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Clinical trials for Heart Failure

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44346   clinical trials with a EudraCT protocol, of which   7374   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    1,476 result(s) found for: Heart Failure. Displaying page 6 of 74.
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    EudraCT Number: 2013-001498-25 Sponsor Protocol Number: CRLX030A2301 Start Date*: 2013-09-09
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A multicenter, randomized, double-blind, placebo-controlled phase IIIb study to evaluate the efficacy, safety and tolerability of Serelaxin when added to standard therapy in acute heart failure pa...
    Medical condition: Acute heart failure
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SK (Completed) BE (Completed) SE (Completed) IE (Completed) BG (Completed) HU (Completed) PT (Completed) LT (Prematurely Ended) IT (Completed) CZ (Completed) AT (Completed) EE (Completed) DK (Completed) ES (Completed) LV (Prematurely Ended) NL (Completed) GR (Completed) GB (Completed) PL (Completed) NO (Completed)
    Trial results: View results
    EudraCT Number: 2021-005394-66 Sponsor Protocol Number: ESR-20-21070 Start Date*: 2022-02-21
    Sponsor Name:AZIENDA OSPEDALIERA UNIVERSITARIA SENESE
    Full Title: Effects of Dapagliflozin on cardiac deformation and clinical outcomes in heart failure with reduced and mildly reduced ejection fraction
    Medical condition: heart failure with left ventricular ejection fraction <50%
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10024102 Left cardiac failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-002823-16 Sponsor Protocol Number: 02-2011 Start Date*: 2011-07-27
    Sponsor Name:A.O. UNIVERSITARIA INTEGRATA DI VERONA
    Full Title: Effects of Vitamin D in patients affected by heart failure
    Medical condition: Heart failure is a condition that occurs when the heart loses its normal ability to pump blood to maintain vital body functions and, therefore, works with lower efficiency. Several studies have sho...
    Disease: Version SOC Term Classification Code Term Level
    14.1 10007541 - Cardiac disorders 10007541 Cardiac disorders SOC
    Population Age: Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2011-001117-13 Sponsor Protocol Number: C3BS-C-11-01 Start Date*: 2012-11-14
    Sponsor Name:Celyad SA
    Full Title: Efficacy and Safety of Bone Marrow-Derived Mesenchymal Cardiopoietic Cells (C3BS-CQR-1) for the Treatment of Chronic Advanced Ischemic Heart Failure
    Medical condition: Chronic advanced symptomatic heart failure secondary to ischemic cardiomyopathy
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004849 10010684 Congestive heart failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) GB (Completed) HU (Completed) PL (Completed) SE (Completed) ES (Completed) IE (Completed) BG (Completed) LT (Completed) EE (Prematurely Ended) HR (Completed)
    Trial results: View results
    EudraCT Number: 2009-013929-42 Sponsor Protocol Number: 39588146AHF2001 Start Date*: 2010-07-08
    Sponsor Name:Janssen-Cilag International NV
    Full Title: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Investigate the Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of JNJ-39588146 in Subjects with Heart Failure
    Medical condition: JNJ-39588146 is being developed for the treatment of heart failure.
    Disease: Version SOC Term Classification Code Term Level
    12.1 10019279 Heart failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) BE (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2020-005302-26 Sponsor Protocol Number: DW.0701.005.2020P Start Date*: 2023-01-05
    Sponsor Name:John Paul II Hospital
    Full Title: The effect of sacubitril/valsartan versus ramipril on left ventricular function and remodeling in patients with ischemic heart failure with mid-range ejection fraction
    Medical condition: heart failure with moderately reduced ejection fraction (HFmrEF)
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10010684 Congestive heart failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2009-011441-11 Sponsor Protocol Number: LAICA/09 Start Date*: 2009-09-21
    Sponsor Name:Dr. Francisco Marrero Rodríguez. Hospital Universitario de Canarias
    Full Title: Estudio Randomizado Doble Ciego y Controlado con Placebo Para Evaluar la Eficacia y Seguridad de la Administración Intermitente y a Largo Plazo de Levosimendan en Pacientes con Insuficiencia Cardia...
    Medical condition: Insuficiencia Cardiaca avanzada
    Disease: Version SOC Term Classification Code Term Level
    9 10019282 Heart failure (NOS) LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2008-007407-86 Sponsor Protocol Number: LevoRep Start Date*: 2009-09-14
    Sponsor Name:Medizinische Universität Innsbruck - Universitätsklinik für Innere Medizin III
    Full Title: Efficacy and safety of pulsed infusions of levosimendan in outpatients with advanced heart failure
    Medical condition: Chronic heart failure
    Disease: Version SOC Term Classification Code Term Level
    9.1 10008908 Chronic heart failure LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed) GR (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2010-021258-20 Sponsor Protocol Number: EAST Start Date*: 2011-06-15
    Sponsor Name:Kompetenznetz Vorhofflimmern e.V. (AFNET)
    Full Title: Early treatment of Atrial fibrillation for Stroke prevention Trial (EAST)
    Medical condition: Atrial fibrillation, stroke, heart failure, myocardial infarction, cognitive dysfunction
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10003658 Atrial fibrillation PT
    20.0 10007541 - Cardiac disorders 10019280 Heart failures HLGT
    21.1 10029205 - Nervous system disorders 10061256 Ischaemic stroke PT
    20.0 10037175 - Psychiatric disorders 10009841 Cognitive and attention disorders and disturbances HLGT
    20.0 10007541 - Cardiac disorders 10028596 Myocardial infarction PT
    21.1 10029205 - Nervous system disorders 10019016 Haemorrhagic stroke PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) DK (Completed) NL (Completed) CZ (Completed) BE (Completed) ES (Completed) PL (Completed) IT (Ongoing)
    Trial results: View results
    EudraCT Number: 2016-004193-18 Sponsor Protocol Number: LEVOS-001 Start Date*: 2017-02-16
    Sponsor Name:Semmelweis University, Heart and Vascular Center
    Full Title: Effect of repetitive levosimendan treatment on clinical outcomes of chronic heart failure patients: focus on optimal patient selection based on novel cardiac biomarkers.
    Medical condition: A total of 80 symptomatic patients with severe ischaemic or non-ischaemic cardiomyopathy will be enrolled in the study. Those, who were implanted a device and proved to be non-responders or low res...
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: HU (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-003460-13 Sponsor Protocol Number: GN16CA007 Start Date*: 2018-02-13
    Sponsor Name:NHS Greater Glasgow and Clyde [...]
    1. NHS Greater Glasgow and Clyde
    2. University of Glasgow
    Full Title: The effects of sacubitril/valsartan compared to valsartan on left ventricular remodelling in patients with asymptomatic left ventricular systolic dysfunction after myocardial infarction: a randomi...
    Medical condition: Asymptomatic (New York Heart Association ≤2) left ventricular systolic dysfunction (defined as ejection fraction ≤40% measured by Simpson's biplane using transthoracic echocardiography) at least 3...
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10019279 Heart failure LLT
    20.1 10007541 - Cardiac disorders 10064079 Heart failure NYHA class I LLT
    20.0 10007541 - Cardiac disorders 10069501 Left ventricular systolic dysfunction LLT
    20.0 10007541 - Cardiac disorders 10000891 Acute myocardial infarction PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2017-002914-30 Sponsor Protocol Number: LCZ696-17 Start Date*: 2017-11-06
    Sponsor Name:FIMABIS
    Full Title: LCZ696 in heart failure patients with reduced ejection fraction and high comorbidity: effect on left ventricular remodeling and fibrosis assessed by novel heart failure biomarkers and cardiac magne...
    Medical condition: Chronic heart failure NYHA class II-IV with reduced ejection fraction (EF =< 40%) and elevated NT-proBNP ≥ 600 pg/mL, but 400 pg/mL if hospitalized for heart failure within 12 months
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-005325-10 Sponsor Protocol Number: DC2008exe001 Start Date*: 2009-04-08
    Sponsor Name:VU University Medical Center
    Full Title: The effect of exenatide compared to insulin glargine on cardiac function and metabolism in type 2 diabetic patients with congestive heart failure (NYHA II): a randomized-controlled trial
    Medical condition: Cardiac function and metabolism in type 2 diabetic patients with congestive heart failure
    Disease: Version SOC Term Classification Code Term Level
    9.1 10045242 Type II diabetes mellitus LLT
    9.1 10010684 Congestive heart failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-000972-32 Sponsor Protocol Number: P-110875-01 Start Date*: 2011-06-14
    Sponsor Name:FERRER INTERNACIONAL, S.A
    Full Title: Estudio randomizado, abierto, con endpoint enmascarado, cruzado, de dosis única para comparar la farmacodinamia de TORASEMIDA- LP 10 mg, TORASEMIDA-LI 10 mg y FUROSEMIDA-LI 40 mg en pacientes con i...
    Medical condition: INSUFICIENCIA CARDIACA COMPENSADA
    Disease: Version SOC Term Classification Code Term Level
    14.1 10007541 - Cardiac disorders 10007554 Cardiac failure PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-004667-13 Sponsor Protocol Number: N/A Start Date*: 2018-04-24
    Sponsor Name:King's College London [...]
    1. King's College London
    2. King’s College Hospital NHS Foundation Trust
    Full Title: Effect of Iron (III) Isomaltoside 1000 on Cardiac Energetics in Anaemic and Non-anaemic Patients with Symptomatic Chronic Heart Failure and Iron Deficiency: The Ferric Iron in Heart Failure (FERRIC...
    Medical condition: Chronic Heart Failure
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10008908 Chronic heart failure LLT
    20.0 10027433 - Metabolism and nutrition disorders 10022970 Iron deficiency PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2013-002513-35 Sponsor Protocol Number: CRLX030A3301 Start Date*: 2013-11-28
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A multicenter, prospective, randomized, open label study to assess the effect of serelaxin versus standard of care in acute heart failure (AHF) patients.
    Medical condition: Acute heart failure
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended) AT (Prematurely Ended) HU (Prematurely Ended) IT (Prematurely Ended) CZ (Prematurely Ended) SK (Prematurely Ended) BE (Completed) PT (Prematurely Ended) BG (Completed) LT (Completed) PL (Prematurely Ended) LV (Prematurely Ended) EE (Completed) FI (Prematurely Ended) SI (Prematurely Ended) GR (Prematurely Ended) ES (Prematurely Ended) HR (Prematurely Ended) DK (Prematurely Ended) IS (Prematurely Ended) FR (Completed)
    Trial results: View results
    EudraCT Number: 2006-005767-26 Sponsor Protocol Number: 2006-KarviD-II Start Date*: 2007-05-22
    Sponsor Name:The Department of Calcium- and Bone-metabolic Diseases
    Full Title: The effect of calcium and vitamin D on the heartmusclef unction
    Medical condition: Effect of intervention with vitamin D on degree of cardiac incompensation: Degree of cardiac incompensation has been related to vitamin D deficiency and secondary hyperparathyroidism in clinical st...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10010684 Congestive heart failure LLT
    9.1 10047626 Vitamin D deficiency LLT
    9.1 10020708 Hyperparathyroidism secondary LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-002396-18 Sponsor Protocol Number: 2015-602295-02 Start Date*: 2015-11-30
    Sponsor Name:Ethicare GmbH
    Full Title: ORODISPERSIBLE MINITABLETS OF ENALAPRIL IN YOUNG CHILDREN WITH HEART FAILURE DUE TO CONGENITAL HEART DISEASE
    Medical condition: Heart Failure due to Congenital Heart Disease
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004850 10010495 Congenital heart disease NOS LLT
    Population Age: Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: HU (Completed) GB (Prematurely Ended) NL (Ongoing) AT (Completed) DE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-001637-18 Sponsor Protocol Number: CKI- 302 Start Date*: 2006-11-13
    Sponsor Name:NovaCardia Inc (wholly owned subsidiary of Merck & Co. Inc)
    Full Title: A multicentre, randomised, double-blind, placebo-controlled study of the effects of KW-3902 Injectable Emulsion on heart failure signs and symptoms and renal function in subjects with acute heart f...
    Medical condition: Patients being admitted to hospital for acute heart failure (AHFS) with volume overload and renal impairment.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10000803 Acute heart failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) FI (Completed) CZ (Completed) BE (Completed) DK (Prematurely Ended) GB (Completed) HU (Completed) DE (Completed) NL (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2008-001637-10 Sponsor Protocol Number: 12008 Start Date*: 2008-09-18
    Sponsor Name:HUCH, Division of Cardiology
    Full Title: Acute heart failure in acute coronary syndrome: Double blind comparison of levosimendan and placebo
    Medical condition: Acute coronary syndrome treated with percutaneous coronary intervention (PCI) Patients suffering from acute heart failure after the procedure will be randomised to the study
    Disease: Version SOC Term Classification Code Term Level
    9.1 10000803 Acute heart failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Prematurely Ended)
    Trial results: (No results available)
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