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Clinical trials for Therapeutic use

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44346   clinical trials with a EudraCT protocol, of which   7374   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    4,382 result(s) found for: Therapeutic use. Displaying page 1 of 220.
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    EudraCT Number: 2017-005103-27 Sponsor Protocol Number: BETASBMA Start Date*: 2021-11-18
    Sponsor Name:AZIENDA OSPEDALIERA DI PADOVA
    Full Title: A PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF CLENBUTEROL IN PATIENTS WITH SPINAL AND BULBAR MUSCULAR ATROPHY (SBMA)
    Medical condition: Motor neuron disease characterized by atrophy and muscle weakness in the spinal and bulbar region
    Disease: Version SOC Term Classification Code Term Level
    20.1 10010331 - Congenital, familial and genetic disorders 10068597 Bulbospinal muscular atrophy congenital PT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2020-001025-31 Sponsor Protocol Number: 2019PI255 Start Date*: 2021-07-29
    Sponsor Name:CHRU Nancy
    Full Title: HIGHLIGHTING THE BENEFITS OF THERAPEUTIC GARDENS IN ALZHEIMER'S DISEASE with 18F-FDG Cerebral PET / CT
    Medical condition: atients followed at the Memory and Research Center (CMRR) and diagnosed with mild to moderate Alzheimer's disease (MMS 15-23)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-000723-15 Sponsor Protocol Number: IP-REM-AC-01 inc. A1,D1,2,3,4,5; Start Date*: 2004-11-15
    Sponsor Name:Fresenius Biotech GmbH
    Full Title: Two-arm, randomized (2:1), open-label phase II/III study in EpCAM positive cancer patients with symptomatic malignant ascites using paracentesis plus the tri-functional antibody removab (anti-EpCAM...
    Medical condition: Cancer : Malignant Ascites
    Disease: Version SOC Term Classification Code Term Level
    8.1 10025538 Malignant ascites LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) LT (Completed) GB (Completed) EE (Completed) LV (Completed) AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-003785-77 Sponsor Protocol Number: 59244 Start Date*: 2017-03-16
    Sponsor Name:
    Full Title: Microdosing as a tool to individualize docetaxel dosing: development of a limited sampling model
    Medical condition: Patients with breast-, prostate or non-small cell lung cancer (NSCLC), who are eligible for treatment with docetaxel.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2019-004538-40 Sponsor Protocol Number: BC-5429 Start Date*: 2020-11-20
    Sponsor Name:Ghent University Hospital
    Full Title: A multicentric randomised controlled clinical trial to study the impact of bedside model-informed precision dosing of vancomycin in critically ill children.
    Medical condition: Gram positive infection
    Disease:
    Population Age: Preterm newborn infants, Newborns, Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-003670-31 Sponsor Protocol Number: BC-10433 Start Date*: 2021-09-22
    Sponsor Name:Ghent University Hospital
    Full Title: Impact of Model-Informed Precision Dosing of Vancomycin in Adults: A randomized, controlled clinical trial
    Medical condition: Gram positive infection
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-020103-70 Sponsor Protocol Number: 1 Start Date*: 2012-08-14
    Sponsor Name:University of Tartu
    Full Title: Pharmacokinetics of intravenous phenobarbital and lidocaine in the treatment of neonatal seizures of term neonates requireing therapeutic hypothermia
    Medical condition: Neonatal seizures
    Disease:
    Population Age: Newborns, Under 18 Gender: Male, Female
    Trial protocol: EE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2022-000559-35 Sponsor Protocol Number: 0 Start Date*: 2022-07-14
    Sponsor Name:None
    Full Title: COMPLICATIONS AND DEGREE OF TOLERANCE OF THE ADMINISTRATION OF LOCAL ANESTHESIA IN DIAGNOSTIC / THERAPEUTIC THORACOCENTESIS PROCEDURES
    Medical condition: There is no consensus about the most appropriate local anesthetic, and 1% mepicavain and 2% lidocaine uses can be postulated indistinctly. This project was born with the intention of highlighting t...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-002376-14 Sponsor Protocol Number: ELLOUZE_ORION_2018 Start Date*: 2019-10-15
    Sponsor Name:CHU Dijon Bourgogne
    Full Title:
    Medical condition:
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2008-001786-28 Sponsor Protocol Number: 2008-6-CC Start Date*: 2009-08-20
    Sponsor Name:Academical Medical Center
    Full Title: Innovative approaches for cocaine pharmacotherapy using fMRI: The case of varenicline
    Medical condition: cocaine addiction
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-003143-11 Sponsor Protocol Number: CHUBX201620 Start Date*: 2016-10-27
    Sponsor Name:CHU de Bordeaux
    Full Title: Effect of intra-venous ocytocine injection after fetal expulsion in management of third-stage of labor after second trimester medical pregnancy termination
    Medical condition: second trimester medical pregnancy termination
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004865 10043285 Termination of pregnancy - medical LLT
    Population Age: Adults Gender: Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2015-002856-28 Sponsor Protocol Number: UF94602 Start Date*: 2015-07-20
    Sponsor Name:CHU de Montpellier
    Full Title: Utilisation de l’Ultiva® associé à la Xylocaïne® dans les procédures de fœticide : essai randomisé de phase III
    Medical condition: Interruptions Médicales de Grossesse (IMG)
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004865 10043406 Therapeutic abortion LLT
    Population Age: Adults Gender: Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-000650-10 Sponsor Protocol Number: LAS-213 Start Date*: 2020-02-12
    Sponsor Name:Octapharma
    Full Title: An open-label, multicenter, Post-Marketing Requirement study to investigate the safety and tolerability of octaplas™ in the management of pediatric patients who require therapeutic plasma exchange.
    Medical condition: Therapeutic plasma exchange
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2016-001520-66 Sponsor Protocol Number: UC-0106/1607 Start Date*: 2018-06-13
    Sponsor Name:UNICANCER
    Full Title: Efficacy and safety of fentanyl citrate in painful access induced during diagnostic or therapeutic examinations in cancer patients
    Medical condition: Cancer patient
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-003601-21 Sponsor Protocol Number: ZX-2021-FES-ESTROTIMP-4. Start Date*: 2021-09-22
    Sponsor Name:Zionexa
    Full Title: Impact of 18F-FES TEP on therapeutical management in patients with metastatic breast cancer, ER positive and HER2 negative, in relapse after a first line of treatment combining hormonal therapy
    Medical condition: Patients with metastatic breast cancer initially presenting with overexpression of estrogen receptors (ERs) and absence of overexpression of HER2, relapsing after a first therapeutic line combining...
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004864 10027475 Metastatic breast cancer LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2010-022874-15 Sponsor Protocol Number: 10084 Start Date*: 2010-11-08
    Sponsor Name:University of Nottingham
    Full Title: Comparison of 30% nitrous oxide with therapeutic dose nimodipine on cerebral and systemic vascular physiology
    Medical condition: This is part of a series of studies investigating the potential therapeutic use of low dose nitrous oxide in the treatment of cerebral vasospasm, a condition which occurs following brain injury and...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-003933-33 Sponsor Protocol Number: 12K3-S-140708 Start Date*: 2006-12-20
    Sponsor Name:Bundeswehr
    Full Title: Clinical value of Choline-Positron-Emission-Tomography combined with Magnetic Resonance Imaging by software fusion for pre-therapeutic staging of prostate cancer
    Medical condition: Clinical value of Choline-Positron-Emission-Tomography combined with Magnetic Resonance Imaging by software fusion for pre-therapeutic staging of prostate cancer referring to histopathological, pos...
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-002569-19 Sponsor Protocol Number: Final version Start Date*: 2004-12-15
    Sponsor Name:Department of Asthma, Allergy and Respiratory Science, GKT School of Medicine, King's College London
    Full Title: The effects of systemic vitamin D administration on production of interleukin-10 by peripheral blood T cells in asthmatics and controls.
    Medical condition: This trial is being conducted to test the hypothesis that short-term systemic administration of calcitriol in standard therapeutic dosages increases interleukin-10 production by peripheral blood T-...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2018-004809-58 Sponsor Protocol Number: HEBRO-001 Start Date*: 2019-04-04
    Sponsor Name:Institute for study, research, education and therapy of vascular, heart, brain and kidney nosologies (I.N.A.K.E.N)
    Full Title: Comparative study of eplerenone-based treatment strategy versus irbesartan-based blood pressure lowering in obese hypertensive patients (HEBRO Study)
    Medical condition: Primary Hypertension and Obesity
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004866 10020775 Hypertension arterial LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2019-003463-22 Sponsor Protocol Number: CLOTOT3-16IA03 Start Date*: 2020-04-29
    Sponsor Name:Laboratorios Salvat, S.A.
    Full Title: A Phase III, Multicenter, Randomized, Double-Blind Clinical Trial to Assess the Efficacy and Safety of Clotrimazole 1% Otic Solution Compared to Placebo for the Treatment of Fungal Otitis Externa (...
    Medical condition: Fungal Otitis Externa (Otomycosis)
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021881 - Infections and infestations 10052557 Otitis externa fungal PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing) PT (Completed) BG (Completed) RO (Completed)
    Trial results: View results
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    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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