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Clinical trials for 5-aminolevulinic acid (5-ALA)

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    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

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    24 result(s) found for: 5-aminolevulinic acid (5-ALA). Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2020-001135-27 Sponsor Protocol Number: 000000 Start Date*: 2020-09-11
    Sponsor Name:University of Oxford / Clinical Trials and Research Governance
    Full Title: Pre-operative 5-Aminolevulinic acid to activate haem oxygenase to improve outcomes in cardiac surgery: A dose finding study
    Medical condition: Cardioprotection for coronary artery bypass graft surgery
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004863 10017501 Functional disturbances following cardiac surgery LLT
    20.0 100000004863 10007602 Cardiac and vascular procedural complications HLT
    21.1 10042613 - Surgical and medical procedures 10066123 Cardiopulmonary bypass PT
    20.1 10007541 - Cardiac disorders 10051624 Myocardial reperfusion injury PT
    20.0 10005329 - Blood and lymphatic system disorders 10018910 Haemolysis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2013-003230-32 Sponsor Protocol Number: 5-ALA_Meningiomas Start Date*: 2015-11-17
    Sponsor Name:Medizinische Universität Graz
    Full Title: The use of 5-aminolevulinic acid (gliolan) mediated protoporphyrin IX fluorescence to label neighbouring infiltration zones in meningiomas
    Medical condition: Surgical candidates with supratentorial meningiomas
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-005809-77 Sponsor Protocol Number: NL38217 Start Date*: 2013-01-31
    Sponsor Name:Maastricht University Medical Centre
    Full Title: Treatment of superficial basal cell carcinoma by topical photodynamic therapy with fractionated 5-aminolevulinic acid 20% versus two stage topical photodynamic therapy with methylaminolevulinate
    Medical condition: Superficial basal cell carcinoma
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-000314-20 Sponsor Protocol Number: ALA-AK-CT001 Start Date*: 2006-09-26
    Sponsor Name:Biofrontera Bioscience GmbH
    Full Title: A randomized placebo-controlled clinical trial of topical photodynamic therapy with a nanoemulsion formulation of 5-aminolevulinic acid for the treatment of actinic keratosis
    Medical condition: actinic keratosis (AK)
    Disease: Version SOC Term Classification Code Term Level
    10000614
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2014-005669-54 Sponsor Protocol Number: UKM2013-0034 Start Date*: 2020-06-02
    Sponsor Name:Universität Münster c/o Universitätsklinikum Münster, Geschäftsbereich Personal und Recht
    Full Title: Clinical safety study on 5-Aminolevulinic acid (5-ALA) in children and adolescents with brain tumours
    Medical condition: intra-axial brain tumor (malignant glioma, astrocytoma, malignant ependymoma, AT/RT, Oligodendroglioma, etc.)
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10006154 Brain tumor NOS LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: DE (Trial now transitioned) NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2004-004258-26 Sponsor Protocol Number: 02_2004 Start Date*: 2005-06-23
    Sponsor Name:University Clinic of Dermatology Division of Special and Enviromental Dermatology
    Full Title: Photodynamic Therapy (PDT) vs Chemopeeling for the treatment of multiple actinic keratoses on the underarms
    Medical condition: Actinic Keratosis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2013-002645-11 Sponsor Protocol Number: SPP1C302 Start Date*: 2013-12-04
    Sponsor Name:SBI Pharmaceuticals Co., Ltd.
    Full Title: An Open-label, Randomized Study to Evaluate Safety, Tolerability and Pharmacokinetics of 5-ALA/SFC in Cancer Patients with Solid Tumors with Chemotherapy Induced Anemia.
    Medical condition: Cancer Patients with Solid Tumors with Chemotherapy Induced Anemia
    Disease: Version SOC Term Classification Code Term Level
    16.1 10005329 - Blood and lymphatic system disorders 10002034 Anaemia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2020-003089-38 Sponsor Protocol Number: FG001-CT-001 Start Date*: 2020-09-03
    Sponsor Name:FluoGuide A/S
    Full Title: An open-label, dose escalation, single-dose administration, multi-center phase I/II trial of FG001 (an imaging agent), in patients with glioblastoma scheduled for neurosurgery
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10018337 Glioblastoma multiforme PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed) SE (Completed)
    Trial results: View results
    EudraCT Number: 2010-022496-66 Sponsor Protocol Number: UCL/09/0398 Start Date*: 2011-02-21
    Sponsor Name:Joint UCLH and UCL Biomedical Research Unit
    Full Title: An Evaluation of the Tolerability and Feasibility of combining 5-Amino-Levulinic Acid (5-ALA) with Carmustine Wafers (Gliadel) in the Surgical Management of Primary Glioblastoma (GALA-5 Trial)
    Medical condition: Primary glioblastoma
    Disease: Version SOC Term Classification Code Term Level
    14.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10018336 Glioblastoma PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-004760-31 Sponsor Protocol Number: CG/7657 Start Date*: 2007-04-17
    Sponsor Name:University of Dundee
    Full Title: Role and efficacy of topical 5-Aminolevulinic Acid (5-ALA) in Photodynamic detection (PDD) in determining malignant potential of oral lichen planus
    Medical condition: Oral Lichen Planus
    Disease: Version SOC Term Classification Code Term Level
    8.1 10030983 Oral lichen planus LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2018-004397-96 Sponsor Protocol Number: CF20112018 Start Date*: 2019-04-09
    Sponsor Name:Merete Hædersdal
    Full Title: Impact of thermo-mechanical intervention on Protoporphyrin IX accumulation and biodistribution in normal skin following topical 5-aminolevulinic acid at high and low vehicle viscosity
    Medical condition: Healthy skin on the upper back on 3 participants in study a and 12 participants in study b.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10022891 - Investigations 10022891 Investigations SOC
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2021-004631-92 Sponsor Protocol Number: WWU20_0041 Start Date*: 2022-07-26
    Sponsor Name:Westfälische Wilhelms-Universität Münster, C/o Universitätsklinikum Münster Geschäftsbereich Recht u. Drittmittel
    Full Title: Phase I/II dose escalation trial of radiodynamic therapy (RDT) with 5-Aminolevulinic acid in patients with first recurrence of glioblastoma
    Medical condition: recurrence of glioblastoma
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10018336 Glioblastoma PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-000263-24 Sponsor Protocol Number: IPOT2_01.05.2011 Start Date*: 2012-06-05
    Sponsor Name:Medizinische Universität Wien, Univ. Klinik f. Dermatologie
    Full Title: Comparative study for efficacy and tolerability of topical imiquimod 5% cream therapy versus photodynamic therapy (ALA-PDT) of actinic keratoses on the hands and forearms in organ transplant recipi...
    Medical condition: actinic keratoses
    Disease: Version SOC Term Classification Code Term Level
    14.1 10040785 - Skin and subcutaneous tissue disorders 10000614 Actinic keratosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2012-002623-15 Sponsor Protocol Number: GS11/9681 Start Date*: 2013-09-30
    Sponsor Name:University of Leeds
    Full Title: GLiSten: Next generation intraoperative lymph node staging for stratified colon cancer surgery- Development Phase
    Medical condition: Colon cancer
    Disease: Version SOC Term Classification Code Term Level
    17.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10009944 Colon cancer PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Prematurely Ended) GB (Completed)
    Trial results: View results
    EudraCT Number: 2010-018399-25 Sponsor Protocol Number: MuSH_1.2 Start Date*: 2011-03-17
    Sponsor Name:Medizinische Universität Wien, Univ.Klinik für Zahn-,Mund-u.Kieferheilkunde,Klin.Abt.f.orale Chirurg
    Full Title: A randomized controlled trial: Photodynamic Treatment for the therapy of premalignant mucosal oral lesions.
    Medical condition: Leukoplakia and oral lichen ruber.
    Disease: Version SOC Term Classification Code Term Level
    12.1 10062037 Leukoplakia LLT
    12.1 10062037 Leukoplakia PT
    12.1 10030983 Oral lichen planus LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-003374-30 Sponsor Protocol Number: SONIC-ALA Start Date*: 2021-10-25
    Sponsor Name:FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA
    Full Title: A pilot study to Evaluate the Safety and Feasibility of Sonodynamic Therapy Using the ExAblate MRI-Guided Focused Ultrasound in the Treatment of Cerebral Glioblastomas.
    Medical condition: IV degree lobar glioblastoma with a diameter of less than 5 cm.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10018336 Glioblastoma PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-001493-34 Sponsor Protocol Number: OM01 Start Date*: 2014-12-02
    Sponsor Name:photonamic GmbH & Co. KG
    Full Title: Evaluation of the suitability of PD P 506 A in the photodynamic therapy of Distal Subungual Onychomycosis (DSO) of the great toenail.
    Medical condition: Onychomycosis (OM) is a chronic fungal infection of the finger- or toenails and one of the commonest dermatological conditions. It accounts for one third of fungal skin infections and constitutes a...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2006-002606-54 Sponsor Protocol Number: 8/2006 Start Date*: 2006-03-02
    Sponsor Name:ASL SALERNO 1
    Full Title: Investigational use of 5-ALA for fluorescence-guided resection of malignant glioma
    Medical condition: Glioblastoma multiforme
    Disease: Version SOC Term Classification Code Term Level
    6.1 10018336 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-002727-25 Sponsor Protocol Number: UKM12_0017 Start Date*: 2017-10-20
    Sponsor Name:Universitätsklinikum Münster
    Full Title: Controlled clinical trial to evaluate the safety and efficacy of stereotactical photodynamic therapy with 5-aminolevulinic acid (Gliolan®) in recurrent glioblastoma
    Medical condition: Recurrent glioblastoma
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10018336 Glioblastoma PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2018-002422-23 Sponsor Protocol Number: twostepala Start Date*: 2019-01-08
    Sponsor Name:Akershus University Hospital
    Full Title: Extracorporeal photopheresis of patients with Crohns disease using 5- aminolevulinic acid.
    Medical condition: Crohns disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 10017947 - Gastrointestinal disorders 10011401 Crohn's disease PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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