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Clinical trials for Topical treatment

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    1,292 result(s) found for: Topical treatment. Displaying page 1 of 65.
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    EudraCT Number: 2007-002895-32 Sponsor Protocol Number: ML21308 Start Date*: 2007-08-29
    Sponsor Name:Roche AB
    Full Title: A phase II trial assessing Metronidazol Actavis 1% topical cream in the prevention and treatment of Erlotinib associated rash
    Medical condition: Erlotinib associated rash
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2009-016613-22 Sponsor Protocol Number: OxyPeP-001 Start Date*: 2010-06-14
    Sponsor Name:PeP-Tonic Medical AB
    Full Title: A double-blind, placebo controlled multi-centre study to evaluate the effects of topical Oxytocin on vaginal atrophy in postmenopausal women.
    Medical condition: Vaginal atrophy in postmenopausal women
    Disease: Version SOC Term Classification Code Term Level
    12.1 10047782 Vulvovaginal atrophy LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: SE (Completed) GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-000660-22 Sponsor Protocol Number: Benzylbenzoat-Permethrin-5020 Start Date*: 2022-06-14
    Sponsor Name:Landeskrankenhaus Salzburg
    Full Title: Investigation to assess the efficacy of topical benzyl benzoate 10/25% emulsion versus permethrin 5% creme for scabies treatment
    Medical condition: Scabies
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-000390-30 Sponsor Protocol Number: ML20128 Start Date*: 2006-05-18
    Sponsor Name:Helsinki University Central Hospital, Skin and Allergy Hospital
    Full Title: A phase II trial assessing dapsone topical gel in the prevention and treatment of erlotinib associated rash
    Medical condition: The study population are patients with non-small cell lung carcinoma eligible for treatment with erlotinib (TarcevaTM). A significant number of these patients develop acne-like rash as a side effec...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-001697-26 Sponsor Protocol Number: 055-006 Start Date*: 2011-12-12
    Sponsor Name:Professor Reich
    Full Title: Optimising outpatient care in mild to moderate psoriasis by a newly developed ‘Topical Treatment Optimising Programme’ - an international study using Daivobet®/Dovobet® Gel (‘PSO-TOP’)
    Medical condition: Mild to moderate active plaque psoriasis despite topical psoriasis treatment
    Disease: Version SOC Term Classification Code Term Level
    14.1 10040785 - Skin and subcutaneous tissue disorders 10050576 Psoriasis vulgaris LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) DK (Completed) IT (Completed) DE (Completed) GB (Completed) NL (Completed) ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-001726-26 Sponsor Protocol Number: I4V-MC-JAIY Start Date*: 2018-11-06
    Sponsor Name:Eli Lilly and Company
    Full Title: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Baricitinib in Combination with Topical Corticosteroids in Adult Patients with Mode...
    Medical condition: Atopic Dermatitis
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004858 10003639 Atopic dermatitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) AT (Completed) ES (Completed) PL (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2018-001359-11 Sponsor Protocol Number: PHRN17-AM-TOPICAL/DR180115 Start Date*: 2019-02-22
    Sponsor Name:CHRU TOURS
    Full Title: 0.1% topical sirolimus in the treatment of cutaneous microcystic lymphatic malformations in children and adults: phase II, split-body randomized, double-blind, vehicle-controlled clinical trial
    Medical condition: Cutaneous microcystic lymphatic malformations (CMLM) in children and adults
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004850 10003229 Arteriovenous malformations LLT
    Population Age: Children, Under 18, Adults Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-000232-12 Sponsor Protocol Number: SYNC-01-AC-P1 Start Date*: 2007-01-31
    Sponsor Name:Syntopix Group plc
    Full Title: Novel topical therapies for acne vulgaris: a randomised, controlled, double blind comparison of the antibacterial efficacy of 1% w/v formulations of tert-butylhydroquinone, zinc pyrithione and benz...
    Medical condition: Healthy volunteer study. The product under development will be used for the treatment of acne vulgaris.
    Disease:
    Population Age: Adolescents, Under 18, Adults Gender: Male
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-001802-23 Sponsor Protocol Number: ALOSTOP Start Date*: 2022-08-24
    Sponsor Name:Fundación para la Investigación Biomédica Hospital Ramón y Cajal
    Full Title: Exploratory clinical trial of safety and efficacy of daily application of topical dutasteride in emulsion in men with androgenic alopecia.
    Medical condition: Male androgenetic alopecia
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-001647-46 Sponsor Protocol Number: IIBSP-END-2018-96 Start Date*: 2020-01-20
    Sponsor Name:Institut de Recerca H. de la Santa Creu i Sant Pau
    Full Title: Evaluation of the regenerative efficacy of Endoret® (PRGF-Plasm Rich in Growth Factors) on the ocular surface of glaucoma patients treated chronically with ocular hypotensive drugs
    Medical condition: Glaucoma
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-005809-77 Sponsor Protocol Number: NL38217 Start Date*: 2013-01-31
    Sponsor Name:Maastricht University Medical Centre
    Full Title: Treatment of superficial basal cell carcinoma by topical photodynamic therapy with fractionated 5-aminolevulinic acid 20% versus two stage topical photodynamic therapy with methylaminolevulinate
    Medical condition: Superficial basal cell carcinoma
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-002835-40 Sponsor Protocol Number: AK701 Start Date*: 2020-01-28
    Sponsor Name:Akari Therapeutics Plc
    Full Title: Topical rVA576 for treatment of atopic keratoconjunctivitis: a randomised placebo double masked parallel trial (TRACKER)
    Medical condition: Moderate to severe atopic keratoconjunctivitis (AKC), Vernal keratoconjunctivitis (VKC), Severe allergic conjunctivitis (seasonal (SAC) or perennial (PAC))
    Disease: Version SOC Term Classification Code Term Level
    20.0 10015919 - Eye disorders 10069664 Atopic keratoconjunctivitis PT
    21.0 10015919 - Eye disorders 10081000 Vernal keratoconjunctivitis PT
    21.0 10015919 - Eye disorders 10081002 Vernal keratoconjunctivitis perennial LLT
    20.0 10015919 - Eye disorders 10001709 Allergic conjunctivitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2007-005082-34 Sponsor Protocol Number: A2620383 Start Date*: 2007-12-14
    Sponsor Name:GlaxoSmithKline Consumer Healthcare
    Full Title: A Proof of Principle Study to Investigate the Efficacy of a Medical Device and Topical Analgesic Combination for the Treatment of Pain and Performance Related Function in Osteoarthritis
    Medical condition: To compare the efficacy of 72 hours (hrs) treatment of topical diclofenac plus a heat patch with 72 hrs treatment of topical diclofenac plus a placebo patch on the primary endpoint of mobility in p...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2022-002434-13 Sponsor Protocol Number: 01-INSULINAGLAUCOMA-2022 Start Date*: 2023-01-18
    Sponsor Name:Barbara Burgos-Blasco
    Full Title: RANDOMIZED CLINICAL TRIAL DOUBLE BLIND (WITH BLIND EVALUATOR) TO DETERMINE THE EFFECTIVENESS AND SAFETY OF TOPICAL INSULIN IN THE TREATMENT OF DRY EYE IN PATIENTS WITH TOPICAL HYPOTENSIVE DRUGS
    Medical condition: Dry eye disease in glaucoma
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-002531-18 Sponsor Protocol Number: 69HCL16_0062 Start Date*: 2018-10-31
    Sponsor Name:Hospices Civils de Lyon
    Full Title: Topical Everolimus versus placebo for the treatment of facial angiofibromas in patients with tuberous sclerosis complex. A phase II/III, multicentre, randomized, double-blind, placebo-controlled st...
    Medical condition: angiofibromas
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10002429 Angiofibroma PT
    Population Age: Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-000410-38 Sponsor Protocol Number: LP0066-1019 Start Date*: 2013-10-25
    Sponsor Name:LEO Pharma A/S
    Full Title: Topical Aprepitant in Prurigo Patients (iTAPP) An exploratory phase IIa trial with topically applied aprepitant in patients with prurigo
    Medical condition: Prurigo can present either with hyperkeratotic nodules as prurigo nodularis or without nodules as Prurigo simplex. The disease is characterised by intensely pruritic, lichenified, or excoriated pap...
    Disease: Version SOC Term Classification Code Term Level
    16.0 100000004858 10037084 Prurigo nodularis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2018-000731-27 Sponsor Protocol Number: AN2728-AD-301 Start Date*: 2018-05-14
    Sponsor Name:Pfizer Inc.
    Full Title: A Multicenter, Randomized, Double-Blind, Vehicle-Controlled Study Of The Safety And Efficacy Of AN2728 Topical Ointment, 2% In Children, Adolescents, And Adults (Ages 2 Years And Older) With Atopic...
    Medical condition: Atopic Dermatitis
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2021-005490-30 Sponsor Protocol Number: PP21/14 Start Date*: 2022-04-28
    Sponsor Name:Hospital Universitario Son Llàtzer
    Full Title: EFFECTIVENESS OF TREATMENT WITH ANTISEPTICS VERSUS TOPICAL ANTIBIOTICS IN MILD IMPETIGO IN PEDIATRIC PATIENTS
    Medical condition: Impetigo is a bacterial infection of very common skin in the pediatric population. In the usual clinical practice, the treatment of this infection has been based on topical antibiotics. The widespr...
    Disease:
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-014572-22 Sponsor Protocol Number: CDP0902 Start Date*: 2010-07-22
    Sponsor Name:AZIENDA OSPEDALIERA DI BOLOGNA POLICLINICO S. ORSOLA M. MALPIGHI
    Full Title: The use of topical propranolol in pyogenic granulomas
    Medical condition: pyogenic granulomas
    Disease: Version SOC Term Classification Code Term Level
    9.1 10029539 LLT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-003792-52 Sponsor Protocol Number: PAAI04 Start Date*: 2011-04-19
    Sponsor Name:Medizinische Universität Wien, Univ.Klinik fuer Dermatologie
    Full Title: Azelaic acid iontophoresis versus topical azelaic acid cream in the treatment of melasma – An open randomized, controlled, prospective, single blinded clinical trial
    Medical condition: clinical diagnosis of melasma
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: AT (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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