Flag of the European Union EU Clinical Trials Register Help

Clinical trials for Anal Fissure

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44336   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
    How to search [pdf]
    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
    Advanced Search: Search tools
     
    18 result(s) found for: Anal Fissure. Displaying page 1 of 1.
    EudraCT Number: 2007-004114-13 Sponsor Protocol Number: 956 Start Date*: 2008-01-07
    Sponsor Name:POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI
    Full Title: TOPIC LEVETIRACETAM IN ANAL FISSURE. A PILOT STUDY ABOUT EFFECTIVENESS AND TOLERABLENESS
    Medical condition: Anal fissure
    Disease: Version SOC Term Classification Code Term Level
    9.1 10002153 Anal fissure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-002656-42 Sponsor Protocol Number: GTN 07 Start Date*: 2008-03-27
    Sponsor Name:SOFAR SPA
    Full Title: Efficacy and tolerability of a 0.25%glyceryl trinitrate ointment in the treatment of chronic rectal fissures.A multicentric, randomised, open study,controlled vs. Antrolin cream.
    Medical condition: chronic anal fissures
    Disease: Version SOC Term Classification Code Term Level
    9.1 10002153 Anal fissure LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2005-001958-24 Sponsor Protocol Number: DIL 05 Start Date*: 2005-10-18
    Sponsor Name:SOFAR SPA
    Full Title: Efficacy and tolerability of Diltiazem cream in the treatment of chronic anal fissure: a prospective,randomized, double blind study versus glyceryl trinitrate.
    Medical condition: Treatment of chronic anal fissures.
    Disease: Version SOC Term Classification Code Term Level
    6.1 10002153 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2006-003931-63 Sponsor Protocol Number: D-CAF-06 Start Date*: 2007-02-19
    Sponsor Name:S.L.A. Pharma (UK) Ltd
    Full Title: A double-blind, placebo-controlled, randomised, multi-centre, dose-ranging study to determine the safety and efficacy of three concentrations of topical diltiazem cream in the treatment of chronic ...
    Medical condition: Chronic anal fissure
    Disease: Version SOC Term Classification Code Term Level
    8.1 10002153 Anal fissure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2008-005172-26 Sponsor Protocol Number: D-AF-09 Start Date*: 2010-09-06
    Sponsor Name:S.L.A. Pharma (UK) Ltd
    Full Title: A Randomised, Double-Blind, Placebo-Controlled Trial of the Safety and Efficacy of Diltiazem Hydrochloride Cream in Subjects with Anal Fissure
    Medical condition: Symptomatic relief of pain related to anal fissure (AF).
    Disease: Version SOC Term Classification Code Term Level
    12.1 10002153 Anal fissure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) GB (Completed) LT (Completed) ES (Completed) BG (Completed) SK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-001216-11 Sponsor Protocol Number: FISAN-BOT-2017-01 Start Date*: 2017-04-25
    Sponsor Name:Dra. A. Teresa Calderón Duque
    Full Title: Usefulness of botulinum toxin type A in the treatment of chronic anal fissure
    Medical condition: Chronic anal fissure
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-018506-37 Sponsor Protocol Number: NITRODIL-2010 Start Date*: 2010-11-25
    Sponsor Name:Mª Isabel Fernández García
    Full Title: Ensayo clínico randomizado, de grupos paralelos para estudiar la eficacia y seguridad de diltiazem frente a nitroglicerina en pacientes con fisura anal.
    Medical condition: Fisura anal
    Disease: Version SOC Term Classification Code Term Level
    11 10002153 Fisura anal PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-003351-65 Sponsor Protocol Number: RDD110 Start Date*: 2016-03-16
    Sponsor Name:RDD Pharma Ltd.
    Full Title: The Effect of Intra-anal Nifedipine, Used As Add-on to Conservative Therapy, on Pain in Patients with Anal Fissure
    Medical condition: Anal Fissure
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BG (Completed) PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-000853-30 Sponsor Protocol Number: DRGT119C01 Start Date*: 2019-05-31
    Sponsor Name:Druggability Technologies Holdings Ltd
    Full Title: A Randomized, Double-Blind, Adaptive Trial with an Open-Label Treatment Extension to Determine the Efficacy and Safety of Topical DRGT-119 0.1% and 0.2% Gels in Patients with Chronic Anal Fissure
    Medical condition: chronic anal fissure
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004856 10071195 Chronic anal fissure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2021-002819-60 Sponsor Protocol Number: FAC-BOTOX Start Date*: 2021-08-19
    Sponsor Name:Hospital Universitario de Burgos
    Full Title: Treatment of chronic anal fissure with ultrasound-guided intersphincteric infiltration of botulinum toxin A.
    Medical condition: Chronic anal fissure
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-003627-54 Sponsor Protocol Number: 150601 Start Date*: 2016-05-11
    Sponsor Name:Tecnimede, Sociedade Técnico-Medicinal, S.A.
    Full Title: Randomized, multicenter, placebo-controlled, double blind study to assess the efficacy and tolerability of 2% diltiazem hydrochloride in the treatment of chronic anal fissure and a 24 week follow-u...
    Medical condition: Cronic Anal fissure (CAF) The underlying pathogenesis of chronic anal fissure involves initial local trauma (generally caused by hard stools), resulting in a wound, internal anal sphincter spasm an...
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000016260 10071195 Chronic anal fissure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2005-005675-15 Sponsor Protocol Number: DIL-UBI-DEX-CLOII/2003/003/PT Start Date*: 2008-10-08
    Sponsor Name:Tecnimede, Sociedade Técnico-Medicinal S.A.
    Full Title: Randomized, multicenter, placebo-controlled, single blind study to assess the efficacy and tolerability of a combination of a cream containing ubidecarenone, dexpanthenol and chlorohexidine and a p...
    Medical condition: Cronic Anal fissure (CAF) The underlying pathogenesis of chronic anal fissure involves initial local trauma (generally caused by hard stools), resulting in a wound, internal anal sphincter spasm an...
    Disease: Version SOC Term Classification Code Term Level
    16.0 100000004856 10071195 Chronic anal fissure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PT (Completed) CZ (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2012-003753-28 Sponsor Protocol Number: VEN307-AF-001 Start Date*: 2013-09-09
    Sponsor Name:Ventrus Biosciences
    Full Title: A Phase 3B, Randomized, Double-Blind, Placebo-controlled, Parallel-Treatment Group, Multicenter Efficacy and Safety Study of Topical Diltiazem Hydrochloride 2% Cream in subjects with Anal Fissure
    Medical condition: Pain associated with anal fissures
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Completed) BG (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-023538-22 Sponsor Protocol Number: LY107 Start Date*: 2011-08-30
    Sponsor Name:Lipid Pharmaceuticals
    Full Title: Lýsi sem hægðalyf fyrir börn
    Medical condition: The primary objective of this trial is to investigate the laxative effect of Lysisstílar (Free Fatty Acids suppositories) as compared to Klyx. Participants are children aged 1 year old to 17 year...
    Disease:
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IS (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-002811-33 Sponsor Protocol Number: LAINCO1107 Start Date*: 2017-12-11
    Sponsor Name:LAINCO S.A
    Full Title: Unilateral, open and randomized phase IV study of 2 groups to assess the degree of comfort with simple Emuliquen® in patients undergoing proctological surgery
    Medical condition: Surgery proctological
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000016398 10042759 Symptoms involving digestive system LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2013-003346-16 Sponsor Protocol Number: 2012-01-ANE Start Date*: 2017-02-16
    Sponsor Name:Hospital Universitari Sagrat cor
    Full Title: Comparative study between continuous perfusion and split doses in the treatment of postoperative pain
    Medical condition: Analgesic efficacy in postoperative acute pain
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-000245-12 Sponsor Protocol Number: Repha_1436 Start Date*: 2020-01-20
    Sponsor Name:Repha GmbH
    Full Title: Controlled clinical trial to evaluate the efficacy and safety of MYRRHINIL-INTEST® versus placebo in patients with diarrhea-dominant irritable bowel syndrome (IBS-D) and patients with mixed-type ir...
    Medical condition: A confirmed diagnosis of irritable bowel syndrome (IBS-D or IBS-M) by a specialist in gastroenterology and/or internal medicine and/or general medicine
    Disease: Version SOC Term Classification Code Term Level
    20.0 10017947 - Gastrointestinal disorders 10023002 Irritable bowel LLT
    26.0 10017947 - Gastrointestinal disorders 10060845 Diarrhea predominant irritable bowel syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2014-002072-92 Sponsor Protocol Number: B5161002 Start Date*: 2014-12-30
    Sponsor Name:Pfizer Inc. 235 East 42nd Street, New York, NY 10017
    Full Title: A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study to Evaluate The Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of PF-06252616 In Ambulatory Boys With ...
    Medical condition: Duchenne's Muscular Dystrophy
    Disease: Version SOC Term Classification Code Term Level
    19.0 10010331 - Congenital, familial and genetic disorders 10013801 Duchenne muscular dystrophy PT
    Population Age: Children, Adolescents, Under 18 Gender: Male
    Trial protocol: GB (Prematurely Ended) IT (Prematurely Ended) PL (Prematurely Ended) BG (Prematurely Ended)
    Trial results: View results
    Download Options:
    Number of Trials to download:
    Download Content:
    Download Format:
    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
    Query did not match any studies.
    For support, Contact us.
    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

    European Medicines Agency © 1995-Tue May 20 09:29:25 CEST 2025 | Domenico Scarlattilaan 6, 1083 HS Amsterdam, The Netherlands
    EMA HMA