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Clinical trials for Craniotomy

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
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    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    36 result(s) found for: Craniotomy. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2014-000962-23 Sponsor Protocol Number: REDEX Start Date*: 2014-07-10
    Sponsor Name:Consorci Parc de Salut Mar
    Full Title: Effect of dexmedetomidine on monitoring of motor evoked potentials in patients undergoing supratentorial craniotomy or brainstem surgery
    Medical condition: Patients scheduled for supratentorial craniotomy or brainstem surgery with intraoperative monitoring of motor evoked potentials (MEP).
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-006089-14 Sponsor Protocol Number: MIV-PK/PD-90255 Start Date*: 2008-02-21
    Sponsor Name:Neus Fabregas Julia - Hospital Clinic de Barcelona
    Full Title: Farmacocinética y farmacodinámica del mivacurio en los pacientes tratados de forma crónica con anticomiciales
    Medical condition: Anestesia en pacientes sometidos a neurocirugía
    Disease: Version SOC Term Classification Code Term Level
    9.1 10011322 Craniotomy LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-003954-15 Sponsor Protocol Number: BIOS-14-002 Start Date*: 2015-05-06
    Sponsor Name:Ethicon, Inc.
    Full Title: A single blinded, randomized, controlled study to evaluate the safety and effectiveness of EVICEL® Fibrin sealant (Human) compared to a Hydrogel sealant as an adjunct to sutured dural repair
    Medical condition: Cerebrospinal fluid leakage in posterior fossa or supratentorial procedures (craniectomy or craniotomy) during neurosurgery
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed) BE (Completed)
    Trial results: View results
    EudraCT Number: 2017-002616-13 Sponsor Protocol Number: Unknown Start Date*: 2018-03-14
    Sponsor Name:Maastricht Universitair Medisch Centrum
    Full Title: The effect of perioperative intravenous s-ketamine on acute and chronic postoperative craniotomy pain compared to placebo
    Medical condition: Post operative craniotomy pain
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2009-016501-41 Sponsor Protocol Number: 400-09-001 Start Date*: 2010-06-29
    Sponsor Name:Omrix Biopharmaceuticals Ltd
    Full Title: A Randomized, Controlled Study to Evaluate the Safety and Effectiveness of Evicel as an Adjunct to Sutured Dural Repair
    Medical condition: tissue adhesion/sealing and suture support in neurosurgery and surgical procedures where contact with cerebrospinal fluid or dura mater can occur e.g. otologic, rhinologic, ophthalmic and vertebral...
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: DE (Completed) BE (Completed) NL (Completed) FI (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2013-003558-26 Sponsor Protocol Number: BIOS-13-006 Start Date*: 2014-07-21
    Sponsor Name:Ethicon Inc
    Full Title: A Prospective, Randomized, Controlled, Study Evaluating the Safety and Efficacy of EVICEL® used for Suture-line sealing in Dura-Mater Closure during Paediatric Neurosurgical Cranial Procedures
    Medical condition: Subjects undergoing neurosurgical cranial procedures, requiring water-tight closures (suture-line sealing) in dura-mater during the surgery
    Disease:
    Population Age: Newborns, Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2017-002776-83 Sponsor Protocol Number: Neuro-Ox-2018 Start Date*: 2018-04-17
    Sponsor Name:Bispebjerg Hospital
    Full Title: Neuro-Ox-2018: Assessment of cerebral oxygenation under three clinically relevant conditions
    Medical condition: Patients undergoing neurosurgery
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004865 10053764 Brain tumor operation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-003346-42 Sponsor Protocol Number: Start Date*: 2006-09-14
    Sponsor Name:University Hospital
    Full Title: Does substituting isoflurane with propofol during the last hour of intracranial surgery shorten recovery time and reduce PONV?
    Medical condition: Postoperative nausea and vomiting (PONV) and postoperative recovery time.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-003032-23 Sponsor Protocol Number: AADC-010 Start Date*: 2019-10-09
    Sponsor Name:National Taiwan University Hospital
    Full Title: A Phase I/II Clinical Trial for Treatment of Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency Using AAV2-hAADC
    Medical condition: Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency
    Disease:
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2019-003072-39 Sponsor Protocol Number: NTUH-AADC-011 Start Date*: 2019-10-09
    Sponsor Name:National Taiwan University Hospital
    Full Title: A Clinical Trial for Treatment of Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency Using AAV2-hAADC - An Expansion
    Medical condition: Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency
    Disease:
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2015-005535-40 Sponsor Protocol Number: 3599-001 Start Date*: 2016-07-21
    Sponsor Name:Baxter Healthcare Corporation
    Full Title: A Randomised Controlled Study to Evaluate the Efficacy and Safety of Fibrin Sealant, Vapour Heated, Solvent/Detergent Treated (FS VH S/D 500 s-apr) Compared to DuraSeal Dural Sealant as an Adjunct ...
    Medical condition: Intra-operative CSF leak
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004852 10024091 Leakage of cerebrospinal fluid LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) CZ (Completed) ES (Completed) PL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2019-001542-17 Sponsor Protocol Number: T109/2019Xe-SAH Start Date*: 2020-09-17
    Sponsor Name:Timo Laitio
    Full Title: Effect of xenon on brain injury, neurological outcome and survival in patients after aneurysmal subarachnoid hemorrhage
    Medical condition: Acute rupture of cerebral aneurysm, subarachnoid hemorrhage (SAH), unconsciousness, brain injury.
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004852 10008078 Cerebral arterial aneurysm LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2007-005279-32 Sponsor Protocol Number: NeuroMorfeo - FARM6FKJKK Start Date*: 2007-12-10
    Sponsor Name:A.O. San Gerardo di Monza
    Full Title: ANESTHESIOLOGICAL STRATEGIES IN ELECTIVE CRANIOTOMY: RANDOMIZED, EQUIVALENCE, OPEN TRIAL
    Medical condition: Study population. This is a multicenter randomized, open label, controlled trial, utilizing an equivalence design and evaluating three different anesthesiological strategies in patients undergoin...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10053302 Nervous system surgery LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2012-003618-15 Sponsor Protocol Number: IRFMN-GBM-6272 Start Date*: 2013-09-17
    Sponsor Name:IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri"
    Full Title: Multicenter, randomized, non-comparative, open-label phase II trial on the efficacy of Ortataxel and Fotemustine in recurrent glioblastoma
    Medical condition: Glioblastoma in recurrence/progression after surgery (or biopsy), radiotherapy and chemotherapy with temozolomide
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2006-000113-38 Sponsor Protocol Number: UCL/05/177 Start Date*: 2007-03-07
    Sponsor Name:University College London
    Full Title: A randomised phase II double blind placebo controlled trial of Whole Brain Radiotherapy (WBRT) and Tarceva (OSI-774, erlotinib) in patients with advanced non-small cell lung cancer (NSCLC) with mul...
    Medical condition: Advanced non-small cell lung cancer with multiple brain metastases
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: Removed from public view
    EudraCT Number: 2018-003858-24 Sponsor Protocol Number: 252BN201 Start Date*: 2019-08-13
    Sponsor Name:Biogen Idec Research Limited
    Full Title: A Multicenter, Double-Blind, Multidose, Placebo-Controlled, Randomized, Parallel-Group, Phase 2 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 for Patients with Brain Contusion
    Medical condition: Brain contusion
    Disease: Version SOC Term Classification Code Term Level
    20.0 10022117 - Injury, poisoning and procedural complications 10052346 Brain contusion PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended) IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2012-003138-17 Sponsor Protocol Number: MO28347 Start Date*: 2013-06-13
    Sponsor Name:F. Hoffmann-La Roche Ltd
    Full Title: A double-blind, placebo-controlled, randomised, Phase II study evaluating the efficacy and safety of addition of continuous multiple line bevacizumab treatment to lomustine in second (2nd)-line f...
    Medical condition: Glioblastoma
    Disease: Version SOC Term Classification Code Term Level
    19.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10018336 Glioblastoma PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed) LT (Prematurely Ended) IT (Completed) IE (Prematurely Ended) EE (Prematurely Ended) GB (Prematurely Ended) LV (Prematurely Ended) ES (Completed) FI (Prematurely Ended) SE (Completed) PT (Prematurely Ended) BG (Prematurely Ended) GR (Completed) HR (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2007-006006-22 Sponsor Protocol Number: ICH01 Start Date*: 2009-01-14
    Sponsor Name:Newcastle upon Tyne Hospitals NHS Trust [...]
    1. Newcastle upon Tyne Hospitals NHS Trust
    2. Johns Hopkins University
    Full Title: Minimally Invasive Surgery plus rt-PA for ICH Evacuation
    Medical condition: intracerebral hemorrhage
    Disease: Version SOC Term Classification Code Term Level
    13.1 10042613 - Surgical and medical procedures 10062025 Intracerebral haematoma evacuation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2009-011696-68 Sponsor Protocol Number: 09014 Start Date*: 2009-10-09
    Sponsor Name:University of Nottingham
    Full Title: The effect of drugs used to reverse neuromuscular blockade on intra-cranial pressure
    Medical condition: intracranial pressure changes following craniotomy
    Disease: Version SOC Term Classification Code Term Level
    9.1 10050598 Brain operation NOS LLT
    9.1 10058952 Brain swelling LLT
    9.1 10061019 Brain neoplasm LLT
    9.1 10061030 Brain tumour LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2019-001906-61 Sponsor Protocol Number: 20180115 Start Date*: 2020-05-18
    Sponsor Name:Amgen Inc.
    Full Title: Phase 2 Study of Talimogene Laherparepvec in Combination With Pembrolizumab in Subjects With Unresectable/Metastatic Stage IIIB-IVM1d Melanoma Who Have Progressed on Prior Anti PD-1 Based Therapy
    Medical condition: Unresectable/Metastatic Stage IIIB-IVM1d Melanoma
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004864 10027481 Metastatic melanoma LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed) GR (Completed) PL (Prematurely Ended) ES (Ongoing) FR (Prematurely Ended) GB (GB - no longer in EU/EEA) DE (Completed) IT (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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