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Clinical trials for Corneal disease

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    124 result(s) found for: Corneal disease. Displaying page 1 of 7.
    1  2  3  4  5  6  7  Next»
    EudraCT Number: 2007-003253-88 Sponsor Protocol Number: 802/07 Start Date*: 2008-04-04
    Sponsor Name:POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI
    Full Title: morpho-functional evaluation of eye disease with corneal neovascularitation after subconjuctival injection of bevacizumab. Interventional pilot study.
    Medical condition: disease with corneal neovascularization
    Disease: Version SOC Term Classification Code Term Level
    12.0 10055665 Corneal neovascularisation LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-007984-17 Sponsor Protocol Number: PETC1002 Start Date*: 2009-03-02
    Sponsor Name:Moorfields Eye Hospital NHS Foundation Trust
    Full Title: Pilot randomised placebo-controlled double-masked clinical trial of subconjunctival Bevacizumab on eyes with recent onset of corneal neovascularisation
    Medical condition: Corneal neovascularisation
    Disease: Version SOC Term Classification Code Term Level
    9.1 10055665 Corneal neovascularisation LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2010-022858-16 Sponsor Protocol Number: I07034 Start Date*: 2011-06-27
    Sponsor Name:CHU de Limoges
    Full Title: EFFECT OF BEVACIZUMAB SUBCONJUNCTIVAL INJECTIONS ON CORNEAL NEWVESSELS
    Medical condition: Corneal neovascularisation
    Disease: Version SOC Term Classification Code Term Level
    14.0 10015919 - Eye disorders 10055665 Corneal neovascularisation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2007-007787-25 Sponsor Protocol Number: RE OC-02/2007 Start Date*: 2007-12-18
    Sponsor Name:AZIENDA OSPEDALIERA ARCISPEDALE S. MARIA NUOVA
    Full Title: Use of subconjunctival Bevacizumab (Avastin) in treatment of corneal neovascularization non curable with standard protocols (topical and sistemic steroids).
    Medical condition: Corneal neovascularization
    Disease: Version SOC Term Classification Code Term Level
    9.1 10055665 Corneal neovascularisation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-017161-28 Sponsor Protocol Number: EO031109 Start Date*: 2010-01-19
    Sponsor Name:Juha Holopainen
    Full Title: VEGF-estäjä bevasitsumabi sarveiskalvon uudissuonituksen hoidossa.
    Medical condition: Tutkittavilla henkilöillä on sarveiskalvolla patologinen uudissuonitus, jonka etiologia voi olla esim. keratiitti tai limbusalueen sairaus. Sarveiskalvon uudissuonitus johtaa sarveiskalvon samentum...
    Disease: Version SOC Term Classification Code Term Level
    12.1 10011031 Corneal neovascularization LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2010-020683-38 Sponsor Protocol Number: CHUBX 2009/30 Start Date*: 2010-07-23
    Sponsor Name:CHU de Bordeaux
    Full Title: Injection sous-conjonctivale de ranibizumab (Lucentis®) dans le traitement de la néovascularisation cornéenne : étude pilote de phase I/II
    Medical condition: néovascularisation cornéenne
    Disease: Version SOC Term Classification Code Term Level
    12.1 10055665 Corneal neovascularisation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-024290-40 Sponsor Protocol Number: CAH/Ulc/2010 Start Date*: 2012-12-04
    Sponsor Name:FUNDACIÓN PROGRESO Y SALUD
    Full Title: Multicenter clinical trial to evaluate the safety and feasibility of allogeneic tissue engineered product (human nanostructured artificial cornea) in patients with advanced corneal trophic ulcers r...
    Medical condition: trophic corneal ulcers refractaries to conventional treatment
    Disease: Version SOC Term Classification Code Term Level
    14.1 10015919 - Eye disorders 10048492 Corneal ulcer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: View results
    EudraCT Number: 2019-002475-34 Sponsor Protocol Number: REC0559-B-001 Start Date*: 2020-03-03
    Sponsor Name:Recordati Rare Diseases
    Full Title: Efficacy, Safety and Pharmacokinetics of 3 Doses of REC 0/0559 Eye Drops for the Treatment of Stage 2 (Moderate) and 3 (Severe) Neurotrophic Keratitis in Adult Patients
    Medical condition: Neurotrophic Keratitis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10015919 - Eye disorders 10069732 Neurotrophic keratopathy PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) FR (Completed) GB (GB - no longer in EU/EEA) DE (Completed) ES (Ongoing) IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-001841-23 Sponsor Protocol Number: I.2016.010 Start Date*: 2016-11-16
    Sponsor Name:Banc de Sang i Teixits
    Full Title: A multicenter, randomized, open-label, two-arms phase I/II clinical trial to asses efficacy and safety of cord blood eye drops in neurotrophic keratopathy
    Medical condition: Neurotrophic Keratitis, stage 2 or 3
    Disease: Version SOC Term Classification Code Term Level
    19.0 10015919 - Eye disorders 10064996 Ulcerative keratitis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2014-002845-23 Sponsor Protocol Number: CCD-GPLSCD01-03 Start Date*: 2015-12-16
    Sponsor Name:Holostem Terapie Avanzate s.r.l.
    Full Title: Multinational, multicentre, prospective, open-label, uncontrolled clinical trial to assess the efficacy and safety of Autologous Cultivated Limbal Stem Cells Transplantation (ACLSCT) for restoratio...
    Medical condition: corneal lesions with associated moderate to severe limbal stem cell deficiency due to ocular burns
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004853 10011012 Corneal epithelium opacity LLT
    Population Age: Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) GB (GB - no longer in EU/EEA) BE (Completed) NL (Ongoing) FR (Completed) PL (Completed) ES (Ongoing) IT (Completed)
    Trial results: View results
    EudraCT Number: 2012-002527-15 Sponsor Protocol Number: NGF0212 Start Date*: 2013-03-01
    Sponsor Name:Dompé farmaceutici s.p.a
    Full Title: Study Brand Name : REPARO Study full title: An 8-week phase I/II, multicenter, randomized, double-masked, vehicle controlled parallel group study with a 48 or 56 week follow-up period to evaluat...
    Medical condition: Adult patients diagnosed with unilateral stage 2 (persistent epithelial defect) and stage 3 (corneal ulcer) NK refractory to one or more conventional non-surgical treatments. Patients with Controla...
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004853 10032064 Other forms of keratitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed) PT (Completed) HU (Completed) ES (Completed) PL (Completed) BE (Completed)
    Trial results: View results
    EudraCT Number: 2015-003326-13 Sponsor Protocol Number: BTI-011-EC/15/QUER Start Date*: 2016-01-05
    Sponsor Name:BTI Biotechnology Institute I mas D
    Full Title: Randomized, parallel groups, multicenter and blind to evaluators clinical trial, to evaluate the efficacy and safety of PRGF-Endoret eye drops, in patients with stage 2 and 3 neurotrophic keratitis.
    Medical condition: Neurotrophic Keratitis (NK)
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-000523-14 Sponsor Protocol Number: EI17-00523 Start Date*: 2021-11-26
    Sponsor Name:Universidad Miguel Hernandez
    Full Title: Transplantation of autologous mesenchymal stem cells of adipose origin for the treatment of corneal diseases
    Medical condition: Corneal Diseases
    Disease: Version SOC Term Classification Code Term Level
    20.0 10015919 - Eye disorders 10023353 Keratoconus PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-000908-17 Sponsor Protocol Number: Siena Eye Cross Linking 2004 Start Date*: 2007-01-11
    Sponsor Name:AZIENDA OSPEDALIERA SENESE
    Full Title: Medical therapy of keratoconus with Riboflavin/Ultraviolet-A collagen Cross-Linking and investigation of the corneal stromal and Keratocytes modifications apoptosis and stromal repopulation with ...
    Medical condition: Patients affected by keratoconus worsening
    Disease: Version SOC Term Classification Code Term Level
    6.1 10023353 PT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-000608-16 Sponsor Protocol Number: 5466 Start Date*: 2011-12-21
    Sponsor Name:The Newcastle upon Tyne Hospitals NHS Foundation Trust [...]
    1. The Newcastle upon Tyne Hospitals NHS Foundation Trust
    2. The Newcastle upon Tyne Hospitals NHS Foundation Trust
    Full Title: To evaluate the safety and effectiveness of human ex vivo expanded autologous limbal stem cells for the treatment of unilateral total limbal stem cell deficiency
    Medical condition: unilateral total limbal stem cell deficiency
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2012-004410-34 Sponsor Protocol Number: FOM_PER_1_12 Start Date*: 2013-01-11
    Sponsor Name:Cristina Peris Martínez
    Full Title: Influence of timolol maleate (ophthalmic gel 1 mg/g) on the keratometry and the parameters of corneal biomechanics in patients with keratoconus.
    Medical condition: Keratoconus
    Disease: Version SOC Term Classification Code Term Level
    14.1 10015919 - Eye disorders 10023353 Keratoconus PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-005757-38 Sponsor Protocol Number: OFTACAMPOS_08_01 Start Date*: 2009-02-10
    Sponsor Name:AZIENDA OSPEDALIERA DI BOLOGNA POLICLINICO S. ORSOLA M. MALPIGHI
    Full Title: CORD BLOOD SERUM IN THE TREATMENT OF OCULAR SURFACE DISEASES (PILOT STUDY.)
    Medical condition: severe ocular surface disorders and the enhancement of corneal wound healing
    Disease: Version SOC Term Classification Code Term Level
    9.1 10011049 Corneal structural change, deposit and degeneration HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-024409-11 Sponsor Protocol Number: LSC-001 Start Date*: 2011-08-11
    Sponsor Name:Scottish National Blood Transfusion Service [...]
    1. Scottish National Blood Transfusion Service
    2. NHS Lothian
    Full Title: Pilot Clinical Assessment of Ex Vivo Expanded Corneal Limbal Stem Cell Transplantation in Patients with Severe Ocular Surface Disease (OSD) Arising from Limbal Stem Cell Deficiency
    Medical condition: Severe Ocular Surface Disease (OSD)
    Disease: Version SOC Term Classification Code Term Level
    14.1 10015919 - Eye disorders 10067103 Ocular surface disease PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2010-024254-11 Sponsor Protocol Number: CF101-301KCS Start Date*: 2011-03-30
    Sponsor Name:Can-Fite BioPharma, Ltd
    Full Title: A Phase 3, Randomized, Double-Masked, Placebo-Controlled, Dose-Finding, Parallel-Group Study of the Safety and Efficacy of Daily CF101 Administered Orally in Patients with Moderate-to-Severe Dry Ey...
    Medical condition: Moderate-to-severe Dry Eye disease
    Disease: Version SOC Term Classification Code Term Level
    14.1 10015919 - Eye disorders 10013774 Dry eye PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BG (Completed)
    Trial results: View results
    EudraCT Number: 2017-002490-19 Sponsor Protocol Number: UKER-FECD-RIPA-01 Start Date*: 2017-12-07
    Sponsor Name:Universitätsklinikum Erlangen
    Full Title: Prospective single-centre randomized observer-blind placebo-controlled parallel-group phase IIa clinical trial to investigate the safety and efficacy of ripasudil 0.4% eye drops after descemetorhex...
    Medical condition: Moderate to advanced Fuchs endothalial corneal dystrophy (FECD)
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004850 10062973 Fuchs' endothelial dystrophy LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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