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Clinical trials for Vitamin K

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44336   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    144 result(s) found for: Vitamin K. Displaying page 1 of 8.
    1  2  3  4  5  6  7  8  Next»
    EudraCT Number: 2010-022826-34 Sponsor Protocol Number: 08092010 Start Date*: 2011-04-28
    Sponsor Name:
    Full Title: Randomised trial to investigate possible differences in biological availability and effectiveness between vitamin K solution in oil and vitamin K tablets.
    Medical condition: Lowering anticoagulant effect of vitamin K antagonists in case of over-anticoagulation or pending diagnostic or therapeutic invase action.
    Disease: Version SOC Term Classification Code Term Level
    12.1 10053755 Vitamin K antagonist LLT
    12.1 10058768 Vitamin K LLT
    12.1 10011970 Decreased INR LLT
    12.1 10037818 Raised INR LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-004578-15 Sponsor Protocol Number: 01082007 Start Date*: 2008-03-03
    Sponsor Name:Dutch Heart Foundation
    Full Title: A randomised, double blind placebo controlled trial to (A) assess the optimal vitamin K dosage for supplementation, and (B) to access whether complications of anticoagulation treatment will diminis...
    Medical condition: Anti-coagulationtreatment with vitamine K antagonists.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10058768 Vitamin K LLT
    9.1 10053755 Vitamin K antagonist LLT
    9.1 10009728 Coagulation and bleeding analyses HLT
    9.1 10043607 Thrombosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-004906-88 Sponsor Protocol Number: NL69395.042.19 Start Date*: 2020-04-24
    Sponsor Name:University Medical Center Groningen
    Full Title: Placebo-controlled double-blind randomized controlled trial investigating vitamin K supplementation on vascular calcification propensity in vitamin K deficient renal transplant recipients
    Medical condition: Vitamin K deficiency is highly prevalent among renal transplant recipients, promotes vascular calcification, and is associated with an increased risk of cardiovascular disease. Supplementation of ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-001007-18 Sponsor Protocol Number: 2989 Start Date*: 2005-06-03
    Sponsor Name:Royal Victoria Infirmary
    Full Title: Reversal of warfarin anticoagulation with oral vitamin K: towards a better management of over-anticoagulation
    Medical condition: Patients with thromboembolic disorders are anticogulated with warfarin. However excessive over-anticoagulation can increase the patient risk of bleeding. Oral vitamin K is routinely used for revers...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-006238-87 Sponsor Protocol Number: 4717 Start Date*: 2010-01-22
    Sponsor Name:Newcastle upon Tyne Hospitals NHS Foundation Trust
    Full Title: Improving the safety and efficacy of anticoagulation therapy for thromboembolic disease through vitamin K
    Medical condition: Patients will be recruited who are receiving long term warfarin therapy for the treatment or prevention of venous or arterial thrombosis or embolism
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2018-002291-41 Sponsor Protocol Number: 1 Start Date*: 2018-08-30
    Sponsor Name:Gelderse Vallei Hospital
    Full Title: The effect of administering VITamin K preprocedural on the vitamin K dependent coagulation factors and the INR in patients anticoagulated with ACEnocoumarol
    Medical condition: Adult patients using acenocoumarol and planned to undergo an invasive procedure for which the effect of the anticoagulants should be reversed.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-005306-39 Sponsor Protocol Number: VitaminKStudy Start Date*: 2009-06-29
    Sponsor Name:RWTH Aachen University, represented by the rector, himself represented by Clinical Trial Center Aachen (CTC-A)
    Full Title: Food supplementation with Vitamin K for MGP-activation and inhibition of progression of aortic valve calcification
    Medical condition: progression of aortic valve calcification
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10050559 Aortic valve calcification PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2008-006451-52 Sponsor Protocol Number: 4474 Start Date*: 2009-01-27
    Sponsor Name:Newcastle upon Tyne Hospitals NHS Foundation Trust
    Full Title: An investigation of the association between vitamin K intake, vitamin K epoxide reductase subunit (VKORC1) genotype and anticoagulation response to warfarin
    Medical condition: Patients will be recruited who are receiving long term warfarin therapy for the treatment or prevention of venous or arterial thrombosis or embolism
    Disease: Version SOC Term Classification Code Term Level
    9.1 10043566 Thromboembolism LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-004265-32 Sponsor Protocol Number: 0206 Start Date*: 2012-01-24
    Sponsor Name:Academic Medical Center
    Full Title: Left Ventricular Thrombus Formation after Acute Myocardial Infarction - a randomized multi-center trial comparing 2 different anti-thrombotic regimens
    Medical condition: Left Ventricular thrombus formation after acute myocardial infarction
    Disease: Version SOC Term Classification Code Term Level
    14.0 10042613 - Surgical and medical procedures 10053755 Vitamin K antagonist LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-000845-12 Sponsor Protocol Number: 070219 Start Date*: Information not available in EudraCT
    Sponsor Name:Canisius Wilhelmina Ziekenhuis
    Full Title: The effectiveness of vitamin D suppletion on improving symptoms of fatigue in children between 12 and 18 years old
    Medical condition: Fatigue
    Disease:
    Population Age: Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-003949-41 Sponsor Protocol Number: 36810 Start Date*: 2014-11-06
    Sponsor Name:VU medical Center
    Full Title: Role of different phosphate binders on absorption of vitamin K, metabolism of matrix γ-carboxy-glutamaat (Gla) proteïne (MGP).
    Medical condition: Vascular calcification, phosphate binders and patients on hemodialysis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2010-022587-12 Sponsor Protocol Number: VitK Start Date*: 2015-01-20
    Sponsor Name:Guy's and St. Thomas' NHS Foundation Trust
    Full Title: The Additive effect of Vitamin K Supplementation and Bisphosphonate on Fracture Risk in Post-menopausal Osteoporosis
    Medical condition: Post-menopausal osteoporosis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031285 Osteoporosis postmenopausal PT
    20.1 10028395 - Musculoskeletal and connective tissue disorders 10031286 Osteoporosis senile LLT
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031283 Osteoporosis fracture LLT
    21.0 10028395 - Musculoskeletal and connective tissue disorders 10017082 Fracture due to osteoporosis LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-004898-41 Sponsor Protocol Number: NBK241/1/2020 Start Date*: 2021-03-31
    Sponsor Name:MEDICAL UNIVERSITY OF GDAŃSK
    Full Title: A multicentre, parallel group, randomised, double blind, placebo-controlled, phase II study evaluating the efficacy and safety of reperfusion thrombolytic therapy with intravenous recombinant tissu...
    Medical condition: Acute ischemic stroke
    Disease: Version SOC Term Classification Code Term Level
    22.1 10029205 - Nervous system disorders 10061256 Ischaemic stroke PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2006-000945-20 Sponsor Protocol Number: vitk2006 Start Date*: 2006-08-22
    Sponsor Name:Barts and the London NHS Trust
    Full Title: To investigate the effect of vitamin K supplementation on markers of bone turnover and bone density in adolescents and adults with cystic fibrosis
    Medical condition: Cystic Fibrosis
    Disease: Version SOC Term Classification Code Term Level
    8.1 10011762 Cystic fibrosis LLT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2014-000392-33 Sponsor Protocol Number: 2014PROPER3 Start Date*: 2015-06-30
    Sponsor Name:University Medical Center Groningen
    Full Title: Fixed versus variable dosing strategy of prothrombin complex concentrate for bleeding complications of vitamin K antagonists
    Medical condition: Major bleeding complications of vitamin K antagonists
    Disease: Version SOC Term Classification Code Term Level
    17.0 10042613 - Surgical and medical procedures 10009678 Clotting factor transfusion PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-001557-26 Sponsor Protocol Number: CV185-048 Start Date*: 2008-04-29
    Sponsor Name:Bristol Myers Squibb International Corporation
    Full Title: Apixaban Versus Acetylsalicyclic Acid (ASA) to Prevent Stroke in Atrial Fibrillation Patients Who Have Failed or are Unsuitable for Vitamin K Antagonist Treatment: A Randomized Double Blind Trial ...
    Medical condition: Patients with atrial fibrillation and at least one additional risk factor for stroke who have failed or are unsuitable for vitamin K antagonist therapy.
    Disease: Version SOC Term Classification Code Term Level
    13.1 10029205 - Nervous system disorders 10042244 Stroke LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) FR (Completed) SE (Completed) BE (Completed) DE (Completed) FI (Completed) ES (Completed) DK (Completed) CZ (Completed) AT (Completed) GR (Completed) PL (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2010-021264-14 Sponsor Protocol Number: 10-003 Start Date*: 2012-09-25
    Sponsor Name:RWTH Aachen University represented by the rector, himself represented by the dean of the Medical Faculty
    Full Title: Vitamin K1 to slow vascular calcification in hemodialysis patients. Multicenter, multinational, randomized controlled clinical trial
    Medical condition: dialysis patients
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) BE (Completed)
    Trial results: View results
    EudraCT Number: 2008-002387-33 Sponsor Protocol Number: VitalD Start Date*: 2008-06-03
    Sponsor Name:Hôpital Erasme
    Full Title: Impact of 25-hydroxy vitamin D deficiency and its correction on mineral and bone disorde among hemodialysis patients
    Medical condition: 25-OH vitamin D deficiency and mineral - bone disorder in hemodialysis patients
    Disease: Version SOC Term Classification Code Term Level
    9.1 10061292 Mineral metabolism disorder LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-000600-29 Sponsor Protocol Number: UX023-CL301 Start Date*: 2016-09-15
    Sponsor Name:Ultragenyx Pharmaceuticals Inc
    Full Title: A Randomized, Open-Label, Phase 3 Study to Assess the Efficacy and Safety of KRN23 Versus Oral Phosphate and Active Vitamin D Treatment in Pediatric Patients with X-linked Hypophosphatemia (XLH)
    Medical condition: X-linked hypophosphatemia (XLH) is a disorder of renal phosphate wasting, defective bone mineralisation, and impaired growth plate or endochondral ossification caused by inactivating mutations in t...
    Disease: Version SOC Term Classification Code Term Level
    19.1 100000004850 10016206 Familial hypophosphataemic rickets LLT
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: DK (Prematurely Ended) IE (Completed) DE (Completed) ES (Prematurely Ended) SE (Completed) GB (Completed) IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2016-002649-41 Sponsor Protocol Number: LEX-209 Start Date*: 2017-06-19
    Sponsor Name:Octapharma Pharmazeutika Produktionsges.m.b.H
    Full Title: A Phase III, randomized, double-blind, multicenter study to assess the efficacy and safety of OCTAPLEX, a four-factor prothrombin complex concentrate (4F-PCC), compared to the 4F-PCC Beriplex® P/N ...
    Medical condition: Reversal of vitamin K antagonist (VKA) induced anticoagulation in patients needing urgent surgery associated with significant bleeding risk.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10065667 Haemorrhage prophylaxis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) PL (Completed) ES (Prematurely Ended) BG (Completed) RO (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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