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Clinical trials for Musculoskeletal diseases

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44347   clinical trials with a EudraCT protocol, of which   7375   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    1,431 result(s) found for: Musculoskeletal diseases. Displaying page 8 of 72.
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    EudraCT Number: 2014-003482-25 Sponsor Protocol Number: CBYM338E2202 Start Date*: 2015-01-30
    Sponsor Name:Novartis Farmacéutica, S.A.
    Full Title: A 28 week, randomized, double-blind, placebo-controlled, multi-center, parallel group dose range finding study to assess the effect of monthly doses of bimagrumab 70, 210, and 700 mg on skeletal mu...
    Medical condition: sarcopenia
    Disease: Version SOC Term Classification Code Term Level
    17.1 10028395 - Musculoskeletal and connective tissue disorders 10063024 Sarcopenia PT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: ES (Completed) DK (Completed) BE (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2011-004465-32 Sponsor Protocol Number: 2011/386 Start Date*: 2011-12-12
    Sponsor Name:Dept. of Cardiothoracic & Vascular Surgery, Aarhus University Hospital, Skejby
    Full Title: Can post-operative treatment with parathyroid hormone enhance bone healing and quality of newly formed bone after sternotomy in cardiac surgery patients?
    Medical condition: Sternotomy
    Disease: Version SOC Term Classification Code Term Level
    14.1 10042613 - Surgical and medical procedures 10051332 Surgical procedure LLT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-004622-18 Sponsor Protocol Number: BAYO9867/100201 Start Date*: 2015-01-12
    Sponsor Name:Bayer HealthCare AG
    Full Title: A prospective, open-label, non-randomized, naturalistic, long-term safety surveillance, observational study of either ciprofloxacin (either as oral suspension, oral tablets or sequential IV followe...
    Medical condition: Infectious Diseases
    Disease:
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2016-000852-91 Sponsor Protocol Number: W15.032 Start Date*: 2016-06-02
    Sponsor Name:Leiden University Medical Center
    Full Title: Zoledronic Acid to Maintain Bone Mass After Denosumab Discontinuation: AfterDmab
    Medical condition: Treatment of patients with with postmenopausal osteoporosis
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004865 10050213 Prophylaxis against postmenopausal osteoporosis LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2010-023485-53 Sponsor Protocol Number: IJG-PAR-2010 Start Date*: 2011-04-20
    Sponsor Name:IDIAP JORDI GOL I GURINA
    Full Title: Evaluation of the relationship between effervescent acetaminophen and blood pressure. A clinical trial.
    Medical condition: Evaluation of whether paracetamol effervescent formulation increases blood pressure compared with effervescent paracetamol formulation does not
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2016-000784-16 Sponsor Protocol Number: NCPACI Start Date*: 2016-04-15
    Sponsor Name:Akershus University Hospital
    Full Title: Focal cartilage defects in the knee – A randomized controlled trial comparing Autologous Chondrocyte Implantation with arthroscopic debridement
    Medical condition: Symptomatic focal cartilage defects in the knee
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-002521-30 Sponsor Protocol Number: CAIN457F2304E1 Start Date*: 2019-05-09
    Sponsor Name:Novartis Pharma AG
    Full Title: An extension study of subcutaneous secukinumab to evaluate the long-term efficacy, safety and tolerability up to 4 years in patients with Juvenile Idiopathic Arthritis subtypes of Juvenile Psoriati...
    Medical condition: Enthesitis-Related Arthritis and Juvenile Psoriatic Arthritis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10072745 Enthesitis related arthritis LLT
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10076674 Juvenile psoriatic arthritis PT
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: DE (Completed) ES (Ongoing) PL (Completed) BE (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2012-001285-15 Sponsor Protocol Number: IIBSP-DEN-2012-24 Start Date*: 2012-10-05
    Sponsor Name:Institut de Recerca Hospital Sant Pau
    Full Title: Ensayo clínico aleatorizado, doble ciego, de grupos paralelos, controlado con placebo para la valoración de la eficacia del denosumab subcutáneo para la disminución de la resorción periprotésica en...
    Medical condition: Periprosthetic bone mineral density Masa ósea periprotésica
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-000047-33 Sponsor Protocol Number: VitD-EX1.0 Start Date*: 2014-03-20
    Sponsor Name:VU University Medical Centre
    Full Title: The effect of high-resistance muscle strength training and vitamin D supplementation in persons with knee osteoarthritis
    Medical condition: knee osteoarthritis vitamin D deficiency
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-003899-13 Sponsor Protocol Number: NL65803.078.18 Start Date*: 2018-12-20
    Sponsor Name:
    Full Title: The effect of IntraDialytic Parenteral Nutrition on nutritional status and quality of life in hemodialysis patients
    Medical condition: Malnutrition / Sarcopenia (loss of muscle mass) in hemodialyse patients.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-003709-25 Sponsor Protocol Number: PRPVol Start Date*: 2019-06-11
    Sponsor Name:Hospital Son Llatzer
    Full Title: Value of ultrasound-guided treatment with Platelet Rich Plasma or high volume injection in the rotator cuff tendon: Prospective randomized clinical trial. EudraCT number 2018-003709-25
    Medical condition: Shoulder pain due to rotator cuff tendinopathy or partial tears of the supraspinatus tendon
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-003574-66 Sponsor Protocol Number: 34964 Start Date*: 2013-01-04
    Sponsor Name:Ortopædkirurgisk Forskning - Aarhus Universitetshospita
    Full Title: Osseointegrated transdermal femoral amputation prostheses - Denusomab Trial
    Medical condition: leg amputee
    Disease: Version SOC Term Classification Code Term Level
    16.0 10042613 - Surgical and medical procedures 10024124 Leg amputation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2014-002984-14 Sponsor Protocol Number: AC-064A201 Start Date*: 2015-06-05
    Sponsor Name:ACTELION Pharmaceuticals Ltd
    Full Title: A multicenter, randomized, double-blind, placebo-controlled, dose-response study to investigate the biological activity, safety, tolerability, and pharmacokinetics of ACT-334441 in subjects with sy...
    Medical condition: Systemic lupus erythematosus
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BG (Completed)
    Trial results: View results
    EudraCT Number: 2017-004612-19 Sponsor Protocol Number: IIBSP-COR-2017-98 Start Date*: 2018-03-20
    Sponsor Name:Institut de Recerca Hospital de la Santa Creu i Sant Pau
    Full Title: EFFICACY OF THE SUPRAESCAPULAR NERVE APPROACH WITH CORTICOIDS ADMINISTRATION VERSUS PULSED RADIOFREQUENCY IN CHRONIC SHOULDER PAIN. DOUBLE BLIND RANDOMIZED CLINICAL TRIAL
    Medical condition: Chronic shoulder pain
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-004117-40 Sponsor Protocol Number: Q03.13.01 Start Date*: 2013-12-19
    Sponsor Name:Fidia Farmaceutici SpA
    Full Title: Randomized, controlled, double-blinded clinical trial, with open-label extension on the efficacy of ultrasound guided injection of hyaluronic acid (500-730 KDa) (HYALGAN®) versus saline solution in...
    Medical condition: Achilles tendinopathy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2012-005214-19 Sponsor Protocol Number: S127AMCGolimumabPsA Start Date*: 2013-06-20
    Sponsor Name:Academic Medical Center, Department of Rheumatology
    Full Title: A randomized, double-blind, placebo-controlled trial of golimumab+methotrexate versus methotrexate alone in methotrexate-naïve patients with psoriatic arthritis
    Medical condition: active psoriatic arthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-004103-73 Sponsor Protocol Number: 0881A1-207 Start Date*: 2015-03-12
    Sponsor Name:Wyeth Kabushiki Kaisha (Wyeth K.K.)
    Full Title: A long-term, open-label study of TNR-001 in Japanese Juvenile Idiopathic Arthritis Subjects.
    Medical condition: Juvenile idiopathic arthritis (JIA)
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2017-000327-27 Sponsor Protocol Number: ISIS396443-CS2 Start Date*: 2017-01-26
    Sponsor Name:Ionis Pharmaceuticals, Inc.
    Full Title: An Open-Label, Dose Escalation Study to Assess the Safety, Tolerability and Dose-Range Finding of Multiple Doses of ISIS 396443 Delivered Intrathecally to Patients With Spinal Muscular Atrophy
    Medical condition: Spinal Muscular Atrophy (SMA)
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2016-004755-75 Sponsor Protocol Number: MICROPREP Start Date*: 2017-09-28
    Sponsor Name:Clinique Juge
    Full Title: Intra articular injection of microfat and platelet-rich plasma in the treatment of knee osteoarthritis : a pilot study
    Medical condition: knee osteoarthritis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-000693-57 Sponsor Protocol Number: Ledin03 Start Date*: 2011-11-29
    Sponsor Name:Håkan Ledin (investigator initiated trial)
    Full Title: A Randomized, Placebo-controlled, Double-blind, Two-center Study with Denosumab in Subjects Undergoing Elective Total Knee Replacement Surgery
    Medical condition: Patients with idiopathic osteoarthritis of the knee, scheduled for a cemented total knee prosthesis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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