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Clinical trials for Tolerability

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44341   clinical trials with a EudraCT protocol, of which   7370   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    14,030 result(s) found for: Tolerability. Displaying page 34 of 702.
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    EudraCT Number: 2013-001259-11 Sponsor Protocol Number: 80-83600-98-10006 Start Date*: 2013-12-19
    Sponsor Name:Zon MW
    Full Title: Tacrolimus suppositories versus beclomethason suppositories for the treatment of proctitis refractory to local 5-ASA.
    Medical condition: Refractory and/of recurrent ulcerative proctitis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing) BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-000016-10 Sponsor Protocol Number: 3098A1-201-EU Start Date*: 2004-10-12
    Sponsor Name:Wyeth Research Division of Wyeth Pharmaceuticals Inc., Clinical Research and Development
    Full Title: A 3-MONTH, RANDOMIZED, DOUBLE-BLIND, PLACEBO- CONTROLLED, MULTICENTER, SAFETY, TOLERABILITY, AND EFFICACY STUDY OF 3 DOSES OF SRA-333 IN OUTPATIENTS WITH MILD TO MODERATE ALZHEIMER’S DISEASE WITH ...
    Medical condition: Alzheimer's Disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-000794-47 Sponsor Protocol Number: CTIN816A12201 Start Date*: 2023-01-13
    Sponsor Name:Novartis Farmacéutica, S.A.
    Full Title: A randomized, multi-centric, placebo-controlled, participant and investigator-blinded study to evaluate the safety, tolerability and efficacy of TIN816 in adult patients at risk for acute kidney in...
    Medical condition: Acute kidney injury
    Disease: Version SOC Term Classification Code Term Level
    21.1 10038359 - Renal and urinary disorders 10069339 Acute kidney injury PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing) DE (Trial now transitioned) FR (Trial now transitioned) CZ (Trial now transitioned) HU (Trial now transitioned) BE (Trial now transitioned) EE (Trial now transitioned) LT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-002769-33 Sponsor Protocol Number: EP0132 Start Date*: 2021-05-28
    Sponsor Name:UCB Biopharma SRL
    Full Title: A Multicenter, Open-Label, Single-Arm Study to Evaluate Long-Term Safety, Tolerability, and Efficacy of Brivaracetam in Study Participants 2 to 26 Years of Age With Childhood Absence Epilepsy or Ju...
    Medical condition: Childhood absence epilepsy (CAE) Juvenile absence epilepsy (JAE)
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: HU (Prematurely Ended) BE (Completed) IT (Completed) PL (Completed) SK (Completed) Outside EU/EEA RO (Completed) ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-001266-17 Sponsor Protocol Number: DMD114349 Start Date*: 2011-08-08
    Sponsor Name:GlaxoSmithKline Research and Development LTD
    Full Title: An open-label extension study of the long-term safety, tolerability and efficacy of GSK2402968 in subjects with Duchenne Muscular Dystrophy
    Medical condition: Duchenne Muscular Dystrophy
    Disease: Version SOC Term Classification Code Term Level
    16.0 10010331 - Congenital, familial and genetic disorders 10013801 Duchenne muscular dystrophy PT
    Population Age: Children, Adolescents, Under 18 Gender: Male
    Trial protocol: BE (Prematurely Ended) FR (Ongoing) DE (Completed) GB (Prematurely Ended) NL (Prematurely Ended) ES (Prematurely Ended) IT (Prematurely Ended) Outside EU/EEA BG (Prematurely Ended) HU (Prematurely Ended) DK (Prematurely Ended) CZ (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2016-000371-24 Sponsor Protocol Number: DOBO-01-16 Start Date*: 2016-05-24
    Sponsor Name:Laboratorios Ordesa
    Full Title: Multicenter pilot study for comparison of the efficacy of vaginal capsules with boric acid and L. gasseri and L. rhamnosus versus other vaginal drugs, in patients with bacterial or candida Vulvovag...
    Medical condition: Bacterial or candidiasic vulvovaginitis
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-004316-18 Sponsor Protocol Number: 2006-05 Start Date*: 2017-11-21
    Sponsor Name:Jazz Pharmaceuticals
    Full Title: Defibrotide for Patients with Hepatic Veno-occlusive Disease (VOD): A Treatment IND Study
    Medical condition: Hepatic Veno-Occlusive Disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004871 10047207 Veno-occlusive liver damage LLT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2018-002978-52 Sponsor Protocol Number: CNTO1959HDS2002 Start Date*: 2019-07-16
    Sponsor Name:Universitair Medisch Centrum Groningen
    Full Title: Guselkumab for hidradenitis suppurativa, a mode of action study.
    Medical condition: Hidradenitis suppurativa
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-002284-13 Sponsor Protocol Number: CRx-197-003 Start Date*: 2009-01-19
    Sponsor Name:CombinatoRx, Incorporated
    Full Title: A MULTI-CENTER, RANDOMIZED, DOUBLE-BLIND, CONTROLLED STUDY TO ASSESS THE ANTI-INFLAMMATORY PROPERTIES OF TOPICAL CRX-197 IN LESIONAL SKIN OF ADULT SUBJECTS WITH MILD TO MODERATE ATOPIC DERMATITIS
    Medical condition: mild to moderate atopic dermatitis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-005509-79 Sponsor Protocol Number: VR040/2/003 Start Date*: 2006-12-21
    Sponsor Name:Vectura Group plc
    Full Title: A Clinic-Based, Phase IIa, Randomised, Double-Blind, Placebo-Controlled, Ascending-Dose, Multicentre Study Investigating the Safety, Tolerability, Efficacy, and Pharmacokinetics of VR040 in Patient...
    Medical condition: Idiopathic Parkinson's Disease patients who have motor fluctuations with recognisable motor “off” periods
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2005-000635-15 Sponsor Protocol Number: 307970 Start Date*: 2005-09-07
    Sponsor Name:Schering AG
    Full Title: Randomized, multicentre, prospective, two-arm, open-label Phase II study to investigate the efficacy and safety of two ZK219477 i.v. infusions (3-hour infusion of 16mg/m2 versus 0.5-hour infusion o...
    Medical condition: Recurrent ovarian cancer
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2005-004138-42 Sponsor Protocol Number: CLP1000080 Start Date*: 2006-01-23
    Sponsor Name:BRAINSGATE LTD
    Full Title: A multicenter prospective study Safety and feasibility of NeuropathTM Activation during chemiotherapy on Inoperable and Recurrent Glioblastoma Multiforme Patients
    Medical condition: Recurrent Glioblastoam multiforme
    Disease: Version SOC Term Classification Code Term Level
    10018337 PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-000168-10 Sponsor Protocol Number: BVT.28949-002 Start Date*: 2006-08-09
    Sponsor Name:Biovitrum AB
    Full Title: A 4-week, double-masked, parallel-group, randomized , multicenter, proof of concept study comparing the efficacy and safety of two dose levels of BVT.28949 with placebo in patients with ocular hype...
    Medical condition: Ocular hypertension or open angle glaucoma
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-011013-24 Sponsor Protocol Number: AC-063A302 Start Date*: 2009-06-03
    Sponsor Name:Actelion Pharmaceuticals Ltd.
    Full Title: A Multicenter, Double-blind, Randomized Study comparing the Safety and Tolerability of Iloprost inhalation solution delivered by I-neb utilizing Power disc-15 and Power disc-6 in Patients with Symp...
    Medical condition: Indication: Symptomatic Pulmonary Arterial Hypertension
    Disease: Version SOC Term Classification Code Term Level
    9.1 10064911 Pulmonary arterial hypertension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2009-015642-35 Sponsor Protocol Number: POVO-2009 Start Date*: Information not available in EudraCT
    Sponsor Name:medphano Arzneimittel GmbH
    Full Title: Doppelblinde, randomisierte, kontrollierte, klinisch-experimentelle Studie der Phase II zum Nachweis der Wirksamkeit mittels Vasokonstriktionstest von Polcortolon® N Spray gegenüber Volonimat® Salb...
    Medical condition: healthy volunteers.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2008-005802-37 Sponsor Protocol Number: CSPP100A2256 Start Date*: 2009-05-25
    Sponsor Name:Novartis Pharma Services AG
    Full Title: An 8 day open-label, multiple-dose, multi-center study to evaluate the safety/tolerability and pharmacokinetics of aliskiren in hypertensive pediatric and adolescent patients 6 – 17 years of age.
    Medical condition: hypertension
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: HU (Completed) BE (Completed) Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2013-001090-24 Sponsor Protocol Number: CAIN457F2314 Start Date*: 2014-01-08
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A randomized, double-blind, placebo-controlled phase III multicenter study of secukinumab to demonstrate the efficacy at 16 weeks and to assess the long-term safety, tolerability and efficacy up to...
    Medical condition: Ankylosing spondylitis
    Disease: Version SOC Term Classification Code Term Level
    18.1 10028395 - Musculoskeletal and connective tissue disorders 10002556 Ankylosing spondylitis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) CZ (Completed) ES (Completed) PT (Completed) GR (Completed) GB (Completed) BE (Completed) NO (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-005159-15 Sponsor Protocol Number: DORI-NOS-1008 Start Date*: 2012-03-05
    Sponsor Name:Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
    Full Title: An Open-Label, Parallel-Group Study to Evaluate the Single-Dose Pharmacokinetics and Safety of Doripenem in Pediatric Patients 3 Months to 17 Years of Age, Inclusive
    Medical condition: Bacterial infections
    Disease:
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2011-004199-12 Sponsor Protocol Number: RG_11-139vitd Start Date*: 2012-01-04
    Sponsor Name:University of Birmingham
    Full Title: An open label dose ranging study to optimise vitamin D levels prior to oesophagectomy
    Medical condition: perioperative inflammation in patients undergoing oesophagectomy.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-005417-13 Sponsor Protocol Number: 13-HMedIdeS-02 Start Date*: 2014-04-24
    Sponsor Name:Hansa Medical AB [...]
    1. Hansa Medical AB
    2. Hansa Medical AB
    Full Title: A PHASE II STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND EFFICACY OF INTRAVENOUS IDES AFTER ADMINISTRATION OF ASCENDING DOSES IN CHRONIC KIDNEY DISEASE PATIENTS
    Medical condition: Chronic kidney disease (CKD) stage 5 and on waiting list for renal transplantation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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