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Clinical trials for Valvular disease

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44338   clinical trials with a EudraCT protocol, of which   7368   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    101 result(s) found for: Valvular disease. Displaying page 1 of 6.
    1  2  3  4  5  6  Next»
    EudraCT Number: 2009-017625-20 Sponsor Protocol Number: NAROSYD Start Date*: 2010-06-22
    Sponsor Name:Pawel Florkiewicz
    Full Title: Continuous ropivacaine infusion in treatment of postoperative pain in cardiac surgery.
    Medical condition: Research is to verify whether continuous infusion of ropivacaine reduces post-operative analgesic requirement after cardiac surgery.
    Disease: Version SOC Term Classification Code Term Level
    12.1 10019316 Heart valve disorders LLT
    12.1 10052895 Coronary artery insufficiency LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-001752-43 Sponsor Protocol Number: SEVO-AIFA-FARM6H73Z9 Start Date*: 2008-07-17
    Sponsor Name:OSPEDALE S. RAFFAELE
    Full Title: CARDIAC PROTECTION WITH SEVOFLURANE IN PATIENTS WITH HIGH RISK UNDERGOING HEART SURGERY. RANDOMIZED, CONTROLLED STUDY.
    Medical condition: adult patients affected by cardiac valve and heart patology undergoing elective surgery
    Disease: Version SOC Term Classification Code Term Level
    9.1 10061406 Cardiac valve disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2019-002353-29 Sponsor Protocol Number: HUB-NEF-HEMOCIONA.EC Start Date*: 2019-11-12
    Sponsor Name:HOSPITAL UNIVERSITARI DE BELLVITGE- IDIBELL
    Full Title: PHARMACOKINETICS, PHARMACODYNAMICS AND SAFETY OF APIXABAN IN PATIENTS IN HEMODAFILTRATION
    Medical condition: Chronic kidney disease, non-valvular atrial fibrillation
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004857 10076412 Chronic kidney disease stage 5 LLT
    20.0 10007541 - Cardiac disorders 10003658 Atrial fibrillation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2020-004178-23 Sponsor Protocol Number: T39/2021 Start Date*: 2021-04-14
    Sponsor Name:Turku University Hospital
    Full Title: Ultrasound Guided Repeated Bilateral Transversus Thoracis Muscle Plane Block (TTP) via catheter and postoperative pain in Cardiac Surgery
    Medical condition: cardiac disease necessitating surgery with sternotomy
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10046972 Valvular heart disease NOS LLT
    20.0 100000004849 10055218 Ischemic heart disease LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: View results
    EudraCT Number: 2007-003162-17 Sponsor Protocol Number: 04062007 Start Date*: 2007-10-11
    Sponsor Name:Markku Kupari
    Full Title: Lääkehoito aorttaläpän stenoosin ehkäisyssä Angiotensiinireseptorin salpaajan vaikutukset stenoottisen aorttaläpän tulehdukseen, fibroosiin ja kalkkiutumiseen
    Medical condition: Aorttaläpän stenoosi
    Disease: Version SOC Term Classification Code Term Level
    9.1 10002918 Aortic valve stenosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-001685-33 Sponsor Protocol Number: 07-002 Start Date*: 2007-12-28
    Sponsor Name:RWTH Aachen University
    Full Title: Prospective Comparison of Phenpocoumon (Marcumar) and Acetylsalicylic Acid (ASS) as to Progression of the Valvular and Coronary Calcification.
    Medical condition: Treatment with oral anti-coagulants prevents thromboembolic complications e.g at atrial fibrillation or artificial heart valves. Primary objective of the study is the prospective comparison of the ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2007-005070-31 Sponsor Protocol Number: CHUBX 2007/19 Start Date*: 2007-12-04
    Sponsor Name:CHU de Bordeaux
    Full Title: Analyse prospective des pontages et valves aortiques sous anticoagulation conventionnelle versus hemi-dose en système clos et coa
    Medical condition: Cardiopahtie / Valvulopathie
    Disease: Version SOC Term Classification Code Term Level
    9.1 10057103 Cardiac valvulopathy LLT
    9.1 10011077 Coronary artery bypass LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-000608-40 Sponsor Protocol Number: No-DAPT-TAVI Start Date*: 2018-07-06
    Sponsor Name:AOU DI BOLOGNA POLICLINICO S.ORSOLA-MALPIGHI
    Full Title: Aspirin versus Aspirin plus Clopidogrel in Patients Undergoing Transcatheter Aortic Valve Replacement: a Randomized Multicenter Study
    Medical condition: valvular aortic stenosis submitted to TAVI
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10002918 Aortic valve stenosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2010-018490-38 Sponsor Protocol Number: 1616 Start Date*: 2010-06-14
    Sponsor Name:Anæstesiologisk Afd. I, Skejby Sygehus
    Full Title: Effekten af levosimendan på systolisk deformation og diastolisk funktion hos patienter med operationskrævende aortastenose og svær hypertrofi af venstre ventrikel
    Medical condition: Aortaklapsstenose Diastolisk dysfunktion
    Disease: Version SOC Term Classification Code Term Level
    12.1 10002906 Aortic stenosis LLT
    12.1 10052337 Diastolic dysfunction LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2011-000111-26 Sponsor Protocol Number: MEIN/10/Ran-Did/002 Start Date*: 2011-07-01
    Sponsor Name:A. MENARINI PHARMA U.K.,
    Full Title: Effect of late sodium current inhibition on MRI measured diastolic dysfunction and myocardial perfusion reserve in aortic stenosis - a proof of concept study.
    Medical condition: Aortic stenosis
    Disease: Version SOC Term Classification Code Term Level
    13.1 10007541 - Cardiac disorders 10002918 Aortic valve stenosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2012-003391-39 Sponsor Protocol Number: 9026 Start Date*: 2012-10-26
    Sponsor Name:University Hospital of Montpellier
    Full Title: Ballon aortic valvuloplasty performed without heparin to decrease vascular and bleeding complications of the procedure
    Medical condition: Aortic stenosis
    Disease: Version SOC Term Classification Code Term Level
    14.1 10047065 - Vascular disorders 10002906 Aortic stenosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2016-002291-27 Sponsor Protocol Number: RIVAR-CTP-01 Start Date*: 2016-11-07
    Sponsor Name:Aalborg University Hospital
    Full Title: Randomized trial of aspirin versus rivaroxaban after replacement of the aortic valve with a biological valve prosthesis
    Medical condition: Aortic valve stenosis
    Disease: Version SOC Term Classification Code Term Level
    19.0 10007541 - Cardiac disorders 10002918 Aortic valve stenosis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-003927-13 Sponsor Protocol Number: REAC-TAVI2 Start Date*: 2021-10-15
    Sponsor Name:Fundación Biomédica Galicia Sur
    Full Title: Single antiplatelet therapy with Ticagrelor vs Aspirin after Transcatheter Aortic Valve Implantation: multicenter randomized clinical trial. REAC TAVI 2
    Medical condition: Symptomatic severe aortic stenosis
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004865 10077017 TAVI LLT
    20.0 10007541 - Cardiac disorders 10002918 Aortic valve stenosis PT
    20.1 10047065 - Vascular disorders 10002906 Aortic stenosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-002015-17 Sponsor Protocol Number: 2016-002015-17 Start Date*: 2017-03-10
    Sponsor Name:Odense University Hospital
    Full Title: Low-flow Low-gradient Aortic Stenosis – Diagnostic Usefullness of Ivabradine
    Medical condition: Aortic valve stenosis with reduced ejection fraction
    Disease: Version SOC Term Classification Code Term Level
    19.0 10007541 - Cardiac disorders 10002918 Aortic valve stenosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2009-010191-19 Sponsor Protocol Number: ALS-002-2009 Start Date*: 2010-03-19
    Sponsor Name:Alloksys Life Sciences BV
    Full Title: A randomized, double-blind, placebo-controlled phase IIIa study on bIAP, an anti-inflammatory moiety, in patients undergoing combined aortic valve replacement and coronary artery bypass grafting.
    Medical condition: Patients undergoing invasive cardiac surgery with prolonged perfusion time. This often is associated with potentially life-threatening inflammatory complications due to ischemic periods during surg...
    Disease: Version SOC Term Classification Code Term Level
    12.0 10057944 Combined valvular disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-004653-24 Sponsor Protocol Number: ARBAS041218 Start Date*: 2020-06-15
    Sponsor Name:Odense Universitets Hospital
    Full Title: Impact of an Angiotensin Receptor Blocker in Aortic Stenosis – A Randomized Controlled Trial
    Medical condition: Aortic valve stenosis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10002918 Aortic valve stenosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2008-002650-38 Sponsor Protocol Number: Pre65 Start Date*: 2008-07-01
    Sponsor Name:Organisation name was not entered
    Full Title: Vähentääkö pregabaliini opioidikipulääkityksen tarvetta ja kroonisen kivun esiintyvyyttä alle 65-vuotiailla potilailla sydänleikkauksen jälkeen?
    Medical condition: Tutkimukseen otetaan potilaan suostumuksella alle 65-vuotiaita avosydänleikkauk-seen joko koronaariohitus- tai sydämen läppärekonstruktioon tulevia potilaita, jotka leikatataan perfuusioleikkauksena.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10011099 Coronary disease LLT
    9.1 10002906 Aortic stenosis LLT
    9.1 10027716 Mitral insufficiency LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-005501-27 Sponsor Protocol Number: 80843 Start Date*: 2022-02-04
    Sponsor Name:Rigshospitalet
    Full Title: 64Cu-DOTATATE PET/CT-skanning to diagnose macrophage infiltation in the heart valves of patients with infectiv endocarditis.
    Medical condition: Infective endocarditis
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004862 10014688 Endocarditis, valve unspecified LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2013-003201-26 Sponsor Protocol Number: 1160.186 Start Date*: 2014-07-21
    Sponsor Name:Boehringer Ingelheim AB
    Full Title: A prospective Randomised, open label, blinded endpoint (PROBE) study to Evaluate DUAL antithrombotic therapy with dabigatran etexilate (110mg and 150mg b.i.d.) plus clopidogrel or ticagrelor vs. tr...
    Medical condition: Patients with non valvular atrial fibrillation (NVAF) that have undergone a percutaneous coronary intervention (PCI) with stenting
    Disease: Version SOC Term Classification Code Term Level
    19.0 10007541 - Cardiac disorders 10003658 Atrial fibrillation PT
    19.0 10042613 - Surgical and medical procedures 10065608 Percutaneous coronary intervention PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) DK (Completed) GR (Completed) DE (Completed) PT (Completed) HU (Completed) ES (Completed) FI (Completed) NL (Completed) CZ (Completed) AT (Completed) IT (Completed) BE (Completed) IE (Completed) SK (Completed) SI (Completed) GB (Completed) BG (Completed) HR (Completed) PL (Completed) FR (Completed)
    Trial results: View results
    EudraCT Number: 2015-005630-21 Sponsor Protocol Number: D5130C00173 Start Date*: 2016-06-30
    Sponsor Name:National and Kapodistrian University of Athens
    Full Title: A Prospective, Multicentre, Randomized, Open Label, Blinded Endpoint, Phase 3 Trial to Assess the Safety and Efficacy of Prophylactic TicagrelOr with Acetylsalicylic Acid versus CLopidogrel with Ac...
    Medical condition: Preventing cerebrovascular embolic events during the TAVI procedure
    Disease: Version SOC Term Classification Code Term Level
    19.0 10007541 - Cardiac disorders 10002918 Aortic valve stenosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GR (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
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