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Clinical trials for Spasticity

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44338   clinical trials with a EudraCT protocol, of which   7368   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    126 result(s) found for: Spasticity. Displaying page 6 of 7.
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    EudraCT Number: 2004-000763-98 Sponsor Protocol Number: HP184B/2002 Start Date*: 2004-12-08
    Sponsor Name:Aventis Pharmaceuticals Inc.
    Full Title: A phase II, double-blind, placebo-controlled, multicenter study to assess the efficacy and safety of HP184 at 100, 200 and 400 mg doses administered orally once daily for twenty-four weeks in adult...
    Medical condition: Chronic spinal cord injury
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2015-005786-23 Sponsor Protocol Number: XCEL-SCI-01 Start Date*: 2016-04-20
    Sponsor Name:Banc de Sang i Teixits
    Full Title: A phase I/IIa, randomized, double-blind, single-dose, placebo controlled, two-way crossover clinical trial to assess the safety and to obtain efficacy data in intrathecal administration of expanded...
    Medical condition: Chronic traumatic spinal cord injury
    Disease: Version SOC Term Classification Code Term Level
    18.1 10022117 - Injury, poisoning and procedural complications 10041558 Spinal cord injury thoracic PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-005377-23 Sponsor Protocol Number: SCI-GHD-201 Start Date*: 2012-07-18
    Sponsor Name:Guillem Cuatrecasas Cambra
    Full Title: A phase II, single-center, prospective, randomized, double-blind, parallel and placebo-controlled pilot clinical study to assess the efficacy and safety of NUTROPIN® in combination with intensive r...
    Medical condition: Spinal Cord Injury and Growth Hormone Deficiency
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022117 - Injury, poisoning and procedural complications 10041558 Spinal cord injury thoracic PT
    14.1 10022117 - Injury, poisoning and procedural complications 10041554 Spinal cord injury cervical PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-000346-18 Sponsor Protocol Number: BST-SCI-02 Start Date*: 2021-06-28
    Sponsor Name:Banc de Sang i Teixits
    Full Title: A phase I/II, randomized, double-blind, placebo-controlled, parallel, 2-arms clinical trial to assess the safety and efficacy of intrathecal administration of WJ-MSC in chronic traumatic cervical i...
    Medical condition: Cronic traumatic spinal cord injury
    Disease: Version SOC Term Classification Code Term Level
    20.1 10022117 - Injury, poisoning and procedural complications 10041554 Spinal cord injury cervical PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-000393-47 Sponsor Protocol Number: SP000680 Start Date*: 2004-09-22
    Sponsor Name:AZIENDA UNIVERSITARIA POLICLINICO UMBERTO I DI ROMA
    Full Title: Effect of Cannabis Based Medicine Extract Sativex on brain function as assessed by fMRI and neurophysiologic evaluation in patients with Multiple Sclerosis a double blind, randomised, placebo-co...
    Medical condition: Treatment of spasticity in patients with Multiple Sclerosis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10028245 Multiple sclerosis LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-004129-89 Sponsor Protocol Number: Motor-Neuromod_01, Part I-III Start Date*: 2005-09-19
    Sponsor Name:Universitätsklinikum Münster
    Full Title: Potentiation of procedural motor learning by pharmacological neuromodulation and brain stimulation
    Medical condition: Healthy volunteers Patients in the chronic stage (> 1 year) after stroke
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-005538-23 Sponsor Protocol Number: RB15.213 Start Date*: 2016-02-03
    Sponsor Name:CHRU de Brest
    Full Title: Analgesia and physiotherapy in children with cerebral palsy (ANTALKINECP): Double blind cross-over placebo controlled study of Ibuprofen in children with cerebral palsy undergoing physiotherapy
    Medical condition: Cerebral Palsy
    Disease: Version SOC Term Classification Code Term Level
    18.1 10010331 - Congenital, familial and genetic disorders 10008129 Cerebral palsy PT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-015620-29 Sponsor Protocol Number: 2009/1314 Start Date*: 2010-03-08
    Sponsor Name:
    Full Title: The efficacy of the Botulinum toxin-A on the manual abilities in children with congenital spastic hemiplegia. Interest of the measure of the bimanual task performance.
    Medical condition: The main objective of this study is to investigate the effect of Botulinum toxin A to improve the Upper Limb dysfunction in Hemiplegic Cerebral Palsy Children and in particular, its impact on Up...
    Disease: Version SOC Term Classification Code Term Level
    12.0 10019475 Hemiplegic infantile cerebral palsy LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-006254-85 Sponsor Protocol Number: CeTMad/ELA/2011 Start Date*: 2013-02-08
    Sponsor Name:FUNDACIÓN PROGRESO Y SALUD
    Full Title: Placebo controlled, randomized and triple blind multicentric phase I/II clinical trial to evaluate the safety, feasibility and valoration of efficacy trends of intravenous administration of three d...
    Medical condition: Amyotrophic lateral sclerosis (ALS)
    Disease: Version SOC Term Classification Code Term Level
    14.1 10029205 - Nervous system disorders 10002026 Amyotrophic lateral sclerosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-004837-34 Sponsor Protocol Number: CAEB1102-300A Start Date*: 2019-06-18
    Sponsor Name:Aeglea Biotherapeutics, Inc.
    Full Title: PEACE (Pegzilarginase Effect on Arginase 1 Deficiency Clinical Endpoints): A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of the Efficacy and Safety of Pegzilarginase in Children and ...
    Medical condition: Arginase 1 Deficiency Hyperargininemia
    Disease: Version SOC Term Classification Code Term Level
    20.0 10010331 - Congenital, familial and genetic disorders 10062695 Arginase deficiency PT
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: AT (Completed) DE (Completed) FR (Completed) GB (GB - no longer in EU/EEA) IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-001989-29 Sponsor Protocol Number: F-FR-52120-228 Start Date*: 2016-10-20
    Sponsor Name:Ipsen Pharma
    Full Title: An International, Multicentre, Prospective, Single Arm Study to Assess the Effect on Voluntary Movements of AbobotulinumtoxinA 1500 U Administered in Both Upper and Lower Limbs in Conjunction with ...
    Medical condition: Spastic Hemiparesis
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004852 10058978 Spastic hemiparesis LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: CZ (Completed) FR (Completed)
    Trial results: View results
    EudraCT Number: 2014-002539-32 Sponsor Protocol Number: The_WE_Study Start Date*: 2015-03-23
    Sponsor Name:St. Olavs University Hospital
    Full Title: The WE Study - Walking Easier with cerebral palsy
    Medical condition: cerebral palsy
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004850 10021740 Infantile cerebral palsy LLT
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: NO (Completed) FR (Ongoing) PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-000064-21 Sponsor Protocol Number: TPN-101-AGS-201 Start Date*: 2022-09-20
    Sponsor Name:Transposon Therapeutics Inc
    Full Title: A Phase 2a Study of TPN-101 in Patients with Aicardi-Goutières Syndrome (AGS)
    Medical condition: Aicardi-Goutières Syndrome (AGS)
    Disease: Version SOC Term Classification Code Term Level
    22.1 10010331 - Congenital, familial and genetic disorders 10083189 Aicardi-Goutieres syndrome PT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: IT (Trial now transitioned) FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2007-004358-10 Sponsor Protocol Number: FARM6Y35XM Start Date*: 2007-09-14
    Sponsor Name:AZIENDA OSPEDALIERA OSPEDALE NIGUARDA CA' GRANDA (A.O. DI RILIEVO NAZIONALE)
    Full Title: EVALUATION OF THE TOLERABILITY AND EFFICACY OF ERYTHROPOIETIN (EPO) TREATMENT IN SPINAL SHOCK: COMPARATIVE STUDY VS METHYLPREDNISOLONE (MP)
    Medical condition: PARAPLEGICS AND TETRAPLEGICS
    Disease: Version SOC Term Classification Code Term Level
    9.1 10041552 Spinal cord injury LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-009503-19 Sponsor Protocol Number: TYS-IMA-08-11 Start Date*: 2010-07-20
    Sponsor Name:Biogen Idec International GmbH
    Full Title: A prospective, open label, non-randomised, clinical trial to determine if natalizumab (Tysabri) improves ambulatory measures in relapsing remitting multiple sclerosis (RRMS) patients.
    Medical condition: Multiple sclerosis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10063399 Relapsing-remitting multiple sclerosis LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2014-004650-34 Sponsor Protocol Number: GR-2011-02348985 Start Date*: 2016-06-27
    Sponsor Name:IRCCS FONDAZIONE ISTITUTO NEUROLOGICO NAZIONALE C. MONDINO
    Full Title: Neuromodulation strategies to enhance the effects of gait rehabilitation in multiple sclerosis patients with cerebellar ataxia
    Medical condition: Multiple sclerosis with cerebellar ataxia
    Disease: Version SOC Term Classification Code Term Level
    20.1 10029205 - Nervous system disorders 10028245 Multiple sclerosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-003975-80 Sponsor Protocol Number: SHORTCUT Start Date*: 2018-03-07
    Sponsor Name:Academic Medical Center
    Full Title: Shorter treatment of catheter related urinary tract infections
    Medical condition: Catheter related urinary tract infection (CAUTI)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2021-006042-13 Sponsor Protocol Number: MEDI-TOLP-01 Start Date*: 2022-03-28
    Sponsor Name:MEDITOP Gyógyszeripari Kft.
    Full Title: A randomized double blind placebo controlled multicenter study to assess the efficacy and tolerability of tolperisone as add on treatment with standardized NSAID of acute non specific low back pain.
    Medical condition: Acute, non-specific low back pain
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004859 10024891 Low back pain LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: HU (Completed)
    Trial results: View results
    EudraCT Number: 2019-003549-14 Sponsor Protocol Number: MN-166-ALS-2301 Start Date*: 2020-03-11
    Sponsor Name:MediciNova, Inc.
    Full Title: A PHASE 2B/3, MULTI-CENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, 12 MONTH CLINICAL TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF MN-166 (IBUDILAST) FOLLOWED BY AN OPEN-LABEL EXTENSION IN SU...
    Medical condition: Amyotrophic Lateral Sclerosis
    Disease: Version SOC Term Classification Code Term Level
    21.1 10029205 - Nervous system disorders 10002026 Amyotrophic lateral sclerosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2022-002372-36 Sponsor Protocol Number: 2022-16039 Start Date*: 2024-01-02
    Sponsor Name:Wageningen Research Stichting
    Full Title: The CanISleepinMS Study: Effect of cannabidiol (CBD) on sleep quality in patients with multiple sclerosis, a series of 15 randomised, placebo controlled N-of-1 trials
    Medical condition: Insomnia
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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