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Clinical trials for Antimicrobial therapy

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    120 result(s) found for: Antimicrobial therapy. Displaying page 1 of 6.
    1  2  3  4  5  6  Next»
    EudraCT Number: 2016-004447-36 Sponsor Protocol Number: ZonMw848015005 Start Date*: 2017-06-23
    Sponsor Name:Stichting Rotterdams Onderzoeksconsortium Kindergeneeskunde
    Full Title: INTRAVENOUS-TO-ORAL ANTIBIOTIC SWITCH THERAPY FOR SUSPECTED NEONATAL BACTERIAL INFECTIONS: CLINICAL EFFICACY, SAFETY AND COST-EFFECTIVENESS
    Medical condition: Neonatal probable bacterial infection
    Disease:
    Population Age: Preterm newborn infants, Newborns, Under 18 Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-001376-73 Sponsor Protocol Number: INN-TOP-003 Start Date*: 2008-12-16
    Sponsor Name:Innocoll Technologies
    Full Title: A Randomized, Controlled, Open-Label Study to Investigate the Safety and Efficacy of a Topical Gentamicin-Collagen Sponge (Collatamp® G) in Combination With Antimicrobial Therapy Compared to Antimi...
    Medical condition: Diabetic patients with a moderate infection of a lower extremity skin ulcer
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012664 Diabetic foot ulcer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2005-001363-58 Sponsor Protocol Number: PPAPR0202 Start Date*: 2006-11-14
    Sponsor Name:Photopharmica Ltd
    Full Title: Phase IIa randomised, placebo controlled trial to investiagte antimicrobial photodynamic therapy in chronic leg ulcers and diabetic foot ulcers.
    Medical condition: Chronic leg ulcers and chronic diabetic foot ulcers
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-005079-90 Sponsor Protocol Number: PPA/904W/003 Start Date*: 2008-12-18
    Sponsor Name:Photopharmica Ltd
    Full Title: Phase II randomised, placebo controlled trial to investigate repeat dose antimicrobial photodynamic therapy in patients with chronic leg ulcers
    Medical condition: Chronic leg ulcers
    Disease: Version SOC Term Classification Code Term Level
    9.1 10066677 Chronic leg ulcer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2017-002532-16 Sponsor Protocol Number: 02 Start Date*: 2017-12-05
    Sponsor Name:Cliniques Universitaires Saint-Luc
    Full Title: Adjunctive systemic antimicrobial therapy in the surgical treatment of peri-implantitis. A prospective randomized clinical study
    Medical condition: To treat patients with chronic infection of dental implants. One group with antibiotics and one group without.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-004333-42 Sponsor Protocol Number: SISPCT Start Date*: Information not available in EudraCT
    Sponsor Name:Friedrich-Schiller-University of Jena
    Full Title: Prospective randomized clinical multicenter trial about the effect of an adjunctive intravenous treatment with sodium selenite (selenase®T, double-blind) and a procalcitonin guided causal therapy (...
    Medical condition: severe sepsis / septic shock
    Disease: Version SOC Term Classification Code Term Level
    14.1 10021881 - Infections and infestations 10040047 Sepsis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-002197-78 Sponsor Protocol Number: APHP200011 Start Date*: 2021-08-19
    Sponsor Name:Assistance Publique - Hôpitaux de Paris
    Full Title: Antimicrobial Stewardship For Ventilator Associated Pneumonia in Intensive Care Acronym: ASPIC
    Medical condition: ventilator associated neumonia in intensive care
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2008-000036-41 Sponsor Protocol Number: IPTG-01 Start Date*: 2014-04-08
    Sponsor Name:Dermal Laboratories Ltd
    Full Title: An antimicrobial cream for the treatment of impetigo
    Medical condition: The condition to be studied is uncomplicated localised primary non-bullous impetigo, suitable for topical antibacterial therapy alone.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021881 - Infections and infestations 10021531 Impetigo PT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2013-002148-95 Sponsor Protocol Number: SHORTEN Start Date*: 2014-05-21
    Sponsor Name:Fundación Pública Andaluza para la Gestión en Salud de Sevilla (FISEVI)
    Full Title: Optimal duration of the antimicribial treatment for bloodstream infections produced by Enterobacteriaceae. Clinical trial "SHORTEN".
    Medical condition: Adult patients with bloodstream infections produced by Enterobacteriaceae.
    Disease: Version SOC Term Classification Code Term Level
    16.1 10021881 - Infections and infestations 10060945 Bacterial infection PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-003931-30 Sponsor Protocol Number: CBS-EAM-10d Start Date*: Information not available in EudraCT
    Sponsor Name:Hôpital Universitaire Des Enfants Reine Fabiola
    Full Title: A prospective open-label study on efficacy and tolerability of colloidal bismuth sub-citrate as adjunctive therapy to a combination of esomeprazole, amoxicillin and metronidazole for 10 days for He...
    Medical condition: Helicobacter pylory infection
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004862 10019377 Helicobacter pylori infection LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-004211-30 Sponsor Protocol Number: 2005-23 Start Date*: 2005-10-17
    Sponsor Name:The Norwegian Radium Hospital
    Full Title: Penicillin G and an aminoglycoside versus meropenem as initial empiric antibiotic therapy in lymphoma and leukemia patients with febrile neutropenia
    Medical condition: Lymphoma and leukemia patients with febrile neutropenia
    Disease:
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-000136-17 Sponsor Protocol Number: Target_ZKSJ0085 Start Date*: 2016-08-22
    Sponsor Name:Friedrich Schiller University Jena
    Full Title: Prospective, randomized, multicenter clinical trial on the impact of Therapeutic Drug Monitoring (TDM) of piperacillin on organ functions and survival in the treatment of severe sepsis or septic shock
    Medical condition: Patients with a severe sepsis oder a septic shock treatet with piperacillin/tazobactam
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2021-001396-16 Sponsor Protocol Number: OP0595-6 Start Date*: 2023-03-29
    Sponsor Name:Meiji Seika Pharma Co., Ltd.
    Full Title: A Phase 3, Multi-Center, Randomized, Single-Blind Study to Assess the Efficacy and Safety of Cefepime/Nacubactam and Aztreonam/Nacubactam Versus Best Available Therapy in Adults With Complicated Ur...
    Medical condition: Complicated urinary tract infection (cUTI), acute uncomplicated pyelonephritis (AP), hospital acquired bacterial pneumonia (HABP), ventilator-associated bacterial pneumonia (VABP), and complicated ...
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004862 10080628 Complicated urinary tract infection LLT
    20.1 100000004862 10079985 Uncomplicated pyelonephritis LLT
    21.1 100000004862 10081414 Ventilator associated bacterial pneumonia LLT
    20.1 100000004862 10079983 Complicated intra-abdominal infection LLT
    21.1 100000004862 10081416 Hospital acquired bacterial pneumonia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned) SK (Trial now transitioned) GR (Trial now transitioned) LV (Trial now transitioned) ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-001376-38 Sponsor Protocol Number: LOCKIA Start Date*: 2019-08-13
    Sponsor Name:María Dolores Sousa Regueiro
    Full Title: Antimicrobials Local Administration for Intraabdominal Abscesses Treatment: Controlled, Randomized, Open, Parallel Groups, Clinical Trial
    Medical condition: Intra-abdominal abscesses
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-007640-10 Sponsor Protocol Number: J&P002/2007 Start Date*: 2009-01-28
    Sponsor Name:PD Dr. med. K-H. Konz
    Full Title: Tissue pharmacokinetics of daptomycin measured by in vivo microdialysis in patients with diabetic foot infection
    Medical condition: A group of adult male or female patients with documented diabetes and bacterial soft tissue infection of the foot who must be subjected to undergo intravenous antimicrobial therapy with broad-spect...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-006153-41 Sponsor Protocol Number: J&P004/2008 Start Date*: 2009-03-30
    Sponsor Name:Medical university Graz, Department of Plastic Surgery
    Full Title: Target site pharmacokinetics of linezolid after repetitive doses in diabetic patients with bacterial foot infection
    Medical condition: The study population will consist of a representative group of adult male or female patients with documented diabetes and bacterial soft tissue infection of the foot complicated by osteomyelitis. P...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2008-006949-75 Sponsor Protocol Number: J&P005/2008 Start Date*: 2009-08-13
    Sponsor Name:Medical University Graz, Department for Plastic Surgery
    Full Title: Tissue pharmacokinetics of daptomycin measured by in vivo microdialysis in patients with diabetic foot infection
    Medical condition: A group of adult male or female patients with documented diabetes and bacterial soft tissue infection of the foot who must be subjected to undergo intravenous antimicrobial therapy with broad spect...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2006-001855-37 Sponsor Protocol Number: OCT02-2006 Start Date*: 2007-05-14
    Sponsor Name:Schülke & Mayr GmbH
    Full Title: Effect of an octenidine-based topical antimicrobial agent (Octenisept) on wound healing of chronic venous leg ulcers: a prospective, twelve-week comparison versus local treatment with Ringer soluti...
    Medical condition: Chronic venous leg ulcers In Germany, approximately three million people suffer from chronic leg ulcers of various origins. These ulcers are often very painful and extremely cost-intensive disease...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10066677 Chronic leg ulcer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) FR (Completed) HU (Prematurely Ended) GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2014-004037-10 Sponsor Protocol Number: CE01-119 Start Date*: 2014-10-10
    Sponsor Name:Cempra Pharmaceuticals, Inc.
    Full Title: A phase 1, open-label, multi-centre study to determine the PK and safety of a 5-day oral dosing of solithromycin as add-on therapy to antimicrobial agent administered to adolescent with suspected o...
    Medical condition: suspected or confirmed bacterial infection
    Disease:
    Population Age: Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2011-000064-10 Sponsor Protocol Number: Fistula-SD-MD Start Date*: 2011-03-17
    Sponsor Name:Med. Univ. Wien, Klinik für klinische Pharmakologie
    Full Title: Target site pharmacokinetics of linezolid or tigecycline in patients with severe skin and skin structure infections (SSSI) associated with chronic fistulas.
    Medical condition: The findings of the present study will enable assessing whether currently employed therapy regimens with linezolid or tigecycline provide effective antimicrobial concentrations at the target site o...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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