Postoperative analgesia for Total Knee Replacement
    Disease: Version SOC Term Classification Code Term Level
    14.0 10007541 - Cardiac disorders 10007521 Cardiac arrhythmias HLGT
    14.0 10022117 - Injury, poisoning and procedural complications 10029177 Nerve damage LLT
    14.0 10029205 - Nervous system disorders 10010914 Convulsions LLT
    14.0 10038738 - Respiratory, thoracic and mediastinal disorders 10038678 Respiratory depression PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2018-001963-22 Sponsor Protocol Number: 02KET2018 Start Date*: 2018-08-29
    Sponsor Name:Celon Pharma SA
    Full Title: A multicentre, double-blind, randomised, placebo - controlled phase II study to assess efficacy, safety and pharmacokinetics of inhaled Esketamine in subject with treatment-resistant depression in ...
    Medical condition: Eketamine, ketamine’s enantiomer, is designed for use in tretment resistant depression, both unipolar and bipolar. Many publications have demonstrated the effect of ketamine/esketamine (mainly admi...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-018233-21 Sponsor Protocol Number: WEC 0910 Start Date*: 2010-03-31
    Sponsor Name:Leiden University Medical Centre
    Full Title: Modeling the respiratory effects of subanesthetic doses of propofol under closed-loop or non-steady-state conditions without and with a remifentanil background infusion in healthy volunteers.
    Medical condition: This study is performed in healthy volunteers. The study is aimed at investigating the effect of propofol and remifentanil-propofol interaction on breathing in awake, non-artificially ventilated vo...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-000242-18 Sponsor Protocol Number: DEXSAR-Trial Start Date*: 2013-05-23
    Sponsor Name:
    Full Title: Low dose dexamethasone in newly diagnosed sarcoidosis
    Medical condition: Patients with newly diagnosed, pulmonary sarcoidosis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2022-000043-74 Sponsor Protocol Number: PNAS0122 Start Date*: 2023-07-27
    Sponsor Name:Medical University of Vienna
    Full Title: Defining and predicting neonatal inadaptation after gestational exposure to antidepressants: longitudinal exploratory analysis of psychoneuroendocrine risk factors and complications
    Medical condition: major depressive disorder poor neonatal adaptation syndrome (after antidepressant use during pregnancy)
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2022-001603-40 Sponsor Protocol Number: P22-XXX Start Date*: 2022-07-18
    Sponsor Name:Leiden University Medical Center
    Full Title: Combined effect of Pregabalin and Oxycodone, and Lacosamide and Oxycodone, on breathing: an exploratory study in healthy volunteers the POLO study
    Medical condition: Healthy Volunteers
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-004587-38 Sponsor Protocol Number: ESKETINTRD3004 Start Date*: 2015-08-05
    Sponsor Name:Janssen-Cilag International NV
    Full Title: An Open-label, Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression
    Medical condition: Treatment-resistant Major Depression
    Disease: Version SOC Term Classification Code Term Level
    19.0 10037175 - Psychiatric disorders 10057840 Major depression PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) BE (Completed) DE (Completed) ES (Completed) GB (Completed) AT (Completed) PL (Completed) BG (Completed) LT (Completed) FI (Completed) IT (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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