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Clinical trials for Subchondral bone

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    15 result(s) found for: Subchondral bone. Displaying page 1 of 1.
    EudraCT Number: 2020-002127-10 Sponsor Protocol Number: 19-AOI-11 Start Date*: 2020-09-01
    Sponsor Name:CHU de Nice
    Full Title: Evaluation of pain after intra-articular injections of botulinum toxin in carpometacarpal osteoarthritis of the thumb
    Medical condition: Rhizarthrosis
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10062893 Rhizarthrosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2020-000624-20 Sponsor Protocol Number: ILONA Start Date*: 2021-06-17
    Sponsor Name:Leipzig University
    Full Title: Core decompression versus core decompression followed by infusion of Iloprost in the treatment of non-traumatic avascular necrosis of the femoral head
    Medical condition: non-traumatic avascular necrosis of the femoral head (N-ANFH)
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10003860 Avascular necrosis femoral head LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2012-003721-22 Sponsor Protocol Number: A4091058 Start Date*: 2016-01-14
    Sponsor Name:Pfizer Inc, 235 East 42nd Street, New York, NY 10017
    Full Title: A PHASE 3 RANDOMIZED, DOUBLE-BLIND, ACTIVE-CONTROLLED, MULTICENTER STUDY OF THE LONG-TERM SAFETY AND EFFICACY OF SUBCUTANEOUS ADMINISTRATION OF TANEZUMAB IN SUBJECTS WITH OSTEOARTHRITIS OF THE HIP ...
    Medical condition: Osteoarthritis of the hip or knee
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10023476 Knee osteoarthritis LLT
    20.0 100000004859 10020108 Hips osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BG (Completed) SK (Completed) LT (Completed) HR (Completed)
    Trial results: View results
    EudraCT Number: 2006-000925-71 Sponsor Protocol Number: HUM 05-032 Start Date*: 2006-04-27
    Sponsor Name:University Hospital Ghent
    Full Title: TNF-blockade for the treatment of erosive osteoarthritis (OA) of interphalangeal finger joints. Randomized, double blind, placebo-controlled study to evaluate the efficacy of adalimumab 40 mg sc ev...
    Medical condition: Erosive interphalangeal osteoarthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-003939-38 Sponsor Protocol Number: P160404J Start Date*: 2017-12-19
    Sponsor Name:ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
    Full Title: Short-term efficacy of a single ultrasound-guided intra-articular injection of botulinum toxin A associated with splinting for base-of-thumb osteoarthritis on pain at 3 months: A randomized placebo...
    Medical condition: Patients referred to our Physical Medicine Rehabilitation Department of a tertiary care center in Paris, France, for the management of Base-of-thumb osteoarthritis (BTOA)
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10062893 Rhizarthrosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2012-001431-31 Sponsor Protocol Number: EMR700692-007 Start Date*: 2013-05-02
    Sponsor Name:Merck KGaA
    Full Title: A multicenter, randomized, double-blind, placebo-controlled, parallel-group, Phase II trial to investigate the efficacy and safety of 30 mcg and 100 mcg AS902330 given as one cycle of three intra-a...
    Medical condition: Knee Cartilage Injury
    Disease: Version SOC Term Classification Code Term Level
    15.1 10022117 - Injury, poisoning and procedural complications 10007710 Cartilage injury PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2013-002611-96 Sponsor Protocol Number: ANAK/IL-01 Start Date*: 2014-02-12
    Sponsor Name:Consorci Mar Parc de Salut de Barcelona (Parc de Salut MAR)
    Full Title: Pilot study to determine the efficacy of anakinra (antagonist of interleukin-1 receptor) administered for 3 months in improving inflammatory signs observed by MRI in patients with erosive/inflammat...
    Medical condition: Patients with erosive/inflammatory hand osteoarthritis.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-004143-21 Sponsor Protocol Number: OA-orMSCp-01 Start Date*: Information not available in EudraCT
    Sponsor Name:Bioinova, a.s.
    Full Title: Efficacy of autologous bone marrow-derived mesenchymal stem cells seeded on a 3D scaffold in treatment of knee cartilage defects. A randomized, controlled, open-label, multi-centre clinical trial.
    Medical condition: Knee Cartilage Defect
    Disease: Version SOC Term Classification Code Term Level
    27.0 10022117 - Injury, poisoning and procedural complications 10007710 Cartilage injury PT
    21.1 10022117 - Injury, poisoning and procedural complications 10007705 Cartilage damage LLT
    20.0 10042613 - Surgical and medical procedures 10057104 Cartilage repair LLT
    21.0 10028395 - Musculoskeletal and connective tissue disorders 10072638 Articular cartilage defect LLT
    20.0 10042613 - Surgical and medical procedures 10052913 Cartilage operation PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: CZ (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2021-006817-12 Sponsor Protocol Number: 2031-38 Start Date*: 2022-06-24
    Sponsor Name:ASSITANCE PUBLIQUE HOPITAUX DE MARSEILLE
    Full Title: Evaluation of the efficacy of an intra-articular injection of autologous microfat combined with autologous platelet-enriched plasma in the treatment of radiocarpal osteoarthritis: a randomized cont...
    Medical condition: radiocarpal osteoarthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2016-001906-41 Sponsor Protocol Number: MRHT_ES-IF_RCT001 Start Date*: 2016-08-08
    Sponsor Name:Royal College of Surgeons in Ireland
    Full Title: A randomised control trial of intra articular injectates in knee osteoarthritis: A comparison of corticosteroid (Methylprednisolone Acetate) and NSAID (Ketorolac tromethamine) injections
    Medical condition: Knee osteoarthritis is the condition of interest. Osteoarthritis is a common musculoskeletal complaint, with an underlying pathogenesis related to bio-mechanical stress loading, resulting in initia...
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-003594-28 Sponsor Protocol Number: BCCT2011 Start Date*: 2013-11-07
    Sponsor Name:BioTissue Technologies GmbH
    Full Title: A Comparative Observational Prospective Randomized Open-Label Study on Efficacy of BioSeed®-C and chondrotissue® Treatment of Local Femoral Cartilage Defects in the Knee.
    Medical condition: focal femoral cartilage defects in the knee joint
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004863 10007705 Cartilage damage LLT
    16.1 100000004865 10057104 Cartilage repair LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-022072-31 Sponsor Protocol Number: R5242A789 Start Date*: 2013-04-15
    Sponsor Name:RJAH Orthopaedic Hospital
    Full Title: Autologous Cell Therapy for Osteoarthritis: An evaluation of the safety and efficacy of autologous transplantation of articular chondrocytes and/or bone marrow-derived stromal cells to repair chond...
    Medical condition: osteochondral defects of the knee (early osteoarthritis)
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2019-005000-17 Sponsor Protocol Number: JU-BioMiStem-01 Start Date*: 2021-09-20
    Sponsor Name:Jagiellonian University
    Full Title: A Randomized, Double Blind, Two Arms, Controlled Phase I/II Safety and Efficacy Study on MesoCellA-Ortho Tissue Engineered Product Intraarticularly Administrated in Adult Patients with Osteoarthrosis
    Medical condition: articular knee diseases
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-000623-27 Sponsor Protocol Number: EC_01_2017 Start Date*: 2017-09-11
    Sponsor Name:Fundacion para la investigacion biomedica HUPA
    Full Title: Role of autologous biological therapy in knee osteoarthritis. Intraosseous application of plasma rich in growth factors , improve of functional capacity and pain, compared to intraarticular applic...
    Medical condition: Knee osteoarthritis.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031161 Osteoarthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-002494-75 Sponsor Protocol Number: CL3-12911-018 Start Date*: 2006-04-26
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: The efficacy and safety of two doses of strontium ranelate (1g and 2g per day) versus placebo administered orally for 3 years in the treatment of knee osteoarthritis. A prospective multicentre, int...
    Medical condition: Osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    7.0 10031161 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) AT (Completed) BE (Completed) GB (Completed) ES (Completed) IT (Completed) DK (Completed) PT (Completed) LT (Completed) EE (Completed) CZ (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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