Flag of the European Union EU Clinical Trials Register Help

Clinical trials for hypothyroidism

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

  • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).


    The EU Clinical Trials Register currently displays   43801   clinical trials with a EudraCT protocol, of which   7272   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
    How to search [pdf]
    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
    Advanced Search: Search tools
     
    129 result(s) found for: hypothyroidism. Displaying page 1 of 7.
    1  2  3  4  5  6  7  Next»
    EudraCT Number: 2010-023481-41 Sponsor Protocol Number: salerno1 Start Date*: 2011-02-22
    Sponsor Name:UNIVERSITA` DEGLI STUDI DI NAPOLI FEDERICO II
    Full Title: Evaluation of long term risk-benefit profile of levothyroxin treatment in children with congenital hypothyroidism:influence of initial levothyroxine dose on neurodevelopment, growth, cardiovascular...
    Medical condition: Congenital hypothyroidism
    Disease: Version SOC Term Classification Code Term Level
    9.1 10021115 LLT
    Population Age: Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-001261-25 Sponsor Protocol Number: T3T42017 Start Date*: 2018-01-04
    Sponsor Name:AOU FEDERICO II
    Full Title: PHARMACOLOGICAL, NO PROFIT, PROSPECTIVE RANDOMIZED, DOUBLE-BLIND PLACEBO, CONTROLLED STUDY TO EVALUATE THE EFFICACY OF LEVOTHYROXINE AND LIOTIRONINE (LT4+LT3) IN POST-SURGICAL HYPOTHYROIDISM PATIE...
    Medical condition: POST-SURGICAL HYPOTHYROIDISM
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004863 10036429 Postsurgical hypothyroidism LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-001248-12 Sponsor Protocol Number: THYR69 Start Date*: 2015-10-30
    Sponsor Name:AZIENDA OSPEDALIERO-UNIVERSITARIA MEYER
    Full Title: Randomized crossover trial for the evaluation of the possible effects in the intestine of two different pharmaceutical forms of L - Thyroxine in patients with primary acquired hypothyroidism
    Medical condition: Primary acquired hypothyroidism
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004860 10000559 Acquired hypothyroidism LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2013-002139-15 Sponsor Protocol Number: 10660/13 Start Date*: 2013-12-18
    Sponsor Name:POLICLINICO GEMELLI
    Full Title: STUDY COMPARING LIQUID FORMULATION OF LEVOTHYROXINE AND SOLID FORMULATION OF LEVOTHYROXINE ON THE STATE OF WELL- BEING QUALITY OF LIFE AND THE HORMONAL AND METABOLIC PARAMETERS IN THYROIDECTOMIZED ...
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004863 10036429 Postsurgical hypothyroidism LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-000687-41 Sponsor Protocol Number: LEVOLIO Start Date*: 2016-08-01
    Sponsor Name:AZIENDA UNITÀ SANITARIA LOCALE DI MODENA
    Full Title: COMBINED SUBSTITUTIVE THERAPY WITH LEVOTHYROXINE AND LIOTHYRONINE IN THYROIDECTOMIZED PATIENTS: EFFECTS ON PERIPHERICAL TISSUES. A PROSPECTIVE RANDOMIZED CONTROLLED DOUBLE BLIND STUDY.
    Medical condition: Post-surgical hypothyroidism in substitutive therapy
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004863 10036429 Postsurgical hypothyroidism LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-002614-36 Sponsor Protocol Number: 05ICHF/T407 Start Date*: 2007-04-20
    Sponsor Name:IBSA
    Full Title: Multicentre, controlled, randomised, open-label, cross-over clinical study of the efficacy and tolerability of L-thyroxine T4 soft capsules, in comparison to L-thyroxine tablets, in thyroidectomi...
    Medical condition: Substitutive and/or TSH suppressive therapy in thyroidectomized patients
    Disease: Version SOC Term Classification Code Term Level
    9.1 10021117 Hypothyroidism postoperative LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended) FR (Completed)
    Trial results: View results
    EudraCT Number: 2007-005242-21 Sponsor Protocol Number: 07_ENDO_66 Start Date*: 2008-05-07
    Sponsor Name:THE CHRISTIE NHS FOUNDATION TRUST
    Full Title: A pilot study of replacement therapy with recombinant TSH in central hypothyroidism
    Medical condition: Central Hypothyroidism which is due to deficiency of TSH caused by the disease, surgery or radiotherapy of the pituitary gland.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2014-000574-19 Sponsor Protocol Number: LT4RAIT Start Date*: 2014-03-24
    Sponsor Name:AZIENDA OSPEDALIERO-UNIVERSITARIA DI PARMA
    Full Title: Experimental study for the evaluation of the effect of radioactive iodine therapy on free thyroxine circulating levels after oral administration of sodium levo-thyroxine in patients thyroidectomiz...
    Medical condition: patients thyroidectomized for differentiated thyroid cancer
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004863 10057242 Post surgical hypothyroidism LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-001760-38 Sponsor Protocol Number: T4drops-02 Start Date*: 2018-10-01
    Sponsor Name:Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A.
    Full Title: Clinical study of the efficacy of liquid (drops) versus classic (tablets) formulations of levothyroxine in replacement therapy of adults with clinical hypothyroidism.
    Medical condition: Hypothyroidism in adults
    Disease: Version SOC Term Classification Code Term Level
    20.0 10014698 - Endocrine disorders 10021114 Hypothyroidism PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GR (Completed)
    Trial results: View results
    EudraCT Number: 2015-002462-24 Sponsor Protocol Number: T4drops-01 Start Date*: 2015-11-18
    Sponsor Name:UNI-PHARMA SA
    Full Title: Clinical study of the efficacy of liquid (drops) versus classic (tablets) formulations of Levothyroxine in replacement therapy of congenital hypothyroidism in infancy and childhood
    Medical condition: Hypothyroidism in children.
    Disease: Version SOC Term Classification Code Term Level
    18.1 10014698 - Endocrine disorders 10021114 Hypothyroidism PT
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: GR (Completed)
    Trial results: View results
    EudraCT Number: 2010-018663-42 Sponsor Protocol Number: T3S01-10 Start Date*: 2010-06-15
    Sponsor Name:BRACCO
    Full Title: Substitutive therapy of hypothyroid patients with L-thyroxine (T4) plus T3 sulfate (T3S). A Phase II, open-label, single centre, parallel group study on therapeutic efficacy and tolerability
    Medical condition: Thyroidectomized patients without endogenous hormonal production (Tg<5) in stable substitutive therapy with T4
    Disease: Version SOC Term Classification Code Term Level
    9.1 10021117 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2016-001516-38 Sponsor Protocol Number: MISEM/2016 Start Date*: 2017-02-16
    Sponsor Name:PROF.EFISIO PUXEDDU, SEZIONE MEDICINA INTERNA SCIENZE ENDOCRINE E METABOLICHE, UNIVERSITà DI PERUGIA
    Full Title: Levothyroxine soft-gel efficacy with variation of intaking time in hypothyroidism replacement therapy
    Medical condition: patients who underwent total thyroidectomy followed or not by ablative radioiodine therapy for differentiated thyroid carcinoma and then treated with levothyroxine replacement therapy, in disease r...
    Disease: Version SOC Term Classification Code Term Level
    20.0 10014698 - Endocrine disorders 10021114 Hypothyroidism PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-000824-14 Sponsor Protocol Number: T3S01-11 Start Date*: 2011-05-12
    Sponsor Name:BRACCO
    Full Title: Pharmacokinetics of orally aministered single doses (40-60-80 mcg) of T3 sulfate (T3S)-sodium salt. A single blind, randomized, placebo-controlled clinical study in healthy subjects
    Medical condition: Healthy subjects (hypothyroidism)
    Disease: Version SOC Term Classification Code Term Level
    14.0 10014698 - Endocrine disorders 10021114 Hypothyroidism PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2012-003677-25 Sponsor Protocol Number: 12I/T405 Start Date*: 2013-01-27
    Sponsor Name:IBSA INSTITUT BIOCHIMIQUE SA
    Full Title: Safety and bioavailability of Tirosint (Levothyroxine Sodium) Oral Solution administered as single dose with or without water in hypothyroid patients.
    Medical condition: Both genders thyroidectomized patients, with thyroglobulin (Tg) circulating levels below 5 ng/mL and no evidence of Tg antibodies (Tg-Ab), at stable (at least 3 months) 100 μg/day levothyroxine ...
    Disease: Version SOC Term Classification Code Term Level
    14.1 10014698 - Endocrine disorders 10021114 Hypothyroidism PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2012-005732-28 Sponsor Protocol Number: LE-9999-401-BE Start Date*: 2013-06-14
    Sponsor Name:Takeda Belgium
    Full Title: A multicentre, open-label switch study to investigate the necessity of dose adjustment after switching from L-Thyroxine Christiaens® to the new levothyroxine sodium test formulation in (near) total...
    Medical condition: Patient that underwent a near total thyroidectomy and therefore are compelled to take levothyroxine hormone substition therapy.
    Disease: Version SOC Term Classification Code Term Level
    16.0 100000004865 10043777 Thyroidectomy total LLT
    16.0 10014698 - Endocrine disorders 10021114 Hypothyroidism PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2019-000239-21 Sponsor Protocol Number: 2019-000239-21 Start Date*: 2019-10-09
    Sponsor Name:Birte Nygaard, Dept of Endocrinology, Herelv Hosptial, University og Copenhagen,
    Full Title: Characterization of L-T4 treated patients with persistent hypothyroid symptoms - Effect of Synthetic LT4/L-T3 combination therapy versus desiccated animal thyroid extract?
    Medical condition: Hypothyroidism
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004860 10045920 Unspecified hypothyroidism LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2021-006055-33 Sponsor Protocol Number: HypoGI Start Date*: 2023-03-05
    Sponsor Name:Medical University of Vienna
    Full Title: Assessing the feasibility of pharmacologically induced hypothyroidism in patients with advanced pancreatic cancer - a pilot study
    Medical condition: Patients with newly diagnosed metastatic pancreatic cancer
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-000942-39 Sponsor Protocol Number: NL34476.068.11 Start Date*: 2011-06-20
    Sponsor Name:CTMM, the Center for Translational Molecular Medicine
    Full Title: Effects of thyroid hormone treatment on mitochondrial function, ectopic fat accumulation, insulin sensitivity and brown adipose tissue in type 2 diabetes mellitus.
    Medical condition: This trial includes overweight patients with both hypothyroidism and type 2 diabetes.
    Disease: Version SOC Term Classification Code Term Level
    13.1 10014698 - Endocrine disorders 10021114 Hypothyroidism PT
    13.1 10027433 - Metabolism and nutrition disorders 10045242 Type II diabetes mellitus LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-004876-20 Sponsor Protocol Number: GRAV12 Start Date*: 2012-11-13
    Sponsor Name:FONDAZIONE IRCCS CA' GRANDA OSPEDALE MAGGIORE POLICLINICO DI MILANO
    Full Title: Study on the effectiveness of two different formulations of L-thyroxine compress and liquid oral solution) in pregnant patients affected with hypothyroidism.
    Medical condition: Hypothyroidism in pregnant patients
    Disease: Version SOC Term Classification Code Term Level
    14.1 10014698 - Endocrine disorders 10014698 Endocrine disorders SOC
    Population Age: Adults Gender: Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-003673-34 Sponsor Protocol Number: BioCellThyr Start Date*: 2018-04-05
    Sponsor Name:Oslo University Hospital, Department of Endocrinologi, Morbid Obesity and Preventive Medicine
    Full Title: Identification of non-responders to levothyroxine-therapy: development of biomarkers reflecting T4 and T3 action at the tissue level
    Medical condition: Women with dysregulated hypothyroidism
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    Download Options:
    Number of Trials to download:
    Download Content:
    Download Format:
    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
    1  2  3  4  5  6  7  Next»
    Query did not match any studies.
    For support, Contact us.
    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

    European Medicines Agency © 1995-2024 | Domenico Scarlattilaan 6, 1083 HS Amsterdam, The Netherlands
    EMA HMA