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Clinical trials for Levels of biomarkers

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44347   clinical trials with a EudraCT protocol, of which   7375   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    1,169 result(s) found for: Levels of biomarkers. Displaying page 3 of 59.
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    EudraCT Number: 2007-005103-18 Sponsor Protocol Number: NC20971 Start Date*: 2008-03-21
    Sponsor Name:F.Hoffmann-La Roche Ltd.
    Full Title: A phase III, double-blind, randomized placebo-controlled study, to evaluate the effects of RO4607381 on cardiovascular (CV) risk in stable CHD patients, with a documented recent Acute Coronary Synd...
    Medical condition: Stable CHD patients, with a documented recent Acute Coronary Syndrome (ACS)
    Disease: Version SOC Term Classification Code Term Level
    9.1 10007649 Cardiovascular disorder LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed) HU (Prematurely Ended) GB (Prematurely Ended) CZ (Prematurely Ended) AT (Prematurely Ended) NL (Prematurely Ended) SK (Completed) ES (Prematurely Ended) IE (Prematurely Ended) DK (Prematurely Ended) DE (Prematurely Ended) SE (Prematurely Ended) BE (Prematurely Ended) IT (Prematurely Ended) FI (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2008-001395-74 Sponsor Protocol Number: MER-101-03 Start Date*: 2008-06-30
    Sponsor Name:Merrion Pharmaceuticals plc
    Full Title: A multi-center Phase II study to compare MER-101 20mg tablets to intravenous Zometa® 4mg in male bisphosphonate-naïve, hormone-refractory prostate cancer patients
    Medical condition: Hormone - refractory prostate cancer with bone metastases and no prior bisphoshonate treatment
    Disease: Version SOC Term Classification Code Term Level
    9.1 10062904 Hormone-refractory prostate cancer LLT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: EE (Completed) LV (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-000893-69 Sponsor Protocol Number: BN42082 Start Date*: 2020-10-28
    Sponsor Name:F. Hoffmann-La Roche Ltd
    Full Title: A PHASE IIIB MULTICENTER, RANDOMIZED, DOUBLE-BLIND, CONTROLLED STUDY TO EVALUATE THE EFFICACY, SAFETY AND PHARMACOKINETICS OF A HIGHER DOSE OF OCRELIZUMAB IN ADULTS WITH RELAPSING MULTIPLE SCLEROSIS
    Medical condition: Relapsing Multiple Sclerosis (MS)
    Disease: Version SOC Term Classification Code Term Level
    20.1 10029205 - Nervous system disorders 10028245 Multiple sclerosis PT
    21.1 10029205 - Nervous system disorders 10063399 Relapsing-remitting multiple sclerosis PT
    20.0 10029205 - Nervous system disorders 10048393 Multiple sclerosis relapse PT
    20.1 10029205 - Nervous system disorders 10039720 Sclerosis multiple LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: PL (Trial now transitioned) PT (Trial now transitioned) GB (GB - no longer in EU/EEA) HU (Trial now transitioned) NL (Ongoing) DE (Trial now transitioned) FR (Trial now transitioned) DK (Trial now transitioned) BE (Trial now transitioned) GR (Trial now transitioned) IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2011-005763-24 Sponsor Protocol Number: CTSUBEST-D Start Date*: 2012-06-28
    Sponsor Name:University of Oxford
    Full Title: BEST-D (Biochemical efficacy and safety trial of vitamin D): a dose-finding trial assessing biochemical and vascular effects of high dose vitamin D
    Medical condition: BEST-D is a trial assessing the efficacy and safety of vitamin D3 supplements (two doses 50μg and 100μg); hence there are no specific medical conditions under study. Volunteers aged 65 years or old...
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004861 10047630 Vitamin depletion LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2010-022529-14 Sponsor Protocol Number: WC25501 Start Date*: 2011-02-04
    Sponsor Name:F.Hoffmann-La Roche
    Full Title: A phase III, double-blind, randomized, placebo-controlled, multi-center study evaluating the efficacy and safety of dalcetrapib on lipids, lipoproteins, apolipoproteins and markers of CV risk in pa...
    Medical condition: Coronary Heart Disease
    Disease: Version SOC Term Classification Code Term Level
    14.0 10007541 - Cardiac disorders 10068617 Coronary heart disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) GB (Completed) NL (Completed)
    Trial results: Removed from public view
    EudraCT Number: 2005-005347-25 Sponsor Protocol Number: INEF Start Date*: 2006-01-17
    Sponsor Name:Johannes Gutenberg-Universität Mainz, II. Med. Klinik (ausführende Stelle), Prof. Dr. med. T. Münzel
    Full Title: Impact of 12 weeks of oral niacin on endothelial function, lipid composition and cardiovascular biomarkers in patients with coronary artery disease: A prospective, randomized, double-blind, placebo...
    Medical condition: Women or men > 35 and < 80 years of age with a documented, clinically stable coronary artery disease (CAD) and a flow-mediated vasodilatation (FMD) of less than 8% from the heart catheter register ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-004913-32 Sponsor Protocol Number: DG-051-CV-202 Start Date*: 2008-04-15
    Sponsor Name:deCODE genetics ehf.
    Full Title: A randomized, double-blind, placebo-controlled evaluation of the pharmacodynamics, pharmacokinetics, and safety of DG-051 in patients with a history of MI
    Medical condition: Cardiovascular diseases
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IS (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2011-002233-19 Sponsor Protocol Number: ASA-CABG-01 Start Date*: 2011-10-14
    Sponsor Name:Karolinska Institute
    Full Title: Antiplatelet effects of once versus twice daily dosing of aspirin after coronary artery bypass grafting
    Medical condition: Patients having successfully undergone coronary artery bypass graft (CABG) surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2011-003179-12 Sponsor Protocol Number: MN0511_1 Start Date*: 2012-01-09
    Sponsor Name:University Hospital of Wuerzburg, Medical Director
    Full Title: Mineralocorticoid Receptor antagonists in End stage reNal DiseAse
    Medical condition: Hemodialysis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2020-000148-76 Sponsor Protocol Number: 3.0 Start Date*: 2021-08-04
    Sponsor Name:Stockholm Health Care Services
    Full Title: Effects of Montelukast on neuroinflammation in Parkinson's Disease. An open-label single-center trial.
    Medical condition: Parkinson's disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2014-002282-30 Sponsor Protocol Number: 2014-2 Start Date*: 2014-07-30
    Sponsor Name:County council of Ostergotland
    Full Title: Effects of oxygen treatment on mechanisms involved in ischemia-reperfusion injury: A pilot study in healthy volunteers.
    Medical condition: Study performed in healthy male vonlunteers.
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-000135-31 Sponsor Protocol Number: TABENETOC Start Date*: 2022-01-12
    Sponsor Name:Region Östergötland
    Full Title: The Effect of tinzaparin on Biomarkers in FIGO Stage III-IV Ovarian Cancer Patients Undergoing Neoadjuvant Chemotherapy – A randomized pilot study
    Medical condition: Epithelial ovarian cancer
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: SE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2015-002701-11 Sponsor Protocol Number: ACE Start Date*: 2016-06-13
    Sponsor Name:Oslo University Hospital
    Full Title: ADJUVANT CHEMOTHERAPY IN ELDERLY – GERIATRIC ASSESSMENT AND PROGNOSTIC GENE SIGNATURES
    Medical condition: undergone R0-resection of for colon cancer stage III
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: NO (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2013-000900-41 Sponsor Protocol Number: WB28850 Start Date*: 2013-05-10
    Sponsor Name:F. Hoffmann-La Roche, Ltd.
    Full Title: A STUDY TO MEASURE SERUM PERIOSTIN, ASTHMA-RELATED BIOMARKERS AND RESPONSE TO PREDNISOLONE IN ADULT AND ADOLESCENT PATIENTS WITH SEVERE ORAL CORTICOSTEROID-DEPENDENT ASTHMA
    Medical condition: Severe corticosteroid-dependent asthma
    Disease:
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2019-003529-36 Sponsor Protocol Number: mRNA-3927-P101 Start Date*: 2020-12-18
    Sponsor Name:ModernaTX, Inc
    Full Title: A Global, Phase 1/2, Open-label, Dose Optimization Study to Evaluate the Safety, Pharmacodynamics, and Pharmacokinetics of mRNA-3927 in Participants with Propionic Acidemia
    Medical condition: Propionic Acidemia- Propionic acidemia is an autosomal recessive disorder caused by loss-of-function mutations in PCCA or PCCB (and in rare instances, mutations in both PCCA and PCCB), resulting in...
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004850 10080615 Propionic acidemia LLT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2023-000061-14 Sponsor Protocol Number: BCN04-DASA Start Date*: 2023-05-26
    Sponsor Name:Institut de Recerca Germans Trias i Pujol
    Full Title: Safety and Impact of Dasatinib on Viral Persistence and Inflammation in People with HIV under Antiretroviral Treatment
    Medical condition: Human immunodeficiency virus (HIV)
    Disease: Version SOC Term Classification Code Term Level
    20.1 10021881 - Infections and infestations 10020161 HIV infection PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-000760-18 Sponsor Protocol Number: 13.034 Start Date*: 2014-11-24
    Sponsor Name:Prof. Peter Licht
    Full Title: Supplementary Epidural Analgesia in Video-Assisted Thoracic Surgery (VATS) - The SEAVATS Study.
    Medical condition: Cancer pulmones
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2016-001867-35 Sponsor Protocol Number: NNCIT-02 Start Date*: 2019-04-24
    Sponsor Name:TikoMed AB
    Full Title: Open, Randomized, Active Comparator-controlled, Multi-Center Study to Evaluate Safety and Efficacy of IBsolvMIR® in Islet Transplantation
    Medical condition: Type 1 Diabetes
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004861 10045228 Type I diabetes mellitus LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Prematurely Ended) NO (Prematurely Ended) NL (Completed)
    Trial results: View results
    EudraCT Number: 2016-004223-23 Sponsor Protocol Number: NI-0501-06 Start Date*: 2017-04-14
    Sponsor Name:Novimmune SA
    Full Title: A pilot, open-label, single arm, multicenter study to evaluate safety, tolerability, pharmacokinetics and efficacy of intravenous administrations of NI-0501, an anti-interferon gamma (anti-IFNγ) mo...
    Medical condition: Macrophage activation syndrome / Secondary hemophagocytic lymphohistiocytosis (MAS/sHLH) in patients with Systemic Juvenile Idiopathic Arthritis (sJIA)
    Disease: Version SOC Term Classification Code Term Level
    19.1 100000004851 10053867 Macrophage activation syndrome LLT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IT (Completed) FR (Completed) GB (GB - no longer in EU/EEA) ES (Completed) NL (Completed)
    Trial results: View results
    EudraCT Number: 2012-000756-34 Sponsor Protocol Number: 2012.001 Start Date*: 2012-11-02
    Sponsor Name:NeuroVive Pharmaceutical AB
    Full Title: Copenhagen Head Injury Ciclosporin (CHIC) Study: An open-label, uncontrolled Phase II -study to investigate pharmacokinetics, safety and biomarkers of effectiveness of NeuroSTAT® (ciclosporin) i...
    Medical condition: Severe Traumatic Brain Injury
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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